Clinical trials: Tolerance
Chronic Respiratory Failure, Non-invasive Ventilation
Clinical Impact of Patient-ventilator Asynchrony
The investigator wish to carry out this study to explore the link between patient-ventilator asynchrony with the efficiency and tolerance of NIV but also the quality of life in patients with chronic respiratory failure on…
- Conditions
- Chronic Respiratory Failure, Non-invasive Ventilation, Asynchrony Between Patient and Ventilator, Efficacy and Tolerance of Non-invasive Ventilation
- Trial name
- INSPIRER (NCT05796297)
- Testing
- Transcutaneous Capnography
- Where
- France
- Volunteers
- 35 people
- Sponsor
- Nantes University Hospital
Quality of Life, Postoperative Complications
Low Pressure Pneumoperitoneum and Deep Neuromuscular Block vs. Standard During RARP to Improve Quality of Recovery; a Randomized Controlled Study.
Intra-abdominal pressure (IAP) needed to create sufficient workspace during laparoscopic surgery affects the surrounding organs with ischemia-reperfusion injury and a systemic immune response.
- Conditions
- Quality of Life, Postoperative Complications, Acute Pain, Immune System Tolerance
- Trial name
- RECOVER-2 (NCT04250883)
- Testing
- Low intra-abdominal pressure, Deep neuromuscular blockade (NMB), Standard intra-abdominal pressure
- Where
- Netherlands
- Volunteers
- 97 people
- Sponsor
- Radboud University Medical Center
Safety Issues, Tolerance
First-in-human Trial to Evaluate the Safety, Tolerability and Pharmacokinetics of C106 in Healthy Subjects
This is a FIH, double-blind, placebo-controlled, within-group randomised, trial designed to evaluate the safety, tolerability, and pharmacokinetics (PK) of single and multiple ascending oral doses of compound 106 (C106) in…
- Conditions
- Safety Issues, Tolerance, Idiopathic Pulmonary Fibrosis, Pulmonary Hypertension
- Trial name
- NCT05427253
- Testing
- C106 solution
- Where
- Sweden
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Vicore Pharma AB
Impaired Glucose Tolerance
Postprandial Fatty Acid Metabolism in the Natural History of Type 2 Diabetes (T2D)
Lipotoxicity-causing fatty acid overexposure and accretion in lean tissues leads to insulin resistance and impaired pancreatic β-cell function - the hallmarks of T2D - contributing to associated complications such as heart…
- Trial name
- AGL11 (NCT02808182)
- Testing
- Nicotinic acid, [7,7,8,8-2H]-palmitate, [U-13C]-palmitate
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Infertility, Success Rate of Assisted Reproductive Therapy
Impact of Uterine Immune Profiling and Personalized Treatments in Patients Receiving a Single Blastocyst: a Matched Controlled Study
A recent randomised controlled trial and previous large cohort studies have shown that the uterine immune environment is a crucial element in improving the performance of Assisted Reproductive therapy (ART).
- Conditions
- Infertility, Success Rate of Assisted Reproductive Therapy, Single Embryo Transfer, Pregnancy Outcomes
- Trial name
- UTIMPROSET (NCT06503952)
- Where
- 2 sites in France
- Volunteers
- 340 people
- Sponsor
- Matricelab Innove
Carcinoma Breast, Radiation Therapy for Primary Breast Cancer
Dosimetric Comparison of Target Volume, Heart and Left Lung in Post Mastectomy Radiotherapy (RT) of Left Sided Breast Cancer by Free Breathing (FB) Versus Deep Inspiration Breath Hold (DIBH) Technique
Breast cancer is a leading cancer among Bangladeshi female. For breast cancer, there are different available treatment options according to the stage of disease. One of the important ones is radiotherapy (RT).
- Conditions
- Carcinoma Breast, Radiation Therapy for Primary Breast Cancer, Radiation Tolerance, Radiation Induced Cardiac Damage
- Trial name
- FB DIBH RT (NCT06746142)
- Testing
- Deep inspiration breath hold radiotherapy, Free breathing radiotherapy
- Where
- 4 sites in Bangladesh
- Volunteers
- 50 people
- Sponsor
- Nishat Tasnim
Norm, Social, Literacy
The Optimization and Evaluation of the Extremism and Intolerance Curriculum for the Kingdom of Bahrain.
Researcher from UNC Greensboro have partnered with Prevention Strategies and key stakeholders from the Kingdom of Bahrain to conduct a study using the innovative, engineering-inspired methodological approach, the Multiphase…
- Conditions
- Norm, Social, Literacy, Resistance Skills, Beliefs About Consequences
- Trial name
- NCT05088694
- Testing
- Peaceful Coexistence
- Where
- United States
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Greensboro
Type 2 Diabetes Mellitus, Prediabetes (Insulin Resistance, Impaired Glucose Tolerance)
Antidiabetic Effect of Olive Pomace Oil
This clinical trial aims at assessing whether consumption of olive pomace oil in the diet may benefit persons with type 2 diabetes mellitus or persons at risk of developing the disease (prediabetic persons).
- Conditions
- Type 2 Diabetes Mellitus, Prediabetes (Insulin Resistance, Impaired Glucose Tolerance), Prediabetic State, Diabetes
- Trial name
- OPODIABE (NCT06723886)
- Testing
- Experimental arm: Olive pomace oil, High-oleic acid sunflower oil
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Instituto de Ciencia y Tecnología de Alimentos y Nutrición
Safety Issues, Tolerance
Study to Evaluate LPH-5 in Healthy Subjects
This study will explore the safety, pharmacokinetics (PK) and pharmacodynamics (PD) of LPH-5.
- Trial name
- NCT06722820
- Testing
- LPH-5
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Lophora
Immune System Tolerance, Depression
ESAN II - Energy Sensing in Depression
The purpose of this study is to assess the effects of polyphenols from natural aronia juice on the immune system. Therefore, the study aims to distinguish the effects of natural juices that are rich in phytonutrients such as…
- Conditions
- Immune System Tolerance, Depression, Obesity, Microbial Colonization
- Trial name
- NCT05432362
- Testing
- Aronia Juice
- Where
- Austria
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Impaired Glucose Tolerance
HSK7653 in Chinese Patients with Impaired Glucose Tolerance
This study is being done to evaluate the efficacy, safety of HSK7653 in chinese participants with impaired glucose tolerance.
- Trial name
- NCT04727580
- Testing
- HSK7653 10mg Q2W, HSK7653 25mg Q2W
- Where
- China
- Volunteers
- 99 people
- Sponsor
- Haisco Pharmaceutical Group Co., Ltd.
Safety Issues, Tolerance
Phase 1 SAD/MAD Study of CVN766 in Healthy Volunteers
Randomized, Double-Blind, Placebo-Controlled, Safety, Tolerability, and Pharmacokinetic Study of Escalating Single and Multiple Doses of CVN766 in Healthy participants.
- Trial name
- NCT05105243
- Testing
- CVN766
- Where
- Australia
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Cerevance
PreDiabetes, Glucose Tolerance Impaired
A Study to Evaluate Efficacy and Safety of Distal Jejunal-release Dextrose Beads Formulation in Subjects With a Pathological Oral Glucose Tolerance Test
The primary purpose of the study is to evaluate the efficacy and safety of APHD-012 (distal jejunal-release dextrose [Aphaia technology, AT]) in participants with pre-diabetes (pathological Oral Glucose Tolerance Test (OGTT)).
- Trial name
- NCT05803772
- Testing
- APHD-012, APH-012P
- Where
- 3 sites in Slovakia
- Volunteers
- 31 people
- Sponsor
- Aphaia Pharma US LLC
Pulmonary Diseases, Oxygen Therapy
Effects of High-Flow Nasal Cannula on Exercise Outcomes in Lung Transplant Candidates: A Pilot Study
The study evaluated patients on the national lung transplant waiting list. It was pioneering in assessing high-complexity patients with severe pulmonary diseases subjected to a cardiopulmonary rehabilitation protocol using a…
- Conditions
- Pulmonary Diseases, Oxygen Therapy, High-flow Nasal Cannula, Exercise Tolerance
- Trial name
- NCT06620081
- Testing
- Performance Tests, Functional Tests
- Where
- Brazil
- Volunteers
- 10 people
- Sponsor
- Hospital Israelita Albert Einstein
Subjects in Need of a Human Milk Fortifier (HMF), Growth
Renoir: A Randomised, Double-blind, Controlled Trial to Evaluate the Effects of a New Human Milk Fortifier on Growth and Tolerance in Preterm Infants.
Preterm birth (birth before start of the 37th week of gestation) is a major determinant of neonatal morbidity and mortality and has long-term adverse consequences for health and neurodevelopment.
- Conditions
- Subjects in Need of a Human Milk Fortifier (HMF), Growth, Tolerance, Safety
- Trial name
- Renoir (NCT03315221)
- Testing
- Test product, Control product
- Where
- 15 sites in France, Germany and 2 more
- Volunteers
- 207 people
- Sponsor
- Nutricia Research
Tolerance
Acceptability and Tolerance Study of a High Energy Tube Feed with Food Derived Ingredients
Enterally fed adults and children who are assessed by the dietitian as requiring an adult high-energy, fibre-containing enteral formula will be recruited.
- Trial name
- NCT06034951
- Testing
- Compleat 1.5 HP
- Where
- United Kingdom
- Volunteers
- 16 people
- Sponsor
- Société des Produits Nestlé (SPN)
Tolerance, Capsaicin
Intranasal Capsaicinoid Spray
Rhinitis is inflammation of the inside of the nose. Symptoms of rhinitis include itchiness, sneezing, and a "runny" nose (rhinorrhea).
- Conditions
- Tolerance, Capsaicin, Rhinitis
- Trial name
- NCT03952845
- Testing
- Capsaicinoid
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Nova Scotia Health Authority
Precursor Cell Lymphoblastic Leukemia-Lymphoma, Drug-Induced Diabetes Mellitus
Glucose Intolerance and Diabetes Related to Treatment With Steroids and PEG- Asparaginase in Children and Adolescents With ALL and Lymphoma
The overall survival of acute lymphoblastic leukemia (ALL) and lymphoma in children and adolescents is above 90%. The survival rate has increased significantly during the last decades as a consequence of more intensive…
- Conditions
- Precursor Cell Lymphoblastic Leukemia-Lymphoma, Drug-Induced Diabetes Mellitus, Impaired Glucose Tolerance, Lymphoma
- Trial name
- NCT05873322
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Aarhus University Hospital
Type 2 Diabetes, Glucose Tolerance Impaired
Effect of Novel Glucagon Receptor Antagonist REMD-477 on Glucose and Adipocyte Metabolism in T2DM
With REMD's glucagon receptor antagonist, the study team propose to provide a comprehensive examination of the effect of elevated plasma glucagon concentrations in Type 2 Diabetes Mellitus (T2D) patients on: (i) glucose…
- Conditions
- Type 2 Diabetes, Glucose Tolerance Impaired, Insulin Sensitivity
- Trial name
- NCT05093517
- Testing
- REMD-477
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Tolerance
Clinical Trial to Evaluate Safety and Tolerability of a Novel Hydration Drink in Healthy Volunteers
This clinical trial design aims to evaluate the safety and tolerability of a novel hydration drink in health volunteers.
- Trial name
- NCT05428748
- Testing
- 1 serving of test product, 2 servings of test product, 3 servings of test product
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Liquid I.V.