Clinical trials: Tissue Adhesions, open to volunteers
Meningioma
3D MRE-Based Evaluation of Meningioma Mechanical Properties and Histological Features
This prospective single-center study aims to evaluate the feasibility and clinical utility of three-dimensional magnetic resonance elastography (3D MRE) in assessing tumor stiffness and adhesion in patients with meningioma…
- Trial name
- NCT06955208
- Testing
- Magnetic Resonance Elastography, Intraoperative Assessment and Recording
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Shengjing Hospital
Intrauterine Adhesions
Clinical Study of i-PRF Intrauterine Perfusion for Endometrial Regeneration and Repair in Moderate to Severe Intrauterine Adhesions
Intrauterine adhesions (IUA) caused by endometrial basal layer injury can lead to reduced menstrual flow, infertility, recurrent pregnancy loss, and poor reproductive outcomes.
- Trial name
- IPRF-IUA (NCT07536971)
- Testing
- Injectable Platelet-Rich Fibrin, Sodium Hyaluronate
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Beijing Obstetrics and Gynecology Hospital
Tendon Adhesion, Zone II Flexor Tendon Injury
Ultrasound-Guided Repeated Saline Injections to Prevent and Treat Tendon Adhesions After Hand Tendon Repair
Scar tissue can form around a repaired tendon and restrict finger movement. This study will evaluate whether repeated ultrasound-guided normal saline injections, in addition to standard postoperative rehabilitation, can help…
- Trial name
- NCT07861568
- Testing
- Ultrasound-Guided Repeated Normal Saline Injections
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Kai Wang
Adhesions Bowel
Lap Adhesiolysis in Intestinal Obstruction
Comparison between the results of laparotomy and laparoscopy in adhesive intestinal obstruction and introduce the use of laparoscopy to the emergency setting in Asyut University Hospital.
- Trial name
- NCT06446440
- Testing
- Laparoscopic adhesiolysis, Open adhesiolysis
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Assiut University
Intrauterine Adhesions
hBMSC Uterine Artery Infusion for Severe IUA-Related Infertility
The goal of this clinical trial is to test a new approach: delivering human bone marrow mesenchymal stem cells (hBMSCs) via the uterine artery to treat infertility caused by severe intrauterine adhesions (IUA).
- Trial name
- NCT07176143
- Testing
- Delivering human bone marrow mesenchymal stem cells via the uterine artery
- Volunteers
- 60 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Giant Cell Arteritis, Polymyalgia Rheumatica
Assessing Biomarker in Giant Cell Arteritis and Polymyalgia Rheumatic
The GCAIO study is an innovative, multimodal research initiative designed to enhance the understanding, diagnosis, and management of giant cell arteritis (GCA) and frequently associated polymyalgia rheumatica (PMR).
- Trial name
- GCAIO (NCT06460142)
- Testing
- Aortic/ cardiac magnetic resonance imaging, Vascular ultrasound, Transorbital Ultrasound
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Bonn
Neuroendocrine Neoplasm, Neuroendocrine Carcinomas
Study of CTX-471 in Patients With Neural Cell Adhesion Molecule (NCAM) Positive Neuroendocrine Neoplasms
This study will enroll patients with central lab confirmed NCAM (CD56 IHC) positive metastatic neuroendocrine neoplasms that have progressed after standard of care treatment.
- Conditions
- Neuroendocrine Neoplasm, Neuroendocrine Carcinomas, Neuroendocrine Tumors
- Trial name
- NCT07684170
- Testing
- CTX-471
- Volunteers
- 58 people
- Sponsor
- Compass Therapeutics
Primary Immunodeficiency (PID), Congenital Bone Marrow Failure Syndromes
Data Collection Study of Patients With Non-Malignant Disorders Undergoing UCBT, BMT or PBSCT With RIC
This is a data collection study that will examine the general diagnostic and treatment data associated with the reduced-intensity chemotherapy-based regimen paired with simple alemtuzumab dosing strata designed to prevented graft…
- Conditions
- Primary Immunodeficiency (PID), Congenital Bone Marrow Failure Syndromes, Inherited Metabolic Disorders (IMD), Hereditary Anemias
- Trial name
- PRO-RIC (NCT04528355)
- Testing
- data collection
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Paul Szabolcs
Moderate-Severe Intrauterine Adhesions
A Study of GD007 (Human iPSC-Exosome Liquid Dressing) for Safety and Dose-Finding in Moderate-Severe Intrauterine Adhesions
Intrauterine adhesions (IUA) remain highly prevalent in China, with incidence rates steadily increasing due to the rising number of intrauterine procedures.
- Trial name
- GD007 (NCT07101484)
- Testing
- GD007 Low-dose drug group, GD007 Mid-dose drug group, GD007 High-dose drug group
- Where
- China
- Volunteers
- 29 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Pregnancy Complicated With Intrauterine Adhesion
Comparison of Operative Hysteroscopy and Vacuum Aspiration for Terminating First-trimester Pregnancy With Intrauterine Adhesions
In cases of early pregnancy complicated with intrauterine adhesions (IUAs), termination of pregnancy is prone to incomplete abortion with retained gestational products, failed abortion or uterine perforation due to altered…
- Trial name
- NCT07883057
- Testing
- Vacuum Aspiration Group, Hysteroscopy adhesiolysis combined with vacuum aspiration
- Where
- China
- Volunteers
- 360 people
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
Complete Edentulism
Microbial Adhesion and Peri-Implant Tissue Health in All-on-Four Hybrid Prostheses Supported by Zantex or Zirconia Frameworks
This study compares two materials (Zantex and Zirconia) used to make fixed full-arch dental prostheses supported by four dental implants (the "All-on-Four" technique) in patients who have no natural teeth in the lower jaw.
- Trial name
- NCT07811661
- Testing
- Zirconia Framework, Zantex Framework
- Where
- Egypt
- Volunteers
- 14 people
- Sponsor
- Kafrelsheikh University
Dysmenorrhea, Cesarean Section
Abdominopelvic Fascial Release for Post-Cesarean Menstrual Pain and Scar Mobility
The goal of this randomized controlled clinical trial is to determine whether adding abdominopelvic fascial release to a standardized stretching exercise program is more effective than stretching exercises alone in reducing…
- Conditions
- Dysmenorrhea, Cesarean Section, Postoperative Adhesions
- Trial name
- NCT07717983
- Testing
- Abdominopelvic fascial Release
- Volunteers
- 58 people
- Sponsor
- Cairo University
Infertile Women With Pelvic Adhesions
Role of Saline Infusion Sonohysterography in Detection of Pelvic Adhesions in Infertile Women
Infertility is agrowing concern affecting million of couples worldwide,with infertility being asignificant subset, infertility is define as inability to achieve pregnancy after one year of regular unprotected sexual intercours…
- Trial name
- NCT07416591
- Testing
- Saline infusion sonohysterography in Detection of pelvic Adhesions in infertile women
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Sohag University
Adhesive Small Bowel Obstruction
Predictors of Laparoscopy Conversion in Adhesive Small Bowel Obstruction
The goal of this observational study is to reveal predictors of unsuccessfull laparoscopic intervention in adult patients with adhesive small bowel obstruction.
- Trial name
- NCT07350447
- Testing
- Laparoscopic adhesiolysis, Laparotomic adhesiolysis
- Where
- 7 sites in Russia
- Volunteers
- 170 people
- Sponsor
- Almazov National Medical Research Centre
Glioma
Magnetic Resonance Elastography in Glioma: Exploring Tumor Stiffness and Adhesion
this study will investigate the relationship between tumor stiffness and adhesion in gliomas using MRE. By utilizing preoperative MRE and Intraoperative neuronavigation, followed by comprehensive molecular pathology analysis, we…
- Trial name
- NCT05990244
- Testing
- Magnetic Resonance Elastography, Assessment and Recording
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Shengjing Hospital
Vestibular Schwannoma
3D MRE-Based Evaluation of Vestibular Schwannoma Mechanical Properties and Histological Features
This prospective single-center study aims to evaluate the feasibility and clinical utility of three-dimensional magnetic resonance elastography (3D MRE) in assessing tumor stiffness and adhesion in patients with vestibular…
- Trial name
- NCT07844460
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Shengjing Hospital
Thin Endometrial Lining, Female Infertility
Evaluating Mechanically Engineered Stem Cell Exosomes for Treating Endometrial Injury: A Clinical Study
The goal of this clinical trial is to evaluate if engineered mechanically umbilical cord-derived stem cell exosomes, or conventional umbilical cord -derived stem cell exosomes, can improve endometrial thickness in women with thin…
- Conditions
- Thin Endometrial Lining, Female Infertility, Intrauterine Adhesions
- Trial name
- NCT06896747
- Testing
- Mechanically Engineered Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes, Umbilical cord mesenchymal stem cell-derived exosomes, platelet-rich plasma
- Where
- 2 sites in China
- Volunteers
- 90 people
- Sponsor
- Tang-Du Hospital
Adhesions, Hand Fractures
Lipofilling in Operative Hand Fracture Treatment
Background: Hand fractures are a common clinical problem worldwide and account for a substantial economic burden and workload for experienced hand surgeons.
- Conditions
- Adhesions, Hand Fractures, Tenolysis
- Trial name
- NCT07815444
- Testing
- Lipofilling in Operative Treatment of Proximal Phalanx Fractures and Related Tenolysis
- Where
- Netherlands
- Volunteers
- 130 people
- Sponsor
- Jeroen Bosch Ziekenhuis
Intraperitoneal Adhesions
Accuracy of Transabdominal Ultrasound in Predicting Intraperitoneal Adhesions Prior to Laparoscopy
Detecting Accuracy of transabdominal ultrasound in detecting intraperitoneal adhesions prior to laparoscopy ( which is the gold standard to visualize adhesions ) to detect safety of 1ry trocar insertion .
- Trial name
- NCT07605533
- Testing
- laparoscopy, transabdominal ultrasound
- Where
- Egypt
- Volunteers
- 74 people
- Sponsor
- Sohag University
Myoma
Prevention of Intra-uterine Adhesions Following Laparoscopic and Laparotomic Myomectomy
Clinical study on the prevention of intrauterine adhesions after laparoscopic or laparotomic myomectomy. Myomas are common in women of reproductive age and myomectomy can lead to intra-uterine adhesions, which can be detrimental…
- Trial name
- PALLM (NCT05683041)
- Testing
- Hyalobarrier
- Where
- Belgium
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent