Clinical trials: Tobacco Reduction
Tobacco Use Disorder
Project 1, Study 2: Extended Exposure to Low Nicotine Content Cigarettes in Childbearing Age Women
This study will examine extended exposure to cigarettes varying in nicotine content among disadvantaged women. Disadvantaged women are at increased risk for smoking, nicotine dependence, and using high nicotine yield cigarettes…
- Trial name
- NCT02250534
- Testing
- Very low nicotine content cigarettes
- Where
- 2 sites in United States
- Volunteers
- 775 people, healthy volunteers welcome
- Sponsor
- University of Vermont
Tobacco Use Disorder, Smoking
Electronic Cigarettes (E-cigarettes) as a Harm Reduction Strategy
The purpose of this study is to examine the feasibility of using e-cigarettes as a method for harm reduction and the effects of providing e-cigarettes (or placebo e-cigarettes) on smoking outcomes.
- Trial name
- NCT02628964
- Testing
- e-cigarettes
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Tobacco Smoking in Depressed Patients
Smoking Cessation And Reduction in Depression
It is well established in studies across several countries that tobacco smoking is more prevalent among depressed patients than the general population.
- Trial name
- scarid (NCT02124187)
- Testing
- Ecig 24 mg nicotine, Ecig 0 mg nicotine, Nicotine free inhalator
- Where
- Italy
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Catania
Tobacco Smoking
Smoking Interventions in the General Population
The study takes up two problems: 1) Little research exists about general population interventions for smokers not ready to quit within the foreseeable future.
- Trial name
- NCT00678938
- Testing
- Smoking abstinence oriented expert system intervention, Smoking reduction oriented expert system intervention
- Volunteers
- 1,462 people, healthy volunteers welcome
- Sponsor
- University Medicine Greifswald
Smoking, Tobacco
A Study to Determine the Effects of ENDS Flavor Availability on Abstinence Within Smokers
The overall purpose of this study will be to assess primary combustible cigarette users' abstinence from smoking their usual brand of combustible cigarettes at the end of the study, when provided with an electronic nicotine…
- Trial name
- NCT07598136
- Testing
- P2613422, P2611222, P2615522
- Where
- 7 sites in United States
- Volunteers
- 1,280 people, healthy volunteers welcome
- Sponsor
- RAI Services Company
Smoking Cessation, Harm Reduction
Assisting Smokers to Switch to a JUUL E-Cigarette by Devaluing Combustible Cigarettes
This study will evaluate a reward devaluation strategy in which smokers use the JUUL e-cigarette immediately before any combustible cigarettes (CCs) are smoked.
- Conditions
- Smoking Cessation, Harm Reduction, E-Cig Use, Cigarette Smoking
- Trial name
- RECON (NCT04188197)
- Testing
- JUUL
- Where
- 2 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Rose Research Center, LLC
Infant Environmental Tobacco Smoke Exposure
Reducing Environmental Tobacco Smoke in Neonatal Intensive Care Unit (NICU) Infants' Homes
This study is about reducing the risks of smoke-related infant health problems. Research has shown that infants exposed to secondary smoke have higher risks of delayed lung development, respiratory illnesses, wheeze, cough…
- Trial name
- NCT00670280
- Testing
- Motivational Interviewing intervention, Usual Care, Usual Care - Reduced Measurement
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- The University of Texas Health Science Center, Houston
Nicotine Dependence, Smoking, Cigarette
Isradipine Enhancement of Virtual Reality Cue Exposure for Smoking Cessation
The proposed study represents a crucial and important stage in translating basic research to strategies for treating nicotine dependence.
- Conditions
- Nicotine Dependence, Smoking, Cigarette, Smoking Cessation, Smoking Behaviors
- Trial name
- NCT03083353
- Testing
- Isradipine, Cue Exposure
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Jasper A. Smits
Cardiovascular Diseases, Diabetes Mellitus, Type 2
Evaluating a Web-Based Cardiovascular Disease Risk Factor Reduction Program Among American Indians
Cardiovascular disease (CVD) is a serious health concern for American Indians, but there have been few behaviorally based programs to lessen CVD risk among this population.
- Conditions
- Cardiovascular Diseases, Diabetes Mellitus, Type 2, Hypertension, Obesity
- Trial name
- NCT00608387
- Testing
- Chronic disease management Web-based software
- Where
- United States
- Volunteers
- 149 people
- Sponsor
- Black Hills Center for American Indian Health
Smoking, Tobacco
A Study to Determine the Effect of Access to Multiple Tobacco Flavor Options on Smoking Abstinence Among Primary Cigarette Smokers Using an Electronic Nicotine Delivery System
This is a multi-site, open-label, single arm study to evaluate the rate of smoking abstinence by the end of the study with healthy adult consumers of cigarettes when provided with an e-cigarette over a 13 week study period.
- Trial name
- NCT07879638
- Testing
- FT25614, FT25615, FT25616
- Where
- 5 sites in United States
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- RAI Services Company
Smoking
Engaging Patients in Tobacco Cessation Resources in Dental Settings
The overarching goal of this project is to reduce smoking-associated morbidity and mortality by increasing the number of patients who are referred for tobacco cessation counseling.
- Trial name
- ENGAGE (NCT03656874)
- Testing
- Clinical Decision Support
- Where
- 3 sites in United States
- Volunteers
- 56 people
- Sponsor
- HealthPartners Institute
Smoking, Tobacco Smoking
Reduced Exposure to HPHC in Smokers Switching From Cigarettes to Different Versions of THS
This was a randomized, controlled, open-label, 4 parallel arm study with a stratified randomization by sex (a quota for each sex [females and males] of at least 40% overall).
- Conditions
- Smoking, Tobacco Smoking, Tobacco Use
- Trial name
- NCT05599451
- Testing
- THS Blade device, THS Induction Mono device, THS Induction Mid device
- Where
- United Kingdom
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Philip Morris Products S.A.
Tobacco Smoke Pollution
Reduction of Environmental Tobacco Smoke (ETS) Exposure at Home: the BIBE Study
Main objective: to determine the effectiveness of a brief opportunist educational performance directed to the parents who smoke -- inside the context of programmed visits of paediatrics in primary care -- to reduce the exposure…
- Trial name
- BIBE (NCT00788996)
- Testing
- Brief intervention based in clinical practice guide
- Where
- Spain
- Volunteers
- 552 people, healthy volunteers welcome
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
Cancer
Reduction of Environmental Tobacco Smoke (ETS) Exposure In Pediatric Cancer Patients
SMOKN5 is aimed at studying ways to reduce environmental tobacco smoke (ETS) for children who are being treated for cancer. The study includes St.
- Trial name
- NCT00766766
- Testing
- Health Risk and Behavioral Skills Coaching Sessions, Telephone Coaching Sessions, Physician Feedback Letter
- Where
- United States
- Volunteers
- 166 people
- Sponsor
- St. Jude Children's Research Hospital
Tobacco-flavored EC, Sweet-Cooling EC
Electronic Cigarettes as a Harm Reduction Strategy Among People With Opioid Use Disorder on Buprenorphine
This project aims to investigate the impact of e-cigarette flavors and usage patterns on achieving harm-reduction milestones in a sample of cigarette smokers with opioid use disorder who are taking buprenorphine
- Conditions
- Tobacco-flavored EC, Sweet-Cooling EC, Sweet Non-cooling EC
- Trial name
- SWITCH (NCT07202039)
- Testing
- Brief individual counseling sessions
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Prisma Health-Upstate
Inflammation, Oxidative Stress
Reduction of Exposure, Inflammation, and Oxidative Stress Following at Least 2 Years of Switching to THS Use Compared to Cigarette Smoking
This is a cross-sectional 3-group study with subjects enrolled and matched by region (Asia, Europe), age, sex, and average daily product consumption over the last 2 years as self-reported.
- Conditions
- Inflammation, Oxidative Stress, Smoking, Smoking Abstinence
- Trial name
- NCT05385055
- Testing
- THS use, Cigarette smoking, Smoking abstinence
- Where
- 37 sites in Bulgaria, Czechia and 4 more
- Volunteers
- 974 people, healthy volunteers welcome
- Sponsor
- Philip Morris Products S.A.
Smoking, Smoking Cessation
A Test of Short and Long Term Naturalistic Outcomes of Smokers Who Sample Smokeless Tobacco
This nationwide telephone and mail- based research study will recruit 1,400 cigarette smokers who are not motivated to quit to test the effects of a marketed oral, non-combustible smokeless tobacco product on cigarette smoking…
- Trial name
- NCT01509586
- Testing
- Potentially Reduced Exposure Product (PREP): a smokeless, spit-free tobacco product
- Where
- United States
- Volunteers
- 1,236 people
- Sponsor
- Medical University of South Carolina
Cigarette Smoking, Tobacco Use
Catalyzing Cigarette Smoking Cessation Through Harm Reduction Sampling Among People Unmotivated to Quit
This study aims to investigate harm-reduction sampling in a choice format versus medicinal nicotine sampling on smoking behavior, identify mechanisms of sampling's effects, and explore moderators of these effects among a national…
- Conditions
- Cigarette Smoking, Tobacco Use, Cigarette Smoking Behavior
- Trial name
- NCT07199517
- Testing
- HRP Sampling period, NPL Sampling period
- Where
- United States
- Volunteers
- 472 people, healthy volunteers welcome
- Sponsor
- Abramson Cancer Center at Penn Medicine
Smoking Reduction, Smoking Cessation
Development and Assessment of a Teacher-led Intervention in Preventing Tobacco Use Among the Youth in Ghana
The main purpose of this experimental study is to compare the existing health education program for School Health and Education Program (SHEP) in the Junior High Schools with a new health education model (Smart-Kids') for the…
- Conditions
- Smoking Reduction, Smoking Cessation, Smoking, Tobacco, Smoking Behaviors
- Trial name
- NCT04891939
- Testing
- Health education lessons (Smart-Kid's program), School Health and Education Program (SHEP)
- Volunteers
- 2,314 people, healthy volunteers welcome
- Sponsor
- Ghana Health Services
Substance Withdrawal Syndrome, Nicotine Dependence
Electronic Cigarettes in Daily Dependent Smokers
The aim of this study is to measure nicotine cue- and withdrawal-induced craving in current smokers under four distinct conditions: after smoking a conventional cigarette, an electronic cigarette (e-Cigarette) containing…
- Trial name
- NCT02108626
- Testing
- Nicotine
- Where
- Canada
- Volunteers
- 43 people
- Sponsor
- Centre for Addiction and Mental Health