Clinical trials: Total Hip Surgery
Neuromuscular Blockade, Innate Inflammatory Response
Impact of Deep Neuromuscular Blockade During Total Hip Replacement Surgery on Postoperative Recovery and Immune Function
Monocenter randomized controlled trial to compare the effect of deep neuromuscular blockade (NMB) versus moderate NMB during total hip replacement surgery on postoperative quality of recovery and innate immune function.
- Conditions
- Neuromuscular Blockade, Innate Inflammatory Response, Quality of Life, Postoperative Complications
- Trial name
- HIPPO (NCT05562999)
- Testing
- Rocuronium Bromide
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- Radboud University Medical Center
Total Hip Surgery, Pericapsular Nerve
Comparison of Pericapsular Nerve Group Block and Quadratus Lumborum Block
Adequate pain management following total hip arthroplasty (THA) is a key component for patient satisfaction and early ambulation.
- Conditions
- Total Hip Surgery, Pericapsular Nerve, Quadratus Lumborum
- Trial name
- NCT05654519
- Testing
- PENG/LFCN and QL Blocks
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Konya Necmettin Erbakan Üniversitesi
Obturator Nerve Block, Total Hip Replacement
Postoperative Analgesia After Elective Hip Surgery - Effect of Obturator Nerve Blockade
The study investigates the effect of an obturator nerve block on the postoperative pain and opioid consumption after total hip replacement.
- Trial name
- NCT03064165
- Testing
- Bupivacaine-epinephrine, Obturator nerve block, Sodium Chloride 9mg/mL
- Where
- Denmark
- Volunteers
- 62 people
- Sponsor
- University of Aarhus
Wound of Knee, Wound of Hip
Study to Compare Negative Pressure Wound Therapy or Standard Dressings After Orthopedic Surgery
The aim of this study is to assess the prevention of incision healing complications in patients undergoing Total Knee Arthroscopy (TKA) and Total Hip Arthroscopy (THA) treated with either Single-Use Incisional NPWT (Negative…
- Trial name
- PICO (NCT02064270)
- Testing
- Single-Use Negative Pressure Wound Therapy, Standard postsurgical dressings
- Where
- United States
- Volunteers
- 526 people
- Sponsor
- University of Missouri-Columbia
Regional Anesthesia Block, Regional Anesthesia
PENG and LFCN Block Versus FIC Block for Multimodal Analgesia After Total Hip Replacement Surgery: a Retrospective Analysis Focused on Movement (Retro-PvF)
Total hip arthroplasty is a major surgical procedure performed on a growing number of patients. Optimal pain control with limited muscle weakness is paramount for a swift initiation of physical therapy and ambulation, thus…
- Conditions
- Regional Anesthesia Block, Regional Anesthesia, Total Hip Replacement Surgery, Total Hip Arthroplasty \(THA\)
- Trial name
- Retro-PvF (NCT06342102)
- Testing
- PENG + LFCN block, FIC block
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Ospedale Edoardo Bassini
Venous Thromboembolism
Dose Ranging Study in Elective Total Hip Replacement Surgery
The primary objective is to: demonstrate the efficacy of SR123781A in the prevention of venous thromboembolism (VTE) by the demonstration of a dose-response in patients undergoing total hip replacement surgery.
- Trial name
- DRIVE (NCT00338897)
- Testing
- SR123781A
- Where
- 14 sites in Argentina, Bulgaria and 12 more
- Volunteers
- 1,090 people
- Sponsor
- Sanofi
Arthroplasty, Replacement, Prevention of Venous Thromboembolism
Treatment of Patients Undergoing Primary Unilateral Elective Total Knee or Hip Replacement With Dabigatran Etexilate
To supplement the current evidence of the effect of Pradaxa® (dabigatran etexilate) on coagulation parameters, including a calibrated thrombin time test, in patients with moderate renal impairment undergoing elective total hip…
- Conditions
- Arthroplasty, Replacement, Prevention of Venous Thromboembolism, Moderate Renal Impairment (CrCl 30-50 mL/Min)
- Trial name
- NCT01184989
- Testing
- Dabigatran etexilate
- Where
- 10 sites in Austria, Canada and 4 more
- Volunteers
- 142 people
- Sponsor
- Boehringer Ingelheim
Total Hip Replacement, Arthroplasty Complications
REVISITS: Revision Single or Two Stage Surgery
Hip replacement surgery is common, with over 60,000 cases in Canada annually. After hip replacement, about 1-2% patients develop a deep infection in their artificial hip implant, called a periprosthetic joint infection (PJI).
- Trial name
- REVISITS (NCT03741296)
- Testing
- Single stage revision, Two-stage revision
- Volunteers
- 110 people
- Sponsor
- Unity Health Toronto
Total Hip Replacement
Study of Total Hip Arthroplasty Using Radlink Surgical Positioning Software
This is a prospective, randomized study of total hip arthroplasty with and without the use of Radlink surgical positioning software.
- Trial name
- NCT02536573
- Testing
- Radlink Surgical Positioning Software
- Volunteers
- 200 people
- Sponsor
- Anderson Orthopaedic Research Institute
Blood Loss, Surgical
Oral Tranexamic Acid vs. Oral Aminocaproic Acid to Reduce Blood Loss After Total Hip Replacement
This study compares two oral medications (tranexamic acid and aminocaproic acid) as hemostatic agent administered in patients undergoing primary total hip replacement
- Trial name
- NCT04187014
- Testing
- Aminocaproic Acid 1000Mg Tab, Tranexamic acid tablets
- Where
- Mexico
- Volunteers
- 90 people
- Sponsor
- Carlos A Acosta-Olivo
Arthropathy of Hip, Hip Arthropathy
Pericapsular Nerve Group (PENG) Block Combined With Lateral Femoral Cutaneous Nerve (LFCN) Block or Wound Infiltration for Postoperative Analgesia in Anterior Approach Total Hip Arthroplasty: A Randomized Controlled Trial
This prospective, randomized controlled trial aims to compare two multimodal regional anesthesia strategies for postoperative analgesia in elective total hip arthroplasty (THA) performed via anterior approach.
- Conditions
- Arthropathy of Hip, Hip Arthropathy, Locoregional Anesthesia, Complication of Anesthesia
- Trial name
- Peng_lfcn/WI (NCT07284615)
- Testing
- PENG plus LFCN block, PENG plus WI
- Where
- Italy
- Volunteers
- 102 people
- Sponsor
- Ospedale Edoardo Bassini
Osteoarthritis, Knee, Osteoarthritis, Hip
Impact of a POPOP on Preoperative Health, Eligibility, and Clinical & Patient-Reported Outcomes in TJA
In this pilot study, we will test the hypothesis that a POPOP for currently ineligible UAMS orthopedic surgery patients wanting hip or knee replacement improves markers of preoperative health, ability to reach a BMI threshold <40…
- Conditions
- Osteoarthritis, Knee, Osteoarthritis, Hip, Avascular Necrosis, Rheumatoid Arthritis
- Trial name
- NCT04910048
- Testing
- POPOP (preoperative patient optimization program), SOC (standard of care)
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- University of Arkansas
Postoperative Cognitive Dysfunction
Postoperative Cognitive Dysfunction After Total Knee or Hip Replacement Surgery in Fast-track Set-up
The aim of this study is to quantify the incidence of postoperative cognitive dysfunction in the elderly patient (>60y) after total hip or knee replacement surgery.
- Trial name
- NCT01103752
- Testing
- no intervention, descriptive study
- Where
- Denmark
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- Lene Krenk
Primary Hip Osteoarthritis, Secondary Hip Osteoarthritis Due to Idiopathic Femoral Head Necrosis, Childhood or Inflammatory Disease
Fitmore Versus CLS Stem in Total Hip Arthroplasty. Bilateral One-stage Operations
Main question: Will use of a stem design that allows anatomical reconstruction of the hip joint improve the outcome in terms of hip function and patient satisfaction without causing any adverse effects? Background: Total hip…
- Conditions
- Primary Hip Osteoarthritis, Secondary Hip Osteoarthritis Due to Idiopathic Femoral Head Necrosis, Childhood or Inflammatory Disease, Bilateral Hip Disease, Surgical Treatment
- Trial name
- NCT03112785
- Testing
- Total hip arthroplasty (Fitmore or CLS uncemented femoral stem made by Zimmer-Biomet, Warshaw, USA)
- Volunteers
- 44 people
- Sponsor
- Sahlgrenska University Hospital
Cognition
Cognition in Postoperative Total Hip Arthroplasty and Total Hip Resurfacing Patients
Transient cognitive changes after surgery may be due to many different factors. It is estimated that between 5-29% of patients undergoing orthopedic surgery experience a transient decline in their cognition.
- Trial name
- NCT01079468
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Rothman Institute Orthopaedics
Acupuncture, Hip Surgery
Incorporating Acupuncture Into ERAS for Ambulatory Total Hip Replacement (THR) Surgery
At this time, no formal ERAS (enhanced recovery after surgery) protocol exists for THR that incorporates perioperative acupuncture.
- Conditions
- Acupuncture, Hip Surgery, Opioid Use
- Trial name
- NCT05384860
- Testing
- Auricular Trauma Protocol (ATP) Acupuncture, No Acupuncture Group
- Where
- United States
- Volunteers
- 484 people
- Sponsor
- Hospital for Special Surgery, New York
Pain, Postoperative, Anesthesia, Conduction
Effect of a Lateral Nerve of the Thigh Block on Postoperative Pain After Total Hip Replacement Surgery
The purpose of this study was to evaluate the analgesic efficacy of the nervus cutaneous femoral lateralis (NCFL) blockade on postoperative pain after total hip replacement surgery. The NCFL-block is a pure sensory block.
- Conditions
- Pain, Postoperative, Anesthesia, Conduction, Arthroplasty, Replacement, Hip
- Trial name
- NCT02289937
- Testing
- Ropivacaine, An ultrasound-guided Nervus cutaneous femoral lateralis blockade will be given postoperatively
- Volunteers
- 100 people
- Sponsor
- Daniel Hägi-Pedersen
Total Hip Replacement, Patient-Reported Outcomes
Patient Scores and Functional Tests After Hip Surgery
This study aims to explore how well patient self-assessments reflect their actual physical performance following hip replacement surgery.
- Trial name
- NCT07048041
- Testing
- Functional Assessment Battery
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Ordu University
Educational Problems, Hip Arthroplasty
VR Simulation and Basic Skills in THA
This prospective randomised clinical trial aims to test if virtual reality (VR) simulation helps acquire basic surgical skills in total hip arthroplasty (THA) by medical students. The main question[s] it aims to answer are: 1.
- Conditions
- Educational Problems, Hip Arthroplasty, Osteoarthritis, Hip, Medical Students
- Trial name
- MD-VR-THA (NCT05807828)
- Testing
- VR simulation on basic THA skills
- Where
- Greece
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Total Hip Arthroplasty (THA), Kinesiophobia
Preoperative Video-Based Education in Total Hip Arthroplasty
This single-center, prospective, randomized controlled trial aims to evaluate the effect of preoperative video-based mobilization education on postoperative fear of movement (kinesiophobia), pain during first mobilization, and…
- Conditions
- Total Hip Arthroplasty (THA), Kinesiophobia, Postoperative Pain, Early Mobilization
- Trial name
- NCT07279974
- Testing
- Video-Based Mobilization Education, Standard Verbal Education
- Where
- Turkey (Türkiye)
- Volunteers
- 96 people
- Sponsor
- Acibadem University