Clinical trials: Tobacco Abuse
Nicotine Dependence, Tobacco Dependence
Use of Pharmacotherapy to Reduce Cue-responsiveness in Smokers
In this study we, the investigators at the Centre for Addiction and Mental Health, intend to explore whether bupropion is able to reduce smokers' responses to cigarette-related environmental cues, and craving.
- Trial name
- NCT00133757
- Testing
- Bupropion SR
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Cigarette Smoker, Tobacco Use Disorder
Behavioral Activation Therapy and Nicotine Replacement Therapy in Increasing Smoking Cessation
This randomized clinical trial studies how well behavioral activation therapy and nicotine replacement therapy work in increasing smoking cessation.
- Trial name
- NCT02697227
- Testing
- Behavioral Intervention, Laboratory Biomarker Analysis, Nicotine Patch
- Where
- United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Nicotine Dependence
Baclofen Effects in Cigarette Smokers
The proposed project will utilize perfusion functional magnetic resonance imaging (fMRI), a functional candidate gene association approach (of dopaminergic addictions-targeted polymorphisms), and the dopamine-modulating and…
- Trial name
- BAC (NCT01821560)
- Testing
- Baclofen
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Lung Cancer, Tobacco Use Disorder
Feasibility of Delivering a Quitline Based Smoking Cessation Intervention in Cancer Patients
RATIONALE: Continued smoking after a cancer diagnosis has important health consequences beyond the risks associated with smoking in the general population.
- Conditions
- Lung Cancer, Tobacco Use Disorder, Breast Cancer, Colorectal Cancer
- Trial name
- NCT01434342
- Testing
- Nicotine Replacement Patch
- Where
- United States
- Volunteers
- 146 people
- Sponsor
- Wake Forest University Health Sciences
Tobacco Use Disorder
Evaluation of Oral Tobacco as a Harm Reduction Method for Smokers
Recently, tobacco companies have developed new oral tobacco products that are purportedly less harmful than conventional tobacco products.
- Trial name
- NCT00711100
- Testing
- Camel Snus, Marlboro Snus, Stonewall
- Where
- 2 sites in United States
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Tobacco Use Disorder
Progesterone Treatment in Female Smokers - 12
The purpose of this study is to investigate progesterone effects in female smokers
- Trial name
- NCT00000295
- Testing
- Micronized Progesterone
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Nicotine Dependence
A Smoking Cessation Treatment for Adult Women
The purpose of this study is to develop and pilot test a smoking cessation counseling that focuses on the perceived risks of quitting smoking (e.g., weight gain, managing cravings and negative affect, loss of enjoyment).
- Trial name
- NCT01422239
- Testing
- Tailored treatment, Standard Treatment
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Yale University
Tobacco Use Disorder
Effectiveness of a Web-Assisted Quitline for Smokeless Tobacco Users
The purpose of this record is to test whether (a) participants who receive a Web-based smokeless tobacco cessation intervention will be more likely to be abstinent than participants who do not receive this intervention, and (b)…
- Trial name
- NCT00820495
- Testing
- Web + Phone, Web Only, Phone Only
- Where
- 2 sites in United States
- Volunteers
- 1,683 people, healthy volunteers welcome
- Sponsor
- Oregon Research Institute
Smoking, Pulmonary Disease, Chronic Obstructive
Smoking Cessation Versus Long-term Nicotine Replacement Among High-risk Smokers
Long-term NRT has not been studied in patients with COPD, and smokers in the United States with COPD are still asked to choose between immediate quitting or continued smoking.
- Conditions
- Smoking, Pulmonary Disease, Chronic Obstructive, Tobacco Use Disorder
- Trial name
- NCT02148445
- Testing
- Standard Smoking Cessation, Extended Nicotine Replacement Therapy, Nicotine replacement therapy
- Where
- United States
- Volunteers
- 398 people
- Sponsor
- University of Kansas Medical Center
Tobacco Abuse Smoke
Pharmacokinetic Profile of Toxic Substances and Nicotine in Electronic Cigarettes
The aim of the present study is to compare serum nicotine levels of different e-Cigarette strength with usual cigarettes. Serum levels of carcinogenic and toxic substances will be also compared.
- Trial name
- KINECIG (NCT01665066)
- Testing
- Own Brand cigarette, one high 2,4% nicotine, original 7,4 mg nicotine
- Where
- Italy
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Catania
Nicotine Dependence
Combination Nicotine Patch / Lorcaserin for Smoking Cessation
This study plans to compare the efficacy of the nicotine patch / lorcaserin combination treatment vs. the nicotine patch alone in terms of leading to a reduction in smoking behavior and withdrawal symptoms.
- Trial name
- LorNic (NCT02906644)
- Testing
- lorcaserin, nicotine patch
- Where
- United States
- Volunteers
- 97 people
- Sponsor
- Duke University
Nicotine Dependence
N-Acetylcysteine and Smoking Reduction
N-acetylcysteine is an inexpensive agent with a benign side effect profile with preliminary studies in humans suggesting efficacy for the treatment of cocaine dependence.
- Trial name
- NCT00751257
- Testing
- N-acetylcysteine
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Medical University of South Carolina
Tobacco Use Disorder
Project Q: Cue-based Treatment Intervention to Promote Cessation Among People Who Smoke Lightly or Non-daily
This study aims to test the feasibility and acceptability of a remotely delivered cue-based treatment intervention to promote smoking cessation among people who smoke lightly or non-daily.
- Trial name
- NCT07425119
- Testing
- Cognitive Behavioral Therapy (CBT), Cue-based treatment intervention
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Duke University
Nicotine Dependence, Cigarettes, Uncomplicated
Impact of Nicotine Reduction on Adolescent Cigarette Use, Alternative Tobacco Use, and Harm From Tobacco
Adolescents are an important vulnerable population to consider as the FDA moves toward a nicotine reduction policy. Such a policy, which would mandate a reduction of nicotine in all commercially available cigarettes, has the…
- Trial name
- SIREN (NCT03860077)
- Testing
- Very Low Nicotine Content Cigarettes, Normal Nicotine Content Cigarettes
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Brown University
Alcohol Drinking, Cigarette Smoking
Brief Voluntary Alcohol and Drug Intervention for Middle School Youth
We are currently working in 16 middle schools across Los Angeles, Santa Monica and Torrance to test out a voluntary after school program called Project CHOICE, which focuses on helping students decrease their alcohol and drug…
- Conditions
- Alcohol Drinking, Cigarette Smoking, Marijuana Smoking
- Trial name
- CHOICE (NCT01081119)
- Testing
- Project CHOICE
- Where
- United States
- Volunteers
- 6,455 people
- Sponsor
- RAND
Tobacco Dependence
C-Raven, a Virtual Tobacco Cessation Intervention in the Community
In low-income housing units in Baltimore, the investigators propose to conduct a pilot two-arm hybrid type 1 effectiveness-implementation RCT comparing a) an avatar-delivered computerized intervention (CI) for tobacco cessation…
- Trial name
- NCT06545669
- Testing
- C-Raven Virtual Tobacco Cessation Counseling, Nicotine Replacement Product, Community Health Worker
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Johns Hopkins University
Vaping Teens, Vaping Behaviors
Developing an E-Cigarette Cessation Intervention for Hispanic/Latina(o) Youth in Florida: The BReATHE Study
Electronic (e-)cigarettes are the most used nicotine product among U.S. youth. Hispanic/Latino (H/L) youth are at greater risk for e-cigarette use, yet few evidence-based cessation programs exist for youth, and even fewer are…
- Conditions
- Vaping Teens, Vaping Behaviors, Vaping Cessation, Tobacco Use Disorder
- Trial name
- NCT07192601
- Testing
- E-cigarette Cessation Manual
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Florida International University
Addiction, Behavioral Addiction
Mobile Health for Problematic Behaviors and Substance Use
The aim of the study is to evaluate the effectiveness of long-term and short-term app-based self-guided psychological interventions to reduce craving and lapse risk in problematic behaviors (compulsive sex, pornography…
- Conditions
- Addiction, Behavioral Addiction, Nicotine Addiction, Nicotine Dependence
- Trial name
- NCT05434429
- Testing
- mobile application
- Where
- Poland
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- PredictWatch
Nicotine Dependence, Smoking Cessation
Accelerated iTBS in Smoking Cessation
Cigarette smoking is one of the foremost causes of preventable disease and premature death. In 2014, 68% of adult smokers wanted to quit smoking and in 2017, 55.1% of adult smokers had made a quit attempt.
- Trial name
- NCT05271175
- Testing
- Active intermittent theta burst stimulation
- Where
- Cyprus
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Cyprus rTMS Center
Nicotine Dependence
GABA (Gamma Amino Butyric Acid) Medication for Tobacco
The goal of this study is to examine the effects of a GABA (gamma amino butyric acid)-enhancing medication, pregabalin (300 mg/day), on smoking behavior, tobacco withdrawal and cigarette craving in smokers.
- Trial name
- NCT00644137
- Testing
- pregabalin, cigarettes
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Yale University
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