Clinical trials: Tongue Diseases
Tongue Neoplasms
Use of ST250 to Reconstruct Lateral Tongue Defects
To assess the use of SupraThel 250 for mucosal reconstruction in the Head \& Neck region. The membrane is applied to reconstruct lateral tongue defects .
- Trial name
- NCT06988449
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- Cairo University
Parkinson Disease
Colorado Oral Strengthening Device
University of Colorado is looking for adults with Parkinson's disease to participate in a research study. The study aims to explore how a novel low technology device can achieve an increase in tongue strength comparable to…
- Trial name
- COSD (NCT05464225)
- Testing
- COSD, SOC
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Colorectal Cancer, Head and Neck Cancer
Boronophenylalanine-Fructose Complex (BPA-F) and/or Sodium Borocaptate (BSH) Followed By Surgery in Treating Patients With Thyroid Cancer, Head and Neck Cancer, or Liver Metastases
RATIONALE: Diagnostic procedures using boronophenylalanine-fructose complex (BPA-F) and/or sodium borocaptate (BSH) to detect the presence of boron in tumor cells may help determine whether patients who have thyroid cancer, head…
- Conditions
- Colorectal Cancer, Head and Neck Cancer, Metastatic Cancer
- Trial name
- NCT00062348
- Testing
- boronophenylalanine-fructose complex, sodium borocaptate, conventional surgery
- Where
- Germany
- Volunteers
- 27 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Tongue Cancer
Normative Ranges of Lingual Strength and Endurance and the Impact of the IOPI Lingual Strength Trainer on Quantitative Functional Outcomes and Patient-Reported Outcomes After Partial Glossectomy or Hemiglossectomy for Oral Tongue Cancer, An Unblinded: Randomized Pilot Study
The purpose of this study is to learn more about tongue strength and endurance by using the Iowa Oral Performance Instrument (IOPI). The IOPI is a device that measures tongue pressure.
- Trial name
- NCT07124520
- Testing
- Iowa Oral Performance Instrument (IOPI)
- Where
- 7 sites in United States
- Volunteers
- 60 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Tongue Carcinoma, Tongue Neoplasms
Submental Island Flap vs Radial Forearm Free Flap in Tongue Reconstruction
This study evaluates and compares the postoperative surgical outcomes and quality of life (QoL) in patients undergoing tongue reconstruction after tongue cancer resection, comparing two reconstructive options: the Submental…
- Conditions
- Tongue Carcinoma, Tongue Neoplasms, Quality of Life
- Trial name
- SIPF-RFFF (NCT07819617)
- Testing
- Submental Island Pedicled Flap (SIPF), Radial Forearm Free Flap (RFFF)
- Where
- Egypt
- Volunteers
- 28 people
- Sponsor
- Al-Azhar University
Obstructive Sleep Disordered Breathing
Prediction of Tongue Base Obstruction During Sleep
This study investigates the hypothesis that, in children, tongue motor functions can predict both the anatomical site and the degree of upper airway obstruction contributing to obstructive sleep-disordered breathing.
- Trial name
- PTOS (NCT06792045)
- Testing
- Physiotherapist assessment, ENT assessment, Drug-Induced Sleep Endoscopy
- Where
- Belgium
- Volunteers
- 48 people
- Sponsor
- Université Catholique de Louvain
Dysphagia, Sleep Apnea, Obstructive
The Effect of Obstructive Sleep Apnea Operations on the Swallowing Function
The investigators hypothesize that partial robotic tongue base resection surgery and / or soft palate surgery, as a treatment for sleep apnea affect the swallowing quality.In order to characterize the dysphagia The investigators…
- Trial name
- NCT03082170
- Testing
- FEES, SDQ, data review
- Volunteers
- 120 people
- Sponsor
- Rambam Health Care Campus
Healthy, Speech Disorders
Development of Normative Ultrasound Databases of Tongue Surface Configuration
Our past ultrasound research has indicated a need for baseline normative tongue data against which to compare our disordered speech populations.
- Trial name
- NCT00001218
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Obstructive Sleep Apnea
Stimulation Therapy for Apnea Reduction (Www.theSTARtrial.Com)
The purpose of this clinical trial is to demonstrate long-term safety and efficacy of the Inspire system. The Inspire Upper Airway Stimulation (UAS) therapy is intended to treat moderate-to-severe obstructive sleep apnea by…
- Trial name
- STAR (NCT01161420)
- Testing
- Inspire Upper Airway Stimulation System
- Where
- 22 sites in United States, Belgium and 3 more
- Volunteers
- 929 people
- Sponsor
- Inspire Medical Systems, Inc.
Obstructive Sleep Apnea
REV 002 Observational Study of the ReVENT Sleep Apnea System: Minimally Invasive Treatment for Obstructive Sleep Apnea
The purpose of this post-market observational study is to assess the effectiveness and patient perception of benefit of the ReVENT Sleep Apnea System in patients diagnosed with Obstructive Sleep Apnea due to primary tongue base…
- Trial name
- NCT02180815
- Testing
- ReVENT Sleep Apnea System
- Where
- 14 sites in Belgium, Czechia and 3 more
- Volunteers
- 50 people
- Sponsor
- Revent Medical International B.V.
Mandible Fracture
Finite Element and z Shap Mini Plate With Lingual Extension
A cone beam CT (CBCT) scan of the patient, will be used to create a 3D scanned image of parasympheseal mandibular fracture 3D images will be introduced to finite element (FA)software to evaluate Stresses (MPa) and Life time…
- Trial name
- NCT06899568
- Testing
- z mini plate with lingual extension, two mini plates
- Volunteers
- 1 people
- Sponsor
- Fayoum University
Dysphagia After Stroke, Aspiration Pneumonias
Tongue Brush (Orabrush) for Reducing Aspiration Pneumonia in Stroke Patients
The investigators conduct a controlled prospective experimental intervention study to examine whether the use of a tongue brush (Orabrush) can improve the rate of aspiration pneumonia and dysphagia in patients with ischemic…
- Conditions
- Dysphagia After Stroke, Aspiration Pneumonias, Ischemic Stroke
- Trial name
- StrOra (NCT06765018)
- Testing
- Tongue Brush (Orabrush)
- Where
- Germany
- Volunteers
- 252 people
- Sponsor
- University Hospital Marburg
Deglutition Disorders, Dysphagia
Facilitation of Oral Bolus Propulsion Using Electropalatography in Patients With Dysphagia
Electropalatography (EPG), a noninvasive device that provides specific visual output on tongue-palate contact, has well-established usefulness as a biofeedback tool in speech therapy.
- Trial name
- NCT00001718
- Testing
- Electropalatography
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
PARKINSON DISEASE (Disorder), Dysphagia
Effortful Swallow Exercise With Visual Biofeedback for Tongue Strength in Parkinson's Disease
The goal of this clinical trial is to learn whether adding visual biofeedback to an effortful swallow exercise program improves tongue strength and swallowing function in adults with Parkinson's disease.
- Trial name
- NCT07906028
- Testing
- Effortful swallow exercise with visual biofeedback, Effortful swallow exercise without visual biofeedback
- Where
- Turkey (Türkiye)
- Volunteers
- 35 people
- Sponsor
- Saglik Bilimleri Universitesi
Diabetes Mellitus, Pre-diabetes
Tongue Fur and Metabolites in Diabetes Mellitus
This study is a prospective cross-sectional study. The investigators enroll participants form the department of endocrinology and of metabolism, China Medical University Hospital.
- Trial name
- NCT04909632
- Testing
- Liquid chromatography-mass spectrometry (LC-MS) analysis
- Where
- Taiwan
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Malocclusion, Angle Class I
The Efficacy of Lingual Aligners in Adults.
The goal of this clinical trial is to test the effectiveness of lingual aligners in adults. The main question to answer is: Are lingual aligners effective in achieving desired and predicted tooth movements?
- Trial name
- NCT06050655
- Testing
- Lingual aligners
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Cancer
Cyclophosphamide and Cryoablation in Treating Patients With Advanced or Metastatic Epithelial Cancer
RATIONALE: Drugs used in chemotherapy, such as cyclophosphamide, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00499733
- Testing
- cyclophosphamide, Cryoablation
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Metastatic Squamous Neck Cancer With Occult Primary Squamous Cell Carcinoma, Recurrent Metastatic Squamous Neck Cancer With Occult Primary
PI3K Inhibitor BKM120 and Cetuximab in Treating Patients With Recurrent or Metastatic Head and Neck Cancer
This pilot randomized phase I/II trial studies the side effects and best dose of PI3K inhibitor BKM120 when given together with cetuximab and to see how well it works in treating patients with recurrent or metastatic head and…
- Conditions
- Metastatic Squamous Neck Cancer With Occult Primary Squamous Cell Carcinoma, Recurrent Metastatic Squamous Neck Cancer With Occult Primary, Recurrent Salivary Gland Cancer, Recurrent Squamous Cell Carcinoma of the Hypopharynx
- Trial name
- NCT01816984
- Testing
- PI3K inhibitor BKM120, cetuximab
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Chicago
Lip and Oral Cavity Squamous Cell Carcinoma, Oral Cavity Verrucous Carcinoma
Direct Visual Fluorescence in Finding Oral Cancer in High-Risk Patients and Patients Undergoing Routine Dental Care
This clinical trial studies direct visual fluorescence in finding oral cancer in high-risk patients and patients undergoing routine dental care.
- Conditions
- Lip and Oral Cavity Squamous Cell Carcinoma, Oral Cavity Verrucous Carcinoma, Stage 0 Lip and Oral Cavity Cancer, Tongue Cancer
- Trial name
- NCT01816841
- Testing
- fluorescence imaging, biopsy, examination
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Diabetes Mellitus
Integrated Clinical Evaluation of Traditional Chinese Medicine (TCM) and Conventional Medicine on Diabetic Patients
In traditional Chinese medicine (TCM), examination of the tongue plays an important role in diagnosis. The characteristics of the tongue(e.g., color of the tongue body, tongue fur, teeth-marked tongue) provides some clues and…
- Trial name
- NCT02564913
- Testing
- clinical evaluation
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Changhua Christian Hospital