Clinical trials: Tolerance
Non-Alcoholic Fatty Liver Disease
Effects of TOTUM-448 on Liver Fat Content, Cardiometabolic Risk Factors and Gut Microbiota Among Participants with MASLD
This clinical trial aims to investigate the effects of TOTUM-448, a mix of 5 plant extracts and choline, consumed at the daily regimen of two times per day, on liver fat content, cardiometabolic risk factors and gut microbiota…
- Trial name
- CARDIO-LIVER (NCT06704321)
- Testing
- TOTUM-448
- Where
- Canada
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Valbiotis
Healthy Adult Volunteers
99mTc-rhAnnexin V-128: a First In Man Study in Healthy Volunteers
The objectives of this study are: To determine the safety and tolerability of a single dose of 99mTc-rhAnnexin V-128 administered as an intravenous bolus over 10-20 seconds.
- Trial name
- NCT02182609
- Testing
- Kit for the Preparation of 99mTc-rhAnnexin V-128
- Where
- Canada
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Advanced Accelerator Applications
Tolerance
Tolerance and Safety of a Ketone-Promoting Food Ingredient
The objective of this study is to capture information on tolerance and safety of a ketone-promoting food ingredient in healthy adults.
- Trial name
- NCT04707989
- Testing
- Ketone- Promoting Food Ingredient #1, Ketone- Promoting Food Ingredient #2
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- BHB Therapeutics, Ireland LTD
Healthy
Compare IBI305 and Bevacizumab on Pharmacokinetics/Safety/Immunogenicity on Healthy Male
To confirm the PK similarity of IBI305 and bevacizumab in healthy volunteers .
- Trial name
- NCT03083990
- Testing
- IBI305(Bevacizumab Biosimilar), Avastin(Bevacizumab)
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Innovent Biologics (Suzhou) Co. Ltd.
Healthy
Study of CM326 Injection in Healthy Subjects
This study is a single-center, randomized, double-blind, placebo-controlled, dose-increasing phase I clinical study.
- Trial name
- NCT05715333
- Testing
- CM326
- Where
- China
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Keymed Biosciences Co.Ltd
Atopic Diathesis, Eczema-prone Skin
Assessment of Skin Tolerance and Efficacy of a Cosmetic Product After 5 Days of Use on Subjects With Atopic Dermatitis
The aim of this study is to compare the efficacy and tolerability and of a cosmetic product to one that is already available on the market (benchmark product).
- Trial name
- NCT05807113
- Testing
- Atopi intensive care BNO 3731, Benchmark product
- Where
- Germany
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Bionorica SE
Prediabetes
Blood Sugar Take Care and Glucose Metabolism
This prospective international clinical trial is a two-arm, double-blind, randomized, placebo-controlled, parallel-group, multicenter study. 112 prediabetic subjects will be randomized to Blood Sugar Take Care or placebo.
- Trial name
- NCT01554020
- Testing
- Blood Sugar Take Care
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- NewChapter, Inc.
Healthy Pregnant Women
Milk Free From A1-Type β-Casein on Inflammation, Gastrointestinal Tolerance, and Pregnancy Outcomes
The aim of the study is to compare the effects of conventional Ultra High Temperature (UHT) milk containing both A1 and A2 type β-caseins (CON) with a2 UHT Milk containing A2 type β-casein only (A1PF) on inflammation, tolerance…
- Trial name
- NCT06980376
- Testing
- a2 UHT milk, Conventional UHT Milk
- Where
- 6 sites in China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- a2 Milk Company Ltd.
Healthy
Study of Multiple-dose Kukoamine B Mesilate in Healthy Volunteers
The purpose of this study is to assess safety, tolerance and pharmacokinetics of Multiple-dose Kukoamine B Mesilate in healthy volunteers
- Trial name
- NCT02690961
- Testing
- Kukoamine B Mesilate
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Tianjin Chasesun Pharmaceutical Co., LTD
Body Weight
Growth and Tolerance of Cow Milk-Based Infant Formulas
This clinical trial will assess growth, tolerance and adverse events of cow milk-based infant formulas in healthy, term infants.
- Trial name
- NCT01122654
- Where
- 24 sites in United States
- Volunteers
- 405 people, healthy volunteers welcome
- Sponsor
- Mead Johnson Nutrition
Rheumatoid Arthritis
A Phase Ⅰ Clinical Trial to Evaluate the Safety, Tolerance, Pharmacokinetics and Pharmacodynamics of SHR-3045 in Healthy Subjects
The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of SHR-3045 in healthy subjects.
- Trial name
- NCT06883695
- Testing
- SHR-3045 Injection
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Guangdong Hengrui Pharmaceutical Co., Ltd
Gastrointestinal Tolerance, Healthy Population
Evaluating the Impact of Incremental Doses of a Sugar Replacer Blend on Gastrointestinal Tolerance in Candies
This study is a randomized, single-blind, crossover trial aiming at evaluating the gastrointestinal tolerance of a sugar replacer blend (inulin + soluble corn fiber + erythritol) at 3 different doses
- Trial name
- NCT05827198
- Testing
- Low-sugar candies compared to regular sugar candies
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mondelēz International, Inc.
Acne Vulgaris
Effectiveness and Tolerance of Effaclar Serum in Women With Mandibular Acne
The role of "dermocosmetics" in acne management is increasingly important, as many patients and even physicians now resort to them as first-line management in mild-to-moderate acne.
- Trial name
- NCT05457621
- Testing
- Effaclar serum
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cosmetique Active International
Skin Care
Evaluation of the Cosmetic Benefit of a Skin Cream in Healthy Females With Mild to Advanced Photo-damaged Facial Skin Who Have Undergone a Glycolic Acid Facial Peel Procedure
Evaluation of the local tolerance and cosmetic efficacy of a topical skin care formulation in healthy female participants with mild to advanced photo-damaged facial skin who have undergone a 70% Glycolic Acid facial peel…
- Trial name
- NCT03103906
- Testing
- Cream (Test product), Cleanser (Reference Product), Sunscreen (Reference Product)
- Where
- 2 sites in Brazil
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Growth and Tolerance
Growth of Infants Fed Hydrolysate Formulas
Effects on weight and weight gain will be monitored in healthy term infants fed assigned infant formulas.
- Trial name
- NCT02006992
- Testing
- RTF Infant Formula, Powder Infant Formula
- Where
- 8 sites in United States
- Volunteers
- 195 people, healthy volunteers welcome
- Sponsor
- Abbott Nutrition
Infant, Newborn
Tolerance of Healthy Term Infants Fed Infant Formulas
The objective of the study is to assess comparative gastrointestinal tolerance of normal term infants to various milk-protein infant formulas.
- Trial name
- NCT00705562
- Testing
- milk protein formulas, varying carbohydrate/protein sources
- Where
- 15 sites in United States
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Abbott Nutrition
Overweight
Glucose Tolerance in Healthy Overweight Adults
The primary objective is to compare the postprandial glycemic response of healthy overweight adults after consuming an amino acid drink mix versus a control drink.
- Trial name
- NCT00974831
- Testing
- Amino Acid Drink Mixture, Glucose drink
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Abbott Nutrition
Growth
A Clinical Study to Investigate the Effects of an Infant Formula Containing Partially Hydrolysed Proteins on Growth, Safety and Tolerance in Healthy Term Infants
It is universally accepted that the best nutrition for a new-born infant is breast milk. Breast milk provides a complete set of nutrients to support growth and development of children in early life, including components that have…
- Trial name
- TENUTO (NCT03062761)
- Testing
- Infant Formula with prebiotics, Standard Infant Formula
- Where
- 15 sites in Finland, France and 4 more
- Volunteers
- 380 people, healthy volunteers welcome
- Sponsor
- Nutricia Research
Healthy
Gastrointestinal Tolerance And General Health Status Of Healthy Term Infants Fed A New Infant Formula
The purpose of this study is to assess stool consistency, in combination with additional health-related parameters including gastrointestinal tolerance and health-related quality of life, in a large sample of Chinese infants.
- Trial name
- NCT01370967
- Testing
- Study formula feeding, Human milk feeding, Mixed feeding
- Where
- 24 sites in China
- Volunteers
- 460 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Health, Subjective
Clinical Study of ALT-BB4 to Determine Tolerance, Safety and Pharmacokinetics in Healthy Volunteer
A Phase I Study to Evaluate the Tolerance, Safety and Pharmacokinetics of ALT-BB4 in Healthy Volunteers
- Trial name
- NCT05232175
- Testing
- ALT-BB4, 0.9%NaCl
- Where
- South Korea
- Volunteers
- 290 people, healthy volunteers welcome
- Sponsor
- Alteogen, Inc.