Clinical trials: Tooth Lesions
White Spot Lesion of Tooth
Bioactive Glass in the Treatment of Enamel White Spot Lesions
the aim of this study is to evaluate the effectiveness of BiominF® and Novamin® in comparison to Casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) in the treatment of enamel white spot lesions
- Trial name
- NCT04401280
- Testing
- BiominF, Novamin, CPP-ACP
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Rania Salah
White Spot Lesion
Remineralization Effect Of Egg Shell Versus Fluoride Varnish On Early Carious White Spot Lesions In Primary Teeth
The goal of this clinical trial is to to assess the remineralization potential of Egg shell hydrogel versus fluoride varnish in early carious white spot lesions in anterior primary teeth.
- Trial name
- NCT06932926
- Testing
- Egg shell hydrogel, Fluoride varnish
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Cairo University
Dental Caries in Children
Partial or Complete Excavation of Deep Caries in Primary Molars
Background: The traditional approach of carious lesions with risk for progression has has been to excavate all infected and demineralised tissue before placement of the restoration.
- Trial name
- PBRN (NCT04614285)
- Testing
- Partial excavation
- Where
- Sweden
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Endodontically Treated Teeth
Evaluation of The Effect of 980nm Diode Laser Intracanal Irradiation on Levels of Interleukin-8 Expression
This clinical trial will be conducted to evaluate the amount of Il-8 expression before and after the application of intracanal irradiation with diode laser 980 nm versus placebo in failed endodontic cases with periapical lesions.
- Trial name
- NCT05603988
- Testing
- Intracanal Diode laser irradiation
- Where
- Egypt
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Cairo University
Dental Caries
Caries Lesion Activity in Orthodontic Patients - Calcivis System
This is a prospective, single-centre clinical study to monitor caries lesion activity in orthodontic patients with the Calcivis System over a 12 week period.
- Trial name
- NCT02771522
- Testing
- Calcivis System
- Where
- United Kingdom
- Volunteers
- 36 people
- Sponsor
- Calcivis Ltd
Dental Caries
Intraoral Appliance (IOA) Model Evaluating the Efficacy of a Whitening Toothpaste
This single-center, randomized, double-blind, three-period crossover in situ study evaluated the enamel remineralization potential and fluoride bioavailability of three dentifrices-one fluoride-free negative control, one positive…
- Trial name
- NCT07419685
- Testing
- Negative Control Toothpaste, Active Comparator, Test Toothpaste
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Church & Dwight Company, Inc.
White Spot Lesion of Tooth
Impact of Lingual Attachment on WSL Development in Clear Aligner Patients: A Randomized Controlled Clinical Trial
White spot lesions (WSLs) are a common esthetic complication during orthodontic treatment. While clear aligners (CAs) generally reduce WSL risk compared to fixed appliances, composite attachments remain plaque-retentive sites.
- Trial name
- NCT07368296
- Testing
- Lingual attachment participants
- Where
- Jordan
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Jordan University of Science and Technology
White Spot Lesion, Orthodontic Treatment
Comparison of Three Toothpastes for the Prevention and Reduction of White Spot Lesions
The purpose of the study is to determine if Clinpro™ 5000, Clinpro™ Tooth Crème, or MI-Paste Plus has an effect on the formation and resolution of white spot lesions for patients undergoing orthodontic treatment.
- Conditions
- White Spot Lesion, Orthodontic Treatment, Decalcification; Teeth
- Trial name
- NCT03440996
- Testing
- Clinpro™ 5000, Clinpro™ Tooth Crème, MI-Paste Plus
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Carious Teeth
Evaluation of Survival of Mature Second Premolar Treated With Regenerative Techniques
This study aims to compare the ability of different regenerative protocols in the treatment of mature necrotic
- Trial name
- NCT02915419
- Testing
- PRP, PRF
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Tooth Diseases
Comparative Evaluation of an Alkasite-based Restorative Material and Two Different Resin Composites
The clinical performance of an an alkasite-based restorative material and two different resin composites will be evaluated and compared in non-carious cervical lesions.
- Trial name
- NCT06375837
- Testing
- an alkasite-based restorative material, hybrid resin composite, a highly filled flowable resin composite
- Where
- Turkey (Türkiye)
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Tooth Wear
Non-Carious Cervical Lesions Restorations Using Different Modes of Universal Adhesive
Objectives: To evaluate the 36-month clinical performance of Single Bond Universal Adhesive (SBU; 3M ESPE, Germany) in non-carious cervical lesions (NCCLs) using different modes adhesion approaches according to the FDI criteria.
- Trial name
- NCT06227715
- Testing
- universal adhesive
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Eskisehir Osmangazi University
White Spot Lesion of Tooth, Orthodontic Malocclusion
A Comparative Assessment of Orthodontic Treatment Outcomes Using the Quantitative Light-Induced Fluorescence Method
The aim of this 2-arm parallel trial was to evaluate enamel demineralization after an indirect bonding technique in comparison to a direct bonding technique group using the quantitative light-induced fluorescence method.
- Trial name
- QLF (NCT03738839)
- Testing
- Quantitative Light-Induced Fluorescence, Direct bonding, Indirect bonding
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Dental Caries in Children, Dental Caries Class II
Treatment of Interproximal Cavities on Primary Molar Teeth With Silver Diamine Fluoride
This study investigates whether 1) Silver diamine fluoride (SDF) application using Super Floss can arrest and/or reverse initial interproximal caries on primary molars and 2) whether SDF applied with Super Floss is more effective…
- Conditions
- Dental Caries in Children, Dental Caries Class II, Dental Caries
- Trial name
- NCT03770286
- Testing
- 5% Fluoride Varnish, 38% Silver diamine fluoride, Super Floss
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Los Angeles
Root Caries
36-Month Clinical Performance of Different Restorative Materials in the Treatment of Root Caries Lesions
This is a split-mouth, randomized clinical study that evaluating the 36-month performance of different restorative materials in the treatment of root caries lesions.
- Trial name
- NCT03722758
- Testing
- Spectrum TPH3, Riva LC
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Dental Caries
Sealing Manifest Occlusal Caries Lesions in the Permanent Dentition
The research project "SEAL-DK" is focusing on advantages and disadvantages of two treatment strategies: non-invasive fissure sealing and invasive restorative treatment of manifest occlusal caries lesions in permanent teeth in…
- Trial name
- SEAL-DK (NCT02573090)
- Testing
- Non-invasive resin based fissure sealing, Invasive resin based restoration
- Volunteers
- 521 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
White Spot Lesion
Self-assembling Peptide With Sodium Fluoride in Treating White Spot Lesionss in Primary Teeth
Regenerative medicine-based approaches for caries treatment focus on biomimetic remineralization of initial carious lesions as a minimally invasive therapy using Self-Assembling Peptide P11-4 (CURODONTTM REPAIR) which enhances…
- Trial name
- NCT05721586
- Testing
- Self Assembling Peptide P11-4 (CURODONTTM REPAIR) + Fluoride varnish (DURAFLOR, Fluoride varnish (DURAFLOR
- Where
- Egypt
- Volunteers
- 24 people
- Sponsor
- Hams Hamed Abdelrahman
Dental Caries, Early Caries Lesions
A Randomized Split-Mouth Clinical Trial Comparing Resin Infiltration and Microabrasion for Early Caries Lesions
This study aims to evaluate and compare the clinical characteristics and treatment outcomes of early caries lesions using resin infiltration (Icon) and microabrasion (Opalustre).
- Conditions
- Dental Caries, Early Caries Lesions, White Spot Lesions[Initial Caries]on Smooth Surface of Tooth
- Trial name
- ICON-CTU (NCT07544849)
- Testing
- Resin Infiltration, Microabrasion
- Where
- Vietnam
- Volunteers
- 30 people
- Sponsor
- Can Tho University of Medicine and Pharmacy
Carious Lesion
Efficacy of Nanoparticle-incorporated Bonding Agent on Post-restorative Sensitivity
Type of study: Randomized Clinical trial To compare post-restorative sensitivity between titania nanoparticle reinforced bonding agent and bonding agent without nanoparticles in posterior composite restorations.
- Trial name
- NCT05744648
- Testing
- Composite resin restoration using Titania nanoparticle reinforced bonding agent, Composite resin restoration without Titania nanoparticle incorporated bonding agent
- Where
- Pakistan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Pakistan Institute of Medical Sciences
Demineralisation, White Spot Lesions
A Trial of Tooth Mousse to Remineralise Post-orthodontic Treatment White Spot Lesions
Fixed dental braces are associated with the risk of developing White Spot Lesions (WSLs), which appear as white chalky marks on the teeth.
- Conditions
- Demineralisation, White Spot Lesions, Orthodontic Treatment
- Trial name
- NCT01344473
- Testing
- Tooth Mousse creme (Casein Phosphopeptide)(RECALDENT)
- Where
- 2 sites in United Kingdom
- Volunteers
- 90 people
- Sponsor
- University of Dundee
Carious Lesion
Silver Diamine Flouride in Arresting Enamel Caries
This interventional study aims to evaluate the effectiveness of 38% Silver Diamine Fluoride (SDF) in arresting enamel caries in adults aged 18-50 years.
- Trial name
- NCT07125937
- Testing
- 38% Silver Diamine Fluoride
- Where
- Pakistan
- Volunteers
- 250 people
- Sponsor
- HITEC-Institute of Medical Sciences