Clinical trials: Tobacco Abuse
Nicotine Dependence
Nicotine Differences in Smokers
The primary aim of this project is to determine the threshold dose of nicotine, which the smokers will be able to differentiate from placebo (saline).
- Trial name
- NCT05159934
- Testing
- 0.05, 0.025, and 0.0125 mg nicotine/pulse of nicotine, Saline
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Yale University
Tobacco Use Cessation, Tobacco Use
Reach Through Equitable Implementation in Utah
The goal of this pragmatic, multilevel Type III Hybrid Effectiveness-Implementation trial is to increase the reach of existing evidence-based interventions (EBIs) for tobacco cessation and to mitigate the impact of adverse Social…
- Conditions
- Tobacco Use Cessation, Tobacco Use, Tobacco Smoking, Tobacco Chewing
- Trial name
- REI-UT (NCT06881069)
- Testing
- Clinic Level: AAC - SDOH, AAC - Tobacco, Non-Bundled, Bundled
- Where
- United States
- Volunteers
- 1,560 people
- Sponsor
- University of Utah
Nicotine Use Disorder
Effects of E-cigarette Flavors on Youth TCORS 2.0
This study is an examination of the influence of sweet and cooling flavors on the appeal and abuse potential of nicotine-containing e-cigarettes among susceptible youth.
- Trial name
- NCT03634839
- Testing
- Flavoring Agents, Nicotine
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Yale University
Smoking, Smoking Cessation
Implementation Science to Reduce the Disparity in Tobacco Treatment Among Individuals With Serious Mental Illness
This is a pilot trial to examine the feasibility and preliminary effect of a multilevel intervention 'Nudges to Quit' on smoking cessation in patients with serious mental illness who smoke in a community mental health center…
- Conditions
- Smoking, Smoking Cessation, Tobacco Use Cessation
- Trial name
- ISRAISE (NCT05952401)
- Testing
- Usual Care, "Nudges"
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- Washington University School of Medicine
Substance-related Disorders, Depression
Primary Care iSBIRT to Reduce Serious Teen Health Risks
The goal of the project is to develop and test an internet/intranet-based Screening, Brief Intervention, and Referral to Treatment (iSBIRT) system for adolescents that targets a broad range of serious health-risks and problem…
- Conditions
- Substance-related Disorders, Depression, High-risk Sex
- Trial name
- NCT00891631
- Testing
- iSBIRT, iSBIRT/TE
- Where
- United States
- Sponsor
- Boston Children's Hospital
Nicotine Dependence
Nicotine Dependence, Withdrawal and Replacement Therapy Assessed by PET Imaging
The proposed research will provide significant new gender-specific information of scientific and clinical relevance on the function of the mu-opioid system in nicotine dependence and therapeutic effectiveness of nicotine…
- Trial name
- NCT01664741
- Testing
- Nicotine patch - transdermal
- Where
- United States
- Volunteers
- 127 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Tobacco Use Disorder, Nicotine Dependence, Cigarettes
Effects of Nicotine Dependence on Multidimensional Health Outcomes
Nicotine, a major toxic component of cigarette smoke, together with carbon monoxide (CO), constitutes a significant environmental exposure with systemic effects.
- Trial name
- NCT07474623
- Testing
- Comprehensive Clinical Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 212 people, healthy volunteers welcome
- Sponsor
- Izmir Democracy University
Cannabis Use, Tobacco Use
Effect of Cannabis on Cigarette Use Behavior
The purpose of this study is to determine the impact of tetrahydrocannabinol (THC) administration on motivational, subjective, and physiological effects of cigarettes.
- Conditions
- Cannabis Use, Tobacco Use, Cigarette Smoking
- Trial name
- NCT06609083
- Testing
- THC 30mg, THC 5mg, THC 0mg
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Tobacco Dependence, Suicidal
DBT for Smoking Cessation in High Risk Veterans
Individuals prone to suicidality are typically excluded from tobacco cessation interventions even though they are disproportionately likely to smoke, and even though smoking cessation has been linked to improved mood and reduced…
- Trial name
- NCT06687577
- Testing
- DBT-C, Treatment as usual
- Where
- United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Veterans Medical Research Foundation
Hospitalized Smokers, Chronic Diseases
Enhancing Tobacco Abstinence Following Hospitalization
The primary aim of this study is to examine the efficacy of a 12-week nurse-delivered relapse management intervention designed with conceptual underpinnings from Self-efficacy Theory to enhance smoking abstinence of hospitalized…
- Conditions
- Hospitalized Smokers, Chronic Diseases, Tobacco Use Disorder
- Trial name
- NCT00222703
- Testing
- Smoking relapse prevention
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Pittsburgh
Nicotine Dependence
Cessation Screening Project
This project will use the Multiphase Optimization Strategy (MOST) to guide the development of optimized treatment strategies for the two most effective smoking cessation medications (Combination Nicotine Replacement [C-NRT] and…
- Trial name
- NCT04188873
- Testing
- Preparation Varenicline and Standard Duration Varenicline, Preparation Varenicline and Extended Duration Varenicline, Standard Duration Varenicline
- Where
- 2 sites in United States
- Volunteers
- 538 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Nicotine Dependence
Smoking Treatment in HIV Clinical Care Settings
The study is designed to evaluate and compare the efficacy and cost effectiveness of 3 smoking cessation treatments with HIV-positive cigarette smokers.
- Trial name
- NCT00297453
- Testing
- Internet-based smoking treatment, Individual Counseling, self-help
- Where
- United States
- Volunteers
- 207 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Tobacco Use Disorder
Smoking-induced Dopamine Release: a [11C]-(+)-PHNO PET Study in Humans
This study will evaluate effects of smoking on the dopaminergic system by using PET tomography with new radioligand, [11C]-(+)-PHNO.
- Trial name
- NCT01302262
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Centre for Addiction and Mental Health
Positron Emission Tomography
Brain Nicotine Receptor Density in Veteran Smokers
Cigarette smoking is more prevalent among Veterans (27%) than the general U.S. population (21%). Smoking is common among people who use marijuana or caffeine heavily, and the use of menthol cigarettes is becoming increasingly…
- Trial name
- BNRDVS (NCT01721473)
- Testing
- positron emission tomography scan
- Where
- 2 sites in United States
- Volunteers
- 184 people
- Sponsor
- VA Office of Research and Development
Tobacco Use Disorder
Influence of tDCS on the Brain Activation Measured During the Decision Not to Smoke in High-risk Situations
Substance use disorders (SUD) are characterized by increased automatized responses to drug-related cues (cue-reactivity) and deficient cognitive control. Cue-reactivity (CR) can be elicited by internal (e.g.
- Trial name
- NCT05875194
- Testing
- active transcranial direct current stimulation (tDCS)
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- University Hospital Tuebingen
Vaping, Vaping Cessation
Social Media Support Groups for Adolescent Vaping Cessation
The purpose of this study is to pilot test feasibility and acceptability of the Quit the Hit Toolkit, a social media-based nicotine vaping cessation program for adolescents and young adults, adapted for use in community settings.
- Conditions
- Vaping, Vaping Cessation, Nicotine Dependence
- Trial name
- NCT07540780
- Testing
- Social Media Intervention
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Nicotine Dependence
Baclofen for Smoking Cessation in a Non-Psychiatric Population
The primary hypothesis for this study is that, in nicotine-dependent tobacco smokers, baclofen will be superior to placebo for smoking abstinence measures.
- Trial name
- Baclofen (NCT01228994)
- Testing
- Baclofen 30 mg/day, Baclofen 60 mg/day
- Where
- Canada
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Smoking Cessation
Message Priming and Enrollment in, and Response to, a Smoking Cessation Program: A Pilot Study
The proposed study has been designed to examine the effect of a message that primes genetic susceptibility on actual enrollment in a smoking cessation program, actual response to smoking cessation treatment, and potential…
- Trial name
- NCT00596882
- Testing
- Message Prime
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Nicotine Addiction, Panic Attack
Enhancing Panic and Smoking Reduction Treatment With D-Cycloserine
The purpose of the current study is to evaluate the efficacy of d-cycloserine in augmenting treatment of smoking cessation for individuals with panic attacks.
- Trial name
- DCS/PSRT (NCT01944423)
- Testing
- d-cycloserine, Nicotine replacement therapy, Panic and Smoking Reduction Treatment
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Smoking Cessation
Interventions for Smoking Among Persons in Recovery
Examine the efficacy of a stepped-care smoking cessation intervention for current and former smokers in chemical dependency treatment programs.
- Trial name
- INSPIRE (NCT00714896)
- Testing
- Stepped-Care, Control
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
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