Clinical trials: Tooth Lesions
MS (Multiple Sclerosis), Multiple Sclerosis (MS) - Relapsing-remitting
Comparison of Efficacy and Safety in Patients Switching From MabThera® to Rixathon® in Relapsing-Remitting Multiple Sclerosis
This observational study investigates if switching from MabThera® to Rixathon® is associated with changes in disease activity and/or safety in people with multiple sclerosis (MS).
- Conditions
- MS (Multiple Sclerosis), Multiple Sclerosis (MS) - Relapsing-remitting, Multiple Sclerosis (Relapsing Remitting)
- Trial name
- NCT07235644
- Where
- Sweden
- Volunteers
- 184 people
- Sponsor
- Uppsala University
Gingival Recession, Tooth Abrasion
A New Surgical-restorative Approach to Treat Gingival Recessions Associated With Non-carious Cervical Lesions (NCCL)
The aim of the present study is to evaluate the clinical, aesthetic and patient-centered parameters of connective tissue graft associated or not with partial resin composite (RC) for the treatment of gingival recession with NCCL…
- Trial name
- NCT02817763
- Testing
- Connective tissue graft (CTG), CTG plus resin composite restoration, sodium dipyrone
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universidade Estadual Paulista Júlio de Mesquita Filho
Periapical Diseases, Pulp Necroses
Cell-free Autologous Regenerative Endodontics Treatment for Teeth With Periapical Lesions (CARETT)
Conventional endodontic treatment has been the treatment of choice for the management of signs and symptoms of mature permanent teeth with pulpal necrosis and periapical lesion with predictable and favorable results.
- Trial name
- CARETT (NCT05305417)
- Testing
- Autologous Regenerative Endodontic Treatment, Conventional Root Canal Treatment
- Volunteers
- 228 people
- Sponsor
- Universidad de Valparaiso
Dentin Hypersensitivity, Non-carious Cervical Lesions, Bioactive Glass Air Polishing, S-PRG
Desensitizing Effect and Tooth Color Change After Using Giomer-based Varnish Versus Bioactive Glass Air Polishing in Treating Cervical Hypersensitive Lesions
This trial is test the dentin hypersenstivity using Giomer based Varnish versus Bioactive glass air polishing system in patients with non-cervical lesions.
- Trial name
- NCT05981625
- Testing
- Giomer varnish containing surface pre-reacted glass fillers
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
White Spot Lesion of Tooth
Effect of Different Remineralizing Agents on White Spot Lesions Treatment in Children
One hundred children with white spot lesions on their teeth were divivided into 5 groups of different remineralizing agents to assess their effect on color change and remineralization
- Trial name
- RCT (NCT06821724)
- Testing
- Casein phosphopeptide-amorphous calcium phosphate, Casein phosphopeptide-amorphous calcium phosphate + fluoride, Nano hydroxyapatite paste
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Research Centre, Egypt
White Spot Lesion of Tooth
Effect of Low-viscosity Resin Infiltration on Color Change of Enamel White Spot Lesions
this study aimed to assess the effect of the application of the low-viscosity Icon resin infiltrate on the color change of the diagnosed white spot enamel lesions (WSLs) over 3-, 6-, and 12-m follow-up periods.
- Trial name
- NCT05757440
- Testing
- Icon resin application
- Where
- Egypt
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- National Research Centre, Egypt
Dental Caries
Preventive Regimens With Herbal and Fluoride Toothpaste on Remineralization in High Caries Patients With Initial Lesions
This study will be conducted to assess the effect of different preventive regimens using herbal toothpaste versus fluoride toothpaste on the management of remineralization and caries risk in high caries risk patients.
- Trial name
- NCT04446390
- Testing
- Himalaya complete care toothpaste, colgate cavity protection
- Where
- 2 sites in Egypt
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Cairo University
Pulp Disease, Dental
Effect of Cavity Disinfectants on Post Operative Pain & Success of Partial Caries Removal
To investigate The Effect of Sodium hypochlorite and Chlorhexidine as cavity Disinfectants on the post operative pain and Success of Partial Caries Removal in deep carious lesion with moderate pulpitis in permanent teeth
- Trial name
- NCT06836882
- Testing
- Selective caries removal, Selective caries removal with NaOCl, Selective caries removal with CHX
- Where
- India
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Relapsing Multiple Sclerosis
Efficacy and Safety of Remibrutinib Compared to Teriflunomide in Participants With Relapsing Multiple Sclerosis (RMS) (REMODEL-2)
To compare the efficacy and safety of remibrutinib versus teriflunomide in patients with relapsing multiple sclerosis (RMS)
- Trial name
- NCT05156281
- Testing
- Remibrutinib, Teriflunomide
- Where
- 223 sites in United States, Argentina and 25 more
- Volunteers
- 1,007 people
- Sponsor
- Novartis Pharmaceuticals
Dental Caries Tooth Demineralization, Post-Orthodontic Esthetic Defects
Evaluation of Self-assembling Peptides Versus Amorphous Calcium Phosphate in the Treatment of White Spot Lesions
This clinical trial aims to compare the effectiveness of two remineralizing treatments for white spot lesions (WSLs) on the enamel surfaces of the front teeth.
- Trial name
- NCT07146464
- Testing
- Self-Assembling Peptide P11-4 Self-Assembling Peptide P11-4 is a biomimetic material applied topically to white spot lesions on the enamel. It diffuses into the lesion body and forms a three-dimension
- Where
- Egypt
- Volunteers
- 18 people
- Sponsor
- Ain Shams University
Demineralization, Remineralization
Clinical Study to Evaluate the Anti-cavity Efficacy of Three Dentifrices: An In Situ Model
Clinical study to evaluate the anti-cavity effectiveness of three dentrifices using an intra-oral enamel Demineralization and Remineralization In-Situ Model.
- Conditions
- Demineralization, Remineralization, Dental Cavity, Enamel Lesions
- Trial name
- NCT07134231
- Testing
- Fluoride free toothpaste in a chalk base, Fluoride Toothpaste, Fluoride free toothpaste in a PCC/RNCC base
- Where
- Brazil
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Dental Caries on Smooth Surface Limited to Enamel, Tooth Demineralization
Resin Infiltration and Fluoride Varnish Lesion Arresting Efficacy on Non-cavitated Proximal Lesion
Protection of dental hard tissues is one of the most important points of cariology. For this purpose, oral hygiene training (effective brushing and motivation), non-invasive approaches such as flouride varnish applications and…
- Conditions
- Dental Caries on Smooth Surface Limited to Enamel, Tooth Demineralization, Dental Caries, Dentistry, Operative
- Trial name
- NCT05202665
- Testing
- ICON DMG Resin Infiltration (micro-invasive approach), ClinproTM White Varnish, 3M ESPE Fluoride Varnish (non-invasive approach)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ege University
White Spot Lesion of Tooth
RMGI Varnish Versus APF Gel in Prevention of White Spot Lesions During Orthodontic Treatment
evaluate the effect of a single application of Clinpro XT varnish on enamel demineralization adjacent to orthodontic brackets during fixed orthodontic treatment in comparison with acidulated phosphorus fluoride gel.
- Trial name
- NCT03721198
- Testing
- Acidulated phosphorous flouride, Resin modified glass ionomer varnish
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Mohamed zidan
Dental Caries
Three Measures for the Prevention of Carious Lesions in Preschool Children
Analysis different measures preventive effect on carious Lesions incidence and oral microecological system change of preschool children
- Trial name
- NCT02341352
- Testing
- fluoride varnish, Immunoglobulin Yolk, Probiotics
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Zhejiang University
Hydrocephalus, Normal Pressure, Biochemical Lesions Head Region
Role of Brain Specific Biomarkers in Hydrocephalus
Normal pressure hydrocephalus (NPH) is a neurodegenerative disease of unclear etiology characterized by a clinical trias named after the neurosurgeon Hakim.
- Conditions
- Hydrocephalus, Normal Pressure, Biochemical Lesions Head Region, Brain Damage
- Trial name
- NCT06083233
- Testing
- Lumbar puncture, External lumbar drainage, Ventriculo-peritoneal shunt placement
- Where
- Czechia
- Volunteers
- 32 people
- Sponsor
- University Hospital Hradec Kralove
White Spot Lesions
One Year Clinical Evaluation of White Spot Lesions Treated With Newly Introduced Resin Modified Glass Ionomer in Comparison to Resin Infiltration in Anterior Teeth Split Mouth Technique
The aim of this study is to evaluate the addition of new technology of resin modified glass-ionomer in comparison to resin infiltration in treating post-orthodontic white spot lesions; both applies into the same patient's mouth…
- Trial name
- NCT02912741
- Testing
- Vanish xt Extended Contact Varnish, resin infiltration
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Cairo University
Heating and Activation of Sodium Hypochlorite
Minimal Instrumentation With Intracanal Heating and Activation of Sodium Hypochlorite for the Management of Teeth With Periapical Lesions
this study is the first to demonstrate the efficacy of minimally invasive root canal treatment combined with intracanal heating and activation of NaOCl using a prototype needle on the healing of asymptomatic apical periodontitis…
- Trial name
- NCT06461728
- Testing
- a new prototye device that heat and activate sodium hyochlorite (Aseptico)
- Where
- Lebanon
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Saint-Joseph University
Dental Caries
Diammine Silver Fluoride in Arresting Enamel Caries Lesions on Babies' Occlusal Surfaces
This study aims to verify the actual possibility of using silver diammine fluoride (SDF) in arresting enamel caries lesions on occlusal surfaces of primary molars in babies.
- Trial name
- NCT02789202
- Testing
- Silver diamine fluoride, Fluoride Varnish
- Where
- Brazil
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Incipient Caries
Clinical and Cost-Effectiveness of Silver Diamine Fluoride and Silver Fluoride, With or Without Application of LED, in Arresting Incipient Permament Molar Caries
The study aims to compare the effect of international brand ammonia based 38% SDF, water based silver fluoride solution (AgF), an aqueous silver fluoride solution, and local brand ammonia based SDF with and without LED light…
- Trial name
- SDF and AgF (NCT07366645)
- Testing
- International Sliver Diamine Fluoride, Local brand Egyptian Silver Diamine Fluoride, Silver Fluoride
- Volunteers
- 366 people
- Sponsor
- Cairo University
White Spot Lesion of Tooth
White Spot Lesions Prevention During Orthodontic Fixed Appliance Treatment: a Randomized Clinical Trial
The aim of this study is to evaluate the effectiveness of calcium fluoride nanoparticles containing orthodontic primer in preventing or decreasing the incidence WSLs over a period of 6 months in patients with fixed orthodontic…
- Trial name
- NCT04994314
- Testing
- nCaF2 primer, Control primer
- Where
- Iraq
- Volunteers
- 31 people
- Sponsor
- University of Baghdad