Clinical trials: Tongue Diseases
Metastatic Squamous Neck Cancer With Occult Primary Squamous Cell Carcinoma, Recurrent Metastatic Squamous Neck Cancer With Occult Primary
S0420, Sorafenib in Treating Patients With Recurrent or Metastatic Head and Neck Cancer
Sorafenib may stop the growth of tumor cells by blocking the enzymes necessary for their growth. It may also stop the growth of tumor cells by stopping blood flow to the tumor.
- Conditions
- Metastatic Squamous Neck Cancer With Occult Primary Squamous Cell Carcinoma, Recurrent Metastatic Squamous Neck Cancer With Occult Primary, Recurrent Salivary Gland Cancer, Recurrent Squamous Cell Carcinoma of the Hypopharynx
- Trial name
- NCT00096512
- Testing
- sorafenib tosylate, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- National Cancer Institute (NCI)
Ankyloglossia, Tongue-tie
Healing Efficacy of Diode Laser in Lingual Frenectomy
This study aims to compare the wound healing efficacy and postoperative experiences between the 940 nm diode laser technique and the traditional electrosurgery method for treating ankyloglossia (tongue-tie) in children aged 3 to…
- Trial name
- NCT07557875
- Testing
- Lingual Frenectomy using 940nm Diode Laser, Lingual Frenectomy using High-frequency Electrosurgery
- Where
- 2 sites in Vietnam
- Volunteers
- 53 people
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City
Temporomandibular Disorder, Motor Imagery
Assessing Motor Imagery Ability of Tongue and Mouth in Subjects With and With no Temporomandibular Disorders
Temporomandibular disorder (TMD) is the symptomatic expression of a muscular or an articular impairment at the manducatory tract. TMD affects between 30 to 65% of the population with a higher prevalence for young women.
- Trial name
- TMIQ (NCT04102306)
- Testing
- reliability and validity construct of the TMIQ
- Where
- France
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Cabinet de Kinesitherapie SCM Saint-Alexandre
Recurrent Hypopharyngeal Squamous Cell Carcinoma, Recurrent Laryngeal Squamous Cell Carcinoma
Cisplatin With or Without WEE1 Inhibitor MK-1775 in Treating Patients With Recurrent or Metastatic Head and Neck Cancer
This randomized phase II trial studies how well cisplatin with or without WEE1 inhibitor MK-1775 works in treating patients with head and neck cancer that has come back or has spread to other parts of the body.
- Conditions
- Recurrent Hypopharyngeal Squamous Cell Carcinoma, Recurrent Laryngeal Squamous Cell Carcinoma, Recurrent Laryngeal Verrucous Carcinoma, Recurrent Lip and Oral Cavity Squamous Cell Carcinoma
- Trial name
- NCT02196168
- Testing
- Cisplatin, Laboratory Biomarker Analysis, Pharmacological Study
- Where
- 3 sites in Canada
- Volunteers
- 6 people
- Sponsor
- National Cancer Institute (NCI)
Dementia, Dysphagia
Interventions for Patients With Alzheimer's Disease and Dysphagia
The overall purpose of this project is to develop effective dysphagia rehabilitative interventions for patients with Alzheimer's Disease and related dementias at risk for pneumonia development.
- Conditions
- Dementia, Dysphagia, Alzheimer Disease
- Trial name
- NCT03682081
- Testing
- Isometric tongue strengthening facilitated by Iowa Oral Performance Instrument (IOPI), Biotene Oral Balance Gel
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- University of Wisconsin, Madison
Pollen Allergy
Comparison of the Efficacy and the Safety of Different Schedules of Administration of Sub-lingual Immunotherapy
The dose and the mode of administration of sublingual therapy remain open questions to determine the efficacy and safety of this desensitization therapy, the main purpose of this study is to evaluate if different routes of…
- Trial name
- NCT01500642
- Testing
- Slit One, Slit One ragweed
- Where
- Italy
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- ASST Fatebenefratelli Sacco
Periodontitis, Tongue Coating
Effect of Periodontal Treatment on Tongue Coating and Smell Function
This study aims to investigate the effect of periodontal treatment on olfactory function in patients with periodontitis by comparing pre- and post-treatment periodontal indices, Winkel tongue coating scores, and Sniffin' Sticks…
- Conditions
- Periodontitis, Tongue Coating, Olfactory Dysfunction
- Trial name
- EPTOS (NCT07326319)
- Testing
- Non-Surgical Periodontal Treatment (Scaling and Root Planing
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 108 people
- Sponsor
- Batman University
Head and Neck Cancer
Vaccine Therapy in Treating Patients With Head and Neck Cancer
RATIONALE: Vaccines made from a person's dendritic cells mixed with peptides may help the body build an effective immune response to kill tumor cells.
- Trial name
- NCT00404339
- Testing
- mutant p53 peptide pulsed dendritic cell vaccine, tetanus toxoid helper peptide, adjuvant therapy
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Robert Ferris
Maxillary Deficiency
Comparative Results of Maxillary Deficiency Treatment by Tongue Plate and Facemask in Growing Patients
A new appliance will be used to transfer the tongue force during its physiological activity to advance the nasomaxillary complex; this method will be compared with the traditional method which uses a Facemask appliance.
- Trial name
- NCT00519415
- Testing
- Tongue plate, Facemask
- Where
- Iran
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Shahid Beheshti University of Medical Sciences
Dental Anxiety, Pain
Effectiveness of Hand/Eyes/Mouth Behavior Management Technique During Local Anesthesia in Preschool Children
This will be a randomized, controlled, parallel-group clinical trial. The aim of this studio will be to evaluate the effectiveness of "Hands/Eyes/mouth" behavior management technique versus a conventional technique (covering the…
- Conditions
- Dental Anxiety, Pain, Infant Behavior, Heart Rate and Rhythm Disorders
- Trial name
- NCT02591797
- Testing
- inferior alveolar and lingual nerve block procedure
- Where
- Spain
- Volunteers
- 52 people
- Sponsor
- Cardenal Herrera University
Dysgeusia
Gustin Gene Polymorphism and 6-n-propylthiouracil (PROP) Taste
The investigators evaluate the possible association of PROP taste with gustin gene polymorphism rs2274333 (A/G), salivary zinc ion concentration and BMI.
- Trial name
- gustinprop (NCT01097915)
- Where
- Italy
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- University of Cagliari
Speech Disorders
Visual Feedback of Tongue by Ultrasound Echography for Speech Trouble Rehabilitation
Speech is a privileged means of communication for humans: its trouble can thus prove being extremely handicapping. Standard speech therapy is limited in some cases by the lack of sensory feedback available to the patient…
- Trial name
- REVISON (NCT02752425)
- Testing
- Visual feedback
- Where
- 2 sites in France
- Volunteers
- 18 people
- Sponsor
- Hospices Civils de Lyon
Obstructive Sleep Apnea
Randomized Cross-over TRD and CPAP for OSA
The objectives of this study is to compare short-term outcomes of CPAP and TRD in the treatment of obstructive sleep apnea. Study design is a randomized cross-over trial during 3-weeks period of each treatment in 36 patients.
- Trial name
- NCT02788487
- Testing
- Tongue retaining device, CPAP
- Where
- Thailand
- Volunteers
- 36 people
- Sponsor
- Mahidol University
Erythema Migrans
Different Amoxicillin Treatment Regimens in Erythema Migrans Patients
The purpose of this study is to compare the efficacy of different amoxicilline treatment regimens in patients with erythema migrans.
- Trial name
- NCT03966014
- Testing
- EM-amoxicillin 3 x 10 days, EM-amoxicillin 3 x 14 days, Controls
- Where
- 2 sites in Slovenia
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Ljubljana
Colorectal Neoplasms, Gastrointestinal Microbiome
Predicting Adenomatous Polyps in the Colon Using Images of a Human Tongue
This is a prospective, multicenter, single-arm clinical investigation designed to evaluate the accuracy of the Gixam™ System in identifying subjects with colorectal adenomas compared to optical colonoscopy.
- Trial name
- NCT06305364
- Testing
- Gixam
- Where
- 3 sites in United States
- Volunteers
- 426 people, healthy volunteers welcome
- Sponsor
- Jubaan Ltd.
Neonatal Tongue-tie, Maternal Nipple Pain Upon Breastfeeding
Use of Topical Benzocaine for Analgesia in Lingual Frenotomy of the Newborn
Frenotomy of tongue-tie is commonly performed to resolve breastfeeding difficulties, eg maternal nipple pain and infant's latching difficulties. The procedure carries minor discomfort for the infants.
- Conditions
- Neonatal Tongue-tie, Maternal Nipple Pain Upon Breastfeeding, Neonatal Latch Difficulties
- Trial name
- NCT01274247
- Testing
- Topical Benzocaine
- Where
- Israel
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Obstructive Sleep Apnea
Barbed Suspension of the Tongue Base for Treatment of Obstructive Sleep Apnea Patients
Obstructive sleep apnea syndrome (OSAS) is a common clinical condition in which the throat narrows or collapses repeatedly during sleep, causing obstructive sleep apnea events.
- Trial name
- NCT04928404
- Testing
- tongue base suspension using barbed suture
- Where
- Egypt
- Volunteers
- 13 people
- Sponsor
- Sohag University
TMD, TMD/Orofacial Pain
Effects Exercises in Temporomandibular Joint Disorders on Pain, Joint and Tongue Functions
The goal of this clinical trial is to learn if orofacial exercises works to treat temporomandibular disorders in adults. It will also learn about the safety of orofacial exercises on temporomandibular disorders.
- Trial name
- NCT07304557
- Testing
- Exercise, Manual therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- Tayfun ISIK
Diabetes Mellitus, Pre-diabetes
Tongue Fur and Metabolites in Diabetes Mellitus
This study is a prospective cross-sectional study. The investigators enroll participants form the department of endocrinology and of metabolism, China Medical University Hospital.
- Trial name
- NCT04909632
- Testing
- Liquid chromatography-mass spectrometry (LC-MS) analysis
- Where
- Taiwan
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Tongue Carcinoma, Tongue Neoplasms
Submental Island Flap vs Radial Forearm Free Flap in Tongue Reconstruction
This study evaluates and compares the postoperative surgical outcomes and quality of life (QoL) in patients undergoing tongue reconstruction after tongue cancer resection, comparing two reconstructive options: the Submental…
- Conditions
- Tongue Carcinoma, Tongue Neoplasms, Quality of Life
- Trial name
- SIPF-RFFF (NCT07819617)
- Testing
- Submental Island Pedicled Flap (SIPF), Radial Forearm Free Flap (RFFF)
- Where
- Egypt
- Volunteers
- 28 people
- Sponsor
- Al-Azhar University