Clinical trials: Tolerance
Congenital Heart Disease in Children
Impact on the Nitrogen Balance, Autonomy, Safety and Tolerance of Enteral Diets Made of With Nutrilon Without Lactose® Fortified by Concentration Versus by Maltodextrin and Oil Supplementation,After Surgery for Congenital Heart Disease, in Infants.
An adequate nutritional support after a cardiac surgery enhances the morbidity and mortality. After a cardiac surgery, the energy expenditure is estimated to be around 55 kcal/kg/d.
- Trial name
- DIETCHIRCARD (NCT03136900)
- Testing
- Nutrilon without lactose® fortified by concentration, Nutrilon without lactose® fortified by Maltodextrin and oil supplementation
- Where
- Belgium
- Volunteers
- 41 people
- Sponsor
- Queen Fabiola Children's University Hospital
Glucose Tolerance, Appetite Sensations
Effects of Nopal Fractions on Postprandial Glucose Regulation and Appetite Variables in Healthy Humans
Postprandial effects of Nopal fractions on glucose and appetite regulation will be investigated in healthy humans, in a randomised controlled crossover trial
- Trial name
- NCT04439630
- Testing
- Nopal fractions, Test product without the active components
- Where
- Sweden
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Lund University
Glucose Tolerance, Lipid Homeostasis
Herbal Preparation and Glucose Homeostasis
Rationale: The incidence of obesity and type 2 diabetes (T2D) is increasing rapidly and accounts for a considerable part of health care costs.
- Conditions
- Glucose Tolerance, Lipid Homeostasis, Vascular Function, Inflammation
- Trial name
- Herbie (NCT02065271)
- Testing
- herbal supplement
- Where
- Netherlands
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Wageningen University
Sedation During Bronchoscopy
Comparison of Respiratory Tolerance to I.V. Versus Sublingual Sedation During Bronchoscopy. (TORSIV)
Bronchoscopy is a technique which currently allows the investigation of many respiratory diseases (infections, neoplasia, inflammation…) as well as endobronchial therapeutic procedures.
- Trial name
- TORSIV (NCT01698892)
- Testing
- I.V Sedation, sublingual sedation
- Where
- France
- Volunteers
- 85 people
- Sponsor
- Nantes University Hospital
Diabetes Mellitus, Glucose Intolerance
Japan Prevention Trial of Diabetes by Pitavastatin in Patients With Impaired Glucose Tolerance (J-PREDICT)
The purpose of this study is to evaluate the effects of pitavastatin for preventing diabetes in a population with impaired glucose tolerance.
- Trial name
- NCT00301392
- Testing
- life-style intervention, Life style interventions plus concomitant use of pitavastatin.
- Where
- Japan
- Volunteers
- 1,240 people
- Sponsor
- Tokyo University
Parastomal Hernia
Prospective Study of the Use of a Mesh to Prevent Parastomal Hernia After Laparoscopic Abdominoperineal Resection
Introduction: parastomal hernia (PH) is a frequent complication after an ostomy, despite the many prevention and treatment techniques that have been described.
- Trial name
- NCT01722565
- Testing
- laparoscopic abdominoperineal resection with a lightweight mesh (polypropylene and poliglecaprone 25)
- Where
- Spain
- Volunteers
- 32 people
- Sponsor
- Corporacion Parc Tauli
Impaired Glucose Tolerance
The Role of Pulsatile Insulin Secretion (A Study Investigating the Effects of Partial Pacreatectomy on Glucose Metabolism)
The purpose of this study is to examine changes in sugar metabolism that may occur in subjects who have previously had part of their pancreas removed due to a benign lesion.
- Trial name
- Pilot OGTT (NCT00841867)
- Testing
- All subjects will undergo a 120 minute Oral Glucose Tolerance Test at study visit 2.
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Immune Tolerance
Clinico-immunological Characterization and Immune Tolerance Breakdown in HU-autoimmunity
Phenotypic characterization of patients with Hu-Abs, including the different neurological presentation and the presence or not of an underlying cancer.
- Trial name
- CarTo-Hu (NCT05745792)
- Testing
- Description of clinical, immunological and tumor features of patients harboring Hu Abs
- Where
- France
- Volunteers
- 400 people
- Sponsor
- Hospices Civils de Lyon
HIV Infections
Efficacy and Tolerance of the Switch From Enfuvirtine to Raltegravir in Antiretroviral Therapy Regimen in HIV Patients With Undetectable Viral Load
Switching from enfuvirtide to raltegravir in the treatment of HIV-infected patients who sustain viral suppression with a combination therapy including enfuvirtide (or : with an enfuvirtide-based combination therapy)
- Trial name
- EASIER (NCT00454337)
- Testing
- FTC/TDF + EFV or LPV/R +T20, FTC/TDF + EFV or LPV/R
- Where
- France
- Volunteers
- 170 people
- Sponsor
- French National Agency for Research on AIDS and Viral Hepatitis
Smoking Cessation, Mood Tolerance
Mood and Smoking: A Comparison of Smoking Cessation Treatments
Objectives: The long term objectives of this research program are: 1. To advance the mission of the VHA Boston Healthcare System to deliver comprehensive quality healthcare that meets the needs of patients (in this case, who have…
- Conditions
- Smoking Cessation, Mood Tolerance, Mood Management, Nicotine Replacement Therapy
- Trial name
- NCT00075972
- Testing
- Mood Tolearance, Mood Management, Nicotine Replacement therapy
- Where
- United States
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Wound
HEAL Study: Healing Results, Efficacy and Acceptability of a New Contact Layer
Assessment of efficacy, tolerance and acceptability for the wound dressing URGO AWC_019 in the treatment of acute wounds, chronic wounds and epidermolysis bullosa skin lesions
- Trial name
- HEAL (NCT03640871)
- Testing
- URGO AWC_019 dressing (AWC=Advanced Wound Care)
- Volunteers
- 80 people
- Sponsor
- Laboratoires URGO
Inflammatory Myopathies
Inspiratory Muscle Training in Patients With Inflammatory Myopathy
Inflammatory myopathies are rare autoimmune diseases leading to progressive muscle weakness, often including the respiratory muscles.
- Trial name
- NCT07274267
- Testing
- Inspiratory Muscle Training (IMT)
- Where
- Poland
- Volunteers
- 33 people
- Sponsor
- Józef Piłsudski University of Physical Education
Stable Angina, Positive ETT
Diagnostic Value of HS-CRP in Stable Angina.
The aim of this study was to assess the amount of additive value of HS-CRP levels to a positive exercise tolerance test (ETT) in predicting coronary artery disease (CAD) using coronary angiography as the gold standard.
- Trial name
- NCT00719992
- Testing
- coronary angiography
- Where
- Iran
- Volunteers
- 97 people
- Sponsor
- Shiraz University of Medical Sciences
Exertional Heat Injury
Integrating Cognitive Assessments Into the Heat Tolerance Test After Exertional Heat Injury
This prospective observational study is to evaluate soldiers post-exertional heat injury (EHI) during a heat tolerant test (HTT) to investigate the impact on their cognitive performance.
- Trial name
- NCT06764264
- Where
- Israel
- Volunteers
- 70 people
- Sponsor
- Medical Corps, Israel Defense Force
Effect of ISABel Bed 1 Ans ISABel Bed 2
ISABel: Intelligent Sleep Apnoea Bed
The aim of this trial is to assess the effect of two automated beds on severity of POSA as well as the feasibility of these beds as POSA treatment.
- Trial name
- ISABel (NCT04713267)
- Testing
- ISABel Bed 1
- Where
- Switzerland
- Volunteers
- 10 people
- Sponsor
- Swiss Federal Institute of Technology
Growth and Tolerance
Growth of Infants Fed Hydrolysate Formulas
Effects on weight and weight gain will be monitored in healthy term infants fed assigned infant formulas.
- Trial name
- NCT02006992
- Testing
- RTF Infant Formula, Powder Infant Formula
- Where
- 8 sites in United States
- Volunteers
- 195 people, healthy volunteers welcome
- Sponsor
- Abbott Nutrition
Prediabetes, Obesity & Overweight
Postprandial Glucose Kinetics After Carbohydrate Restriction
The goal of this study is to test whether a low-carbohydrate diet (LCD), comparred with a Mediterranean diet (MED) producing similar weight loss, differentially affects fasting and postprandial glucose metabolism in individuals…
- Conditions
- Prediabetes, Obesity & Overweight, Diet Interventions, Carbohydrate Metabolism
- Trial name
- NCT07802275
- Testing
- Low-carbohydrate diet, Mediterranean Diet
- Where
- Italy
- Volunteers
- 29 people
- Sponsor
- Azienda Ospedaliero, Universitaria Pisana
Alzheimer Disease
Blood Brain Barrier Opening in Alzheimer' Disease
In Alzheimer's disease (AD) an imbalance between the production and clearance of the ß-amyloid peptide is hypothesized as the driving event of the disease.
- Trial name
- BOREAL1 (NCT03119961)
- Testing
- SONOCLOUD®
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Prediabetes (Insulin Resistance, Impaired Glucose Tolerance), Female
Wild Blueberries for Gut, Brain, and Cardiometabolic Health in Prediabetes
The goal of this clinical trial is to determine the effectiveness of using a freeze-dried wild blueberry powder on cardiometabolic health, cognitive function, and gut microbiota composition in adult women with prediabetes.
- Conditions
- Prediabetes (Insulin Resistance, Impaired Glucose Tolerance), Female, Adult, Endothelial Function (Reactive Hyperemia)
- Trial name
- NCT06735651
- Testing
- Wild Blueberry
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Georgia State University
Heart Failure, Hypertension, Pulmonary
Dietary Nitrate for Heart Failure
The purpose of this study is to determine if nitrates in a food, in this case - beetroot juice (BRJ) - is efficacious in improving exercise tolerance and/or peak power in patients with heart failure.
- Trial name
- NCT01682356
- Testing
- Beetroot juice
- Where
- 2 sites in United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine