Clinical trials: Tobacco Smoking
Nicotine Dependence
Prize Reinforcement for Smoking Cessation
Nicotine dependence is prevalent in society, cigarette smoking is associated with several known health risks, and most dependent individuals find it very difficult to stop smoking cigarettes.
- Trial name
- NCT00865254
- Testing
- Standard Treatment, Traditional Contingency Management, Early Enhanced Contingency Management
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Wayne State University
Tobacco Use Disorder, Smoking Cessation
p16 Methylation for Smoking Cessation
Smoking cessation is often difficult for smokers to achieve for a variety of reasons including: difficulty with nicotine withdrawal, failure to perceive the benefits of smoking cessation, and failure to perceive the risks…
- Conditions
- Tobacco Use Disorder, Smoking Cessation, Lung Cancer
- Trial name
- NCT01038492
- Testing
- p16 Methylation and Lung Cancer Education
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Duke University
Secondhand Exposure, Smoking Status
An Integrated Intervention to Reduce Secondhandsmoke in Children
This is a community essay to assess the effectiveness of a multi-level (individual, family, and school) school-based intervention to prevent the exposure to secondhand smoke (SHS) in a population of 1,734 schoolchildren (12-14…
- Trial name
- RESPIR·NET (NCT01881607)
- Testing
- RESPIRNET Program
- Where
- Spain
- Volunteers
- 1,779 people, healthy volunteers welcome
- Sponsor
- Institut Català d'Oncologia
Smoking Cessation
Interventions for Smoking Among Persons in Recovery
Examine the efficacy of a stepped-care smoking cessation intervention for current and former smokers in chemical dependency treatment programs.
- Trial name
- INSPIRE (NCT00714896)
- Testing
- Stepped-Care, Control
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Nicotine Dependence, Tobacco Use Disorder
Effectiveness of Using Reduced Nicotine Cigarettes in Men and Women Smokers to Combat Nicotine Addiction
This is a 2-year study involving the progressive reduction in the nicotine content of cigarettes. The investigators believe that at the end of the study smokers of cigarettes with progressively reduced nicotine content will be…
- Trial name
- NCT00264342
- Where
- United States
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Stereotyped Behavior, Tobacco Smoking Behavior
"EASY EFFECTIVE SMOKELESS" With NICORETTE®
The actually most accepted method of effective smoking cessation is based on structured consultation and medical care in combination with supportive medical treatment.
- Trial name
- NCT01323491
- Testing
- Nicotine replacement therapy
- Where
- Germany
- Volunteers
- 184 people
- Sponsor
- Johnson & Johnson GmbH
Tobacco Dependence, HIV Infections
Reducing Ethnic Health Disparities: Motivating HIV+ Latinos to Quit Smoking
The purpose of this study is to develop and evaluate a brief clinic-based culturally tailored smoking cessation treatment for a largely low-income, Latino, HIV+ population.
- Trial name
- AURORA (NCT00503230)
- Testing
- Standard Care Intervention (SCI), Culturally Tailored Intervention (CTI)
- Where
- 8 sites in United States
- Volunteers
- 400 people
- Sponsor
- Butler Hospital
Tobacco Dependence, Smoking Cessation
Tailoring Varenicline to Individual Needs (TVIN Study)
Varenicline is a partial nicotinic agonist which acts on alpha4 beta2 nicotinic receptors. It is presumed to alleviate withdrawal discomfort, but also to diminish rewarding effects of cigarettes.
- Trial name
- TVIN (NCT01206010)
- Testing
- Varenicline
- Where
- United Kingdom
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Queen Mary University of London
Smoking, Tobacco Use Disorder
Chantix & Bupropion for Smoking Cessation
The overarching goal of this line of research is to increase smoking abstinence rates using a combination of existing pharmacotherapies.
- Trial name
- ChanBan (NCT00587769)
- Testing
- Bupropion SR & Varenicline
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Smoking Cessation, Harm Reduction
In-vivo Extraction of Lead, Cadmium and Tobacco Specific Nitrosamines From Swedish 'Snus' in Regular Snus Users
In an open label, randomized, two-way cross-over study, 32 male healthy regular snus users will be given repeated doses of four different types of portion snus: "General", "Catch", "Catch Mini" and "Catch Dry Mini".
- Trial name
- SMWS03 (NCT01838473)
- Testing
- Buccal Administration of nicotine
- Where
- Sweden
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Contract Research Organization el AB
Smoking, Nicotine Dependence
A Brief Dental Office Intervention With Tobacco Quitline
The novel and exploratory nature of this intervention relates to the concept of incorporating patient-specific oral health information obtained during a dental hygiene visit into the tobacco quitline counseling.
- Trial name
- NCT00273156
- Testing
- Telephone quitline
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Nicotine Dependence
Targeted Interventions for Weight-Concerned Smokers
Weight gain after quitting smoking is an important barrier to treatment for many smokers. This study will test a drug called naltrexone with weight-concerned smokers to investigate whether or not this drug both improves smoking…
- Trial name
- NCT00105482
- Testing
- Naltrexone, Transdermal nicotine replacement, Behavioral counseling
- Where
- United States
- Volunteers
- 172 people
- Sponsor
- Yale University
Nicotine Dependence
Tobacco Use in Opioid Agonist Treated Pregnant Women
The primary objective of the proposed study is to evaluate the efficacy of tobacco abstinence-contingent voucher incentives versus non-tobacco abstinence-contingent incentives for reducing or eliminating tobacco use during…
- Trial name
- ROSE (NCT00497068)
- Testing
- tobacco abstinent contingent, non-contingent, control
- Where
- United States
- Volunteers
- 210 people
- Sponsor
- Johns Hopkins University
Nicotine Dependence, Smoking Cessation
Smoking Cessation and Reduction With an Electronic Nicotine Delivery Device (ENDD)
The study's major aim is to investigate the ability of a commercial Electronic Nicotine Delivery Device (ENDD) to induce long-term smoking reduction/abstinence in smokers unwilling to quit.
- Trial name
- NCT01195597
- Testing
- E-Cigarette 7.2 mg nicotine
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Catania
Smoking Cessation, Tobacco Use Cessation
Smoking Cessation Invention in the Emergency Department (ED)
The emergency department (ED) serves a vital and growing role in the US health care system, responsible for both the delivery of emergent medical care and for safety-net care for populations without traditional access to health…
- Conditions
- Smoking Cessation, Tobacco Use Cessation, Health Behavior
- Trial name
- NCT01173653
- Testing
- Smoking Cessation
- Where
- United States
- Volunteers
- 199 people
- Sponsor
- Vanderbilt University
Smokers
Nicotine Patch Safety Study
The purpose of this study is to evaluate the safety profile of a repeated application of a new transdermal patch compared to a reference product during 3 weeks, in a large population.
- Trial name
- NCT01655082
- Testing
- V0116 transdermal patch, Nicotine transdermal patch
- Where
- 4 sites in France
- Volunteers
- 160 people
- Sponsor
- Pierre Fabre Medicament
Healthy Smokers
Nicotine Patch Bioequivalence Study
The purpose of this study is to compare the relative bioavailability of nicotine following single application of a new transdermal formulation to that of a reference formulation.
- Trial name
- NCT01658202
- Testing
- V0116 transdermal patch (Test treatment ), Nicotine transdermal patch (Reference Treatment )
- Where
- France
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Pierre Fabre Medicament
Healthy Smokers
Nicotine Patch - Multidose Bioequivalence Study
The purpose of this study is to compare the relative bioavailability of nicotine following repeated applications of a new transdermal formulation to that of a reference formulation. Up to day 7
- Trial name
- NCT01658215
- Testing
- V0116 transdermal patch (Test treatment ), Nicotine transdermal patch (Reference treatment )
- Where
- France
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Pierre Fabre Medicament
Smoking Among Youth
Hutchinson Smoking Prevention Project
The Hutchinson Smoking Prevention Project is a 16-year, group-randomized trial to determine the extent to which a school-based (grades 3-10), theory-based, social-influences tobacco use prevention intervention can deter youth…
- Trial name
- HSPP (NCT00115869)
- Testing
- Social-influences
- Where
- United States
- Volunteers
- 8,388 people
- Sponsor
- Fred Hutchinson Cancer Center
Smoking Cessation, Tobacco Dependence
tDCS as Add on Therapy for Treatment of Tobacco Dependence by Standardized Behaviour Therapy
As an add-on treatment to behavioural therapy for tobacco dependence, anodal transcranial direct current stimulation (tDCS) significantly increases the cessation rate compared to treatment with sham tDCS; endpoint analysis will…
- Trial name
- NCT01729507
- Testing
- tDCS, standardised behavioural therapy
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Ludwig-Maximilians - University of Munich