Clinical trials: Tobacco Smoking
Tobacco Use Cessation, Tobacco Use Disorder
Feasibility of a Medical-Legal Partnership Model to Connect Coal Miners QuitAid
Coal miners in Central Appalachia have among the highest rates of tobacco and nicotine product (TNP) use of any occupational group and face elevated rates of lung cancer and coal workers' pneumoconiosis ("black lung").
- Conditions
- Tobacco Use Cessation, Tobacco Use Disorder, Nicotine Dependence, Smokeless Tobacco Use
- Trial name
- NCT07694492
- Testing
- QuitAid (pharmacist-delivered MTM), Nicotine Replacement Therapy (NRT)
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Smoking Cessation
Comparison of Efficacy and Safety of Rimonabant 20mg/Day Versus Placebo in Smoking Cessation
The primary objective is to assess the efficacy a 20mg/day fixed dose of rimonabant versus placebo on abstinence from tobacco use in cigarette smoker.
- Trial name
- STRATUS-META (NCT00464256)
- Testing
- rimonabant
- Where
- United States
- Volunteers
- 533 people
- Sponsor
- Sanofi
Schizophrenia, Schizoaffective Disorder
Nicotinic Receptors and Schizophrenia
The investigators hypothesize that sustained-release DMXB-A-SR (3-2,4 dimethoxybenzylidene anabaseine sustained release) will provide clinical improvement in cognition in patients with schizophrenia who are smokers and who are…
- Trial name
- NCT01400477
- Testing
- DMXB-A-SR
- Where
- 2 sites in United States
- Volunteers
- 97 people
- Sponsor
- University of Colorado, Denver
Smoking
Effect of Donepezil on Smoking
The objective of this proof-of-concept pilot study is to evaluate Donepezil HCL (Aricept) for side effects and effects on smoking behavior and performance on neurocognitive tasks in a population of dependent smokers.
- Trial name
- NCT01250977
- Testing
- Donepezil
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Abramson Cancer Center at Penn Medicine
Smoking Cessation
Smoking Response Inhibition Training
The current study tests a response inhibition retraining program, implemented on a mobile device, as a mechanism to increase relapse prevention during a smoking cessation attempt.
- Trial name
- NCT02218944
- Testing
- Response Inhibition Training
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- North Dakota State University
Smoking, Smoking Cessation
Opioids and Smoking Cessation
The selection hypothesis of smoking prevalence posits that smokers who are not able to quit successfully are "burdened" by specific characteristics that make it more challenging to quit1.
- Conditions
- Smoking, Smoking Cessation, Smoking, Tobacco, Opioid Use
- Trial name
- NCT03857139
- Testing
- Nicotine patch
- Where
- United States
- Sponsor
- University of Houston
Smoking, Depression
Smoking Cessation for Depressed Smokers
Objectives: Primary Aim: To conduct a preliminary randomized trial in smokers with current recurrent major depressive disorder (MDD), current MDD with a single episode of 2 years or more, and current dysthymia comparing combined…
- Trial name
- NCT00494728
- Testing
- Smoking Cessation Treatment, Nicotine Replacement Therapy, CBASP
- Where
- United States
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Tobacco Use Disorder
Persistence-Targeted Smoking Cessation
The investigators propose to develop a theory-based smoking cessation intervention (called Persistence-targeted smoking cessation; PTSC).
- Trial name
- PTSC (NCT01654107)
- Testing
- Persistence Targeted Smoking Cessation, Clearing The Air, Nicotine lozenge
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Smoking Cessation
Interventions for Maximizing Patient And Family Smoking Cessation Together
This feasibility study evaluates the effectiveness of a household-based smoking cessation intervention for patients and their household members.
- Trial name
- IMPACT (NCT07267936)
- Testing
- Household member support
- Where
- United Kingdom
- Volunteers
- 231 people
- Sponsor
- Papworth Hospital NHS Foundation Trust
Smoking
'Questions About Quitting' Smoking Cessation Trial
The current study tested the effectiveness of four potentially important tailoring factors (decisional framework, self-efficacy, navigation autonomy, and proactive outreach) in the context of an online motivational intervention…
- Trial name
- Q2 (NCT00992264)
- Testing
- Message Tone, Navigation, Proactive Outreach
- Where
- United States
- Volunteers
- 1,865 people
- Sponsor
- Kaiser Permanente
Bladder Cancer
Determinants of Bladder Cancer Recurrence Study (The DETER Study)
The purpose of this study is to learn how different lifestyle factors, such as cigarette smoking and body weight, change after a diagnosis of bladder cancer, and how they influence who gets a bladder cancer recurrence and who…
- Trial name
- NCT02400944
- Testing
- questionnaires, Saliva and/or urine sample
- Where
- 4 sites in United States
- Volunteers
- 600 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Smoking Cessation
Manitoba Pharmacist Initiated Smoking Cessation Pilot Project
A single arm pilot study conducted to assess the feasibility of having Manitoba Pharmacists provide support (product and cognitive) to low-income (receiving social assistance) smokers wishing to quit smoking.
- Trial name
- NCT02554071
- Testing
- Pharmacist - Smoking Cessation Support
- Where
- Canada
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Smoking, Lung Diseases
Evaluation of Lungs of Normal Individuals by Lung Lavage, Brushing and Bronchial Wall Biopsy
The purpose of this study is to obtain biologic materials from the blood and lungs of normal individuals to establish a set of normal range for various parameters.
- Trial name
- NCT00224185
- Testing
- Bronchopulmonary Lung Lavage, Bronchial Brushing, Bronchial Wall Biopsy
- Where
- United States
- Volunteers
- 196 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Healthy Adult Participants
Urban Exposome and Biological Age
The goal of this observational study is to evaluate the impact of the urban exposome, including air pollution and lifestyle-related stressors, on biological aging, inflammatory pathways, oxidative stress, and DNA methylation…
- Trial name
- IDEA (NCT07817836)
- Where
- Italy
- Volunteers
- 151 people
- Sponsor
- University of Pavia
Colorectal Disorders
Post-operative Complications and Smoking Habits in Colorectal Surgery
PASSAGE is a national multicenter retrospective and prospective observational cohort study in which patients who will undergo colorectal surgery will be enrolled.
- Trial name
- PASSAGE (NCT06339671)
- Where
- Italy
- Volunteers
- 1,527 people
- Sponsor
- IRCCS Ospedale San Raffaele
Smoking
The Contribution of a Smartphone Application to Acceptance and Commitment Therapy Group Treatment for Smoking Cessation
The purpose of this study is to evaluate the efficacy of a smartphone application in enhancing Acceptance and Commitment Therapy group treatment for smoking cessation.
- Trial name
- NCT02901171
- Testing
- ACT group treatment combined with smartphone application, ACT group treatment, Group based Behavioural Support Programme
- Where
- Ireland
- Volunteers
- 150 people
- Sponsor
- University College Dublin
Periodontal Disease, Periodontitis (Stage 3)
Omega-3 Plus Low-Dose Aspirin in Smokers With Stage III Periodontitis
This randomized double-blind placebo-controlled clinical trial aims to evaluate the clinical and biochemical effects of omega-3 fatty acids combined with low-dose aspirin as an adjunct to scaling and root planing (SRP) in smoker…
- Conditions
- Periodontal Disease, Periodontitis (Stage 3), Smoking Behaviors
- Trial name
- OASP (NCT07673185)
- Testing
- Omega-3 Fatty Acids (EPA plus DHA) plus low dose aspirin
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Al-Azhar University
Tobacco Use Disorder
Project Q: Cue-based Treatment Intervention to Promote Cessation Among People Who Smoke Lightly or Non-daily
This study aims to test the feasibility and acceptability of a remotely delivered cue-based treatment intervention to promote smoking cessation among people who smoke lightly or non-daily.
- Trial name
- NCT07425119
- Testing
- Cognitive Behavioral Therapy (CBT), Cue-based treatment intervention
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Duke University
Cannabis Use, Tobacco Use
Effect of Cannabis on Cigarette Use Behavior
The purpose of this study is to determine the impact of tetrahydrocannabinol (THC) administration on motivational, subjective, and physiological effects of cigarettes.
- Conditions
- Cannabis Use, Tobacco Use, Cigarette Smoking
- Trial name
- NCT06609083
- Testing
- THC 30mg, THC 5mg, THC 0mg
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Tobacco Dependence
Comparisons of Nicotine-free Cigarettes, Extra Low Nicotine Cigarettes vs. Medicinal Nicotine
In this study, smokers will be randomly assigned to one of three conditions for six weeks: 1) nicotine-free cigarettes (0.05mg); 2) extra low nicotine cigarettes (0.3 mg); or 3) medicinal 4 mg nicotine lozenge.
- Trial name
- NCT00777569
- Testing
- Nicotine free cigarettes, Extra-low nicotine cigarettes, Nicotine Lozenge
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
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