Clinical trials: Tobacco Use
Smoking Cessation, Nicotine Addiction
Nicotine Receptor Levels and Smoking Cessation
The investigators propose to use positron emission tomography (PET) imaging to determine whether nicotinic receptor availability at pretreatment predicts smoking cessation success.
- Trial name
- NCT01788943
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Lung Carcinoma, Tobacco Use Disorder
Intermittent or Continuous Acetylsalicylic Acid and Gene Expression in the Nasal Tissue of Current Smokers
This randomized phase II trial studies the safety and effects of acetylsalicylic acid (aspirin) taken continuously or intermittently on gene expression in the nasal tissue of current smokers.
- Trial name
- NCT02123849
- Testing
- Aspirin, Laboratory Biomarker Analysis
- Where
- 2 sites in United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Smoking Reduction, Tobacco Use
Promoting Smoking Cessation in Lung Cancer Screening Through Proactive Treatment
This pragmatic trial will evaluate the value of routinely providing proactive smoking cessation support to current smokers as a part of participating in lung cancer screening within Veterans Health Administration.
- Conditions
- Smoking Reduction, Tobacco Use, Tobacco Smoking, Tomography
- Trial name
- PROACT (NCT03612804)
- Testing
- Unsigned note to provider about cessation medication prescription, Proactive Telephone Counseling from VA Quitline
- Where
- 3 sites in United States
- Volunteers
- 944 people
- Sponsor
- VA Office of Research and Development
Nicotine Dependence, Cigarette Smoking
New Approaches to Smoking Cessation in Heavy Drinkers
The purpose of this study is to develop and test an integrated cognitive-behavioral intervention for smoking and alcohol among heavy drinking smokers.
- Conditions
- Nicotine Dependence, Cigarette Smoking, Alcohol Consumption, Heavy Drinking
- Trial name
- NCT02151591
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Yale University
Tobacco Smoking, Psychiatric Disorder
Acceptance and Commitment Therapy for Tobacco Cessation Among Psychiatric Partial Hospital Patients
People with serious mental illness are three times more likely to smoke cigarettes than people without mental illness. People with mental illness are less likely to be successful in quitting smoking than those without mental…
- Conditions
- Tobacco Smoking, Psychiatric Disorder, Psychiatric Hospitalization
- Trial name
- NCT03911960
- Testing
- Acceptance and Commitment Therapy, Enhanced Usual Care
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- The Miriam Hospital
Nicotine Dependence
Improving the Efficacy of Anti-Nicotine Immunotherapy
The purpose of this study is to find out how vaccine-induced antibodies change the way the body processes nicotine from cigarettes. These antibodies absorb nicotine and can reduce nicotine levels in the brain.
- Trial name
- PETNic002 (NCT01280968)
- Testing
- NIC002 in Aluminum hydroxide (Alum)
- Where
- 2 sites in United States
- Volunteers
- 52 people
- Sponsor
- Alexey Mukhin
Tobacco Use, Tobacco Smoking
Tobacco Cessation at FDNY
At the Fire Department of the City of New York (FDNY) World Trade Center Health Program, 36% of participants in the low dose computed tomography (LDCT) lung cancer screening program are current smokers, despite referral to the…
- Conditions
- Tobacco Use, Tobacco Smoking, Tobacco Use Cessation
- Trial name
- NCT05997225
- Testing
- opt out enrollment, tailored counseling, varenicline started prior to target quit date, opt in enrollment, non-tailored counseling, varenicline started prior to target quit date
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Albert Einstein College of Medicine
Tobacco Dependence, Schizophrenia
Cigarette Smoking in Smokers With and Without Schizophrenia
Higher rates and severity of tobacco dependence in people with schizophrenia, as compared with the general population, contribute to the lower life expectancy seen in this population.
- Trial name
- NCT04001114
- Testing
- Sampling Research Cigarettes
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Nicotine Dependence
Measuring Smoking Behaviors While Using Varenicline
This study will demonstrate the behavioral responses to varenicline, helping to better understand its mechanisms. Hypotheses for the study are to observe decreases in smoking topography and nicotine cigarette choice on…
- Trial name
- NCT00948155
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Tobacco Use Disorder
Effect of a Non-Invasive Brain Stimulation Technique on Smoking Cessation Behaviors
In this pilot study, the feasibility of using tDCS (a non-invasive brain stimulation technique) while performing a task requiring cognitive flexibility will be examined in smokers and initial data will be collected regarding the…
- Trial name
- NCT03386253
- Testing
- active tDCS
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Tobacco Use
A Study to Assess Changes in Cigarette Consumption During a Switch to Very Low Nicotine Cigarettes
This study evaluates the impact of switching from usual brand cigarettes to very low nicotine cigarettes on cigarette consumption, smoking behavior, and biomarkers of exposure.
- Trial name
- NCT03571724
- Testing
- Non-Menthol Very Low Nicotine Cigarettes, Menthol Very Low Nicotine Cigarettes, Subject's UB non-mentholated filtered cigarettes
- Where
- 2 sites in United States
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- 22nd Century Group, Inc.
Smoking Cessation, Smoking
A Quit Smoking Study Using Smartphones
The objective of this research is to determine whether smartphone games show promise for helping smokers increase their chances of quitting.
- Conditions
- Smoking Cessation, Smoking, Nicotine Dependence
- Trial name
- NCT02164383
- Testing
- Nicotine patch, Cessation Counseling, Mobile Games
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Wisconsin, Madison
Cancer, Tobacco Use
Improving Tobacco Treatment Rates for Cancer Patients Who Smoke
The research objective is to identify a simple, pragmatic, innovative way of enhancing Tobacco Use Treatment (TUT) rates within oncology.
- Conditions
- Cancer, Tobacco Use, Smoking, Nicotine Dependence
- Trial name
- NCT04738643
- Testing
- Tobacco Use Treatment Service and Varenicline Management
- Where
- 2 sites in United States
- Volunteers
- 685 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Tobacco Use
A Mobile App Based Cognitive Dissonance Intervention for Smoking Cessation
This research study aims to develop a cognitive dissonance-based mobile app for smoking cessation (Support2Quit) and test the efficacy of the app with 500 adult smokers who express a desire to quit smoking.
- Trial name
- Support2Quit (NCT05797155)
- Testing
- Support2Quit App - Cognitive Dissonance Based Smoking Cessation + Smoking Cessation Tips, Tips for Smoking Cessation App
- Where
- United States
- Volunteers
- 437 people, healthy volunteers welcome
- Sponsor
- Oregon Research Behavioral Intervention Strategies, Inc.
Second Hand Tobacco Smoke, Nicotine Dependence
Babies Living Safe and Smokefree
The purpose of this randomized controlled trial is to develop and test the efficacy of a multilevel, multimodal intervention designed to modify maternal smoking behavior to reduce children's exposure to secondhand tobacco smoke…
- Trial name
- BLiSS (NCT02602288)
- Testing
- Ask, Advise, Refer, Telebased tobacco counseling, Telebased nutrition counseling
- Where
- 2 sites in United States
- Volunteers
- 396 people
- Sponsor
- Temple University
Nicotine Dependence
Extended Cessation Treatment for Teen Smokers
This study is designed to test the efficacy of an extended smoking cessation program for teen smokers. We hypothesize that teen smokers randomized to extended treatment will have a higher abstinence rate at 52 week follow-up than…
- Trial name
- Nicoteens (NCT00459953)
- Testing
- Extended treatment
- Where
- United States
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- Stanford University
Tobacco Use Disorder, Nicotine Addiction
Effects of Semaglutide on Nicotine Intake
Tobacco use remains the foremost cause of preventable deaths in the U.S. and worldwide. Advancing new smoking cessation therapies, including those targeting novel biological mechanisms, is a critical public health priority.
- Trial name
- NCT05530577
- Testing
- Semaglutide
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Tobacco Dependence
Predictors of Treatment Outcome for Smokers With and Without Schizophrenia
The primary purpose of this investigation is to determine the predictive value of task persistence as measured by a mirror tracing task.
- Trial name
- NCT00501007
- Where
- United States
- Volunteers
- 203 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Preterm Birth, Health Care Utilization
Testing Feasibility of Care Coordination and Motivational Interviewing for Women With a Recent Preterm Birth
This study continues an adaptation of care coordination to address the needs of women after preterm birth. This is a small single arm open trial designed to test intervention implementation and refine the intervention before…
- Conditions
- Preterm Birth, Health Care Utilization, Tobacco Use, Contraceptive Usage
- Trial name
- NCT05120843
- Testing
- Care coordination and motivational interviewing
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Smoking Cessation
Behavioral and Enhanced Perinatal Intervention for Cessation (B-EPIC): Reducing Tobacco Use Among Opioid Addicted Women
This study tests an intervention for tobacco cessation (named B-EPIC) in an established community medication assisted treatment (MAT) clinic for pregnant and postpartum women with opioid dependence.
- Trial name
- B-EPIC (NCT03796208)
- Testing
- Behavioral and Enhanced Perinatal Intervention for Cessation (B-EPIC), Treatment As Usual
- Where
- 2 sites in United States
- Volunteers
- 78 people
- Sponsor
- Kristin Ashford