Clinical trials: Tooth Caries
Dental Caries
Healozone Study to Evaluate the Safety and Efficacy of the Use of Ozone for Management of Dental Caries
Caries means demineralization with the formation of cavities and pulp symptoms and necrosis as an end result. The acids in the mouth are mainly produced by oral bacteria like Streptococcus mutans from bacterial biofilms adhering…
- Trial name
- NCT00495495
- Testing
- Ozone treatment
- Where
- 3 sites in United States
- Volunteers
- 394 people, healthy volunteers welcome
- Sponsor
- Indiana University
Dental Caries
Glass-ionomer Cement Containing Chlorhexidine for ART
This study evaluated the clinical and microbiological long-term effects of 1.25% CHX associated with GIC applied in primary molars using Atraumatic Restorative Treatment (ART) technique.
- Trial name
- NCT02459730
- Testing
- ART with GIC containing 1.25% CHX., ART with GIC.
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Campinas, Brazil
Dental Caries in Children
Water From Bottles to Establish Strong Teeth
The waterBEST study is a proof-of-concept, randomized, double-masked, placebo controlled, parallel group study evaluating dental caries-preventive effects of fluoridated bottled water compared to non-fluoridated bottled water in…
- Trial name
- waterBEST (NCT04893681)
- Testing
- Fluoridated bottled drinking water, Non-fluoridated drinking water
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Dental Caries, Child Behavior
Efficacy of Moderate Sedation for Dental Treatment of Young Children
There is lack of clinical trials on pediatric dental sedation. The purpose of this study is to test (using a randomized controlled trial design) the hypothesis that young children behavior during dental treatment improves with…
- Conditions
- Dental Caries, Child Behavior, Conscious Sedation Failure During Procedure
- Trial name
- NCT00902395
- Testing
- Midazolam, Protective stabilization, Midazolam, ketamine
- Where
- Brazil
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Goias
Dental Caries Secondary to Acquired Defects of Tooth Structure
10-years Clinical Trial of Sealed of Margin Failures
Assess the effectiveness of sealing localized marginal defects of amalgam restorations that were initially scheduled for replacement of restorations.
- Trial name
- Sealant (NCT02075801)
- Testing
- Sealing of amalgam margin defects
- Where
- Chile
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Chile
Oral Health, Parkinson Disease
Preliminary Study of the Quality of the Oral Flora in Parkinson's Patients
This is a prospective interventional clinical study whose main objective is to determine the impact of oral hygiene guidance on the oral health status of patients with Parkinson disease
- Trial name
- PARKIDENT (NCT03827551)
- Testing
- Delivery of oral hygiene advices
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Bordeaux
Tooth Decay, Missing Tooth/Teeth
Correlation Study Between Socio-economical Deprivation and Oral Health in Children of 9 Years of Age
Retrospective, observational cohort study. Objectives : To search for correlations between socio-economical deprivation and oral health in french children of 9 years of age.
- Trial name
- PRECA-6 (NCT03817437)
- Where
- France
- Volunteers
- 600,000 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Dental Caries
Effect of Water Rinsing After Topical Fluoride Application on Dental Plaque pH
The aim of this study was to determine whether rinsing with water or cleansing teeth after topical fluoride therapy affect the dental plaque pH.
- Trial name
- NCT01569165
- Testing
- cleansing teeth after topical fluoride therapy
- Where
- Iran
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Mashhad University of Medical Sciences
Dental Caries
Comparison of the Salivary Levels of Streptococcus Mutans in Pediatric Patients With Early Childhood Caries After the Application of Silver Diamine Fluoride or 5% Sodium Fluoride Varnish
Comparison of the salivary levels of Streptococcus mutans in pediatric patients with Early Childhood Caries after the application of Silver Diamine Fluoride or 5% Sodium Fluoride Varnish
- Trial name
- NCT03089567
- Testing
- Sodium Fluoride, Silver diamine fluoride
- Volunteers
- healthy volunteers welcome
- Sponsor
- Yale University
Gingival and Periodontal Disease, Caries, Dental
Clinical Evaluation of the Antibacterial Activity of Thioglycosides Extracted from White Mustard - Bamberka in Oral Hygiene. Evaluation of Periodontal Parameters and Oral Microbiota in Patients.
Brief Summary The goal of this randomized clinical trial is to evaluate the clinical and antibacterial effects of a herbal toothpaste containing white mustard (Sinapis alba) extract in patients diagnosed with gingivitis.
- Trial name
- NCT06908265
- Testing
- Toothpaste including mustard extract
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- Medical University of Warsaw
Root Resorption, Distal Caries
Frequency of External Root Resorption in Mandibular Second Molars Associated With Mandibular Impacted Third Molars Using CBCT
The prevalence of external root resorption and distal caries in mandibular second molars associated with impacted mandibular third molars will be detected in addition to the association of the risk factors.
- Trial name
- NCT03981367
- Volunteers
- 255 people, healthy volunteers welcome
- Sponsor
- Cairo University
Dental Caries in Children, Satisfaction
Comparison of Caries Arrested & Prevented Among SDF, NaF Varnish and Combination in Children
Tooth decay is one of the most common chronic infectious disease found in children worldwide and if left untreated, is rapidly progress.
- Conditions
- Dental Caries in Children, Satisfaction, Cost Effectiveness, Oral Health
- Trial name
- NCT03480516
- Testing
- SDF, Fluoride varnish
- Where
- Thailand
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Khon Kaen University
Primary Teeth
Direct Resin Composite Restoration of Primary Anterior Teeth Using Custom 3D Printed Templates
Esthetic restoration of primary anterior teeth is challenging. Aim of the study: Evaluation of the 12-month clinical performance of direct resin composite restoration of carious vital primary anterior teeth using custom 3D…
- Trial name
- RCT (NCT06478004)
- Testing
- Direct composite restoration of carious primary anterior teeth using custom 3D printed templates, Direct composite restoration of carious primary anterior teeth using conventional strip crowns
- Where
- Egypt
- Volunteers
- 32 people
- Sponsor
- Minia University
Periodontitis, Dental Caries
Using Combination of Synthetic Bone Substitutes During Extractions
The study was designed to assess the effectiveness of conservation ridge preservation (horizontal and vertical dimension) after tooth extraction with and without combination of bone substitutes based on synthetic (calcium sulfate…
- Conditions
- Periodontitis, Dental Caries, Alveolar Bone Losses
- Trial name
- NCT01503593
- Testing
- Calcium Phosphate, Calcium Sulphate
- Volunteers
- 40 people
- Sponsor
- Rambam Health Care Campus
Composite Post, Intracanal Reinfocement
Evaluation of Intracanal Reinforcement with Short Composite Post in Upper Primary Incisors with Severly Carious Teeth As in Early Childhood Caries Cases Using Randomized Clinical Trial
Severely damaged incisors may lead to difficulty in speech, decreased masticatory efficiency, abnormal tongue habits, subsequent malocclusions, and psychological and self-esteem problems.
- Trial name
- NCT06740643
- Testing
- intracanal reinforcement using short composite post, no intracanal reinforcement
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Cairo University
Acute Respiratory Failure, Mechanical Ventilation Complication
Effect of End-inspiratory Airway Pressure Measurements on the Risk of VILI in Ventilated Patients
Mechanical ventilation may be associated with ventilator-induced lung injury (VILI). Several respiratory variables have been employed to estimate the risk of VILI, such as tidal volumes, plateau pressure, driving pressure, and…
- Conditions
- Acute Respiratory Failure, Mechanical Ventilation Complication, Ventilator-Induced Lung Injury
- Trial name
- P1P2Decay (NCT05991258)
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- University of Padova
Primary Dental Caries, Multisurface Origin (Diagnosis)
Clinical Trial NuSmile Crowns
A clinical trial comparing two types of NuSmile anterior crowns to composite strip crowns on anterior dental restorations.
- Trial name
- NCT04975321
- Testing
- Nu Smile Zirconia crown, Nu Smile Pre Veneered crown, Composite strip crown
- Where
- United States
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- University of Washington
Dental Caries
Intraoral Appliance (IOA) Model Evaluating the Efficacy of a Whitening Toothpaste
This single-center, randomized, double-blind, three-period crossover in situ study evaluated the enamel remineralization potential and fluoride bioavailability of three dentifrices-one fluoride-free negative control, one positive…
- Trial name
- NCT07419685
- Testing
- Negative Control Toothpaste, Active Comparator, Test Toothpaste
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Church & Dwight Company, Inc.
Cervical Lesion
Clinical Evaluation of Bulk-fill Alkasite Restoration Versus Resin Modified Glass Ionomer in Adult With Class V Carious
Cention N will have the same clinical performance as resin-modified glass ionomer in cervical carious lesions. Evaluation of restorations will be done at baseline, six months, and one year according (USPHS) criteria.
- Trial name
- NCT04716517
- Testing
- Alkasite bioactive restorative material., Resin Modified Glass Ionomer
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Cairo University
Dental Caries, Dental Pulp Exposure
Stepwise and One Step Techniques In Deep Dentin Lesion
This double blind, randomized, controlled clinical trial aimed to observe the success of stepwise (SW) and one step (OneS) excavation techniques in the management of deep dentin caries.
- Trial name
- NCT04351048
- Testing
- Stepwise Excavation, One Step Excavation
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- TIJEN PAMIR
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