Clinical trials: Tobacco Reduction
Smoking
Reduced Exposure Study Using THS 2.2 Menthol With 5 Days in a Confinement Setting Followed by 86 Days in an Ambulatory Setting
Evaluate if the ad libitum use of the THS 2.2 Menthol (mTHS), a candidate Modified Risk Tobacco Product, for 5 days in confinement, and after 86 days in an ambulatory setting, by apparently adult healthy smokers results in a…
- Trial name
- NCT01989156
- Testing
- THS 2.2 Menthol (mTHS 2.2), Menthol Conventional Cigarette (mCC), Smoking Abstinence (SA)
- Where
- 2 sites in United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Philip Morris Products S.A.
Smoking Cessation, Harm Reduction
In-vivo Extraction of Lead, Cadmium and Tobacco Specific Nitrosamines From Swedish 'Snus' in Regular Snus Users
In an open label, randomized, two-way cross-over study, 32 male healthy regular snus users will be given repeated doses of four different types of portion snus: "General", "Catch", "Catch Mini" and "Catch Dry Mini".
- Trial name
- SMWS03 (NCT01838473)
- Testing
- Buccal Administration of nicotine
- Where
- Sweden
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Contract Research Organization el AB
Cigarette Smoking
Serbian Smoking Reduction/Cessation Trial (2SRT)
The study aims to establish if a low-nitrosamine, smokeless tobacco product (Swedish snus) can help adult smokers to reduce and eventually completely quit smoking.
- Trial name
- 2SRT (NCT00601042)
- Testing
- Swedish snus (smokeless tobacco), Onico
- Where
- 2 sites in Serbia
- Volunteers
- 319 people, healthy volunteers welcome
- Sponsor
- Swedish Match AB
Tobacco Use
Comparative Tobacco Interventions for Individuals With Severe and Persisting Behavioral Health Disorders
The aim of this pilot intervention is to examine the acceptability of a harm reduction intervention approach to tobacco use for individuals with serious behavioral health disorders and its association with a decrease in smoking.
- Trial name
- THRRP (NCT04523948)
- Testing
- Behavioral and pharmacological support to reduce combustible tobacco use.
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Rose Research Center, LLC
Smoking, Tobacco
A Multi-Site Study to Assess the Effect of Availability of a Heated Tobacco Product on Smoking Abstinence Among Current Primary Cigarette Smokers
The goal of this study is to evaluate the rate of end of study complete cigarette reduction in health adult consumers of cigarettes when given access to a heated tobacco product (HTP).
- Trial name
- NCT07710820
- Testing
- 31237616, 31237617, 31237571
- Where
- 9 sites in United States
- Volunteers
- 1,060 people, healthy volunteers welcome
- Sponsor
- RAI Services Company
Tobacco Dependence
Evaluation of the Safety Profile, Quit and Reduction Rate After Nicorette® Gum and Patch Treatment
To evaluate the safety, smoking cessation and reduction rate during 3 months of active nicotine replacement therapy (NRT) and a follow-up period of 3 months in smoking hospital physicians and staff who are motivated to quit
- Trial name
- NCT00749463
- Testing
- Nicotine Gum, Nicotine Patch
- Where
- 6 sites in China
- Volunteers
- 300 people
- Sponsor
- McNeil AB
Addiction Nicotine
The CONQUER Trial - Cessation Of Nicotine, QUitting With E-cigarette Reduction
This clinical trial evaluates the VapeAway system, a novel, multi-modal intervention designed to address the multifaceted nature of vaping addiction.
- Trial name
- CONQUER (NCT07322432)
- Testing
- VapeAway filter system
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- VapeAway
Tobacco Use Disorder, Smoking
Pilot Study to Evaluate the Safety and Efficacy of Ariva® Silver Wintergreen in Reducing Cigarette Craving in Smokers
Study to determine the safety and effectiveness of Ariva® Silver Wintergreen lozenge on reducing craving for a cigarette in daily smokers.
- Trial name
- NCT01337830
- Testing
- Ariva® Silver Wintergreen, Silver Wintergreen
- Where
- United States
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Star Scientific, Inc
Smoking Cessation, Harm Reduction
Combination of E-cigarettes and Varenicline for Tobacco Harm Reduction
This open-label study will explore the impact of varenicline on the process of switching from combustible cigarettes (CC) to an e-cigarette.
- Trial name
- EVAR (NCT04210180)
- Testing
- Varenicline, e-cigarette
- Where
- 2 sites in United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Rose Research Center, LLC
Smoking, Tobacco Use Disorder
A Pilot Study to Evaluate Safety and Efficacy of CigRx™ in Smokers
A randomized, double-blind, active-controlled, crossover, pilot study to evaluate the safety and efficacy of CigRx™ Lozenge, a dietary supplement, in daily smokers in temporarily reducing the desire to smoke
- Trial name
- NCT01262170
- Testing
- CigRx Lozenge, Tobacco Lozenge
- Where
- United States
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- Rock Creek Pharmaceuticals, Inc.
Smoking
Reduced Exposure Study Using the CHTP 1.2 With 5 Days in a Confinement Setting Followed by 85 Days in an Ambulatory Setting.
The overall goal of the study is to demonstrate reduction in the levels of biomarkers of exposure (BoExp) to selected harmful and potentially harmful constituents (HPHCs) identified in cigarettes and to obtain safety information…
- Trial name
- NCT02641587
- Testing
- CHTP 1.2, CC
- Where
- Poland
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- Philip Morris Products S.A.