Clinical trials: Tongue Diseases
Tongue SCC, Oral Cancer
Use of Ultrasound for Measuring Size of Oral Tongue Cancers
The purpose of this study is to investigate the use intraoral ultrasound for measuring depth of invasion (DOI) in oral tongue squamous cell carcinoma.
- Trial name
- NCT04614896
- Testing
- Transoral ultrasound of tongue tumors
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Oropharynx Cancer
De-escalation of Adjuvant Radiation for Low-Risk HPV Oropharyngeal Cancers
The goal of this clinical trial is to learn whether for intermediate-risk patients who have undergone Transoral Robotic Surgery for HPV/p16(+) oropharyngeal cancer and have minimal smoking history, whether these patients can be…
- Trial name
- NCT06554158
- Testing
- Radiation Therapy
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Georgetown University
Ankyloglossia, Breastfeeding
Breastfeeding Improvement Following Tongue-tie and Lip-tie Release
This study is an observational study to determine outcomes of surgical release of tongue-tie and lip-tie in babies who are experiencing difficulty with breastfeeding.
- Trial name
- NCT02642133
- Testing
- Lingual Frenotomy and/or maxillary labial frenectomy
- Volunteers
- 237 people, healthy volunteers welcome
- Sponsor
- The Oregon Clinic
Alveolar Bone Loss
Comparison of Coronally Advanced Lingual Flap to Modified MPI for Flap Advancement in Partially Edentulous Patients
Comparison of cronally advanced lingual flap to modified periosteal releasing incision (MPRI)
- Trial name
- NCT03466840
- Testing
- The coronally advanced lingual flap, Modified periosteal releasing Incision
- Where
- Egypt
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Cairo University
CKD
The Tongue Features Associated With Chronic Kidney Disease
The Automatic Tongue Diagnosis System (ATDS) was developed to capture tongue images and extract features reliably to assist the diagnosis of TCM practitioners.This project will employ the ATDS verified to extract the tongue…
- Trial name
- NCT04708743
- Testing
- Automatic Tongue Diagnosis System
- Where
- Taiwan
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- China Medical University, Taiwan
Halitosis, Tongue Diseases
Inulin and S. Salivarius Reduce Halitosis
Halitosis associated with tongue coating results from the production of volatile sulfur compounds by bacterial action. The use of prebiotics and probiotics might be useful in treating such condition.
- Trial name
- NCT02794766
- Testing
- Inulin+SS, S salivarius
- Volunteers
- 45 people
- Sponsor
- Universidade de Passo Fundo
Obstructive Sleep Apnea
Barbed Suspension of the Tongue Base for Treatment of Obstructive Sleep Apnea Patients
Obstructive sleep apnea syndrome (OSAS) is a common clinical condition in which the throat narrows or collapses repeatedly during sleep, causing obstructive sleep apnea events.
- Trial name
- NCT04928404
- Testing
- tongue base suspension using barbed suture
- Where
- Egypt
- Volunteers
- 13 people
- Sponsor
- Sohag University
Impacted Third Molar Tooth, Tooth Extraction Status Nos
Clinical Validation of a Novel Classification for Predicting Surgical Complexity in Mandibular Wisdom Teeth Surgery
The study evaluates and validates a new classification proposed by Juodzbalys and Daugela in 2013 predicting the complexity of impacted mandibular third molars surgical extraction, comparing it with other two, scientifically…
- Trial name
- NCT02519426
- Testing
- Mandibular third molar surgery
- Where
- 2 sites in Italy, Lithuania
- Volunteers
- 110 people
- Sponsor
- Lithuanian University of Health Sciences
Head and Neck Cancer
Biomarkers in Tissue Samples From Patients Who Have Undergone Neck Dissection for Oral Cancer
RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT00899704
- Testing
- microarray analysis, allele-specific oligonucleotide real-time quantitative polymerase chain reaction, diagnostic laboratory biomarker analysis
- Where
- United States
- Sponsor
- Alliance for Clinical Trials in Oncology
Esophageal Cancer, Head and Neck Cancer
Computer-Assisted Scheduling of Nicotine Inhaler Use in Participants Who Plan to Stop Smoking
RATIONALE: Computer-assisted scheduling of nicotine inhaler use may be an effective method to help people stop smoking. PURPOSE: Randomized cinical trial to compare the effectiveness of computer-assisted scheduling of nicotine…
- Conditions
- Esophageal Cancer, Head and Neck Cancer, Lung Cancer
- Trial name
- NCT00021138
- Testing
- smoking cessation intervention, nicotine
- Where
- United States
- Sponsor
- Personal Improvement Computer Systems
Recurrent Colon Carcinoma, Recurrent Hypopharyngeal Squamous Cell Carcinoma
Lenalidomide and Cetuximab in Treating Patients With Advanced Colorectal Cancer or Head and Neck Cancer
This phase I trial studies the side effects and the best dose of lenalidomide when given together with cetuximab in treating patients with colorectal cancer or head and neck cancer that has spread to other places in the body and…
- Conditions
- Recurrent Colon Carcinoma, Recurrent Hypopharyngeal Squamous Cell Carcinoma, Recurrent Laryngeal Squamous Cell Carcinoma, Recurrent Laryngeal Verrucous Carcinoma
- Trial name
- ADCC (NCT01254617)
- Testing
- Cetuximab, Laboratory Biomarker Analysis, Lenalidomide
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- National Cancer Institute (NCI)
Peri-Implantitis, Peri-implant Mucositis
Lingual Keratinized Tissue in Fully Edentulous Patients and Its Impact on Implant Health
Cross-sectional study involving the measurement of the width of lingual keratinized tissue (in the implant locations) in fully edentulous patients restored with dental implants.
- Conditions
- Peri-Implantitis, Peri-implant Mucositis, Recession, Gingival
- Trial name
- NCT06166017
- Testing
- Exposure to minimal amount of lingual keratinized tissue width
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- George Eastman Dental Hospital, Italy
Healthy Individuals With no Periodontal Disease
The Effect of Nitrate Supplementation on Tongue Microbiome
The objective of this study is to investigate how the host environment influences microbiome structure. Specifically, the spatial organization of nitrate-metabolizing bacteria that will flourish in high and low salivary nitrate…
- Trial name
- NCT07865481
- Testing
- Nitrate-Supplemented Beet Juice, Nitrate-Depleted Beet Juice
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- The Forsyth Institute
Head and Neck Cancer, Psychosocial Effects of Cancer and Its Treatment
Measuring Patient Satisfaction With Facial Appearance: Development and Validation of a New Patient-Reported Outcome Measure
RATIONALE: Developing a questionnaire that patients can use to assess their quality of life related to the appearance of their face after surgery may help doctors plan the best treatment for patients undergoing surgery and…
- Trial name
- NCT00530049
- Testing
- questionnaire administration, assessment of therapy complications, psychosocial assessment and care
- Where
- 4 sites in United States, Canada and 1 more
- Volunteers
- 1,745 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Tongue Cancer, Jaw Cancer
Quality of Life in Patients Treated for Tongue and/or Jaw Neoplasia Before and After Speech Therapy
This study aims to verify the impact of four speech therapy sessions on the Quality of Life of patients treated for malignant tongue and/or jaw cancer, using as measure specific questionnaires of speech and swallowing.
- Conditions
- Tongue Cancer, Jaw Cancer, Oral Cancer, Intelligibility, Speech
- Trial name
- NCT04126226
- Testing
- Speech-language guidance, Speech therapy exercises for swallowing, Speech therapy exercises for speech
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Obstructive Sleep Apnea
The Efficacy of Tongue Stabilizing Device in Patients With Obstructive Sleep Apnea
The coordination of swallowing and breathing is an important mechanism because the route for air and deglutition is partly shared in the pharynx.
- Trial name
- NCT02329925
- Testing
- Tongue Stabilizing Device (TSD)
- Where
- Canada
- Volunteers
- 41 people
- Sponsor
- University of British Columbia
Erythema Chronicum Migrans
Duration of Antibiotic Treatment of Erythema Migrans
The purpose of this study is to compare the efficacy of 15-day versus 10-day doxycycline treatment in patients with erythema migrans.
- Trial name
- NCT00910715
- Testing
- doxycycline
- Where
- Slovenia
- Volunteers
- 306 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Ljubljana
Stage III Squamous Cell Carcinoma of the Hypopharynx, Stage III Squamous Cell Carcinoma of the Larynx
Cetuximab and Radiation Therapy in Treating Patients With Stage III-IV Head and Neck Cancer
This pilot clinical trial studies cetuximab and radiation therapy in treating patients with stage III-IV head and neck cancer. Monoclonal antibodies, such as cetuximab, may block tumor growth in different ways by targeting…
- Conditions
- Stage III Squamous Cell Carcinoma of the Hypopharynx, Stage III Squamous Cell Carcinoma of the Larynx, Stage III Squamous Cell Carcinoma of the Oropharynx, Stage III Verrucous Carcinoma of the Larynx
- Trial name
- NCT02177838
- Testing
- cetuximab, cisplatin, external beam radiation therapy
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Rutgers, The State University of New Jersey
Mandible Fracture
z Mini-plate With Lingual Extension Versus Conventional 2 Mini Plates
The collected patients according to the eligibility criteria will be randomly distributed into one of these groups: Group I : 10 patients suffering class III mandibular fracture will be managed by patient specific Z shape…
- Trial name
- NCT06898710
- Testing
- z mini plate with lingual extension, conventional 2 mini plates
- Volunteers
- 20 people
- Sponsor
- Fayoum University
Tongue Tie, Frenulum Breve
Lingual Frenulum in Newborn Infants (LINNE)
Oral cavity's structural variations are involved in the successful breastfeeding of the newborn infants. The tongue-tie has been shown to cause breastfeeding problems.
- Conditions
- Tongue Tie, Frenulum Breve, Frenulum; Elongation, Breast Feeding
- Trial name
- LINNE (NCT05560750)
- Testing
- Frenotomy, Oral physiotherapy
- Where
- 3 sites in Finland
- Volunteers
- 300 people
- Sponsor
- University of Oulu