Clinical trials: Toddlers
Vestibular Disorder
Vestibular Function and Motor Development in Small Children
Infants and toddlers with and without vestibular impairment will be tested blinded by pediatric physiotherapist with different age adequate motor scales in order to find out pathological motor patterns specifically associated to…
- Trial name
- NCT07079488
- Testing
- Motor proficiency scales
- Where
- Sweden
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Region Stockholm
Meningococcal Immunisation, Healthy Volunteers
Study on an Investigational Quadrivalent Meningococcal Conjugate Vaccine (MenACYW Conjugate Vaccine) Administered as a 5- and/or 10-year Booster Doses in Children and Adolescents Vaccinated 5 or 10 Years Earlier as Toddlers
The purpose of the MEQ00073 study is to describe the immunogenicity and safety of a booster dose and persistence of a priming dose of MenACYW conjugate vaccine (MenQuadfi®) in adolescents who had been vaccinated approximately 10…
- Trial name
- NCT04936685
- Testing
- Meningococcal Polysaccharide (Serogroups A, C, W, and Y) Tetanus Toxoid Conjugate Vaccine
- Where
- 27 sites in Finland, Germany and 2 more
- Volunteers
- 209 people, healthy volunteers welcome
- Sponsor
- Sanofi Pasteur, a Sanofi Company
Meningococcal Infections
Immunogenicity and Safety of a Booster Dose of a Quadrivalent Meningococcal Conjugate Vaccine in Children
This was an open-label, multi-center study to describe the immune persistence of the priming dose and describe the immunogenicity and safety of a booster dose of Meningococcal Polysaccharide (Serogroups A, C, Y, and W) Tetanus…
- Trial name
- NCT03476135
- Testing
- MenACYW conjugate vaccine
- Where
- 8 sites in Finland
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Sanofi Pasteur, a Sanofi Company
Depression, Anxiety
Building Emotion Awareness and Mental Health (BEAM): Mothers of Toddlers
During the COVID-19 pandemic, the prevalence of maternal depression and anxiety has increased and research suggests that the cognitive development of children born during the pandemic has been impacted.
- Trial name
- NCT05306626
- Testing
- Building Emotion Awareness and Mental Health (BEAM)
- Where
- Canada
- Volunteers
- 140 people
- Sponsor
- University of Manitoba
Sleep Disorder
Associations of Socioeconomic Adversity and Sleep With Allostatic Load Among Toddlers
A longitudinal study to examine the relationships among sleep characteristics, stress, and child behavior problems in a community sample of toddlers (12-24 months- ages 12-15 months at enrollment) living in socioeconomically…
- Trial name
- NCT03419871
- Testing
- Monitoring Sleep, stress biomarkers
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Yale University
Sickle Cell Disease
Testing the Sickle Cell Caregiver Collaboration for Child Development (SCCCD) Intervention
Sickle cell disease affects 100,000 people and 2,000 newborns each year; 50% of these children have a developmental deficit (>2 SD) before the age of 3.
- Trial name
- SCCCD (NCT06562439)
- Testing
- Sickle Cell Collaboration for Child Development
- Where
- United States
- Sponsor
- Washington University School of Medicine
Invasive Candidiasis, Esophageal Candidiasis
Study of Mycamine® in Infants and Toddlers With Fungal Infections to Evaluate Safety and Blood Levels of the Drug
Infants and toddlers with fungal infections will receive 10 to 14 days of treatment with an antifungal drug. Safety and drug blood levels will be assessed
- Conditions
- Invasive Candidiasis, Esophageal Candidiasis, Oropharyngeal Candidiasis, Candidemia
- Trial name
- NCT00607763
- Testing
- Micafungin (Mycamine)
- Where
- 6 sites in United States
- Volunteers
- 9 people
- Sponsor
- Astellas Pharma Inc
Merosin Deficient Congenital Muscular Dystrophy
Retrospective Natural History Study of Infants and Toddlers With LAMA2-CMD
This retrospective chart review study of 75-120 LAMA2-CMD patients will expand the investigators understanding of the natural history of this disease.
- Trial name
- LAMA2 rNHS (NCT04299321)
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Prothelia, Inc.
Diarrhea Toddlers, Escherichia Coli Diarrhea
An Epidemiological Surveillance Study to Determine the Incidence of ETEC in Children and Infants in Lusaka
Diarrhoea is the one of the top five leading causes of death among children below the age of five years, globally. It is estimated that one in ten deaths in children under five is attributed to diarrhoea.
- Trial name
- ETEC-Surv (NCT04838587)
- Testing
- No intervention will be done
- Where
- 4 sites in Zambia
- Volunteers
- 6,828 people, healthy volunteers welcome
- Sponsor
- Centre for Infectious Disease Research in Zambia
Meningococcal Meningitis, Measles
Immunogenicity and Safety of Pediatric Vaccines When Administered With Menactra® in Healthy Toddlers
This is a modified single-blind, randomized, parallel-group, comparative, multicenter study to test Menactra vaccine in toddlers.
- Conditions
- Meningococcal Meningitis, Measles, Mumps, Rubella
- Trial name
- NCT00422292
- Testing
- Meningococcal Polysaccharide Diphtheria Conjugate Vaccine, Measles, Mumps, Rubella and Varicella
- Where
- 88 sites in United States, Puerto Rico
- Volunteers
- 1,664 people, healthy volunteers welcome
- Sponsor
- Sanofi Pasteur, a Sanofi Company
Hepatitis A
Immunogenicity and Persistence of GlaxoSmithKline (GSK) Biologicals' Havrix® in Healthy Adult Subjects Vaccinated at Infancy Under the Hepatitis A Universal Mass Vaccination (UMV) Program in Israel
This study will evaluate the persistence, immunogenicity and safety of Havrix® (hepatitis A vaccine) in adults primed in infancy.
- Trial name
- NCT03183492
- Testing
- Havrix®
- Volunteers
- healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Food Preferences, Parenting
The GAIN Study: Understanding What Helps Children Learn to Like and Eat New Foods
Nutrition supplements have tremendous impact upon the nutritional and developmental status of malnourished children. These products have been designed to be acceptable to children (often by adding nutritive sweeteners to make…
- Trial name
- NCT04544332
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- University of Colorado, Denver
Healthy Volunteers
Milk Free From A1-Type β-Casein With Human Milk Oligosaccharides on Gut Health, Immunity, Cognitive Development, and Temperament in Toddlers
The aim of the study is to compare the effects of HMOs in A1-type β-casein-free formula on gut health, immunity, inflammation, gut microflora, cognitive development, and temperament compared with HMOs in conventional formula in…
- Trial name
- NCT07882043
- Testing
- a2 toddler milk with HMOs, Conventional toddler milk with HMOs
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- a2 Milk Company Ltd.
Obesity
Milk-Tot Study: Impact of Whole Versus Low-fat Milk on Child Health
In the U.S. it is recommended that children consume whole cow's milk (3.5% fat) from ages 1 to 2 years to support rapid early growth and brain development, and then at age 2 years transition to low-fat (1%) or non-fat milk to…
- Trial name
- NCT06230510
- Testing
- Introduction of Milk Type, Child Nutrition Counseling
- Where
- United States
- Volunteers
- 625 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Cerebral Palsy
Independent Walking Onset of Children With Cerebral Palsy
This study will focus the gait analysis, using an optoelectronic system, of children with unilateral cerebral palsy compared to typically developed children in the first 6 months of independent walking.
- Trial name
- BB-AQM (NCT03902886)
- Testing
- gait analysis
- Where
- 2 sites in France, Romania
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Autism Spectrum Disorder
A Trial of Project ImPACT in Early Intervention
Our pilot study will address a number of pressing questions, including: Can community clinicians successfully coach parents of children with ASD in evidence-based practice to achieve positive outcomes for their children and…
- Trial name
- NCT04729127
- Testing
- Project ImPACT
- Where
- United States
- Volunteers
- 79 people
- Sponsor
- University of Pennsylvania
Children With Mobility Disabilities
Advancing Mobility and Socialization in Toddlers With Disabilities: Modified Toy Cars Training With Different Postures
The three purposes of this study are: 1) to examine the feasibility and effects of ride-on car training with two different postures on mobility and socialization in toddlers with disabilities; 2) to quantify whether toddlers with…
- Trial name
- NCT02527356
- Testing
- Ride-On Cars with Standing Posture (ROC-Stand), Ride-On Cars with Standing Postures (ROC-Sit), Regular Therapy Program
- Where
- Taiwan
- Volunteers
- 37 people
- Sponsor
- Chang Gung Memorial Hospital
Autism Spectrum Disorder
A Randomized Clinical Trial for Toddlers With ASD
This research is being done to test the effectiveness of two treatments aimed at increasing language and social skills in children with autism spectrum disorder.
- Trial name
- NCT01008800
- Testing
- Social Communication
- Where
- United States
- Volunteers
- 196 people
- Sponsor
- Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
Infant
Metabolome and Microbiomic in Fecal Samples
The purpose of this study is to evaluate the effects of storage and handling on fecal samples collected for metabolomic, proteomic and microbiomic and analysis.
- Trial name
- MicroMet (NCT00938028)
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Autism Spectrum Disorder
Early Neurodivergent Developmental Trajectories in Autism and in Response to the ESDM Intervention
Early support is thought to be key to ensure a better quality of life for young children on the autism spectrum. Among early support, different evidence-based approaches have combined the principles of developmental and…
- Trial name
- NCT06494605
- Testing
- Early Start Denver Model (ESDM)
- Where
- Italy
- Volunteers
- 33 people
- Sponsor
- Istituto per la Ricerca e l'Innovazione Biomedica