Clinical trials: Tissue Plasminogen Activator
Acute Ischemic Stroke
Thrombolysis Treated With TNK-tPA in Acute Ischemic Stroke Patients （3T Stroke-II）
The trial is prospective, block randomized, open-label, blinded endpoint (PROBE) design. Patients with acute ischemic stroke, who are eligible for standard intravenous thrombolysis within 4.5 hours of stroke onset will be…
- Trial name
- NCT05281549
- Testing
- Alteplase, Tenecteplase
- Where
- 28 sites in China
- Volunteers
- 225 people
- Sponsor
- Beijing Tiantan Hospital
Pulmonary Embolism Acute
Reduced-Dose Versus Full-Dose Alteplase for High-Risk Pulmonary Embolism
High-risk pulmonary embolism is a life-threatening condition requiring immediate reperfusion therapy. Full-dose systemic thrombolysis is recommended as first-line treatment, but its use is limited by the risk of major bleeding…
- Trial name
- REDSTEM (NCT07816978)
- Testing
- Reduced-dose alteplase, Full-dose alteplase
- Where
- 23 sites in Denmark, Norway and 1 more
- Volunteers
- 400 people
- Sponsor
- Sahlgrenska University Hospital
Stroke, Ischemic Stroke
Feasibility Study of IV Recombinant Tissue Plasminogen Activator (rtPA) vs. Primary Endovascular Therapy for Acute Ischemic Stroke
This pilot trial will be the first step toward direct comparison of delivery of endovascular reperfusion therapy to intravenous recombinant tissue plasminogen activator (rt-PA) in a time-to-treatment framework shown as most…
- Trial name
- EARLY (NCT01869478)
- Testing
- Intravenous Thrombolysis, Endovascular Arterial Reperfusion
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Mayo Clinic
Pleural Infection, Empyema
Fibrinolysis Compared to Thoracoscopy for Pleural Infection
The purpose of this prospective randomized clinical trial is to compare two currently accepted standard-of-care treatment strategies: Medical thoracoscopy as compared to instillation of intrapleural tissue Plasminogen Activator…
- Conditions
- Pleural Infection, Empyema, Pleural Diseases, Parapneumonic Effusion
- Trial name
- NCT03468933
- Testing
- tissue plasminogen activator (tPA) and human recombinant deoxyribonuclease (DNase), Medical Thoracoscopy
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Tulane University
Intraventricular Hemorrhage
Clinical Trial on Treatment of Intraventricular Hemorrhage
The specific objective of this trial is to determine the lowest dose and dose frequency possible with the best pharmacokinetic and safety profile and it's ability to remove a blood clot from the ventricular system.
- Trial name
- CLEAR IVH (NCT00650858)
- Testing
- tissue plasminogen activator, rt-PA (thrombolytic) (Cathflo)
- Where
- 25 sites in United States, Canada and 2 more
- Volunteers
- 52 people
- Sponsor
- Johns Hopkins University
HNSCC
Evaluation of the Tolerance of Afatinib in Combination With Docetaxel and Cisplatin in LAHNSCC Induction Chemotherapy
The purpose of the study is to determine the maximum tolerated dose (MTD) of afatinib administrated in combination with docetaxel (Taxotere®) and cisplatin in induction chemotherapy of locally advanced head and neck carcinoma in…
- Trial name
- TAPIS (NCT02216617)
- Testing
- Taxotere, Cisplatin, Afatinib
- Where
- France
- Volunteers
- 8 people
- Sponsor
- Groupe Oncologie Radiotherapie Tete et Cou
Ischaemic Heart Diseases
The Effect of Ischaemic-Reperfusion and Ischaemic Preconditioning on the Endogenous Fibrinolysis in Man
Heart attacks are usually caused by a blood clot blocking an artery supplying blood to the heart. Current treatments are designed at relieving this blockage as quickly as possible to minimise damage to the heart muscle.
- Trial name
- NCT00789243
- Testing
- Forearm vascular study
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Stroke Due to Basilar Artery Occlusion, Acute Cerebrovascular Accidents
Acute Basilar Artery Occlusion: Endovascular Interventions vs Standard Medical Treatment
This trial will provide valuable insights into the safety and efficacy of endovascular treatment for acute ischemic stroke patients with basilar artery occlusion within 8 hours of estimated occlusion time.
- Trial name
- BEST (NCT02441556)
- Testing
- endovascular treatment, standard medical therapy
- Where
- 44 sites in China
- Volunteers
- 131 people
- Sponsor
- Xinfeng Liu
Pulmonary Thromboembolisms, Pulmonary Embolism
Low Dose Rt-PA for Acute Normotensive Pulmonary Embolism With RVD
In selected patients with acute pulmonary embolism(PE), low dose (50mg/2h) recombinant tissue plasminogen activator (rt-PA) regimen had been reported to have less bleeding tendency than the FDA-approved rt-PA 100mg/2h regimen…
- Trial name
- NCT01531829
- Testing
- Recombinant tissue plasminogen activator (rt-PA), Low Molecular Weight Heparin
- Where
- 35 sites in China
- Volunteers
- 460 people
- Sponsor
- Beijing Chao Yang Hospital
Heart Transplantation
Brachial Artery t-PA Release in Heart Transplant Recipients
Bradykinin stimulates t-PA release from intact vessels, but not from endothelial cells in culture. It has been proposed that the nerves of blood vessels are the source of bradykinin stimulated t-PA release.
- Trial name
- P1A3C (NCT00780637)
- Testing
- Bradykinin
- Where
- United States
- Sponsor
- Vanderbilt University
Pleural Infection
Trial of Reduced Alteplase Dose for Parapneumonic Effusion (TRAPPE)
Objectives: A pilot study to assess the feasibility of a randomization trial protocol comparing low (2.5mg) and standard (10mg) doses of intrapleural tissue plasminogen activator (tPA) with deoxyribonucleases (DNase) in…
- Trial name
- NCT05766124
- Testing
- Tissue Plasminogen Activator
- Where
- 2 sites in Hong Kong
- Volunteers
- 30 people
- Sponsor
- Chinese University of Hong Kong
Ischemic Stroke
Thrombectomy in Patients Ineligible for iv tPA
the purpose of this study is to to compare the safety and effectiveness of stent-retrievers as a device class group with best medical care alone in the treatment of acute ischemic stroke (AIS) in patients who are not eligible for…
- Trial name
- THRILL (NCT02135926)
- Testing
- Thrombectomy, Best medical care
- Where
- 19 sites in Austria, Germany
- Volunteers
- 4 people
- Sponsor
- University Hospital Heidelberg
Acute ST-segment Elevation Myocardial Infarction
EARLY Routine Catheterization After Alteplase Fibrinolysis vs. PPCI in ST-Segment-Elevation MYOcardial Infarction
The EARLY-MYO (EARLY routine catheterization after alteplase fibrinolysis vs. primary PCI in acute ST-segment elevation MYOcardial infarction) is an investigator-initiated, prospective, multicenter, randomized (1:1), open-label…
- Trial name
- EARLY-MYO (NCT01930682)
- Testing
- Alteplase, Early post-fibrinolytic catheterisation, Primary PCI
- Where
- China
- Volunteers
- 344 people
- Sponsor
- RenJi Hospital
Myocardial Infarction
Trial to Compare the Efficacy and Safety of a Single Bolus of TNK-tPA (Tenecteplase, Metalyse®) With Accelerated Infusion of Rt-PA (Alteplase, Actilyse®) in Asian Patients With Acute Myocardial Infarction
The objective of this trial was to compare the efficacy and safety of a single bolus of TNK-tPA (tenecteplase, Metalyse®) compared with rt-PA (alteplase, Actilyse®) in Asian patients.
- Trial name
- NCT00148460
- Testing
- TNK-tPA, rt-PA
- Where
- 18 sites in China, Hong Kong and 1 more
- Volunteers
- 270 people
- Sponsor
- Boehringer Ingelheim
Abscess
Safety and Effectiveness of tPA in Intra-abdominal Abscesses
To determine if instillation of tissue plasminogen activator into a percutaneously drained intra-abdominal abscess cavity results in faster resolution of the abscess compared to normal standard of care.
- Trial name
- NCT00417768
- Testing
- Tissue Plasminogen Activator, Normal Saline
- Where
- Canada
- Volunteers
- 35 people
- Sponsor
- University Health Network, Toronto
Pleural Infection
Pleural Irrigation With Normal Saline Versus Intrapleural Fibrinolytic
Parapneumonic effusions caused by an infection of the pleural membranes occur in 40-57% of cases of pneumonia. A variable percentage (10-20%) of parapneumonic effusions progresses to empyema (pus) and/or abscess formation…
- Trial name
- PENTAD-FT (NCT05903417)
- Testing
- Intrapleural fibrinolytic with alteplase 5mg and pulmozyme 5 mg, Saline irrigation with 250 mls normal saline (over 1 hour)
- Where
- Malaysia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- National University of Malaysia
Intracranial Hemorrhages, Cerebrovascular Disorders
Minimally Invasive Surgery and rhTNK-tPA for Intracerebral Hemorrhage Evacuation
The purpose of this trial is to determine the safety of using a combination of robot-assisted stereotactic puncture and clot lysis with rhTNK-tPA to remove intracerebral hemorrhage (ICH) and to provide dose evidence for a phase…
- Conditions
- Intracranial Hemorrhages, Cerebrovascular Disorders, Cerebral Hemorrhage, Hemorrhage
- Trial name
- NCT06668441
- Testing
- Minimally invasive surgery plus low-dose rhTNK-tPA group, Minimally invasive surgery plus medium dose rhTNK-tPA group, Minimally invasive surgery plus high dose rhTNK-tPA group
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Beijing Tiantan Hospital
Myocardial Infarction
Full Dose Tenecteplase (TNK-tPA) Together With Heparin Sodium, Full Dose Tenecteplase With Enoxaparin, Half Dose Tenecteplase Together With Abciximab and Heparin Sodium in Patients With Acute Myocardial Infarction (AMI)
The objective of ASSENT 3 was to evaluate the safety and efficacy of full dose tenecteplase with heparin sodium (group A), full dose tenecteplase combined with enoxaparin (group B) and half dose tenecteplase combined with…
- Trial name
- ASSENT 3 (NCT02181985)
- Testing
- Full dose TNK-tPA, Half dose TNK-tPA, Heparin
- Volunteers
- 5,989 people
- Sponsor
- Boehringer Ingelheim
Stroke, Acute
r-tPA Thrombolytic Therapy in Combination With Remote Ischemic Conditioning for Acute Ischemic Stroke Recovery
to detect the efficiency and safety of intravenous rtPA combined with RIPC in acute ischemic stroke patients
- Trial name
- rtPA-RIC (NCT02886390)
- Testing
- ischemic conditioning
- Where
- 2 sites in China
- Volunteers
- 60 people
- Sponsor
- Capital Medical University
Stroke, Acute
FRALYSE Trial: Comparison of the Classical Rt-PA Procedure With a Longer Procedure in Acute Ischemic Stroke
Data from the literature have suggested that a longer time of thrombolysis might be more effective in ischemic stroke. We, the investigators at Hospices Civils de Lyon, have designed a randomized protocol to test this hypothesis.
- Trial name
- NCT00132509
- Testing
- DFIL, NINDS
- Where
- France
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon