Clinical trials: Tonsillectomy, open to volunteers
Adenotonsillar Hypertrophy
Teleconsultation vs Face-to-Face Evaluation for Perioperative Respiratory Events in Pediatric Adenotonsillectomy
The goal of this clinical trial is to assess whether preoperative anesthesia teleconsultation is at least equivalent to in-person consultation in preventing perioperative respiratory adverse events (such temporary reduction in…
- Trial name
- Teleped (NCT07175779)
- Testing
- Face-to-Face Preanesthesia Consultation, Telemedicine Preanestehsia Consultation
- Where
- Switzerland
- Volunteers
- 106 people
- Sponsor
- Andrea Saporito
Emergence Delirium, Anesthesia
The Effect of Propofol Versus Lidocaine on Emergence Agitation in Children Undergoing Tonsillectomy.
This study aim to compare the effect of intravenous propofol versus intravenous lidocaine on emergence agitation in children undergoing tonsillectomy or adenotonsillectomy under general anesthesia.
- Trial name
- NCT07268924
- Testing
- Propofol, Lidocaine %2 ampoule
- Where
- Egypt
- Volunteers
- 82 people
- Sponsor
- Assiut University
Tonsillitis, Tonsillectomy
Gabapentin Premedication to Reduce Postoperative Pain for Pediatric Tonsillectomy
The purpose of this pilot study: 1) to examine the use of gabapentin in reducing pain in the first 48 hours postoperatively including the total amount of narcotics mg/kg given 2) to record the time to first analgesic…
- Trial name
- NCT03625011
- Testing
- Gabapentin
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Children's Healthcare of Atlanta
Post-Tonsillectomy Bleeding
The Impact of Tonsillectomy Techniques on Secondary Tonsillectomy Bleeding
Post-tonsillectomy hemorrhage (PTH) is one of the most common and potentially life-threatening complications of tonsillectomy. Secondary PTH (Bleeding occurring >24 hours post-operatively) is of particular clinical significance.
- Trial name
- NCT07763704
- Volunteers
- 100 people
- Sponsor
- Assiut University
Sleep-Disordered Breathing, Sleep Apnea Syndromes in Children
Lateral Pharyngoplasty Outcomes in Children Undergoing Tonsillectomy
The goal of this treatment study is to determine if doing lateral pharyngoplasty with tonsillectomy is better for children than doing tonsillectomy alone.
- Conditions
- Sleep-Disordered Breathing, Sleep Apnea Syndromes in Children, Sleep Apnea, Obstructive, Tonsillitis
- Trial name
- NCT05575401
- Testing
- Lateral pharyngoplasty, Tonsillectomy
- Where
- 4 sites in United States
- Volunteers
- 160 people
- Sponsor
- Loma Linda University
Tonsillitis Chronic, Tonsillitis Recurrent
The Effect of Systemic Nonsteroidal Anti-inflammatory Drugs (NSAIDs) Vs Intraoperative Infiltration of Steroids in Tonsillar Bed Following Tonsillectomy on Post Tonsillectomy Pain.
The aim of this study is to compare the efficacy of adding paracetamol to systemic non-steroidal anti-inflammatory drugs (NSAIDs) versus adding dexamethasone as local infiltration to paracetamol on post tonsillectomy pain control.
- Conditions
- Tonsillitis Chronic, Tonsillitis Recurrent, OSA - Obstructive Sleep Apnea
- Trial name
- NSAIDs (NCT07035314)
- Testing
- Dexamethasone, NSAIDs, Control (Standard treatment)
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Ain Shams University
Recurrent Tonsillitis, Chronic Tonsillitis
Recovery From Tonsil Surgery.
The goal of this study is to optimize the duration of sick leave and the usage of opioids following partial tonsillar surgery in adults by comparing the recovery after extracapsular tonsillectomy (ECTE) with recovery after…
- Trial name
- FINITE-2 (NCT07598201)
- Testing
- extracapsular tonsillectomy, intracapsular tonsillectomy
- Volunteers
- 90 people
- Sponsor
- Turku University Hospital
Tonsillitis
Suprazygomatic Maxillary Nerve Block in Pediatric Tonsillectomy
Tonsillectomies are among the most common surgical procedures performed in pediatric populations, with more than 14,000 procedures performed annually in Ontario, with more than 80% being performed to treat sleep-disordered…
- Trial name
- NCT07176533
- Testing
- Suprazygomatic maxillary nerve block (SZMN) with bupivacaine
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Post Surgical Pain, Analgesia
HONEY for the Treatment of POst-Tonsillectomy Pain
Double-blind, randomised, placebo controlled, single-site trial in adults to compare the effect of Manuka honey with standard of care compared to placebo with standard of care on post-tonsillectomy pain and postoperative…
- Trial name
- HONEY-POT (NCT06275698)
- Testing
- Manuka honey MGO 1000, Sugar-based syrup, thickened with sodium alginate and flavoured with honey flavouring
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- East and North Hertfordshire NHS Trust
Postoperative Pain
RADA16 for Adult Tonsillectomy
The purpose of the research is to determine if RADA16 (also known as PuraStat®, PuraGel®, or PuraSinus®) improves patient outcomes following tonsillectomy procedures.
- Trial name
- NCT07060495
- Testing
- RADA16 hydrogel
- Where
- 2 sites in United States
- Volunteers
- 134 people
- Sponsor
- Rutgers, The State University of New Jersey
Perioperative Respiratory Adverse Events, Adenoidectomy
Lateral Positioning for Extubation After Adenotonsillectomy
The postoperative recovery period following general anesthesia has been associated with a 30%-50% incidence of postoperative respiratory adverse events (PRAEs) in pediatric populations, including laryngospasm, airway obstruction…
- Conditions
- Perioperative Respiratory Adverse Events, Adenoidectomy, Tonsillectomy, Children
- Trial name
- NCT07108218
- Testing
- lateral postion, supine position
- Where
- China
- Volunteers
- 350 people
- Sponsor
- Sichuan University
Post Tonsillectomy Emergence Agitation
Melatonin for Post Tonsillectomy Emergence Agitation in Pediatric
The goal of this clinical trial is to learn if melatonin can decrease emergence agitation in pediatric post tonsillectomy. The main questions it aims to answer are: Does melatonin decrease emergence agitation in pediatric post…
- Trial name
- NCT07375342
- Testing
- Melatonin
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Benha University
Hemorrhage, Surgical, Tonsillar Bleeding
TranExamic Atomized for Pediatric Post-Operative Tonsillectomy Hemorrhage: Pilot Study
After a child has their tonsils removed, sometimes they might bleed which can be a problem. There is a special mist medicine called nebulized tranexamic acid (TXA) that might help stop the bleeding without having to touch the…
- Trial name
- TEAPOT (NCT06580509)
- Testing
- Tranexamic Acid Injectable Product, Normal Saline
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Tonsil Neoplasm, Oropharynx Neoplasm
Buccal Fat for Transoral Robotic Lateral Oropharyngectomy Defects to and Postoperative Pain
The goal of this randomized clinical trial is to determine the pain intensity during rest and swallowing in patients undergoing transoral robotic surgery for tonsil lesions with and without buccal fat reconstruction.
- Conditions
- Tonsil Neoplasm, Oropharynx Neoplasm, Transoral Robotic Surgery
- Trial name
- BOLT (NCT06965738)
- Testing
- Buccal fat reconstruction, No buccal fat reconstruction
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University Health Network, Toronto
Emergence Agitation, Emergence Delirium
Transcutaneous Auricular Vagus Nerve Stimulation for Prevention of Emergence Agitation and Delirium in Children Undergoing Tonsillectomy and Adenoidectomy
Brief Summary This study is designed to find out whether transcutaneous auricular vagus nerve stimulation (taVNS) can safely reduce restlessness and confusion when children wake up from anesthesia after tonsillectomy and…
- Trial name
- NCT07394647
- Testing
- Active taVNS Group
- Where
- China
- Volunteers
- 120 people
- Sponsor
- The First Affiliated Hospital of Zhejiang Chinese Medical University
Pain, Postoperative, Tonsillar Hypertrophy
Optimization of Pediatric Tonsillectomy to IMprove AnaLgesia
The purpose of this study is to compare the use of short acting opioids (fentanyl/hydromorphone) with long acting opioids (methadone) for pain control following tonsillectomy surgery in children and adolescents.
- Conditions
- Pain, Postoperative, Tonsillar Hypertrophy, Tonsillitis, Pediatric Sleep Apnea
- Trial name
- OPTIMAL (NCT06576830)
- Testing
- Methadone, Fentanyl/Hydromorphone
- Where
- United States
- Volunteers
- 440 people, healthy volunteers welcome
- Sponsor
- Duke University
Post-tonsillectomy Pain, Tonsillectomy
Topical Magnesium Sulfate Versus Peritonsillar Bupivacaine for Post-Tonsillectomy Pain Relief in Children
Tonsillectomy (tonsil removal) is a very common surgery for children, but it often causes significant throat and ear pain afterward.
- Conditions
- Post-tonsillectomy Pain, Tonsillectomy, Postoperative Pain, Tonsillectomy Distress Syndrome
- Trial name
- NCT07760207
- Testing
- Magnesium Sulfate, Bupivacaine
- Volunteers
- 40 people
- Sponsor
- Assiut University
Tonsillitis, Tonsillectomy
SUPRATHEL 250 as a Treatment for Oropharyngeal Wounds
To assess the use of Suprathel 250 for mucosal reconstruction in oropharyngeal defects. The membrane will be applied after tonsillectomy procedures and compared to bare wounds' healing
- Conditions
- Tonsillitis, Tonsillectomy, Tonsillitis Recurrent
- Trial name
- NCT06543823
- Testing
- Suprathel 250, Comparator
- Where
- Germany
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Alaa Emara
Postoperative Pain
Impact of RADA16 Use on Outcomes Following Tonsillectomy in Children
The purpose of the research is to determine if RADA16 (also known as PuraStat®, PuraGel®, or PuraSinus®) improves patient outcomes following pediatric tonsillectomy procedures.
- Trial name
- RADA16 for Ped (NCT07188779)
- Testing
- RADA16 hydrogel
- Where
- 2 sites in United States
- Volunteers
- 134 people
- Sponsor
- Rutgers, The State University of New Jersey
Sleep Apnea, Obstructives, Tonsil Hypertrophy
Randomized Clinical Trial for Tonsil Surgery in Adults With Obstructive Sleep Apnea and Enlarged Tonsils
The aim is to investigate whether the tissue-preserving tonsil surgery technique is as effective as complete tonsil removal in the treatment of obstructive sleep apnea.
- Trial name
- TONOS (NCT07580170)
- Testing
- Tonsillectomy, Tonsillotomy
- Where
- 4 sites in Finland
- Volunteers
- 132 people
- Sponsor
- Turku University Hospital