Clinical trials: Toothbrushing
Elderly, Periodontal Disease
Oral Hygiene Assistance Training Program
This is an oral health study with a nursing home staff training program and product intervention.
- Conditions
- Elderly, Periodontal Disease, Gingivitis, Caries,Dental
- Trial name
- NCT07807397
- Testing
- Stannous Fluoride Toothpaste (SnF), sodium fluoride 5000 ppm, cetylpyridinium chloride (0.075%) and zinc alcohol free mouthwash
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Gingivitis
Evaluation of the Addition of an Interdental Cleaning Device to Manual Brushing on Gingival Health
This study evaluates the addition of an interdental cleaning device paired with a manual toothbrush compared to using a manual toothbrush only. Plaque removal, reduction of gingival bleeding and reduction of gingival inflammation.
- Trial name
- NCT02836223
- Testing
- Interdental cleaning device, Manual Tooth brush
- Where
- Canada
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Water Pik, Inc.
Corneal Edema, Corneal Endothelial Dysfunction
Study of Safety and Tolerability of EO2002 in the Treatment of Corneal Edema
Corneal edema is the most common indication for corneal transplantation, accounting for approximately 70% of penetrating keratoplasty (PK), and 100% of endothelial keratoplasty (EK) procedures annually.
- Conditions
- Corneal Edema, Corneal Endothelial Dysfunction, Corneal Endothelial Dystrophy, Fuchs Dystrophy
- Trial name
- NCT04894110
- Testing
- EO2002, EO2002 low dose, EO2002 mid dose
- Where
- 8 sites in United States
- Volunteers
- 42 people
- Sponsor
- Emmecell
Whitening
Efficacy of a Toothpaste Containing Hydrogen Peroxide as Compared to a Regular Fluoride Toothpaste Without Hydrogen Peroxide in the Immediate Removal of Tooth Stains After a Single Brushing.
The aim of this study is to evaluate and compare the immediate efficacy of a hydrogen peroxide-containing toothpaste versus a regular fluoride toothpaste without hydrogen peroxide in removing extrinsic tooth stains following a…
- Trial name
- NCT07276672
- Testing
- Optic White Adv Sparkling White (2%HP) Toothpaste, Colgate Great Regular Flavor Toothpaste
- Where
- Dominican Republic
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Oral Hygiene, Toothbrushing
Open-label Trial Evaluating Four Oral Hygiene Regimens Using a Manual Toothbrush, Toothpaste, and Mouthwash
The purpose of this open-label, randomized controlled clinical trial, is to provide preliminary clinical data (efficacy on plaque and gingival sensitivity, and safety and tolerability of two types of toothpaste, a mouthwash, and…
- Conditions
- Oral Hygiene, Toothbrushing, Dental Plaque
- Trial name
- NCT05999175
- Testing
- the toothpaste is used with a standard toothbrush without any claims 3 times a day after the main meals for 28 days., the mint toothpaste and mouthwash are used with the scalar toothbrush 33 medium with antibacterial " Spazzolino tau-marin®" 3 times a day after the main meals for 28 days., subjects of this group will use their routine oral hygiene products.
- Where
- 2 sites in Italy
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Biokosmes Srl
Salivary Bacteria Levels
Efficacy of Salivary Bacteria and Post Brushing
Research study to compare the effects of brushing with two commercially available toothpastes on salivary bacteria after brushing
- Trial name
- NCT00981825
- Testing
- Fluoride, Triclosan/Fluoride
- Where
- India
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
ASD I, ASD2
Documenting Toothbrushing Experiences of Caregivers Who Care for Children With Autism Spectrum Disorders
The objective of this study is to examine caregiver reactions to the use of the hum by Colgate Smart Kids Toothbrush and associated app by children with autism spectrum disorder (ASD).
- Trial name
- humBrush (NCT05552144)
- Testing
- Hum by Colgate Smart Kids Toothbrush (battery powered) - 490000006871
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Colgate Palmolive
Dental Plaque
Development of Clinical Method to Triclosan Retention in Plaque Following Brushing
The objective is to develop a method to determine active ingredient uptake in oral care products.
- Trial name
- NCT00762853
- Testing
- Fluoride, Fluoride and triclosan
- Where
- Thailand
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Gingival Bleeding, Plaque Induced Gingival Disease
Comparative Study to Evaluate the Efficacy of an Alcohol-free Mouthwash Regimen With CPC+Zn, Flossing and Brushing, and an Alcohol-based Mouthwash Regimen With Essential Oils in Reducing Plaque and Gingivitis.
This is a Phase III, randomized, one-center, parallel group, double blinded, clinical study to evaluate the efficacy of an alcohol-free mouthwash containing CPC+Zn as compared to dental flossing and to rising with an essential…
- Conditions
- Gingival Bleeding, Plaque Induced Gingival Disease, Gingival Diseases, Gingivitis and Periodontal Diseases
- Trial name
- PGMWII (NCT06598072)
- Testing
- Mouthwash CPC+Zn+F, Essential oils mouthwash, Dental floss
- Where
- Mexico
- Volunteers
- 120 people
- Sponsor
- Colgate Palmolive
Gingival Diseases
Development of Clinical Method to Determination Triclosan Retention in Plaque Following Brushing.
Clinical research study to determine the anti-plaque efficacy of prototype dentifrices via a 4-day brushing regiment
- Trial name
- NCT00966953
- Testing
- Fluoride, Triclosan/Fluoride toothpaste, antibacterial plant extract
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Dental Plaque
Dental Plaque Removal Ability of Prototype Power Toothbrush Versus a Manual Toothbrush in Healthy Participants
The aim of this study is to evaluate the ability of a prototype power toothbrush (PTB) versus a manual toothbrush in healthy, right-handed manual toothbrush (MTB) participants with no signs of periodontal disease or excessive…
- Trial name
- NCT03809910
- Testing
- Reference MTB, Reference PTB, Prototype PTB (Gum line mode)
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Dental Plaque
Ability of Four Toothpastes to Remove Plaque
The aim of this study is to evaluate and compare the plaque removal efficacy of four experimental toothpastes following a single timed brushing.
- Trial name
- NCT03285984
- Testing
- 67% Sodium Bicarbonate with 6 herbs plus 923parts per million (ppm) Sodium Fluoride, 67% Sodium Bicarbonate without herbs plus 923 ppm Sodium Fluoride, 62% Sodium Bicarbonate with 6 herbs and 5% w/w silica plus 923 ppm Sodium
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Oral Malodor
A Clinical Study Conducted in the Bangkok, Thailand Area, to Investigate the Clinical Efficacy of a New Toothpaste
To investigate the clinical efficacy of a new toothpaste containing 0.454% stannous fluoride as compared to a regular fluoride toothpaste containing 0.76% sodium monofluorophosphate on oral malodor reduction via organoleptic…
- Trial name
- NCT07223073
- Testing
- 0.454% stannous fluoride, 0.76% sodium monofluorophosphate
- Where
- Thailand
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Sensitivity, Tooth
Dentinal Hypersensitivity Reduction Efficacy Study
Assess the clinical efficacy of CSPR Toothpaste containing 8% arginine to provide dentinal hypersensitivity relief
- Trial name
- NCT06960148
- Testing
- CSPR Toothpaste, Colgate Dental Cream Toothpaste
- Where
- China
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Gingivitis, Plaque
Clinical Research Study to Assess the Efficacy of Two Brushing Regimens in the Reduction of Established Dental Plaque and Gingivitis.
Qualified subjects will be enrolled and randomized to one of the two study groups based on their initial Plaque and Gingivitis scores. Subjects will be instructed to use the products according to the instructions provided.
- Trial name
- NCT06244303
- Testing
- manual Tooth Brush + Colgate Total TP (0.454% SnF, 1100 ppm F), manual toothbrush + Colgate dental cream
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Dental Plaque, Gingivitis
Clinical Research Study to Assess the Efficacy of Two Brushing Regimens
The objective of this twelve-week clinical research study is to assess the efficacy of two brushing regimens: 1) toothpaste with mouthwash containing sodium fluoride/zinc and manual toothbrush as compared to 2) regular fluoride…
- Trial name
- NCT06240481
- Testing
- Test Regimen, Control Regimen
- Where
- Spain
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Dental Plaque, Behavior
The Impact of a 21day School Brushing Intervention on the Knowledge, Behaviour and Oral Health of School Children
In this study we aim to study the effectiveness of a specially designed 21 day Brush Day and Night programme for school children aged 6-9 which aims to establish the habit of twice a day toothbrushing for oral health.
- Conditions
- Dental Plaque, Behavior, Behavior, Health
- Trial name
- NCT04001296
- Testing
- 21 day Brush Day and Night school programme
- Where
- 2 sites in Indonesia, Nigeria
- Volunteers
- 2,020 people, healthy volunteers welcome
- Sponsor
- Unilever R&D
Gingivitis
To Compare the Effectiveness of Three Self-care Oral Hygiene Regimens
The study is designed to evaluate the clinical changes in gingival health by measuring the reduction of gingival bleeding and inflammation over 4 weeks.
- Trial name
- NCT04804670
- Testing
- Power device A, Power device B, Routine Oral Hygiene
- Where
- Canada
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Water Pik, Inc.
Dental Plaque
Efficacy of Three Experimental Toothpastes to Remove Plaque
The Dose response of three experimental toothpastes (test product 1, test product 2 and test product 3) to remove plaque after a single brushing, compared to a positive control and negative control dentifrice will be evaluated.
- Trial name
- NCT02992691
- Testing
- 20% w/w sodium bicarbonate, 35% w/w sodium bicarbonate, 50% w/w sodium bicarbonate
- Where
- Germany
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Plaque, Dental
Efficacy of a Eugenol-based Product to Improve the Quality of Toothbrushing and Relieving Gum Discomfort Areas
The objective of this study is to evaluate the efficacy of a eugenol-based product in improving the quality of toothbrushing and relieving areas of gingival discomfort.
- Trial name
- NCT06366568
- Testing
- fluoride toothpaste containing 1450 ppm of MFP in a PCC base and eugenol gum product, fluoride toothpaste containing 1450 ppm of MFP in a PCC base
- Where
- Germany
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive