Clinical trials: Tooth Lesions
Dental Caries
Sealing Microcavitated Carious Lesions
This study aimed to test whether sealing microcavitated ICDAS 3 carious lesions in permanent molars may be arrested by sealing using two different types of materials; a glass ionomer and a resin sealant.
- Trial name
- SealCaries (NCT02849925)
- Testing
- Sealants to arrest microcavitated caries.
- Where
- Chile
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of Talca
Tooth Demineralization
Study of Treatments Used for White Spot Lesions After Orthodontic Treatment.
The purpose of this study is to learn more about the management of white spot lesions that occur after orthodontic treatment. White spot lesions generally improve slightly with time.
- Trial name
- NCT01059058
- Testing
- MI Paste Plus, PreviDent Fluoride Varnish, Normal Home Care
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University of Washington
Dental Caries in Children
Partial or Complete Excavation of Deep Caries in Primary Molars
Background: The traditional approach of carious lesions with risk for progression has has been to excavate all infected and demineralised tissue before placement of the restoration.
- Trial name
- PBRN (NCT04614285)
- Testing
- Partial excavation
- Where
- Sweden
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Deep Caries Lesion of Primary Teeth, Dental Pulp Diseases
Caries Location and Its Effect on the Success Rate of Indirect Pulp Treatment in Primary Molars
The following study will be created to evaluate how the location of caries affects the effectiveness of indirect pulp treatment in primary molars. aiding in the development of evidence-based recommendations for pediatric dentists.
- Conditions
- Deep Caries Lesion of Primary Teeth, Dental Pulp Diseases, Deep Proximal Caries, Deep Occlusal Caries
- Trial name
- NCT06675058
- Testing
- Indirect Pulp Treatment
- Volunteers
- 50 people
- Sponsor
- Cairo University
Tooth Mobility
Assessment of Microfragmented Adipose Tissue Loaded on Bovine Graft Versus Bovine Graft Only on Ridge Preservation.
Evaluation of maxillary alveolar ridge changes (bone quantity and quality as revealed by Radiographic and Histomorphometry) utilizing microfragmented adipose tissue loaded on bovine graft versus bovine graft only for maxillary…
- Trial name
- NCT06457867
- Testing
- microfragmented adipose tissue loaded on bovine graft
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Cairo University
Dental Caries
Intra Oral Appliance (IOA) Model Evaluating the Efficacy of Sensitive Toothpaste
This single-center, randomized, double-blind, three-period crossover in situ study evaluated the enamel remineralization potential and fluoride bioavailability of three dentifrices: a fluoride-free negative control, a positive…
- Trial name
- NCT07419763
- Testing
- Negative Control Toothpaste, Active Comparator, Test toothpaste
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Church & Dwight Company, Inc.
Dental Caries Extending Into Dentin
Comparison of Conventional Versus Conservative Caries Removal in Primary Teeth
The sample will be, at least, 90 primary molars, randomly distributed into three groups: Group 1: IPC; Group 2: SE; Group 3: SCR.
- Trial name
- Caries_removal (NCT03650647)
- Testing
- Carious dentin removal
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Universidade Federal Fluminense
Dental Caries, Secondary Dental Caries
Clinical Criteria for the Evaluation of Caries Lesions Around Restorations in Primary Teeth (CARDEC-03)
There is still great divergence in the aspects related to caries lesions around restorations. The methods and the systems used for the detection of secondary caries lesions have presented low validity.
- Trial name
- CARDEC-03 (NCT03520309)
- Testing
- Dental treatment
- Where
- Brazil
- Volunteers
- 163 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Pain, Postoperative, Root Resorption
Evaluation of Different Medicaments in the Management of Necrotic Primary Molars by Lesion Sterilization and Tissue Repair
Management of non-vital primary molars is challenging due to the natural anatomy of primary teeth, patients' young age, and their behavior toward dental treatment.
- Conditions
- Pain, Postoperative, Root Resorption, Persistent Infection, Necrotic Pulp
- Trial name
- NCT06926322
- Testing
- Conventional double antibiotic paste of Metronidazole 500 mg plus Ciprofloxacin 500 mg mixed with propylene glycol, Double antibiotic paste of Metronidazole and Ciprofloxacin loaded chitosan-coated silver nanoparticles, chitosan-coated silver nanoparticles
- Where
- Egypt
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Demineralization, Tooth, Demineralization, Fissure
Compariing a Bioactive Resin Material Used As A Fissure Sealant To A Conventional Resin
The aim of this study is to investigate the retention, marginal integrity and potential to prevent lesion progression of a bioactive resin material compared to a conventional resin-based flowable composite during management of…
- Conditions
- Demineralization, Tooth, Demineralization, Fissure, Non-Cavitated Caries
- Trial name
- NCT04052802
- Testing
- Fissure sealing
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cairo University
Demineralization, Remineralization
Clinical Study to Evaluate the Anti-cavity Efficacy of Three Dentifrices: An In Situ Model
Clinical study to evaluate the anti-cavity effectiveness of three dentrifices using an intra-oral enamel Demineralization and Remineralization In-Situ Model.
- Conditions
- Demineralization, Remineralization, Dental Cavity, Enamel Lesions
- Trial name
- NCT07134231
- Testing
- Fluoride free toothpaste in a chalk base, Fluoride Toothpaste, Fluoride free toothpaste in a PCC/RNCC base
- Where
- Brazil
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Pulpitis - Irreversible, Ozone
Zinc Oxide Ozonated Olive Oil in LSTR
This study will be carried out to evaluate and compare the clinical and radiographic effect of zinc oxide-ozonated olive oil (ZnO-OO) versus Modified Triple Antibiotic Paste (MTAP) as a Lesion Sterilization and Tissue Repair…
- Conditions
- Pulpitis - Irreversible, Ozone, Pulp Disease, Dental, Primary Teeth
- Trial name
- Zn-OO/MTAP (NCT06854744)
- Testing
- lesion sterlization and tissue repair, Zinc Oxide Ozonated Oil, Modified Triple Antibiotic Paste
- Where
- 2 sites in Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Tanta University
Dental Caries
The Prevalence of White Spot Lesions During Orthodontic Treatment With Fixed Appliances
This study investigates how often cavities develop on the permanent teeth of patients with braces (orthodontic treatment). The hypothesis is that there is no difference in the number of cavities on the permanent teeth of patients…
- Trial name
- WSLs (NCT04186065)
- Where
- United States
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Hiroko Nagaoka
White Spot Lesion of Tooth
Color Stability of S-PRG Resin-Based Light-Cure Varnish and Prophylaxis Paste on White Spot Lesions
The aim of the study is to evaluate and compare the long-term color stability of two bioactive materials used in the management of white spot lesions: Surface Pre-Reacted Glass (S-PRG) containing resin-based light-cured varnish…
- Trial name
- NCT07126366
- Testing
- S-PRG Barrier coat, S-PRG Prophylaxis paste
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Cairo University
Malaligned Teeth, Crowding of Teeth
Effect of Different Adhesive Systems on White Spot Lesions During Fixed Orthodontic Treatment
The primary goal of this study is to compare the number of white spot lesions during fixed appliance therapy between self-etch and one-step bonding systems.
- Trial name
- NCT07753512
- Testing
- Self-etch adhesive, One-Step Adhesive, Conventional Bonding Technique
- Where
- Pakistan
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Foundation University Islamabad
Resorption of Tooth or Root
Clinical & Radiographic Evaluation of LSTR in Non-vital Primary Molars Using Two Different Vehicles
LSTR will be done for primary teeth with significant root resorption needing non-vital pulp therapy to save such teeth for up to 12 months.
- Trial name
- LSTR (NCT05079802)
- Testing
- Double antibiotic paste mixed with chitosan nanoparticles, Double antibiotic paste mixed with propylene glycol
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Decayed Teeth, Carious Lesion
Clinical Comparison Between Stainless-steel Crown, Zirconia Crown and Bioflx Crown in Primary Molars
The purpose of this clinical trial was to compare clinically three different crowns for primary molars; stainless steel crown, zirconia crown and Bioflx crown.
- Trial name
- NCT06706167
- Testing
- stainless steel crown, Zirconia crown, Bioflx crown
- Where
- Egypt
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Delta University for Science and Technology
Pulp Necrosis
Lesion Sterilization and Tissue Repair Antibiotic Paste Versus Zinc Oxide and Eugenol Pulpectomy for Treatment of Primary Molars With Pulp Necrosis
The goal of this clinical trial is to compare the efficacy of lesion sterilization and tissue repair (LSTR) antibiotic paste versus zinc oxide eugenol (ZOE) pulpectomy for the treatment of primary molars with pulp necrosis in…
- Trial name
- LSTR (NCT07475364)
- Testing
- Group A - LSTR Therapy (CTZ Paste), Group B - ZOE Pulpectomy
- Volunteers
- 180 people
- Sponsor
- University of Faisalabad
White Spot Lesions [Initial Caries] on Smooth Surface of Tooth
Effectiveness of Different Toothpastes in Treating White Spot Lesions
This randomized clinical trial and laboratory study was conducted to: Compare the effectiveness of zinc-carbonated nano-hydroxyapatite, arginine, and fluoride-containing toothpastes for treating white spot lesions associated with…
- Trial name
- NCT06128434
- Testing
- zinc carbonate nano-hydroxyapatite toothpaste, 8% arginine toothpaste, Fluoride toothpaste
- Where
- Egypt
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Deep Caries, Carious Exposure of Pulp
Outcome of Selective & Nonselective Caries Removal in Permanent Teeth
Patients presenting with deep decay within permanent teeth presents a common clinical challenge to dentists. The aim of this trial is to compare the success rate of the non-selective caries removal (NSCR) and selective caries…
- Trial name
- RCT-SNCR (NCT06378814)
- Testing
- Selective Caries Removal (No Pulp Exposure), Non-Selective Caries Removal (No Pulp exposure), Partial Pulpotomy (Pulp Exposed)
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- King's College London