Clinical trials: Tissue Engineering
Mesenchymal Stem Cells
Cartilage Tissue Engineering
In this study, the investigators explored the hypothesis that osteoarthritic cartilage fragments can promote chondrogenesis of MSCs.
- Trial name
- NCT01301664
- Testing
- total knee / hip replacement
- Sponsor
- Chin-Hung Chang
Colorectal Cancer, Healthy, no Evidence of Disease
Study of Biomarkers in Blood & Tissue Samples From Patients With Colorectal Cancer or Polyps & Patients Without Polyps
RATIONALE: Studying samples of blood and tissue in the laboratory from patients with cancer, patients with colorectal polyps and from patients without polyps may help doctors learn more about changes that occur in DNA and…
- Conditions
- Colorectal Cancer, Healthy, no Evidence of Disease, Precancerous Condition
- Trial name
- NCT00898378
- Testing
- gene expression analysis, polymerase chain reaction, polymorphism analysis
- Where
- United States
- Volunteers
- 551 people
- Sponsor
- Indiana University
Lumbar Spondylolisthesis Involving L4-L5, and/or, Degenerative Discopathy Involving L4-L5
Safety Study of Mesenchymal Stem Cells and Spinal Fusion
The present prospective, randomized study, compares the spinal fusion obtained after instrumentation and the use of a biologic product (patient's mesenchymal cells obtained from his/her own bone marrow which will be fixed in…
- Trial name
- NCT01552707
- Testing
- XCEL-MT-OSTEO-ALPHA, Standard treatment
- Where
- 5 sites in Spain
- Volunteers
- 69 people
- Sponsor
- Banc de Sang i Teixits
Glaucoma
Ologen (OculusGen)-Glaucoma MMC Control Trial in India
The purpose of this study is to compare the safety and effectiveness of the ologen (OculusGen) Biodegradable Collagen Matrix Implant and the MMC group in filtration surgery.
- Trial name
- NCT00449098
- Testing
- OculusGen Biodegradable Collagen Matrix Implant, Trabeculectomy with MMC
- Where
- India
- Volunteers
- 40 people
- Sponsor
- Pro Top & Mediking Company Limited
Bone Regeneration, Tissue Engineering
In Vivo Investigation of 6 Membranes Including Their Physical, Chemical and Biological Properties.
A wide range of resorbable and non-resorbable membranes have been investigated over the last decades. Barrier membranes protect bone defects from ingrowth of soft tissue cells, provide mechanical stability of the defect area and…
- Trial name
- NCT05443776
- Testing
- Biomaterial implantation
- Where
- Spain
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Universitat Internacional de Catalunya
Retinal Vascular, Normal Eyes
Evaluation of Heidelberg Engineering SPECTRALIS With OCT Angiography Module
Assessment of image quality and clinical relevance of OCT Angiography via comparison to FA/ICGA.
- Trial name
- NCT03279939
- Testing
- OCT Angiography, Color Fundus Photography, Fluorescein Angiography
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Heidelberg Engineering GmbH
Knee Osteoarthritis
Regenerative Medicine of Articular Cartilage: Characterization and Comparison of Chondrogenic Potential and Immunomodulatory Adult Mesenchymal Stem Cells
Articular cartilage can be the seat of many diseases including osteoarthritis and traumatic defaults. The cartilage has no intrinsic ability to repair resulting at long term in function loss in the joints.
- Trial name
- ARTHROSTEM (NCT01879046)
- Testing
- arthroplasty
- Where
- France
- Volunteers
- 35 people
- Sponsor
- Nantes University Hospital
Difficult to Heal Wounds
The Activity of Tissue Engineering Skin Substitutes
The main purpose of this experiment was to evaluate the activity of tissue engineering skin substitutes safety and efficacy studies for the treatment of difficult to heal wounds
- Trial name
- MSCs (NCT02668042)
- Testing
- liveness tissue skin
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Tooth, Impacted
Dental Stem Cells and Bone Tissue Engineering (CELSORDINO)
The main limitation in bone regeneration is the lack of vascularization of the newly shaped tissue. The main objective of this project is to check if the simultaneous differentiation of dental mesenchymal stem cells toward…
- Trial name
- CELSORDINO (NCT03194451)
- Testing
- non-interventional study
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Liver Disease, Liver Cirrhosis
Hepatocyte Matrix Implant Study
This clinical investigation of the hepatocyte matrix implant is an evaluation blinded non-randomized and monocentric pilot study of Phase I, which is conducted as a therapeutic investigation.
- Trial name
- HMI (NCT00935454)
- Testing
- Hepatocyte matrix implantation
- Where
- Switzerland
- Volunteers
- 10 people
- Sponsor
- Baermed
Skin Wound
Study With an Autologous Dermo-epidermal Skin Substitute for the Treatment of Full-Thickness Skin Defects in Adults and Children
This phase II trial aims to evaluate the efficacy and safety of EHSG-KF (synonym denovoSkin) in comparison to meshed STSG in adults and children with full-thickness Skin defects.
- Trial name
- NCT03394612
- Testing
- EHSG-KF, STSG
- Where
- 7 sites in Italy, Netherlands and 1 more
- Volunteers
- 21 people
- Sponsor
- CUTISS AG
Lupus Erythematosus, Systemic
CD19-Directed CAR-T Cell Therapy in Refractory Systemic Lupus Erythematosus
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease in which the immune system mistakenly attacks the body's own tissues and organs.
- Trial name
- CLEVER-SLE (NCT07659704)
- Testing
- Autologous CD19-Directed CAR-T Cells Manufactured at Ribeirão Preto Blood Center
- Where
- 2 sites in Brazil
- Volunteers
- 16 people
- Sponsor
- University of Sao Paulo
Glaucoma, Cataract
Ologen (OculusGen)-Phacotrabeculectomy Historical Control Study in India
1. . Study Objective: The objective of this study is to determine the safety and effectiveness of the OculusGenTM Biodegradable Collagen Matrix Implant in phacotrabeculectomy surgery.
- Trial name
- NCT00477685
- Testing
- OculusGen Biodegradable Collagen Matrix Implant
- Where
- India
- Volunteers
- 10 people
- Sponsor
- Pro Top & Mediking Company Limited
Degenerative Lesion of Articular Cartilage of Knee
Microfracture Versus Adipose Derived Stem Cells for the Treatment of Articular Cartilage Defects
The purpose of this study is to compare two biologic methods for the treatment of articular cartilage defects in the knee. The first method, microfracture, is the standard of care and is routinely used to recruit cells from the…
- Trial name
- NCT02090140
- Testing
- ADSC Application, Microfracture
- Where
- 3 sites in United States
- Volunteers
- 17 people
- Sponsor
- University of Colorado, Denver
Cleft Lip and Palate
Bone Tissue Engineering With Dental Pulp Stem Cells for Alveolar Cleft Repair
Iliac crest autogenous bone graft is accepted as the most effective method for secondary alveolar cleft repair. However this method is associated with complications.
- Trial name
- CLOSE (NCT03766217)
- Testing
- Mesenchymal stem cells associated with biomaterials, Iliac crest autogenous bone graft
- Where
- Brazil
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Hospital Sirio-Libanes
Diabetes Mellitus, Ulcer Foot
Examining the Effectiveness of DermGEN™ in the Treatment of Diabetic Foot Ulcers in First Nations People
The study will examine the effectiveness of a decellularized dermal matrix (i.e., DermGEN™) in improving wound healing, quality of life and associated costs of treatment of DFUs in First Nations people living in the Northwestern…
- Conditions
- Diabetes Mellitus, Ulcer Foot, Ulcer Healing, Diabetic Foot Ulcer
- Trial name
- NCT05251480
- Testing
- Standard of Care, DermGEN™
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- DeCell Technologies Inc.
Meniscus Tear, Knee Meniscus Injury
High-Purity Type I Collagen Augmentation in Meniscal Repair
This prospective, single-arm feasibility study evaluates the safety, procedural feasibility, and early clinical outcomes of High-Purity Type I Collagen used as an adjunct in arthroscopic meniscal repair.
- Conditions
- Meniscus Tear, Knee Meniscus Injury, Meniscal Repair, Knee Arthroscopy (for Diagnostic or Therapy)
- Trial name
- NCT07352410
- Testing
- High-Purity Type I Collagen
- Where
- India
- Volunteers
- 18 people
- Sponsor
- Adichunchanagiri Institute of Medical Sciences, B G Nagara
Multiple Sclerosis
Cytotron® Delivered Rotational Field Quantum Nuclear Magnetic Resonance Therapy for Multiple Sclerosis
The purpose of the study is to evaluate the efficacy of RFQMR therapy in remyelination in cases of Multiple sclerosis. The evaluation will be done based on MRI findings, by clinical/ neurological examination and by assessment of…
- Trial name
- RFQMR (NCT01220830)
- Testing
- Cytotron
- Where
- India
- Volunteers
- 40 people
- Sponsor
- The Centre for Advanced Research & Development, India
Second- or Third-degree Burns
Allogeneic ADSCs and Platelet-Poor Plasma Fibrin Hydrogel to Treat the Patients With Burn Wounds (ADSCs-BWs)
The purpose of this study is to evaluate safety and efficacy of tissue engineered construct based on allogeneic cultured adipose-derived multipotent mesenchymal stromal cells (ALLO-ADSCs) and platelet-poor plasma fibrin hydrogel…
- Trial name
- ADSCs-BWs (NCT03113747)
- Testing
- ALLO-ASCs
- Where
- Ukraine
- Volunteers
- 20 people
- Sponsor
- A.A. Partners, LLC
Normal Cornea, Corneal Abnormality
The Heidelberg Engineering ANTERION Corneal Epithelium Thickness Precision and Agreement Study
This is a prospective clinical study that will be conducted at one clinical site located in the United States to assess corneal epithelial thickness parameters with the ANTERION
- Trial name
- NCT05051813
- Testing
- ANTERION
- Where
- United States
- Volunteers
- 151 people, healthy volunteers welcome
- Sponsor
- Heidelberg Engineering GmbH