Clinical trials: Tobacco Smoking Behavior
Chronic Obstructive Pulmonary Disease - COPD
Formoterol Dose Ranging Study (ACHIEVE Duaklir USA Phase IIb)
To assess the bronchodilation of three doses of formoterol fumarate (6 μg, 12 μg and 24 μg) twice daily (BID) administered via Pressair® compared to placebo and to open-label nebulized formoterol fumarate (20 μg and 40 μg).
- Trial name
- NCT02796651
- Testing
- Formoterol fumarate (6 μg), Formoterol furmarate (20 μg), Formoterol fumarate (12 μg)
- Where
- 20 sites in United States
- Volunteers
- 132 people
- Sponsor
- AstraZeneca
Smoking
A Pharmacokinetic Evaluation of Two Nicotine Patches in Smokers
Bioequivalence study to confirm that a NTS with a polyisobutylene (PIB) adhesive from an alternative supplier delivers the same nicotine blood profile as that of the currently approved NTS with a polyisobutylene adhesive from the…
- Trial name
- NCT01702519
- Testing
- nicotine
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Nicotine Addiction, Smoking Cessation
Evaluation of a Smoking Cessation Program for Long-Term Abstinence
This observational study evaluates a structured smoking cessation program delivered via weekly group sessions. The primary objective is to assess participant-reported smoking abstinence following completion of the program and at…
- Trial name
- ESCaPe (NCT06746025)
- Testing
- Quit Center cessation program
- Where
- United States
- Volunteers
- 371 people
- Sponsor
- Quit Center LLC
Healthy Smokers
Pilot Pharmacokinetic Study of New Nicotine Lozenge Formulations
The purpose of this study is to determine the pharmacokinetic profile of nicotine following a single oral administration of three new nicotine lozenge formulations (V0474) in comparison with two reference products.
- Trial name
- NCT01574898
- Testing
- V0474 - A mg, V0474 - B mg, V0474 - C mg
- Where
- France
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Pierre Fabre Medicament
Cardiovascular Disease, Cigarette Smoking
Cardiovascular Disease Biomarkers in Smokers and Moist Snuff Consumers
This cross-sectional study was primarily a cardiovascular disease (CVD) study designed a) to compare selected CVD biomarker data between subjects who were long-term consumers of cigarettes or moist snuff and non-consumers of…
- Trial name
- NCT01692353
- Testing
- Subject's usual brand (UB) tobacco product
- Where
- United States
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- R.J. Reynolds Tobacco Company
Cigarette Smoking
Characterization of Biomarkers of Tobacco Exposure, Urge-to-Smoke Following Exclusive and Dual Ad Lib Use of Electronic Cigarettes
This is a randomized, open-label, forced-switch, parallel, proof-of-concept study to assess exposure to biomarkers of tobacco exposure following short-term ad lib use of three blu e-cigarette products.
- Trial name
- NCT02385227
- Testing
- Exclusive blu™ e-cigarette A1, Exclusive blu™ e-cigarette A2, Exclusive blu™ e-cigarette A3
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Lorillard Tobacco Company
Tobacco Dependence
Single-dose Pharmacokinetics of Oral Nicotine Replacement Products
This is an explorative study comparing new prototypes of Nicotine Replacement Products with Nicorette® gum.
- Trial name
- NCT01228617
- Testing
- Nicotine, Nicotine Gum
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Johnson & Johnson Consumer and Personal Products Worldwide
Smoking Cessation
Multiple Dose, Dose Escalation Study of Varenicline Controlled Release Formulation in Adult Smokers
The purpose of this study is to evaluate the safety, tolerability and pharmacokinetics of escalating multiple oral doses of varenicline AMT 8 controlled release formulation for 14 days in adult smokers.
- Trial name
- NCT00527150
- Testing
- Varenicline Tartrate
- Where
- 2 sites in United States
- Volunteers
- 48 people
- Sponsor
- Pfizer
Smoking Cessation
An Open Label Study That Compares Varenicline to Transdermal Nicotine Patch for Smoking Cessation
Open-label comparison of standard 12-week regimen of varenicline with standard 10-week regimen of transdermal nicotine patch for smoking cessation.
- Trial name
- NCT00143325
- Testing
- varenicline (CP-526,555)
- Where
- 22 sites in United States, Belgium and 3 more
- Volunteers
- 730 people
- Sponsor
- Pfizer
Smoking, Healthy
Determination of Biomarkers of Exposure and Biomarkers of Potential Harm in Asian Adult Cigarette Smokers
The purpose of this study is to determine biomarkers of exposure to Harmful and Potentially Harmful Constituents (HPHCs) in Cigarette Smoke and cardiovascular-related biomarkers in smokers and non smokers.
- Trial name
- NCT02103751
- Where
- Japan
- Volunteers
- 1,069 people, healthy volunteers welcome
- Sponsor
- Philip Morris Products S.A.
Smoking
A 26-week Extension of the ZRHR-ERS-09-US Study Evaluating Biological and Functional Changes in Healthy Smokers After Switching to THS 2.2
The objective of the ZRHR-ERS-09-EXT-US study is to further assess the effect of the Tobacco Heating System 2.2 (THS 2.2), a candidate Modified Risk Tobacco Product, compared to conventional cigarettes (CC) on the components of…
- Trial name
- NCT02649556
- Testing
- THS 2.2, CC
- Where
- 19 sites in United States
- Volunteers
- 672 people, healthy volunteers welcome
- Sponsor
- Philip Morris Products S.A.
Nicotine Dependence, Nicotine Dependence, Cigarettes
United States Pre-Market Tobacco Application Pharmacokinetics
A Randomized, Open-Label, Cross-Over Study to Assess Nicotine Uptake and Subjective Measures with Use of JUUL 5% Electronic Nicotine Delivery Systems (ENDS) Compared to Usual Brand Combustible Cigarettes, a Comparator…
- Conditions
- Nicotine Dependence, Nicotine Dependence, Cigarettes, Tobacco Use, Tobacco Smoking
- Trial name
- US-PMTA-PK (NCT03719391)
- Testing
- Virginia Tobacco flavored JUUL 5% ENDS, Cool Mint flavored JUUL 5% ENDS, Mango flavored JUUL 5% ENDS
- Where
- United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Juul Labs, Inc.
Smoking Cessation
Smoking Cessation Study for Patients With Schizophrenia or Schizoaffective Disorder
Study will determine whether patients with schizophrenia or schizoaffective disorder can be helped to quit smoking safely while using varenicline and receiving smoking cessation counseling.
- Trial name
- NCT00644969
- Testing
- varenicline (CP-526,555)
- Where
- 14 sites in United States, Canada
- Volunteers
- 128 people
- Sponsor
- Pfizer
Smoking Cessation, Nicotine Addiction
Innovative Digital Therapeutic for Smoking Cessation
This study is comparing the efficacy of two smoking cessation apps.
- Conditions
- Smoking Cessation, Nicotine Addiction, Drug Addiction, Drug Dependence
- Trial name
- NCT03694327
- Testing
- CT-101-M, QuitGuide
- Where
- United States
- Volunteers
- 158 people
- Sponsor
- My Digital Study
Smoking Cessation
A Study Evaluating The Absorption Of Varenicline Into The Body From A Varenicline Patch Applied To The Skin
This study will evaluate the single-dose pharmacokinetics, safety, and tolerability of a varenicline patch applied to the skin.
- Trial name
- NCT01013454
- Testing
- varenicline free base patch
- Where
- Belgium
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Pfizer
Smoking Cessation, Smoking, Tobacco
Pivot Breath Sensor Performance Study
A clinical study enrolling 70 subjects to: evaluate the user performance of the Pivot Breath Sensor compare measurements from the Pivot Breath Sensor to a similar device assess user documentation comprehension obtain feedback on…
- Trial name
- NCT03870022
- Testing
- Pivot Breath Sensor System, Similar Carbon Monoxide breath sensor system
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Jennifer Marler, MD
Smoking Cessation
A Study to Assess the Safety, Tolerability and Pharmacokinetics of AZD4041 in Healthy Volunteers
This is a Phase I, first-in-human (FIH), single-center, randomized, double-blind, placebo controlled, single ascending dose, sequential group study in healthy vasectomized male and female subjects of non-childbearing potential…
- Trial name
- NCT04076540
- Testing
- AZD4041
- Where
- 2 sites in United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Smoking Cessation
Photoirritation and Photoallergic Potential of a New Nicotine Patch
An evaluation of the effects of UV exposure following the use of a new nicotine patch.
- Trial name
- NCT00966901
- Testing
- Nicotine Patch, No Patch Control, UVA and UVB irradiation
- Where
- Germany
- Volunteers
- 43 people
- Sponsor
- McNeil AB
Cholesterol; Lipidosis, Arterial Hypertension
Assessment of Lifestyle, Blood Pressure, Cholesterol and Glycated Hemoglobin in a Specific Population
The project Shall we get to know your health better? Lifestyle assessment, blood pressure and cholesterol in the population of Libbs Farmacêutica employeesLTDA.; consists of a study that will bring knowledge and enable…
- Conditions
- Cholesterol; Lipidosis, Arterial Hypertension, Blood Glucose, High
- Trial name
- LB1901 (NCT04373863)
- Where
- Brazil
- Volunteers
- 2,472 people, healthy volunteers welcome
- Sponsor
- Libbs Farmacêutica LTDA
Smoking Cessation
Drug Use Investigation Of Varenicline (Regulatory Post Marketing Commitment Plan)
The objective of this surveillance is to collect information about 1) adverse drug reaction not expected from the LPD (unknown adverse drug reaction), 2) the incidence of adverse drug reactions in this surveillance, and 3)factors…
- Trial name
- NCT00772941
- Testing
- Varenicline
- Volunteers
- 3,939 people
- Sponsor
- Pfizer