Clinical trials: Tobacco Abuse
Bipolar Disorder, Schizophrenia
Novel Pharmacotherapy Approaches in Smokers With Serious Mental Illness
Approximately 60 chronic smokers with bipolar disorder, schizophrenia or schizoaffective disorder who are motivated to try to quit smoking will be randomized to receive smoking cessation treatment with the FDA-approved…
- Conditions
- Bipolar Disorder, Schizophrenia, Schizoaffective Disorder, Nicotine Dependence
- Trial name
- NCT04011280
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- University of California, San Diego
Smokers
Nicotine Patch Safety Study
The purpose of this study is to evaluate the safety profile of a repeated application of a new transdermal patch compared to a reference product during 3 weeks, in a large population.
- Trial name
- NCT01655082
- Testing
- V0116 transdermal patch, Nicotine transdermal patch
- Where
- 4 sites in France
- Volunteers
- 160 people
- Sponsor
- Pierre Fabre Medicament
Prescription Drug Abuse, Substance Abuse
A High School Program for Preventing Prescription Drug Misuse
This project will develop and evaluate a program to prevent prescription drug misuse in high school students
- Conditions
- Prescription Drug Abuse, Substance Abuse, Substance Use (Drugs, Alcohol)
- Trial name
- NCT03219190
- Testing
- LST High School Hybrid
- Where
- United States
- Volunteers
- 1,804 people, healthy volunteers welcome
- Sponsor
- National Health Promotion Associates, Inc.
Cancer and Tobacco Abuse
A Feasibility Study of Smoking Cessation Program in Radiation Oncology
To test the feasibility of an intensive behavioral and pharmacologic tobacco cessation program for radiation oncology patients and their families/companions.
- Trial name
- NCT00236288
- Testing
- Bupropion and intensive behavioral therapy
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Indiana University
Psychosis, Substance Use
Families With Substance Use and Psychosis: A Pilot Study
The purpose of this study is to develop and evaluate an intervention that adapts Community Reinforcement and Family Training (CRAFT) for families experiencing first episode psychosis and substance use delivered via telemedicine…
- Conditions
- Psychosis, Substance Use, Substance Use Disorders, Family
- Trial name
- NCT04284813
- Testing
- CRAFT-FT
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Asthma, Tobacco Use
Monitoring and Outcome Measures in Asthmatics and Smokers During Pregnancy
Asthma and smoking during pregnancy cause significant morbidity in both the mother and the offspring. Asthma represents the most common respiratory disorder during pregnancy and smoking rates during pregnancy range from 15-30% in…
- Trial name
- NCT00425880
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Kentucky
Social Anxiety Disorder, Tobacco Use Disorder
Adaptive Treatment Strategies for Improving Engagement With a Web-Based Smoking Intervention in Socially Anxious Smokers
This phase I trial will use a pilot sequential multiple assignment randomized trial (SMART) to examine protocol feasibility and acceptability of new components of a web-based intervention for socially anxious smokers.
- Trial name
- NCT04260776
- Testing
- Phase 1: Web-based intervention (MyWebQuit) with 1-way text messages, Phase 1: Web-based intervention (MyWebQuit) with interactive, 2-way text messages, Phase 2: re-engagement text messages
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Fred Hutchinson Cancer Center
Tobacco Use Disorder, Cannabis Use Disorder
Varenicline for the Treatment of Cannabis and Tobacco Use Disorders in Veterans
After initial eligibility screening, Veterans who use both cannabis and tobacco will be randomly assigned to receive either varenicline (Chantix) or placebo for 12 weeks.
- Trial name
- Vet Cat (NCT05294263)
- Testing
- Varenicline
- Where
- United States
- Sponsor
- VA Office of Research and Development
Tobacco Dependence
Effect of Yoga on Reducing Craving in Tobacco Dependent Individuals
Yoga is a culturally acceptable practice that can reduce craving and help people quit tobacco. There is a need to evaluate the feasibility of implementation of a well- designed yoga protocol to address craving in individuals who…
- Trial name
- NCT06488443
- Testing
- Yoga, WHO 5As model intervention
- Where
- India
- Volunteers
- 96 people
- Sponsor
- University of Pittsburgh
Cigarette Smoking, Nicotine Dependence
Evaluation of Low and High Nicotine Tobacco Free Nicotine Pouches
Tobacco-free oral nicotine pouches (such as Zyn brand) are a less harmful alternative to cigarette smoking. Pouches, however, contain nicotine, and addictive substance that is not risk-free.
- Conditions
- Cigarette Smoking, Nicotine Dependence, Smoking Cessation
- Trial name
- Pack2Pouch (NCT06678789)
- Testing
- High Nicotine Dose, Low Nicotine Dose
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Lung Cancer, Tobacco Use Disorder
Screening Methods in Finding Lung Cancer Early in Current or Former Smokers
RATIONALE: Screening may help doctors find lung cancer sooner, when it may be easier to treat. PURPOSE: This clinical trial is studying screening methods to see how well they find lung cancer early in current or former smokers.
- Trial name
- Pan Can (NCT00751660)
- Testing
- laboratory biomarker analysis, screening questionnaire administration, bronchoscopic and lung imaging studies
- Where
- 6 sites in Canada
- Volunteers
- 2,504 people
- Sponsor
- British Columbia Cancer Agency
Nicotine Dependence
Stage Ib Trial of mSMART With Varenicline
The primary aim of this study is to conduct a 60-patient feasibility, acceptability, and preliminary efficacy study of mSMART (Mobile App based Personalized Solutions and Tools for Medication Adherence of Rx Pill), a smartphone…
- Trial name
- mSMART-v (NCT03069768)
- Testing
- mSMART, Chantix
- Where
- United States
- Sponsor
- Duke University
Tobacco Dependence, Veterans
Identifying Effective Treatment for Veterans Unwilling to Quit Smoking
This project will generate knowledge about the effectiveness of Enhanced Chronic Care, an intervention designed to enhance treatment use and smoking abstinence in Veterans who are initially unwilling to quit.
- Trial name
- NCT04061720
- Testing
- Enhanced Chronic Care, Standard Care
- Where
- United States
- Volunteers
- 502 people
- Sponsor
- VA Office of Research and Development
Tobacco Use Disorder
Neural Substrates in Nicotine Withdrawal
This study will test the hypothesis that a medication called tolcapone (Brand Name: Tasmar) will help reduce cognitive problems that smokers experience when they quit.
- Trial name
- NCT01001520
- Testing
- Tolcapone
- Where
- United States
- Volunteers
- 218 people
- Sponsor
- University of Pennsylvania
THC, Cannabis
Understanding the Clinical Pharmacology of Marijuana-Tobacco Co-administration
This is a crossover, randomized, double-blinded clinical pharmacology study enrolling dual cannabis-tobacco smokers to better understand the combined effects of co-administering cannabis and tobacco.
- Conditions
- THC, Cannabis, Cannabis Use, Cannabis Smoking
- Trial name
- CANNIC (NCT05999383)
- Testing
- Cannabis, Nicotine, Pax Loose Leaf Vaporizer
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Alcohol Dependence, Nicotine Dependence
New Treatment for Alcohol and Nicotine Dependence
This research study aims to test whether topiramate (a drug that is being used for seizure) will help individuals who have problems with both alcohol and nicotine.
- Trial name
- NCT01182766
- Testing
- Low-Dose Topiramate, High-Dose Topiramate
- Where
- 4 sites in United States
- Volunteers
- 236 people
- Sponsor
- University of Virginia
Tobacco Dependence, Schizophrenia
The Appeal and Impact of E-cigarettes in Smokers With SMI
This study will evaluate behavioral and psychological appeal, toxicity, and effect of e-cigarettes on smoking behavior and nicotine addiction in chronic smokers with serious mental illness (SMI) who have failed to quit smoking.
- Conditions
- Tobacco Dependence, Schizophrenia, Bipolar Disorder, Schizoaffective Disorder
- Trial name
- NCT03050853
- Testing
- E-cigarette
- Where
- 2 sites in United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Bipolar Disorder
Efficacy of N-Acetyl-Cysteine in Bipolar Disorder and Tobacco Use Disorder
Effects of N-Acetyl-Cysteine in patients with bipolar depression (primary outcome is Hamilton Depression Rating Scale) with and without tobacco use disorder and on inflammatory and oxidative stress biomarkers
- Trial name
- NACBD (NCT02252341)
- Testing
- N-Acetyl-Cysteine
- Where
- Brazil
- Volunteers
- 130 people
- Sponsor
- Universidade Estadual de Maringá
Tobacco Use Disorder
To Assess the Bioequivalence of the 4mg Prototype Mini Nicotine Lozenge to the Reference Product (Nicorette) in Healthy Smokers
This study will assess the bioequivalence of the test product (Nicotine Prototype Mini lozenge 4 milligrams [mg]) to a commercial reference product (nicotine polacrilex mini lozenge 4mg) in healthy smokers under fasting…
- Trial name
- NCT03543137
- Testing
- Nicotine Prototype Mini lozenge, Nicorette Mini Lozenge
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Tobacco Use Disorder, Schizophrenia
Smoking Abstinence and Lapse Effects in Smokers With Schizophrenia and Controls
This project tests two hypotheses concerning the low smoking cessation rates in smokers with schizophrenia. The first hypothesis is that smokers with schizophrenia experience stronger and more sustained effects of smoking…
- Trial name
- WREN (NCT01214005)
- Testing
- smoking abstinence
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Brown University
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