Clinical trials: Tobacco Abuse
Smoking Cessation, Nicotine Addiction
Nicotine Receptor Levels and Smoking Cessation
The investigators propose to use positron emission tomography (PET) imaging to determine whether nicotinic receptor availability at pretreatment predicts smoking cessation success.
- Trial name
- NCT01788943
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Tobacco Dependence
UW Withdraw From Tobacco Study
It is of considerable scientific and clinical importance to assess tobacco withdrawal accurately since withdrawal severity is highly determinant of smoking cessation success.
- Trial name
- NCT04969198
- Testing
- Combination nicotine replacement therapy (Nicotine patch + nicotine mini-lozenge)
- Where
- United States
- Volunteers
- 232 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Smoking Cessation, Cigarette Smoking
Quit With Sense: Using Mindful Smoking and Wearable Device for Smoking Cessation
This pilot randomized controlled trial will test the feasibility of a smoking cessation intervention using mindful smoking practice and a smartphone-based sensor-band among adults who regularly smoke cigarettes.
- Conditions
- Smoking Cessation, Cigarette Smoking, Tobacco Use, Nicotine Dependence
- Trial name
- NCT07789496
- Testing
- Mindful Smoking and Sensor-Band Intervention, Smoking Cessation Information
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Minnesota
Smoking
Varenicline for Light Smokers
The purpose of this study is to determine if varenicline is effective in treating tobacco dependence in adults who smoke 5-10 cigarettes per day.
- Trial name
- ChanLight (NCT01639560)
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Tobacco Dependence
Pharmacokinetics With Two New Oral Nicotine Replacement Products and Nicorette® Gum
Single-dose pharmacokinetics with two new oral nicotine replacement products and Nicorette® gum.
- Trial name
- NCT01152723
- Testing
- Nicotine
- Where
- Sweden
- Volunteers
- 28 people
- Sponsor
- McNeil AB
Tobacco Use Disorder
Pilot Study of Nicotine Replacement for Smoking Cessation During Pregnancy
We plan to examine the feasibility, acceptability, preliminary quit rates, overall nicotine exposure and adverse effects of the nicotine inhaler for smoking cessation in pregnancy.
- Trial name
- NCT00888979
- Testing
- Nicotrol Inhaler
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Hartford Hospital
Tobacco Use Disorder, Nicotine Addiction
Effects of Semaglutide on Nicotine Intake
Tobacco use remains the foremost cause of preventable deaths in the U.S. and worldwide. Advancing new smoking cessation therapies, including those targeting novel biological mechanisms, is a critical public health priority.
- Trial name
- NCT05530577
- Testing
- Semaglutide
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Smoking, Smoking Behaviors
CSD190401: A Study to Assess Elements of Abuse Liability for Nicotine-containing Pouch Tobacco Products
This is a single site, open-label, randomized, cross-over study designed to evaluate elements of abuse liability (AL) including subjective effects and physiological measures (pharmacodynamics [PD]) and plasma nicotine uptake…
- Conditions
- Smoking, Smoking Behaviors, Tobacco Use, Tobacco Smoking
- Trial name
- NCT04372290
- Testing
- Product A, Product B, Product C
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- RAI Services Company
Tobacco Use Disorder
Nicotine Patch and Bupropion to Reduce Smoking Rates in Younger, Low-Income, and Minority Individuals
Nicotine addiction is a serious health problem in the United States; 46 million people smoke cigarettes, and 70% of those are trying to quit.
- Trial name
- NCT00308763
- Testing
- Nicotine Patch, Sustained Release Bupropion
- Where
- United States
- Volunteers
- 594 people, healthy volunteers welcome
- Sponsor
- University of Tennessee
Nicotine Dependence
EEG & Behavioral Predictors of Changes in Smoking Trajectories in Young Light Smokers
The purpose of the proposal is to identify new predictors of smoking progression in young light smokers (YLS: 18-25 years \& cpd < 5) using an 18-month longitudinal design and to relate these predictors of progression to the…
- Trial name
- NCT02129387
- Where
- United States
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Southern Illinois University Carbondale
Smoking Cessation, Depression
Adapting and Pilot Testing a Skills-based Smoking Cessation Intervention to Address Developmental and Health-related Stress Among Adults Who Smoke
Smoking remains the leading preventable cause of death in the United States, and there are persistent and significant disparities in tobacco use among transgender and gender diverse (TGD) individuals.
- Conditions
- Smoking Cessation, Depression, Anxiety, Nicotine Dependence
- Trial name
- NCT06654414
- Testing
- PRIDE QUIT, Enhanced Treatment As Usual (ETAU)
- Where
- 3 sites in United States
- Volunteers
- 100 people
- Sponsor
- Massachusetts General Hospital
Second Hand Tobacco Smoke, Nicotine Dependence
Kids Safe and Smokefree (KiSS)
The study's primary aim is to test the hypothesis that an intervention integrating pediatric clinic-level quality improvement with home-level behavioral counseling (CQI+BC) will result in greater reductions in child cotinine (a…
- Trial name
- KiSS (NCT01745393)
- Testing
- Clinic Quality Improvement + Behavioral Counseling, Clinic Quality Improvement + Attention Control
- Where
- 4 sites in United States
- Volunteers
- 327 people
- Sponsor
- Temple University
Tobacco-Related Carcinoma
Effects of Tobacco Cut and Nicotine Form on the Abuse Liability of Moist Snuff
This clinical trial tests the effects of tobacco cut and nicotine form on the abuse liability in participants who use moist snuff (smokeless tobacco [SLT]).
- Trial name
- NCT06249984
- Testing
- Biospecimen Collection, Carbon Monoxide Measurement, Smokeless Tobacco Use
- Where
- 2 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Smoking Cessation, Tobacco Use Disorder
Comparative Effectiveness of Two Tobacco Cessation Interventions for Employees of Partners HealthCare, Inc.
Specific Aim: To conduct a randomized controlled trial among permanent employees of Partners HealthCare, Inc., and their adult dependents, who are current tobacco smokers.
- Trial name
- PiHQ (NCT02601521)
- Testing
- Internal tobacco coach, External tobacco coach
- Where
- United States
- Volunteers
- 106 people
- Sponsor
- Massachusetts General Hospital
Healthy Smokers
Nicotine Patch - Multidose Bioequivalence Study
The purpose of this study is to compare the relative bioavailability of nicotine following repeated applications of a new transdermal formulation to that of a reference formulation. Up to day 7
- Trial name
- NCT01658215
- Testing
- V0116 transdermal patch (Test treatment ), Nicotine transdermal patch (Reference treatment )
- Where
- France
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Pierre Fabre Medicament
Nicotine Dependence, Depression
Vigorous Exercise for Depressed Smokers
In this project the investigators will develop and pilot test a supervised, vigorous intensity exercise intervention for depressed female smokers.
- Trial name
- NCT01860924
- Testing
- exercise, health education
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Tobacco Use Disorder, Nicotine Dependence
Young Adult Tobacco/Nicotine and Cannabis Co-use
The goal of this project is to better understand the relationship between tobacco/nicotine and cannabis using behavioral economics during a tobacco/nicotine quit attempt.
- Trial name
- YouthCAT (NCT06239350)
- Testing
- Counseling, Contingency management, Text-based support
- Where
- United States
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Tobacco Use Disorder
Team-based Financial Incentives for Smoking Cessation
The purpose of this study is to identify the effectiveness of team-base financial incentives for increasing long-term smoking cessation among employees at St. Paul's Hospital, Korea.
- Trial name
- StPaulKorea (NCT01323725)
- Testing
- Team-based financial incentives
- Where
- South Korea
- Volunteers
- 28 people
- Sponsor
- St.Paul's Hospital, Korea
Tobacco Use Disorder, Homelessness
Abstinence Reinforcement Therapy (ART) for Homeless Veteran Smokers
The goal of this research study is to examine the effects of a treatment for helping homeless veterans who smoke to stop smoking. Participants in the study will be assigned to one of two study groups.
- Trial name
- NCT02245308
- Testing
- Nicotine Patches, mobile contingency management (mCM), Smoking cessation counseling
- Where
- United States
- Volunteers
- 133 people
- Sponsor
- VA Office of Research and Development
Smoking Cessation, Tobacco Dependence
Smoking-cessation: A Spanish-Language Clinical Trial
The purpose of this study is to develop and test a series of culturally relevant and appropriate booklets in Spanish, designed to assist Hispanic smokers in quitting smoking and remaining smoke-free.
- Trial name
- NCT02611076
- Testing
- Stop Smoking for Good Intervention in Spanish (SS-SP), Usual care (UC)
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
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