Clinical trials: Tissue Adhesions
Intrauterine Adhesion
Safety and Effectiveness of Juveena™ Hydrogel System Following Transcervical Gynecologic Procedures (TCGP) At High-Risk for Intrauterine Adhesions
This study is to determine whether intrauterine instillation of Juveena hydrogel following adhesiogenic hysteroscopic procedures (TCGP + Juveena) can safely and effectively reduce the incidence and severity of intrauterine…
- Trial name
- NCT05394662
- Testing
- Juveena Hydrogel System, Transcervical Gynecologic Procedures (TCGP)
- Where
- 15 sites in United States
- Volunteers
- 150 people
- Sponsor
- Rejoni Inc.
Surgical Adhesions
Study of PXL01 Versus Placebo to Inhibit Adhesion Formation After Flexor Tendon Surgery
The objectives of the study are to assess efficacy, safety, and handling of PXL01 in patients with flexor tendon injury in zone I or II.
- Trial name
- PHSU02 (NCT01022242)
- Testing
- PXL01
- Where
- 15 sites in Denmark, Germany and 1 more
- Volunteers
- 138 people
- Sponsor
- Pergamum AB
Epithelial Ovarian Cancer
Seprafilm™ for the Prevention of Intraperitoneal Adhesions and Improved Delivery of Therapy in Women Undergoing Staging and Intraperitoneal Chemotherapy for Advanced Ovarian Cancer
The purpose of this research is to determine if a film to prevent adhesions will improve the area of distribution of a contrast dye (representative of chemotherapy) in the abdominal cavity (belly) of women who have undergone…
- Trial name
- NCT01095367
- Testing
- Seprafilm™
- Where
- 2 sites in United States, Canada
- Volunteers
- 15 people
- Sponsor
- University of British Columbia
Prevenetion of Intrauterine Adhesions by Hyaluronic Acid Gel
Intrauterine Hyaluronic Acid Gel for Prevention of Intrauterine Adhesions
Women undergoing operative hysteroscopy for removal of retained placenta after delivery will be randomized into two groups. 1. study group - immediately after operative hysteroscopy 5 ml hyaluronic acid gel will be injected into…
- Trial name
- NCT04975373
- Testing
- Intrauterine injection of hyaluronic acid
- Where
- Israel
- Volunteers
- 160 people
- Sponsor
- Barzilai Medical Center
Nasal Synechiae, Adhesions of Nasal Cavity
Study of Mitomycin C and Nasal Splint to Treat Nasal Synechiae
This study evaluates whether Mitomycin C is an effective alternative to septal splints in the treatment of nasal synechiae.
- Conditions
- Nasal Synechiae, Adhesions of Nasal Cavity, Nasal Adhesions, Tissue Adhesions
- Trial name
- NCT00966056
- Testing
- Mitomycin C, Teflon nasal septal splint
- Where
- India
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Karnataka Institute of Medical Sciences
Adhesion Formation After Primary Cesarean Delivery
Seprafilm® for Prevention of Adhesions at Repeat Cesarean
Adhesion formation is a result of abdominal and pelvic surgery and is a cause of such diseases as chronic pain syndrome, bowel obstruction and infertility.
- Trial name
- SPARC (NCT00697606)
- Testing
- Seprafilm®, Control
- Where
- United States
- Volunteers
- 450 people
- Sponsor
- Abington Memorial Hospital
Adhesions Abdominal, Surgery
Is Preoperative Prediction of Intra-Abdominal Adhesions Possible?
In this study, it was aimed to evaluate the presence of intra-abdominal adhesion with biochemical markers before the operation, as well as to determine whether there is a relationship between the severity of adhesion and…
- Trial name
- NCT06639906
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people
- Sponsor
- Manisa Celal Bayar University
Small Bowel Obstruction
Early Small Bowel Obstruction Following Laparotomy For Trauma
The formation of intraperitoneal adhesion following abdominal surgery is accepted by clinicians as an inevitable consequence. More than 90% of patients undergoing a surgical procedure in the abdomen will develop intraperitoneal…
- Trial name
- NCT01068340
- Where
- United States
- Volunteers
- 571 people
- Sponsor
- University of Southern California
Myoma
Intrauterine Adhesion Rate After Hysteroscopic Myomectomy and Application of HYALOBARRIER Gel
The purpose of this study is to evaluate the intrauterine adhesion rate after the application of HYALOBARRIER Gel at the end of hysteroscopic myomectomy. Secondary endpoints were tolerance and side effect and subsequent fertility.
- Trial name
- HYGEM (NCT01412489)
- Testing
- HYALOBARRIER Gel
- Where
- France
- Volunteers
- 189 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Asherman Syndrome
Efficiency of Intercoat (Oxiplex/AP Gel)in Decreasing Intrauterine Adhesions
This is a prospective single blind randomized controlled pilot study was designed to investigate whether the biological barrier Intercoat (Oxiplex/AP gel) reduces formation of intrauterine adhesions following hysteroscopic…
- Trial name
- NCT01377779
- Testing
- Oxiplex/AP gel, Normal Saline
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Assaf-Harofeh Medical Center
Obesity, Overweight
Obesity & Pregnancy: Factors Influencing Participation in a Physical Activity and Nutritional Counseling Program
Background: Obesity increasingly affects young women and contributes to increased maternal, fetal and neonatal complications. Maternal obesity contributes to the subsequent development of childhood obesity not only through social…
- Conditions
- Obesity, Overweight, Pregnancy
- Trial name
- OGAN (NCT02701426)
- Testing
- physical activity and nutritional counseling
- Where
- France
- Volunteers
- 195 people
- Sponsor
- University Hospital, Lille
Chronic Sinusitis
Efficacy of Seprapack Sinus Dressing Versus No Dressing in the Prevention of Intranasal Adhesions Following Sinus Surgery
The purpose of this study is to investigate if the space occupying effect of Seprapack will lead to a reduction in post operative adhesions and more healing of the sinus cavity when compared to the use of no packing material.
- Trial name
- NCT00140608
- Testing
- Seprapack Sinus Dressing
- Where
- 3 sites in United States
- Sponsor
- Genzyme, a Sanofi Company
Pelvic Adhesions
A Clinical Study of Alanyl-Glutamine for Reduction of Post-Myomectomy Adhesions
This study evaluates whether L-Alanyl-L-Glutamine can reduce the incidence, extent and severity of adhesions after myomectomy. Half of the participants will receive L-Alanyl-L-Glutamine and the other half of participants will…
- Trial name
- NCT01701193
- Testing
- L-Alanyl/L-Glutamine, Physiologic saline
- Where
- Ukraine
- Volunteers
- 47 people
- Sponsor
- Temple Therapeutics BV
Prostate Cancer, Postoperative Adhesion
The Effect of Guardix-solution for the Prevention of Postoperative Intestinal Adhesion and Intestinal Obstruction After Laparoscopic Pelvic Cavity Surgery
To assess the anti-adhesive effect of treatment with hyaluronic acid-carboxymethylcellulose following laparoscopic pelvic surgery (radical prostatectomy).
- Trial name
- NCT02773251
- Testing
- hyaluronic acid-carboxymethylcellulose
- Volunteers
- 60 people
- Sponsor
- Bucheon St. Mary's Hospital
Thumb Joint Stiffness
Electrical Stimulation to Recover Greater Range of Motion After Surgery
Background One of the potentially debilitative complications of operative repair and subsequent immobilization is stiffness that appears secondary to inflammation and adhesions.
- Trial name
- NCT01082432
- Testing
- electrically induced muscle activation
- Where
- France
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Université Joseph Fourier
Adhesion, Thyroidectomy
Anti-adhesive Effect and Safety of "Thermo-sensitive Adhesion Barrier (MEDICLORE)"
One of most important complication of thyroid surgery is adhesion. There are many anti-adhesive materials, but none of them showed significant outcomes.
- Trial name
- NCT03293186
- Testing
- MEDICLORE
- Where
- South Korea
- Volunteers
- 90 people
- Sponsor
- Seoul National University Hospital
Endometriosis, Adhesion
Ovariopexy for Adhesion Prevention After Laparoscopic Removal of Endometriosis of the Pelvic Side Wall or the Ovary
prospective randomized Trial comparing ovariopexy over 2, 4 or 6 days vs Placebo after surgery because of endometriosis of the pelvic side wall or the ovary or both
- Conditions
- Endometriosis, Adhesion, Surgery
- Trial name
- NCT04669756
- Testing
- ovariopexy
- Where
- Germany
- Volunteers
- 409 people
- Sponsor
- University Hospital Muenster
Breast Cancer
IBCSG Trial 22-00 Serum Substudy
The serum protein research study is a substudy of the core study 'Maintenance Chemotherapy in Hormone Non-responsive Breast Cancer'.
- Trial name
- NCT02393833
- Testing
- Blood samples collection
- Where
- 3 sites in Italy, Nigeria and 1 more
- Volunteers
- 136 people
- Sponsor
- ETOP IBCSG Partners Foundation
Chronic Pain, Adhesions
Benefit of Laparoscopic Adhesiolysis in Patients With Chronische Abdominal Pain
Laparoscopic adhesiolysis as a therapy for chronic pain is still controversial and long term effects are not known. The objective was to to evaluate long term effects of laparoscopic adhesiolysis for treating chronic abdominal…
- Trial name
- NCT02839564
- Testing
- Laparoscopic adhesiolysis, Diagnostic laparoscopy
- Volunteers
- 100 people
- Sponsor
- Groene Hart Ziekenhuis
Sinusitis, Tissue Adhesion, Surgery-Induced
Efficacy and Safety for Medicurtain® in Prevention of Adhesion After Endoscopic Sinus Surgery (Pivotal Study)
This clinical trial is to prove that the treatment group of Medicurtain® is non-inferior to the treatment group of Guardix-sol®, test equipment on adhesion after endoscopic sinus surgery, upon the aspects of adhesion prevention…
- Trial name
- NCT05049434
- Testing
- Medicurtain®, GUARDIX-SG®
- Where
- South Korea
- Volunteers
- 77 people
- Sponsor
- Shin Poong Pharmaceutical Co. Ltd.