Clinical trials: Tooth Development Disorder
Molar-Incisor Hypomineralization
Single Gene Polymorphisms Associated With Molar-Incisor Hypomineralization
The genetic factors associated with Molar-Incisor Hypomineralization (MIH), a dental condition affecting permanent molars in individuals aged 8-13.
- Trial name
- NCT06165055
- Testing
- DNA Sample Collection + DNA genotyping
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Marmara University
Caries, Erosive Tooth Wear
New In Situ Model Design for Caries and Erosion
This study will test simultaneously and independently two novel in situ models, one for caries and one for erosive tooth wear (ETW), based on the simulation of these dental conditions on enamel specimens placed on 3D-printed…
- Trial name
- NCT07849270
- Testing
- 0 ppm fluoride toothpaste, 250 ppm fluoride toothpaste (dose-response control), 1150 ppm fluoride toothpaste
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Indiana University
Molar Incisor Hypomineralisation
Intraosseous Anesthesia in MIH-Affected Teeth
Managing MIH-affected teeth is challenging due to inflammation, sensitivity, rapid caries development, and difficulty achieving anesthesia.
- Trial name
- IO-MIH (NCT07457450)
- Testing
- Intraosseous anesthesia., Local infiltration anesthesia
- Where
- Croatia
- Volunteers
- 50 people
- Sponsor
- University of Zagreb
Hypomineralization Molar Incisor, Hypersensitivity Dentin
Photobiomodulation and New Restorative Material for Teeth With MIH on Control of Hypersensitivity and Longevity
Introduction: Molar incisor hypomineralization (MIH) is a qualitative defect of enamel development that occurs in the mineralization phase. MIH affects one or more permanent molars and, occasionally, permanent incisors.
- Trial name
- NCT06538142
- Testing
- Photobiomodulation + Restoration with Self-cure Composite Resin, Restoration with Self-cure Composite Resin, Photobiomodulation + Restoration with Photopolymerizable Bulk-fill Composite Resin
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Nove de Julho
Dental Plaque, Dental Caries
Development of a Novel Anti-caries Chewing Gum
This research study is designed to evaluate the chewing gum's ability to modulate the oral microbiome in human participants, in addition to its safety.
- Conditions
- Dental Plaque, Dental Caries, Periodontal Disease
- Trial name
- NCT05946473
- Testing
- Gum base containing xylitol and essencial oils, Gum base with no additives
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Toronto