Clinical trials: Tobacco Smoking
Tobacco Use Disorder
Efficacy of Oral Tobacco Products Compared to a Medicinal Nicotine
For the primary goals, we hypothesize that 1) the oral tobacco product will be more efficacious than the medicinal nicotine product in substituting for smoking cigarettes; 2) among non-abstainers, the oral tobacco product will…
- Trial name
- NCT00710034
- Testing
- Oral tobacco, Nicotine Gum
- Where
- 2 sites in United States
- Volunteers
- 391 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Smoking Cessation, Depression
Safety And Efficacy Of 12 Weeks Of Varenicline For Smoking Cessation In Smokers With Depression
Patients with depression tend to have a higher prevalence of smoking as well as increased severity of nicotine dependence. Phase 2 and Phase 3 varenicline clinical trials that demonstrated its efficacy and tolerability have not…
- Trial name
- NCT01078298
- Testing
- varenicline
- Where
- 41 sites in United States, Bosnia and Herzegovina and 6 more
- Volunteers
- 525 people
- Sponsor
- Pfizer
Smoking Cessation
The Impact of COVID-19 Pandemic on the Smoking Behaviour of Young Smokers and the Youth Quitline Service in Hong Kong
The aims of the present study are: 1. To explore the impact of COVID-19 pandemic on the smoking behavior of youth smokers 2. To explore the impact of COVID-19 pandemic on the Youth Quitline service in Hong Kong
- Trial name
- NCT04360863
- Testing
- Telephone survey
- Where
- Hong Kong
- Volunteers
- 150 people
- Sponsor
- The University of Hong Kong
Pulmonary Disease, Chronic Obstructive
Simvastatin Therapy for Moderate and Severe COPD
To determine the effect of daily administration of 40 mgms simvastatin taken for at least 12 months (range 12-36 months) on the frequency of exacerbations of chronic obstructive lung disease (COPD) in patients with moderate to…
- Trial name
- STATCOPE (NCT01061671)
- Testing
- simvastatin
- Where
- 51 sites in United States, Canada
- Volunteers
- 885 people
- Sponsor
- University of Minnesota
Smoking Cessation
Very Brief Smoking Reduction Intervention
A two-arm randomized controlled trial for smokers who are not intent to quit smoking will be proposed in outpatient department clinics of People's Liberation Army General Hospital in Beijing, China.
- Trial name
- NCT02370147
- Testing
- Smoking reduction intervention, Exercise and diet advice control
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Cardiovascular Risk Factor, Smoking
Implementing and Testing a Cardiovascular Assessment Screening Program (CASP)
This study is a randomized controlled trial (RCT) and there will be two groups: an intervention group and a control group. Nurse practitioners (NPs) across Newfoundland and Labrador (NL) who agree to participate will be randomly…
- Conditions
- Cardiovascular Risk Factor, Smoking, Diabetes Mellitus, Dyslipidemias
- Trial name
- CASP (NCT03170752)
- Testing
- Cardiovascular Assessment Screening Program (CASP)
- Where
- Canada
- Volunteers
- 169 people, healthy volunteers welcome
- Sponsor
- Memorial University of Newfoundland
Smoking Cessation
Safety and Pharmacodynamics of SEL-068 Vaccine in Smokers and Non-Smokers
The purpose of this study is to evaluate the safety and pharmacodynamics of SEL-068. Increasing subcutaneous doses of SEL-068 will be administered to healthy non-smoker and smoker volunteers.
- Trial name
- NCT01478893
- Testing
- SEL-068, Saline
- Where
- Belgium
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Selecta Biosciences, Inc.
Any Cancer Type
Mindfulness-Based Ecological Momentary Intervention For Smoking Cessation Among Cancer Survivors
The purpose of the study is to obtain feedback on a new quit-smoking treatment among individuals with a cancer diagnosis using a prototype app we developed.
- Trial name
- NCT06476548
- Testing
- EMI
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Chronic Obstructive Pulmonary Disease, COPD Exacerbation
Efficacy of Varenicline on Smoking Cessation at the Acute Phase of an Exacerbation of Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease of the bronchi with an increasing prevalence. By 2020, the mortality related to COPD is expected to become the 3rd leading death worldwide.
- Conditions
- Chronic Obstructive Pulmonary Disease, COPD Exacerbation, Smoking
- Trial name
- SAVE (NCT01694732)
- Testing
- Varenicline
- Where
- 13 sites in France
- Volunteers
- 83 people
- Sponsor
- University Hospital, Brest
Smoking Addiction
Addictive Threshold of Nicotine
To determine the nicotine threshold dose(s) for discrimination, subjective-rewarding effects, -and reinforcement in smokers with different levels of dependence.
- Trial name
- NCT06096714
- Testing
- Nicotine, Saline
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Yale University
Smoking Cessation
Smartphone-delivered Automated Video-assisted Smoking Treatment for Patrons of a Food Resource Center
The proposed pilot study seeks to address the smoking cessation treatment needs of underserved smokers with limited resources by evaluating the feasibility and preliminary efficacy of a smartphone delivered automated…
- Trial name
- AVAST-FRC (NCT03060278)
- Testing
- Self-help materials, nicotine patch, Smartphone-delivered automated treatment
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Oklahoma
Smoking Cessation, Smoking Behaviors
Clinical Learning Study for a Mobile Smoking Cessation Program
The purpose of this study are to obtain learnings regarding the Digital Therapeutic (DTx) experience of Clickotine, including acceptability and preference of the overall program and specific DTx components, as well as to obtain…
- Conditions
- Smoking Cessation, Smoking Behaviors, Smoking Reduction, Smoking, Cigarette
- Trial name
- NCT04857515
- Testing
- Clickotine®
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Click Therapeutics, Inc.
Secondhand Smoking
COMPLICATIONS RELATED CARBOXYHEMOGLOBIN LEVELS IN SECOND HAND SMOKING PEDIATRIC TONSILLECTOMY PATIENTS
The purpose of this study was to determine whether high carboxyhemoglobin level is a risk factor for postoperative adverse events in children exposured to carbon monoxide, especially enviromental tobacco smoke.
- Trial name
- NCT01942252
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Mustafa Kemal University
Smoking Cessation, Tobacco Use Disorder
Promoting Home Smoking Restrictions: Biomarker Feedback to Smoking and Non-Smoking Adults
This study is directed at decreasing home environmental tobacco smoking (ETS) exposure with a novel approach of adoption of home smoking restrictions.
- Trial name
- NCT01497158
- Testing
- Self-help brochure, Biomarker feedback
- Where
- United States
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Sleep, Lung Diseases
Predicting Sleep, Smoking, and Lung Health Disparities in African American Adults
This 5-year prospective, observational study will: (1) determine the individual, social, and environmental predictors of sleep duration, quality, latency, efficiency, timing and regularity in African American smokers, (2)…
- Conditions
- Sleep, Lung Diseases, Smoking
- Trial name
- NCT03534076
- Testing
- Cohort Observational study
- Where
- United States
- Volunteers
- 303 people, healthy volunteers welcome
- Sponsor
- Temple University
Nicotine Replacement Therapy, Healthcare Professionals
The Efficacy of Combining Music Intervention With Nicotine Replacement Therapy to Reduce Smoking Craving, Among Healthcare Professionals Who Are Trying to Quit.
Tobacco is the leading preventable cause of death and disease worldwide. The health benefits of quitting smoking are well-documented. Healthcare professionals play a key role in the fight against smoking.
- Conditions
- Nicotine Replacement Therapy, Healthcare Professionals, Tobacco Craving, Tabacco Cessation
- Trial name
- MUSICAT (NCT07412717)
- Testing
- Nicotine Replacement Therapy (NRT, nicotine patch), Music intervention, Biological collection
- Where
- France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Poitiers University Hospital
Healthy Volunteers (Middle-aged Smokers)
Effects of Curcumin on Vascular Reactivity
The aim of this study is to determine if an oral loading-dose of curcumin can improve vascular endothelium reactivity in patients with moderate cardiovascular risk
- Trial name
- CURCUMIN (NCT01543386)
- Testing
- Curcumin
- Where
- France
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Smoking, Tibia Fracture
Effect of Tobacco Heating System (THS) on Closed Lower Limb Fracture Healing
The goal of this clinical trial is to investigate the role of switching from cigarette smoking (CS) to tobacco heat system (THS) on the clinical outcome of closed lower limb (tibia and femur) fractures from smokers' orthopedic…
- Trial name
- NCT05859451
- Testing
- Tobacco Heating System (THS), Smoking abstinence
- Where
- Germany
- Volunteers
- 150 people
- Sponsor
- University Hospital Tuebingen
Smoking Cessation, Smoking, Tobacco
High Dose Bupropion for Smoking Cessation - Pilot Study
This study aims to investigate the benefit of administering two differing doses of Bupropion (BUP) to smokers to assist with smoking cessation.
- Conditions
- Smoking Cessation, Smoking, Tobacco, Smoking (Tobacco) Addiction, Cessation, Tobacco
- Trial name
- NCT03326128
- Testing
- Bupropion Hydrochloride
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Nicotine Dependence, Smoking Cessation
Accelerated iTBS in Smoking Cessation
Cigarette smoking is one of the foremost causes of preventable disease and premature death. In 2014, 68% of adult smokers wanted to quit smoking and in 2017, 55.1% of adult smokers had made a quit attempt.
- Trial name
- NCT05271175
- Testing
- Active intermittent theta burst stimulation
- Where
- Cyprus
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Cyprus rTMS Center