Clinical trials: Tissue Transplantation
Blastic Plasmacytoid Dendritic Cell Neoplasm
Tagraxofusp in Treating Patients With Blastic Plasmacytoid Dendritic Cell Neoplasm After Stem Cell Transplant
This phase II trial studies the side effects of tagraxofusp in treating patients with blastic plasmacytoid dendritic cell neoplasm after stem cell transplant.
- Trial name
- NCT04317781
- Testing
- Tagraxofusp-erzs
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- M.D. Anderson Cancer Center
Implant
Soft and Hard Tissue Changes After Immediate Single-tooth Replacement
A recent systematic review (Lee et al, 2016) reported that placement of a soft tissue graft concurrent with immediate implantation may contribute to the stability of gingival level and the augmentation of soft tissue contour.
- Trial name
- NCT03784430
- Testing
- Immediate dental implant placement, Immediate dental implant placement with CTG
- Where
- Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Università Vita-Salute San Raffaele
Tooth Socket, Dental Implants
Impact of Soft Tissue Grafts on Tissue Alterations After Immediate Tooth Replacement
This study evaluates the impact of soft tissue grafts on soft tissue recession following immediate implant, provisional and bone graft placement in compromised sockets.
- Trial name
- NCT02922075
- Testing
- Connective tissue graft, Collagen matrix graft, Immediate implant
- Where
- Brazil
- Volunteers
- 24 people
- Sponsor
- São Paulo State University
Lysosomal Storage Disease, Peroxisomal Disorder
Reduced-Intensity Hematopoietic Stem Cell Transplant for High Risk Lysosomal and Peroxisomal Disorders
This study is designed to test the ability to achieve donor hematopoietic engraftment while maintaining low rates of transplant-related mortality (TRM) in patients with high-risk lysosomal and peroxisomal disorders using a novel…
- Trial name
- NCT01626092
- Testing
- Campath-1H, Clofarabine, Melphalan
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Esthetics
Immediate Versus Late Placement
Patients in need of a single implant in the premaxilla will be invited to participate in this multicenter randomized controlled trial (RCT).
- Trial name
- NCT04741607
- Testing
- Implant placement (BLX implant system, Straumann, Basel, Switzerland), Ridge preservation (Bio-Oss Collagen 250 mg, Geistlich Pharma AG, Wolhusen, Switserland), Socket seal (Mucograft Seal, Geistlich Pharma AG, Wolhusen, Switserland)
- Where
- 2 sites in Belgium
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Ghent
End Stage Renal Disease
Study to Evaluate the Safety of Chronic Administration of Simulect to Subjects Receiving a First Kidney Transplant
The study is undertaken to explore the safety of using Simulect at monthly dose intervals to reduce the need of high dose/level CNI's such as Prograf.
- Trial name
- Simulect (NCT00928811)
- Testing
- basiliximab
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Drexel University College of Medicine
Acute Myeloid Leukemia, Acute Lymphoid Leukemia
Precision-T: A Study of Orca-T in Recipients Undergoing Allogeneic Transplantation for Hematologic Malignancies
This study will evaluate the safety, tolerability, and efficacy of Orca-T, an allogeneic stem cell and T-cell immunotherapy biologic manufactured for each patient (transplant recipient) from the mobilized peripheral blood of a…
- Conditions
- Acute Myeloid Leukemia, Acute Lymphoid Leukemia, Myelodysplastic Syndromes, Acute Leukemia
- Trial name
- NCT04013685
- Testing
- Orca-T
- Where
- 21 sites in United States
- Volunteers
- 155 people
- Sponsor
- Orca Biosystems, Inc.
Systemic Sclerosis, SARS-CoV 2 Vaccination
Acceptance and Effectiveness of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-COV-2) Vaccination in Systemic Sclerosis Patients Treated by Autologous Hematopoietic Stem Cell Transplantation
On December 27th 2020, the implementation of SARS-CoV-2 vaccination in France first became available amongst all immunosuppressed patients at very high risk of severe Coronavirus Disease (COVID-19) infection, specifically for…
- Trial name
- COV2-VACCinSSc (NCT05960058)
- Volunteers
- 72 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Androgenetic Alopecia, Hair Loss/Baldness
Optimizing Parameters for Long-pulsed Nd:YAG Laser for Reducing Hair Shaft Diameter
This study evaluates the optimizing parameters of long pulse Nd:YAG Laser for reducing the size of hair shaft diameter of the donor for hair transplantation.
- Trial name
- NCT03394235
- Testing
- Long-pulsed, 1064nm Nd-YAG laser
- Where
- Thailand
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Institute of Dermatology, Thailand
Ovarian Cancer
Chemotherapy With or Without Peripheral Stem Cell Transplantation in Treating Patients With Persistent Ovarian Epithelial Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Peripheral stem cell transplantation may be able to replace immune cells that were destroyed by chemotherapy…
- Trial name
- NCT00002819
- Testing
- carboplatin, cyclophosphamide, mitoxantrone hydrochloride
- Where
- 64 sites in United States
- Sponsor
- Gynecologic Oncology Group
Immune Related Disorder, Tissue Damage
Clonal Fetal Mesenchymal Stem Cells (cfMSCs) for the Control of Immune-related Disorders
The primary objectives are to evaluate the safety and efficacy of infusion of the third party fully-characterized clonally derived fetal MSCs (cfMSCs) for the control of severe symptoms associated with acute and chronic…
- Trial name
- NCT03123458
- Testing
- clonal fetal MSCs
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Shenzhen Geno-Immune Medical Institute
Dental Implant
Mucograft Seal in ARP Follow-up
Rationale: Early implant placement with alveolar ridge preservation (ARP) using either a collagen matrix or a palatal graft rendered similar esthetic, clinical and PROMs to early implant placement without ARP, up to 1 year after…
- Trial name
- NCT05663385
- Where
- Netherlands
- Volunteers
- 75 people
- Sponsor
- Erasmus Medical Center
Gingival Recession
Effect Of Microneedling With Coronally Advanced Flap For Management of RT1 Gingival Recession In Thin Gingival Phenotype
The goal of this clinical trial is to explore the effect of microneedling to increase the gingival tissue thickness which could improve the outcome of root coverage in coronally advanced flap procedure in thin gingival phenotype.
- Trial name
- RT1 (NCT06988839)
- Testing
- Microneedling followed by coronally advanced flap, Coronally advanced flap with connective tissue graft
- Where
- India
- Volunteers
- 36 people
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Sarcoma
Combination Chemotherapy With or Without Peripheral Stem Cell Transplantation, Radiation Therapy, and/or Surgery in Treating Patients With Ewing's Sarcoma
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells.
- Trial name
- NCT00020566
- Testing
- dactinomycin, busulfan, doxorubicin hydrochloride
- Where
- 103 sites in United States, Australia and 3 more
- Volunteers
- 1,200 people
- Sponsor
- University of Leicester
Gingival Recession
The Influence of Non-Carious Cervical Lesions on Root Coverage
The goal of this prospective cohort study is to evaluate the effect of non-carious cervical lesions (NCCLs) on the outcome of root coverage therapy.
- Trial name
- NCT06438094
- Testing
- Root coverage surgery by means of a coronally advanced flap combined with a connective tissue graft, Reconstruction of the CEJ with a composite restoration followed by root coverage surgery by means of a coronally advanced flap combined with a connective tissue graft
- Where
- Spain
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Gonzalo Blasi
Breast Augmentation
Improved Breast Enlargement Using the Subject's Own Fat Tissue
The goal of this clinical study is to learn if the Medical Device Under Investigation (simply "the device") is safe to use in human adults undergoing breast augmentation surgery.
- Trial name
- SWIFT (NCT07869641)
- Testing
- An injectable, biodegradable hydrogel, in reconstitution medium, Reconstitution medium
- Where
- 2 sites in Belgium
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- 4Tissue
Lymphoma
VP and G-CSF With or Without Rituximab in Autologous Peripheral Stem Cell Transplant For NHL
RATIONALE: Drugs used in chemotherapy, such as busulfan, etoposide, and cyclophosphamide, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00274794
- Testing
- filgrastim, rituximab
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- The Cleveland Clinic
Chronic Effect of Ultraviolet Radiation on Photoaged Skin, Dermatologic Disorders
Safety Study of Bone Marrow Derived Stem Cells on Patients With Cutaneous Photoaging
The purpose of this study is to determine whether a one-time injection of allogeneic mesenchymal bone marrow cells is safe and beneficial in the treatment of photodamage on the face.
- Trial name
- NCT01771679
- Testing
- Allogeneic Mesenchymal Bone Marrow Cells
- Where
- 2 sites in United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Stemedica Cell Technologies, Inc.
Cervical Cancer
Fat Grafting for Vaginal Stenosis in Gynaelogical Cancer
The GRASS study looks at performing a technique called "Fat Tissue Grafting" to assess whether it can reduce the side effects of vaginal stenosis effects and improve the sexual function of participants who wish to preserve…
- Trial name
- GRASS (NCT06015360)
- Testing
- Fat Graft
- Where
- United Kingdom
- Volunteers
- 8 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Periodontitis, Periodontitis (Stage 3)
Morphological Characteristics of Mandibular Molar Furcation Involvement and Efficacy of Regenerative Surgical Treatment
This study consists of two components evaluating furcation involvement in mandibular molars among Stage III or Stage IV periodontitis patients.
- Conditions
- Periodontitis, Periodontitis (Stage 3), Furcation Defects
- Trial name
- NCT07770256
- Testing
- Acellular Dermal Matrix + EMD + Xenograft, Autogenous Connective Tissue Graft + EMD + Xenograft
- Where
- Vietnam
- Volunteers
- 98 people
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City
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