Clinical trials: Tomography, Optical Coherence
Optical Coherence Tomography, Optical Coherence Tomography Angiography
Relationship Between Alzheimer Disease and Diminution of the Three Macular Nervous Retinal Layers
Alzheimer disease is hard, long and expensive to diagnose. In order to help the clinician, a new biomarker in Alzheimer disease seems to be very useful.
- Conditions
- Optical Coherence Tomography, Optical Coherence Tomography Angiography, Retinal Thickening, Alzheimer Disease
- Trial name
- RETEVAL (NCT04794634)
- Testing
- Optical coherence tomography (OCT), Optical coherence tomograpohy angiography (OCTA)
- Where
- France
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Basal Cell Carcinoma
Pilot Study of Line-Field Confocal Optical Coherence Tomography for Detection of Mohs Micrographic Surgery Margins of Basal Cell Carcinomas
To assess the feasibility and provide information on the utility of noninvasive line field confocal optical coherence tomography (LC-OCT) for the presurgical assessment of Mohs micrographic surgery sites in patients undergoing…
- Trial name
- NCT07182240
- Testing
- LC-OCT Imaging
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Roswell Park Cancer Institute
Acute Myocardial Infarction, STEMI
Multi-modality Imaging in Acute Myocardial Infarction
The goal of this study is to use three (3) different imaging techniques:Fractional Flow Reserve (FFR) allows precise measurement of blood flow in the arteries to the heart, and is more reliable than pictures alone to determine…
- Conditions
- Acute Myocardial Infarction, STEMI, Coronary Artery Disease, Atherosclerotic Plaque Disruption With Thrombosis of Artery
- Trial name
- MIAMI (NCT02926755)
- Testing
- Coronary Angiography
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Corewell Health East
Diabetic Macular Edema
Screening For Diabetic Macular Edema Among Diabetic Patients Using Optical Coherence Tomography
Diabetic macular edema is one of the major causes of visual impairment in diabetic retinopathy patients especially in the working age group.
- Trial name
- NCT03240458
- Testing
- Optical Coherence Tomography
- Volunteers
- 100 people
- Sponsor
- Assiut University
Retinopathy of Prematurity, Diabetic Retinopathy
Optical Coherence Tomography Angiography (OCT-A) in Children (≥ 6 <14 Years of Age)
Comparison of OCTA to conventional imaging modalities for the diagnosis of eye diseases in children
- Trial name
- OCTAC (NCT03399825)
- Testing
- OCT-A
- Volunteers
- healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Peripheral Arterial Disease
Ticagrelor and Peripheral Arterial Disease
This is an interventional study assessing the effectiveness of Ticagrelor on the reduction of thrombus burden using optical coherence tomography in patients undergoing peripheral artery stenting.
- Trial name
- NCT02407314
- Testing
- Percutaneous Peripheral Intervention, Optical Coherence Tomography, Ankle Brachial Index
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Arkansas Heart Hospital
Myocardial Infarction, Acute Coronary Syndrome
Identification of Risk Factors for Acute Coronary Events by OCT After STEMI and NSTEMI in Patients With Residual Non-flow Limiting Lesions
The objective of this study is to compare the clinical outcome of Non-ST-elevation myocardial infarction (NSTEMI) and ST-elevation myocardial infarction (STEMI) patients with non-obstructive, non-culprit coronary lesions and…
- Conditions
- Myocardial Infarction, Acute Coronary Syndrome, Coronary Artery Disease
- Trial name
- PECTUS-obs (NCT03857971)
- Testing
- Coronary Optical Coherence tomography
- Where
- Netherlands
- Volunteers
- 438 people
- Sponsor
- Radboud University Medical Center
Barrett Esophagus
OCT Pilot in Esophagus
This is a pilot study to test a newly developed optical coherence tomography (OCT) device to determine 1) whether adequate tissue contact can be attained to acquire high quality images, and 2) to identify if these images can…
- Trial name
- NCT03434834
- Testing
- optical coherence tomography
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- Duke University
Diabetic Retinopathy
Analysis of FAZ in Diabetic Retinopathy Using OCT Angiography
Study and assessment of characteristic changes in foveal avascular zone during different stages of diabetic retinopathy using OCTA.
- Trial name
- NCT05140304
- Testing
- OCT angiography
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Kareem Mohammad Ali
Myopia, Refractive Errors
Effect of Peripapillary Atrophy to Diagnose Glaucoma in High Myopia
This study intends to analyze the characteristics between peripapillary retinal nerve fiber layer thickness and peripapillary area in high myopia with or without glaucoma
- Conditions
- Myopia, Refractive Errors, Eye Diseases, Glaucoma, Primary Open Angle
- Trial name
- NCT05964634
- Testing
- OCT imaging
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Port-Wine Stain, Rosacea
Skin Imaging to Inform Laser Treatments
The purpose of this study is to obtain information (such as lesion depth, depth of the most superficial part of the lesion, and the size and density of blood vessels) with the assistance of an imaging device, and use this…
- Conditions
- Port-Wine Stain, Rosacea, Telangiectasia, Angioma
- Trial name
- NCT04336163
- Testing
- Optical Coherence Tomography
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Percutaneous Coronary Revascularisation, Complex Coronary Lesion
Use of Physiology to Evaluate Procedural Result After PCI CTO
ULTRA-CTO is a prospective multicentre non-randomised investigator-initiated trial designed to enrol 200 subjects with an indication for percutaneous coronary intervention (PCI) of chronic total occluded (CTO) coronary artery.
- Trial name
- ULTRA-CTO (NCT04780971)
- Testing
- post-PCI Pd/Pa
- Where
- 2 sites in Netherlands
- Volunteers
- 200 people
- Sponsor
- Isala
Cardiovascular Diseases, Coronary Artery Disease
Study to Determine the Clinical Significance of Intravascular OCT-NIRAF
There are 2 arms to this study. Arm 1: Participants undergoing coronary angiography for stable or acute coronary disease presentations and eligible for percutaneous coronary intervention (PCI) will be imaged with OCT-NIRAF at…
- Trial name
- NCT06374498
- Testing
- OCT-NIRAF, LUMISIGHT Injection, OCT-NIRAF following LUMISIGHT Injection
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Massachusetts General Hospital
Coronary Artery Disease
Intimal Hyperplasia Evaluated by Optical Coherence Tomography (OCT) in de Novo Coronary Lesions Treated by Drug-eluting Balloon and Bare-metal Stent
Restenosis due to neointimal hyperplasia causes repeat target vessel revascularization in a relevant number of patients undergoing percutaneous coronary interventions (PCI).
- Trial name
- IN-PACT CORO (NCT01057563)
- Testing
- drug (paclitaxel)-eluting balloon (DEB), bare-metal stent (BMS)
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Catholic University of the Sacred Heart
Optical Coherence Tomography, Diabetic Retinopathy
A Longitudinal Study of Choroidal Changes After Cataract Surgery in Eyes With Diabetic Retinopathy
To determine the influence of phacoemulsification on choroidal vasculature in patients with diabetic retinopathy (DR) undergoing cataract surgery
- Conditions
- Optical Coherence Tomography, Diabetic Retinopathy, Choroid
- Trial name
- NCT04499768
- Where
- China
- Volunteers
- 46 people
- Sponsor
- Ruijin Hospital
Macular Holes
Foveal Cone Outer Segment Resumption to Predict Visual Recovery After Macular Hole Surgery
Spectral domain optical coherence tomography (SD-OCT) was used to determine whether the repair of photoreceptor cone outer segment tips defect is significantly correlated with the visual outcomes after macular hole surgery.
- Trial name
- NCT01381965
- Testing
- Vitreous surgery for macular hole
- Where
- Japan
- Volunteers
- 72 people
- Sponsor
- Kyorin University
Retina, Telangiectasis
Intravitreal Bevacizumab for Idiopathic Macular Telangiectasia
Idiopathic Macular Telangiectasia is characterized by incompetent and dilated retinal capillaries in the foveolar region of unknown cause for retinal telangiectasia.
- Trial name
- NCT00451763
- Testing
- Intravitreal Injection of Bevacizumab (1.25 mg/0.05ml)
- Where
- Brazil
- Volunteers
- 31 people
- Sponsor
- University of Sao Paulo
Fuchs' Endothelial Dystrophy
Supine Positioning for Graft Attachment After Descemet Membrane Endothelial Keratoplasty
This randomized controlled trial evaluates the efficacy and safety of postoperative supine head positioning on graft attachment after Descemet membrane endothelial keratoplasty in patients with Fuchs' endothelial corneal…
- Trial name
- SUPER-DMEK (NCT05399095)
- Testing
- Supine positioning: 5 days, Supine positioning: 1 days
- Where
- Germany
- Volunteers
- 90 people
- Sponsor
- University Eye Hospital, Freiburg
Pregnancy Induced Hypertension
Optical Coherence Tomography Angiography Compared to Maternal Doppler in Screening for Hypertension in Pregnancy
Pregnancy related hypertension is one of the most prevalent obstetric complications. The aim of the study is to evaluate the validity and sensitivity of OCT angiography in prediction of pregnancy induced hypertensive disorders in…
- Trial name
- NCT05330949
- Testing
- Optical coherence Tomography Angiography, Uterine artry doppler
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Minia University
Dry Eye Syndrome
Assessment of Tear Film Thickness by Optical Coherence Tomography in Healthy Subjects and Subjects With Dry Eye Disease
Dry eye syndrome (DES) is a highly prevalent ocular condition with severe consequences for the patients reaching from ocular discomfort in its simplest form up to visual impairment and corneal ulceration in severe cases.
- Trial name
- NCT01753596
- Testing
- GENTEAL HA® Eye Drops (NOVARTIS, Switzerland), Physiological Sodium Chloride solution (0,9%)
- Where
- Austria
- Volunteers
- healthy volunteers welcome
- Sponsor
- Medical University of Vienna