Clinical trials: Tobacco Abuse
Nicotine Dependence
Pharmacokinetics and Pharmacodynamics of Different Nicotine Salt Concentration Vape System Pods and Free-base Nicotine
Comparison of the pharmacokinetics and pharmacodynamics of two different nicotine salt concentrations and free-base nicotine using an open vape pod system
- Trial name
- NCT04170907
- Testing
- standardized vaping protocol
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Tobacco Use Disorder
Tobacco Pilot Study for Low Income Smokers
Pilot study to test feasibility of delivering a motivational smoking cessation intervention to low income smokers via a computer tablet.
- Trial name
- NCT03017092
- Testing
- Tablet-guided tobacco intervention
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Tobacco Use Disorder
Way to Quit - Comparative Efficacy, Acceptance and Effectiveness of Health Incentive Structures
Using the NIH-funded Way to Health platform, the investigators will conduct this smoking cessation randomized controlled trial (RCT) among CVS employees.
- Trial name
- NCT01526265
- Testing
- Usual Care, Individual Rewards, Fixed Deposits
- Where
- United States
- Volunteers
- 2,185 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
THC, Cannabis
THC Crossover Study
This is a randomized, crossover study enrolling experienced dual cannabis-tobacco smokers (N=18) to describe the differences in THC and toxicant exposure, examining pharmacokinetic, subjective, and cardiovascular effects from…
- Conditions
- THC, Cannabis, Cannabis Smoking, Cannabis Use, Unspecified
- Trial name
- TRDRP (NCT04429568)
- Testing
- Smoked Cannabis, Vaped Cannabis, Tobacco Cigarette
- Where
- 2 sites in United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Tobacco Use Disorder
Zileuton With or Without Celecoxib As Chemopreventive Agents in Smokers
The goal of this clinical research study is to learn how zileuton alone or the combination of zileuton and celecoxib may affect certain chemicals in the body that may be linked with a risk for smoking-related lung disease.
- Trial name
- NCT01021215
- Testing
- Zileuton, Celecoxib, laboratory biomarker analysis
- Where
- 2 sites in United States
- Volunteers
- 84 people
- Sponsor
- National Cancer Institute (NCI)
Tobacco Use Disorder, Smoking Cessation
Tobacco Treatment Medical Education in 10 Medical Schools
This study compares two methods of teaching the 5As (Ask, Advise, Assess, Assist, Arrange) for tobacco dependence treatment to medical students: 1) traditional medical education (TE), and 2) multi-modal education (MME).
- Trial name
- MSQuit (NCT01905618)
- Testing
- Web-based curriculum on tobacco dependence treatment, Tobacco Counseling Role Play, Preceptor Training and Teaching Medical Students
- Where
- 13 sites in United States
- Volunteers
- 10 people
- Sponsor
- University of Massachusetts, Worcester
Tobacco Use Cessation
Low-Cost Contingency Management for Smoking Cessation
An innovative low-cost form of contingency management has been developed in which participants receive the chance to draw vouchers from a fish bowl depending on whether or not their abstinence from tobacco is confirmed by…
- Trial name
- NCT01040260
- Testing
- Counseling, Contingency management, Nicotine patches
- Where
- United States
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Nicotine Addiction
Effects of ABT-089 on Smoking Abstinence Symptoms and Reward
This Phase IIa within-subject, cross-over pilot study will evaluate the effects of ABT-089 (an experimental medication not approved by the FDA) when administered as 40mg oral once daily dose for 10 days, compared to placebo, on…
- Trial name
- NCT01756053
- Testing
- ABT-089
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- University of Pennsylvania
Nicotine Dependence, Cigarettes, Nicotine Withdrawal
The INITIATE Study: Initiating Nicotine Dependence Treatment for Smokers Admitted to Emergency Departments
The INITIATE Study is a randomized controlled trial that is testing an intervention designed to increase long-term abstinence among tobacco smokers seen in emergency departments (ED) and other high-volume hospital and community…
- Trial name
- INITIATE (NCT04163081)
- Testing
- Quit Card Intervention (QCI)
- Where
- 4 sites in Canada
- Volunteers
- 1,208 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Smoking Cessation, Tobacco Use Disorder
Effectiveness of Various Smoking Cessation Therapies in Reducing Smoking in Adolescents - 1
Currently one in five high school students smokes. Smoking can harm adolescents well before they reach adulthood by causing a number of immediate, sometimes irreversible, health risks and problems.
- Trial name
- NCT00158171
- Testing
- Nicotine Replacement Therapies, Nicotine patch, Folic Acid
- Where
- United States
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Smoking, Smoking Behaviors
Abuse Liability of Four Modern Oral Nicotine Products
This is a single-site, open-label, randomized, 6-way crossover study designed to evaluate elements of abuse liability (AL) including subjective effects, physiological measures (pharmacodynamics [PD]), and plasma nicotine uptake…
- Conditions
- Smoking, Smoking Behaviors, Tobacco Use, Tobacco Smoking
- Trial name
- NCT07685795
- Testing
- Usual Brand (UB) filtered, menthol or non-menthol combustible cigarette, Wintergreen (fleece A), 12 mg nicotine, Wintergreen (fleece A), 9 mg nicotine
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- RAI Services Company
Tobacco Use Disorder
Optimizing Tobacco Dependence Treatment in the Emergency Department
The investigators propose an innovative full-factorial design in a cohort of 1056 adult smokers in an urban emergency department (ED), to test the efficacy of four key intervention components: motivational interviewing…
- Trial name
- NCT02896400
- Testing
- Brief Negotiated Interview (BNI), Nicotine replacement therapy (NRT), CT Smokers Quitline (QL)
- Where
- United States
- Volunteers
- 1,056 people
- Sponsor
- Yale University
Smoking Cessation, Nicotine Dependence
Varenicline and Motivational Advice for Smokers With Substance Use Disorders
The purpose of this study is to evaluate the effects of 12 weeks of varenicline as compared to nicotine replacement therapy for smoking cessation among outpatients in treatment for substance use disorders.
- Trial name
- VARSUD (NCT00756275)
- Testing
- Nicotine Replacement Treatment (NRT), varenicline, Behavioral counseling for smoking cessation
- Where
- United States
- Volunteers
- 158 people
- Sponsor
- Brown University
Tobacco Dependence
Quitline Use in Surgical Patients
Elective surgery represents a teachable moment to deliver tobacco interventions. The overall goal of this proposal is to increase the utilization of the QUITPLANSM Helpline by surgical patients who smoke.
- Trial name
- NCT00656500
- Testing
- Standard brief advice, Quitline intervention
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Mayo Clinic
Tobacco Use Disorder
Nicotine Lozenge to Reduce Smokeless Tobacco Use
Smokeless tobacco (ST), which includes both chewing tobacco and snuff, has as many health risks associated with its use as cigarettes.
- Trial name
- NCT00218283
- Testing
- Nicotine Lozenge, Behavioral Counseling
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Smoking Cessation
Not Quite Ready to Quit
In our communications with the public, the investigators will call this the Not Quite Ready to Quit Smoking Study. One new method to increase quit attempts is to have smokers reduce their cigs/day.
- Trial name
- NCT01866722
- Testing
- Usual care, Reduction, 5Rs
- Where
- United States
- Volunteers
- 560 people
- Sponsor
- University of Vermont
Tobacco Use Disorder
Effect of Paroxetine on Smokers' Cardiovascular Response to Stress - 1
Smokers report that they often smoke cigarettes during stressful times. The combined effect of smoking and exposure to stress leads to exaggerated increases in blood pressure, heart rate and other measures of stress response.
- Trial name
- NCT00218439
- Testing
- Paroxetine
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Tobacco Use Disorder
Effects of Non-invasive Brain Stimulation in Tobacco Use Disorder
The objective of the study is to determine the effect of non-invasive brain stimulation on craving for tobacco and brain metabolites.
- Trial name
- NCT02776319
- Testing
- Non-invasive brain stimulation (active)
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- Laval University
Tobacco Use Disorder
A Comparison of Bupropion SR and Placebo for Smoking Cessation
The purpose of this study is to examine whether the adjunctive use of bupropion SR in the context of a psychoeducational program modified for people with schizophrenia might improve the likelihood of successful abstinence in this…
- Trial name
- NCT00176449
- Testing
- Bupropion SR
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Nicotine Use Disorder
Study to Assess PK, PD, Nicotine Extraction, Palatability, Subjective Effects of Nicotine Pouches - Daily Nicotine Users
This is an explorative, open-label, randomised, 3-way cross-over study to assess pharmacokinetics (PK), pharmacodynamics (PD), safety and tolerability, nicotine extraction, palatability and subjective effects after single use of…
- Trial name
- NCT06170138
- Testing
- Test product 1 - Test product 2 - Comparator product
- Where
- Sweden
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Amplicon AB
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