Clinical trials: Tooth Lesions
Periapical Lesion, Periapical Periodontitis
Comparing Two Medicines for Healing Jaw Bone Infections After Root Canal Treatment
This study compares two commonly used intracanal medicaments-Triple Antibiotic Paste and Calcium Hydroxide-in patients with infected single-rooted teeth.
- Trial name
- NCT07239739
- Testing
- Triple Antibiotic Paste, Calcium Hydroxide (Ca(OH)2)
- Volunteers
- 62 people
- Sponsor
- Faiz ur rahman
Dental Caries
Self Assembling Peptide P11-4 in Patients With Early Occlusal Carious Lesions
Objectives: Occlusal surfaces of erupting permanent molars are highly prone to caries. Self-assembling peptide (P11-4) has proven to enhance biomimetic mineralization of early carious lesions.
- Trial name
- NCT02724592
- Testing
- self assembling peptide P11-4 (Curodont™ Repair), fluoride varnish (Duraphat®)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University Medicine Greifswald
Carious Dentin
Postoperative Hypersensitivity and Digital Radiographic Assessment of a Zinc Modified Versus a Conventional Glass Ionomer Cement in Deep Carious Lesion: Randomized Controlled Clinical Trial
The study aim to evaluate the difference between the effect of zinc modified glass ionomer and conventional glass ionomer on the success of partial caries removel technique
- Trial name
- NCT03285022
- Testing
- Partial caries removel techniques
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Cairo University
Dental Caries
Non-restorative Cavity Control in Anterior Cavitated Caries Lesion of Primary Teeth
Background: Studies have questioned the necessity of restoring cavitated carious lesion on primary teeth, once the control of biofilm is the most important factor to arrest these lesions.
- Trial name
- CEPECO2 (NCT03785730)
- Testing
- Non-restorative cavity control - NRCC group, Restoration with resin composite - RCR group
- Where
- Brazil
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Universidade Ibirapuera
Cervical Caries
Clinical Evaluation of Self-Adhesive Flowable Giomer With and Without Selective Enamel Etching
This randomized clinical trial is to evaluate the clinical performance of the self-adhesive flowable Giomer with and without selective enamel etching compared to flowable Giomer using standard bonding protocol in class V cavity…
- Trial name
- NCT07575646
- Testing
- Beautifil Flow Plus F00, FIT SA after selective enamel etching, FIT SA
- Volunteers
- 75 people
- Sponsor
- Cairo University
Dental Caries
Resin Infiltration to Arrest Early Tooth Decay
The purpose of this study is to determine whether lesion infiltration is an effective management strategy to arrest early tooth decay.
- Trial name
- NCT01584024
- Testing
- Resin infiltration
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- University of Michigan
Tooth; Lesion, White Spot Lesions
Resin Infiltratration on the Sealing of Proximal Early Caries
Material for caries prevention dont have better results compared with non-operatory interventions.
- Trial name
- NCT01659463
- Testing
- ICON, instruction oral hygiene
- Where
- Brazil
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Santa Maria
Endodontic Treatment, Pulp Necrosis
Dexamethasone Treatment for Patients Undergoing Endodontics
This Phase IV randomized clinical trial (RCT) evaluated the efficacy of preoperative administration of a single 4 mg oral dose of dexamethasone in reducing postoperative pain and inflammation following endodontic treatment.
- Conditions
- Endodontic Treatment, Pulp Necrosis, Periapical Lesions, Postoperative Pain
- Trial name
- (DTPE-RCT) (NCT06906315)
- Testing
- Dexamethasone 4 mg, Ibuprofen group
- Where
- Spain
- Volunteers
- 82 people
- Sponsor
- University of Salamanca
Periapical Lesion
Accuracy of Artificial Intelligence Technology in Detecting Periapical Lesions in Human Teeth.
Aims to evaluate the accuracy of using Artificial intelligence software in detecting the presence of periapical lesion compared to CBCT imaging.
- Trial name
- AI (NCT07319182)
- Testing
- Cone beam computed tomography, artificial intelligence software
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Future University in Egypt
Dental Restoration Failure of Marginal Integrity
Outcomes of Restoring Untreated and SDF-treated Dentine Caries Lesions in Primary Teeth of Preschool Children
The primary objective of this proposed clinical study is to compare the success rates of ART restorations placed in untreated and SDF-treated dentine caries lesions in primary teeth.
- Trial name
- NCT03657862
- Testing
- application of 38% silver diamine fluoride solution
- Where
- China
- Volunteers
- 195 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Dental Caries, White Spot Lesion
A Randomized Controlled Trial of Vitamin D Supplementation on Salivary Biomarkers and Cariogenic Oral Microbiome
The goal of this clinical trial is to compare the treatment effect of vitamin D supplementation and topical fluorides in the population having vitamin D deficiency and Initial Carious Lesions (ICL) on the progression of ICL in…
- Conditions
- Dental Caries, White Spot Lesion, Initial Caries, Incipient Enamel Caries
- Trial name
- Incipient (NCT06172764)
- Testing
- Vitamin D supplements along with behavioral modification, Topical fluoride application and Vitamin D supplements along with behavioral modification, Topical fluoride application along with behavioral modification
- Where
- Pakistan
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Dow University of Health Sciences
Dental Sensitivity, Gingival Condition
Effects of DIammine SIlver Fluoride on Tooth Sensitivity
The purpose of the study is to confirm the clinical effectiveness and safety of topical diammine silver fluoride (DASF) as a tooth desensitizer in adulst by comparing it to the application of sterile water.
- Trial name
- NCT01063530
- Testing
- DIammine SIlver fluoride, DIstilled water
- Where
- 2 sites in Peru
- Volunteers
- 144 people
- Sponsor
- Universidad Peruana Cayetano Heredia
Caries
Effect of CPP-ACP With/Without Fl on White Spot Lesion,Salivary pH and fl Release in High Caries Risk Patients
Effect of CPP-ACP pastes with/without Fluoride on White spot lesion progression, salivary pH and fluoride release in high caries risk Patients, over 3 month period using VistaCam, Digital pH meter and Selective ion electrode.
- Trial name
- NCT03656432
- Testing
- CPP-ACP paste
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Cairo University
Dental Pulp Necrosis
Effect Of Different Lining Materials in Stepwise Excavation
Deep carious lesions will encounter the dentist with the challenge of selecting a treatment method that could avoid the pulpal exposure and maintain the pulp vitality.Conventional restorative treatments suggest complete removal…
- Trial name
- NCT01730287
- Testing
- Control, Calcium Hydroxide, Mineral Trioxide Aggregate(MTA)
- Where
- Iran
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Azad University of Medical Sciences
Root Canal Infection, Periapical Diseases
Microbial Load After Apical Enlargement in Asymptomatic Teeth With Periapical Lesion
The goal of this observational study is to define the role of apical shaping and irrigation activation on root canal cleanliness.
- Conditions
- Root Canal Infection, Periapical Diseases, Periapical; Infection, Endodontic Disease
- Trial name
- NCT06035185
- Testing
- apical shaping size
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
White Spot Lesions [Initial Caries] on Smooth Surface of Tooth, Moringa Oleifera
Remineralization Efficacy of Moringa Oleifera Varnish Vs MI Varnish in Initial Carious Lesions Over 6 Months Follow Up: a Randomized Controlled Clinical Trial
This randomized clinical trial aimed to test the remineralization effect of laboratory prepared Moringa Oleifera based varnish compared to MI varnish (CPP-ACP) on incipient carious lesions.
- Trial name
- NCT06905379
- Testing
- Moringa Oleifera, Varnish
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cairo University
Decayed Teeth, Carious Lesion
Clinical Comparison Between Stainless-steel Crown, Zirconia Crown and Bioflx Crown in Primary Molars
The purpose of this clinical trial was to compare clinically three different crowns for primary molars; stainless steel crown, zirconia crown and Bioflx crown.
- Trial name
- NCT06706167
- Testing
- stainless steel crown, Zirconia crown, Bioflx crown
- Where
- Egypt
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Delta University for Science and Technology
Pulpitis - Irreversible, Pulp Necroses
Lesion Sterilization Tissue Repair and Conventional Pulpectomy in Primary Molars
The aim of this study was to compare the clinical and radiographic success of conventional root canal treatment and lesion sterilisation tissue repair methods in deciduous molars with necrotic or irreversible pulpitis.
- Conditions
- Pulpitis - Irreversible, Pulp Necroses, Root Canal Infection
- Trial name
- NCT06811636
- Testing
- Lesion sterilization and tissue repair, Conventional pulpectomy
- Where
- Turkey (Türkiye)
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Çanakkale Onsekiz Mart University
Dental Caries
Evaluation of Reliability of CarieScan PRO Compared With Digital Radiograph and ICDAS-II in Detection of Carious Lesions
The aim of this study is to evaluate the Clinical performance of alternating current impedance spectroscopy (CarieScan PRO) in comparison with digital radiograph and ICDAS-II in detection of occlusal carious lesions.
- Trial name
- NCT04438252
- Testing
- ICDAS II, CariScan Pro, Digital Radiograpgy
- Where
- Egypt
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- Cairo University
Primary Root Caries
Clinical Effect of Photoactivated Disinfection on Primary Root Carious Lesions After Partial Caries Removal
The problem of root caries has been increasing in last decades as the an average life expectancy is rising. Due to progress of medicine and dentistry humans also maintain natural dentition longer.
- Trial name
- PAD (NCT03186352)
- Testing
- photoactivated disinfection
- Where
- Poland
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Medical University of Warsaw