Clinical trials: Tobacco
Smoking Cessation, Nicotine Dependence
Varenicline and Motivational Advice for Smokers With Substance Use Disorders
The purpose of this study is to evaluate the effects of 12 weeks of varenicline as compared to nicotine replacement therapy for smoking cessation among outpatients in treatment for substance use disorders.
- Trial name
- VARSUD (NCT00756275)
- Testing
- Nicotine Replacement Treatment (NRT), varenicline, Behavioral counseling for smoking cessation
- Where
- United States
- Volunteers
- 158 people
- Sponsor
- Brown University
Chronic Pancreatitis, Genetic Mutation
An Observational Study on the Natural Course of Chronic Pancreatitis
To explore the impact on genetic and environmental factors for clinical manifestation, and the progression of chronic pancreatitis, including development of pancreatic insufficiency and other complications.
- Conditions
- Chronic Pancreatitis, Genetic Mutation, Smoking, Tobacco, Drinking, Alcohol
- Trial name
- NCT04574297
- Testing
- smoking and alcohol assumption, genetic sequencing
- Volunteers
- 798 people
- Sponsor
- Changhai Hospital
Tobacco Use Disorder
Neural Substrates in Nicotine Withdrawal
This study will test the hypothesis that a medication called tolcapone (Brand Name: Tasmar) will help reduce cognitive problems that smokers experience when they quit.
- Trial name
- NCT01001520
- Testing
- Tolcapone
- Where
- United States
- Volunteers
- 218 people
- Sponsor
- University of Pennsylvania
Smoking Cessation
Informing Tobacco Treatment Guidelines for African American Non-Daily Smokers
The researchers are testing if counseling alone or counseling plus over-the-counter nicotine replacement therapies (NRT), like the patch,gum, or lozenge, helps African American non-daily smokers quit smoking.
- Trial name
- NCT02244918
- Testing
- Nicotine Replacement Therapy, Smoking Cessation Counseling
- Where
- 2 sites in United States
- Volunteers
- 278 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Smoking Cessation
PATH Partnering to Achieve Tobacco-free Health
The overall aim of this 5-year project is to capitalize on the strong theoretical and promising empirical evidence for Acceptance \& Commitment Therapy (ACT) as an intervention for smoking cessation by comparing the effectiveness…
- Trial name
- PATH (NCT01533974)
- Testing
- Acceptance & Commitment Therapy (ACT), Cognitive Behavioral Therapy (CBT)
- Where
- United States
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Fred Hutchinson Cancer Center
Tobacco Dependence
Low Nicotine Cigarettes Plus Electronic Cigarettes
This study aims to determine the health effects of very low nicotine content in cigarettes, in conjunction with the availability of nicotine-containing electronic cigarettes (e-cigs) among smokers with mental health conditions…
- Trial name
- NCT04058717
- Testing
- Normal Nicotine Content research cigarettes, High Nicotine e-cigarette, Very Low Nicotine Content research cigarettes
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Smoking
Reduced Exposure Study Using THS 2.2 Menthol With 5 Days in a Confinement Setting and 85 Days in an Ambulatory Setting
The main goal of the study is to evaluate if the ad libitum use of the THS 2.2 Menthol (mTHS 2.2) for 5 days in confinement and after 85 days of product use in an ambulatory setting, by Japanese adult healthy smokers results in a…
- Trial name
- NCT01970995
- Testing
- THS 2.2 Menthol (mTHS 2.2), Smoking Abstinence (SA), Menthol Conventional Cigarette (mCC)
- Where
- Japan
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Philip Morris Products S.A.
Smoking, Tobacco Use
Impact of E-cigarette Characteristics on Reinforcement and Tobacco Use Patterns
The purpose of this project is to understand how different e-cigarettes influence their likeability and use among current smokers who try using e-cigarettes.
- Trial name
- NCT03844672
- Testing
- Low Power, High Power, Low Concentration
- Where
- United States
- Volunteers
- 93 people
- Sponsor
- Medical University of South Carolina
Alcohol Use Disorder, Cigarette Smoking
Semaglutide for Alcohol Use Disorder
This is an early-Phase II human laboratory trial using a randomized, placebo-controlled, dose-ranging design to investigate the effects of semaglutide, a GLP-1 receptor agonist, on alcohol-related outcomes in adults with alcohol…
- Trial name
- NCT05520775
- Testing
- Semaglutide
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Insomnia, Nicotine Dependence
Study of Lunesta Versus Placebo for Sleep Problems Related to Smoking Cessation and Zyban
Objectives: The primary objective of this study is to determine the efficacy of eszopiclone at treating sleep problems related to withdrawal from nicotine in healthy smokers attempting smoking cessation.
- Trial name
- NCT00511134
- Testing
- Eszopiclone, Bupropion
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Yale University
Smoking Cessation, Second Hand Tobacco Smoke
Smoke-free Home Intervention in Permanent Supportive Housing
The focus of this study is on expanding access to voluntary smoke-free homes to formerly homeless residents residing in permanent supportive housing and examining the impact of this intervention on reducing tobacco-caused…
- Trial name
- NCT04855357
- Testing
- Resident counselling, Staff Training
- Where
- United States
- Volunteers
- 452 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Tobacco Use Cessation
Engagement With an Adaptive Mobile Health Smoking Cessation Intervention
This is a pilot sequential multiple assignment trial (SMART) to understand the optimal timing to assess response to our smoking cessation text message intervention and to measure how adding medications alone compares to adding…
- Trial name
- NCT04020718
- Testing
- Brief telephone advice plus tailored text messages, Mailed nicotine replacement therapy, Proactive telephone coaching
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Massachusetts General Hospital
Smoking, Cigarette
Perceptions of Cigarette Smoking in Young Adults
This study focuses on menthol (n = 125) and non-menthol (n = 125) smoking young adults (YAs; defined here as ages 18 to 26).
- Trial name
- PRISM (NCT03953508)
- Testing
- Cigarette flavor type
- Where
- United States
- Volunteers
- 199 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Smoking Cessation
Partnering With Food Bank to Provide Tobacco Treatment to Underserved Smokers
This study evaluates the efficacy and economic impact of a theoretically-based, fully automated, interactive smartphone-based smoking cessation intervention.
- Trial name
- NCT05004662
- Testing
- Smartphone-delivered automated treatment, Nicotine patch, Counseling
- Where
- United States
- Volunteers
- 502 people, healthy volunteers welcome
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Little Cigars and Cigarillos (LCC) Use
Little Cigar and Cigarillo Warnings for Youth
This study explores the effect of the little cigars and cigarillos (LCC) warnings on youth who currently use, have ever used, or are susceptible to using LCCs.
- Trial name
- NCT06413797
- Testing
- FDA warnings + Image, FDA Warnings Text-Only, Surgeon General Text-Only Warnings
- Where
- United States
- Volunteers
- 928 people, healthy volunteers welcome
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Cigarette Smoking
Behavioral Activation Intervention for Smoking Cessation in Smokers With Depressive Symptoms
Depression related vulnerabilities are highly comorbid with smoking behavior and dramatically reduce cessation rates among both community and clinical samples.
- Trial name
- NCT01199380
- Testing
- Standard Treatment, Behavioral Activation Treatment for Smoking, Transdermal Nicotine Patch
- Where
- United States
- Volunteers
- 184 people
- Sponsor
- University of Maryland, College Park
Smoking Cessation
Post-Discharge Smoking Cessation Strategies: Helping HAND 4
This randomized controlled trial will compare the effectiveness of two models of post-discharge tobacco cessation treatment for adult smokers admitted to 3 U.S. hospitals.
- Trial name
- HH4 (NCT03603496)
- Testing
- Transitional Tobacco Care Management (TTCM), eReferral to State Tobacco Quitline (QL), Nicotine replacement therapy
- Where
- 3 sites in United States
- Volunteers
- 1,416 people
- Sponsor
- Massachusetts General Hospital
Smoking
Engaging Patients in Tobacco Cessation Resources in Dental Settings
The overarching goal of this project is to reduce smoking-associated morbidity and mortality by increasing the number of patients who are referred for tobacco cessation counseling.
- Trial name
- ENGAGE (NCT03656874)
- Testing
- Clinical Decision Support
- Where
- 3 sites in United States
- Volunteers
- 56 people
- Sponsor
- HealthPartners Institute
Cannabis Use Disorder, Tobacco Use Disorder
Clinical Trial Tobacco Marijuana
Approximately 50% of persons seeking treatment for cannabis-use disorders (CUDs) regularly smoke tobacco. Combining tobacco with cannabis has become a common method of smoking cannabis.
- Trial name
- RCTTM (NCT02277665)
- Testing
- CUD Treatment, Tobacco Treatment
- Where
- 3 sites in United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Smoking Cessation
Treatment of Smoking Lapses and Relapses
Many smokers who try to stop smoking with nicotine medications (NM) such as gum, lozenge and patch, go back to smoking (i.e., a slip or lapse).
- Trial name
- NCT01807871
- Testing
- nicotine patch, experimental use, nicotine patch, labeled use
- Where
- United States
- Volunteers
- 701 people, healthy volunteers welcome
- Sponsor
- University of Vermont