Clinical trials: Tobacco Abuse
Nicotine Dependence
Nicotine Related Brain Activity: The Influence of Smoking History and Blood Nicotine Levels
In this study, we sought to explore brain activity in nicotine-dependent men in response to acute intravenous nicotine using pharmacological magnetic resonance imaging (phMRI).
- Trial name
- NCT01588561
- Testing
- Intravenous Nicotine
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Nicotine Dependence
An Effectiveness Trial of Maintenance Therapy for Nicotine Dependence
The transdermal nicotine patch is the most widely used form of tobacco dependence treatment in the US and Europe, but most smokers are unable to successfully quit with this form of treatment.
- Trial name
- NCT01047527
- Testing
- Transdermal nicotine patch
- Where
- 2 sites in United States
- Volunteers
- 525 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Nicotine Dependence
Treatment for Nicotine Addiction in Women
The purpose of this study is to use a medication tolcapone and or placebo to test if the symptoms of nicotine withdrawal lessens , and or changes in smoking urges, and mental reasoning in female smokers over a 72 hour period.
- Trial name
- NCT02448654
- Testing
- Tolcapone, Sugar Pill
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Yale University
Healthy Smokers
Nicotine Patch Bioequivalence Study
The purpose of this study is to compare the relative bioavailability of nicotine following single application of a new transdermal formulation to that of a reference formulation.
- Trial name
- NCT01658202
- Testing
- V0116 transdermal patch (Test treatment ), Nicotine transdermal patch (Reference Treatment )
- Where
- France
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Pierre Fabre Medicament
Tobacco Use Disorder, Smoking Cessation
Quit-Smoking Study for Native Hawaiians
This study aims to help Native Hawaiian adults quit smoking by testing two common methods: nicotine gum and group-based counseling.
- Trial name
- NCT07075575
- Testing
- Nicotine Polacrilex Gum (2 mg), Cognitive Behavioral Group Therapy (CBGT)
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of Hawaii
Bipolar Disorder, Tobacco Use Disorder
A Future Thinking Intervention for Comorbid Tobacco Use Disorder and Bipolar Disorder
Future Self-BD is a 6-session virtual intervention that encourages participants to vividly generate personal and positive future events that they anticipate may be benefited by smoking cessation.
- Trial name
- NCT06609902
- Testing
- Future Self-BD, Daily Check-Ins
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Massachusetts General Hospital
Nicotine Dependence
Testing Financial Incentive Interventions in Dyadic-Smoker Couples
The proposed study investigates the feasibility and efficacy of FITs in dual-smoker couples [DSCs]. The core design is a three-group mixed repeated measures design, in which participants are randomized into one of three…
- Trial name
- NCT04832360
- Testing
- Financial Incentives
- Where
- United States
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- University of Georgia
Schizophrenia, Nicotine Dependence
Music to Reduce Use of Smoking in Patients With Schizophrenia
The purpose of this study is to explore the impact of self-selected music listening which targets disrupting the reward process maintaining smoking and additionally attenuating the reward processing deficits associated with…
- Conditions
- Schizophrenia, Nicotine Dependence, Smoking, Tobacco
- Trial name
- NCT03190161
- Testing
- Music session
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Tobacco Use Disorder
Tobacco Cessation in Postmenopausal Women (Part I) - 1
The purpose of this study is to evaluate the effects of ERT on appetitive behavior and withdrawal in short-term smoking cessation compared to smoking ad lib in postmenopausal female smokers.
- Trial name
- NCT00061061
- Testing
- Behavior Therapy
- Where
- United States
- Sponsor
- University of Minnesota
Nicotine Dependence
Smoked Nicotine Induced Changes in Hormone Function, Mood States and Behaviors
The proposed clinical studies will evaluate the acute effects of nicotine on the hypothalamic-pituitary-gonadal axis in women to test the hypothesis that nicotine alters gonadal steroid hormones, and/or disrupts feedback…
- Trial name
- NCT01636323
- Testing
- Nicotine
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Major Depressive Disorder, Nicotine Dependence
Treatment of Nicotine Dependence and Acute Depression
The purpose of this study is to assess the safety and feasibility of concurrent treatment of nicotine dependence (cigarette smoking) and acute depression.
- Trial name
- NCT00186446
- Testing
- bupropion and smoking cessation behavioral intervention
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Stanford University
Nicotine Dependence
Cessation Screening Project
This project will use the Multiphase Optimization Strategy (MOST) to guide the development of optimized treatment strategies for the two most effective smoking cessation medications (Combination Nicotine Replacement [C-NRT] and…
- Trial name
- NCT04188873
- Testing
- Preparation Varenicline and Standard Duration Varenicline, Preparation Varenicline and Extended Duration Varenicline, Standard Duration Varenicline
- Where
- 2 sites in United States
- Volunteers
- 538 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Tobacco Use Disorder
Neural Substrates in Nicotine Withdrawal
This study will test the hypothesis that a medication called tolcapone (Brand Name: Tasmar) will help reduce cognitive problems that smokers experience when they quit.
- Trial name
- NCT01001520
- Testing
- Tolcapone
- Where
- United States
- Volunteers
- 218 people
- Sponsor
- University of Pennsylvania
Alcoholism, Nicotine Dependence
Varenicline and Alcohol in Inpatient Addictions Program (IAP)
The overall hypothesis of this line of research is that varenicline will decrease alcohol consumption and tobacco use and will increase alcohol and tobacco abstinence rates.
- Trial name
- NCT01169610
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Mayo Clinic
Tobacco Dependence, Cardiovascular Diseases
Physical Activity as an Aid for Smoking Cessation
Including a tailored moderate-intensity physical activity intervention in a standard smoking cessation treatment program (pharmaceutical treatment and counseling) increases the chances of quitting and reduces nicotine withdrawal…
- Conditions
- Tobacco Dependence, Cardiovascular Diseases, Physical Activity
- Trial name
- PHASMO (NCT00521391)
- Testing
- Allez Hop
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of Lausanne Hospitals
Smoking, Nicotine Dependence
Low-Dose Naltrexone Combined With Bupropion to Stop Smoking With Less Weight Gain
This study will test a combination of the drugs naltrexone and bupropion with weight-concerned smokers to investigate whether or not this combination of drugs improves smoking cessation quit rates and minimizes post quit weight…
- Trial name
- NCT00129246
- Testing
- Naltrexone, Bupropion
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Yale University
Smoking, Tobacco Dependence
Using a Teachable Moment Communication Process to Improve Outcomes of Quitline Referrals
This study will compare the effectiveness of two approaches for delivering smoking cessation advice in the primary care setting.
- Trial name
- NCT02764385
- Testing
- Teachable Moment Communication Process, AAC
- Volunteers
- 15,786 people, healthy volunteers welcome
- Sponsor
- Case Western Reserve University
Smoking
Testing Methylphenidate for Smoking Abstinence
Cigarette smoking continues to be a major public health problem. Tobacco dependence interventions, as recommended by the USPHS Clinical Practice Guideline are not effective for all smokers.
- Trial name
- NCT00549640
- Testing
- Methylphenidate
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Nicotine Addiction
Pharmacogenetics of Nicotine Addiction Treatment
The purpose of this research program is to understand how a biomarker called the "nicotine metabolite ratio" (also referred to as NMR) may influence a smoker's ability to quit smoking.
- Trial name
- NCT01314001
- Testing
- Varenicline, Transdermal Nicotine
- Where
- 4 sites in United States, Canada
- Volunteers
- 1,246 people
- Sponsor
- University of Pennsylvania
Smoking, Acute Coronary Syndrome
Safety and Efficacy of the Novel Selective Nicotinic Receptor Partial Agonist, CHANTIX (Varenicline) in Patients With Acute Coronary Syndrome
Assess the role of a nicotine antagonist in helping patients presenting to hospital with acute coronary syndrome to stop smoking.
- Trial name
- NCT01170338
- Testing
- Varenicline 100 mg by mouth twice daily, control
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Newark Beth Israel Medical Center
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.