Clinical trials: Total Intravenous Anesthesia
Hypophysectomy
Estimating EC95 of Remifentanil for Cough Prevention During Emergence From Total Intravenous Anesthesia With Propofol and Remifentanil in Patients Undergoing Transsphenoidal Hypophysectomy
In patients undergoing hypophysectomy through transsphenoidal approach, preventing cough during anesthetic emergence is important to avoid hemorrhage and cerebrospinal fluid leakage.
- Trial name
- NCT01735019
- Testing
- Administration of remifentanil with TCI system
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Yonsei University
Peritoneal Neoplasms, Postoperative Recovery
Remimazolam Versus Propofol for Early Recovery After Cytoreductive Surgery
The REPAIR Trial is a single-center, prospective, randomized, parallel-group superiority trial enrolling 320 adults scheduled for elective cytoreductive surgery (CRS) with or without hyperthermic intraperitoneal chemotherapy…
- Trial name
- REPAIR (NCT07785557)
- Testing
- Remimazolam, Propofol
- Where
- China
- Volunteers
- 320 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Opioid Analgesic Adverse Reaction
Cardiovascular Protection Conservative Effects of Esketamine Versus µ-opioid Receptor Agonists in General Anesthesia
Pain is 'a double-edged sword', disturbing daily life of the sufferers and activating the intrinsic protective mechanisms. Transient receptor potential vanilloid 1 (TRPV1), play such role as 'a double agent', transmitting the…
- Trial name
- NCT04553536
- Testing
- Esketamine, Sulfentanil or/and Remifentanil
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Second Hospital of Shanxi Medical University
Status; Splenectomy
Effects of Desflurane Versus Propofol on Hemostasis During Splenectomy
The aim of this prospective randomized study is to evaluate the perioperative effects of inhalational anesthesia (desflurane) and intravenous anesthesia (propofol) on hemostasis in patients undergoing splenectomy with liver…
- Trial name
- NCT02079064
- Testing
- Desflurane, Propofol
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Theodor Bilharz Research Institute
Pain Measurement
Intraoperative Nociception Monitoring with Medstorm, Medasense and Anspec-pro During Total Intravenous Anesthesia
The randomized controlled trial study aims to validate a new pain monitor during general anesthesia by comparing the new ANSPEC-PRO monitor (non-CE marked) with already CE-marked pain monitors (Medstorm and Medasense).
- Trial name
- NCT04986163
- Testing
- Non-invasive analgesia monitoring with ANSPEC-PRO monitor and MEDSTORM monitor, Non-invasive analgesia monitoring with ANSPEC-PRO monitor and MEDASENSE monitor, Non-invasive analgesia monitoring with MEDSTORM monitor and MEDASENSE monitor
- Where
- Belgium
- Volunteers
- 70 people
- Sponsor
- University Hospital, Ghent
Rhinosinusitis
Dexmedetomidine Infusion in Either Total Intravenous Anesthesia or Inhalational Anesthesia to Improve Surgical Field Visibility in Endoscopic Sinus Surgery
Dexmedetomidine Infusion in either Total Intravenous Anesthesia or Inhalational Anesthesia to Improve Surgical Field Visibility in Endoscopic Sinus Surgery
- Trial name
- NCT06866145
- Testing
- functional endoscopic sinus surgery, Dexmedetomidine
- Where
- 2 sites in Egypt
- Volunteers
- 50 people
- Sponsor
- Menoufia University
Percutaneous Transhepatic Cholangiography
Total Intravenous Anesthesia in Percutaneous Transhepatic Cholangiography
Percutaneous transhepatic cholangiography is a disturbing procedure for patients. TIVA with short-acting anesthetics such as propofol and remifentanil is characterized by hemodynamic stability and better compilation profile The…
- Trial name
- NCT03103672
- Testing
- Percutaneous transhepatic cholangiography
- Volunteers
- 60 people
- Sponsor
- Inonu University
Pain, Postoperative, Osteoarthritis
Pain Treatment After Total Knee Replacement - Continuous Epidural Versus Intravenous Patient Controlled Analgesia With Morphine
The study purpose is to compare the effectiveness of different methods for post-operative pain treatment after total knee replacement.
- Trial name
- NCT00270322
- Testing
- Marcaine 0.166% + Fentanyl 3.33 mcg/ml, Morphine sulphate
- Where
- Israel
- Volunteers
- 80 people
- Sponsor
- Rambam Health Care Campus
Cardiovascular Surgical Procedure
Benefits of Total Intravenous Anesthesia Compared With Inhaled Anesthesia in Cardiovascular Surgery
This study compares the difference in proinflammatory markers Interleukin 6 (IL-6), Tumor necrosis factor alpha (TNFα) and cortisol in patients undergoing cardiovascular surgery to asses if there is a benefit of using intravenous…
- Trial name
- NCT03233815
- Testing
- Propofol, Sevoflurane
- Where
- Mexico
- Volunteers
- 40 people
- Sponsor
- Coordinación de Investigación en Salud, Mexico
Anesthesia, Anesthesia, Intravenous
Comparability of Invasive and Non-invasive Haemodynamic Monitoring
During general anesthesia the basic non-invasive monitoring of hemodynamic parameters (blood pressure, O2-saturation, cardiogram) is crucial.
- Trial name
- HMPR1 (NCT02197858)
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Total Intravenous Anesthesia, Inhalational Anesthesia
Intravenous Anesthesia by Targeted Controlled Infusion Versus Inhalational Anesthesia on the Surgical Stress Response
This study aims to compare the effect of total Intravenous anesthesia Target-controlled infusion (TIVA-TCI) with inhalational anesthesia on stress response.
- Conditions
- Total Intravenous Anesthesia, Inhalational Anesthesia, Surgical Stress Response, Target-controlled Infusion
- Trial name
- NCT06024733
- Testing
- Sevoflurane, Target Controlled Infusion, Target Controlled Infusion and lidocaine
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Assiut University
Evoked Potentials, Visual
A Novel Method for Capturing the Visual Evoked Potential During Spine Surgery Under Total Intravenous Anesthesia
Spine surgery in the prone position (which involves lying face down) is associated with various visual changes, ranging from temporary changes in acuity (or sharpness) to permanent blindness.
- Trial name
- VEP (NCT02563028)
- Testing
- SightSaver Visual Stimulator
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Hospital for Special Surgery, New York
Adolescent Idiopathic Scoliosis, Multimodal Analgesia
Propofol + Remifentanil vs. Propofol + Dexmedetomidine in Adolescent Idiopathic Scoliosis Patients Having Spine Surgery
Patients with Adolescent Idiopathic Scoliosis may need surgery to correct their scoliosis. General anesthesia is required for this surgery, and a multimodal analgesic regimen using combinations of opioid and non-opioid…
- Conditions
- Adolescent Idiopathic Scoliosis, Multimodal Analgesia, Opioid Induced Hyperalgesia, Remifentanil
- Trial name
- NCT06096181
- Testing
- Remifentanil TIVA, Dexmedetomidine TIVA, Propofol TIVA
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Obesity (BMI>30), Postoperative Cognitive Function
Postoperative Cognitive Function After Different Anesthetic Techniques in Obese Patients
Obese patients are at increased risk of postoperative cognitive dysfunction (POCD). The effects of different anesthetic techniques on postoperative cognitive function remain controversial.
- Trial name
- NCT07665645
- Testing
- Sevoflurane (Volatile Anesthetic), propofol, Remifentanil
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Gaziantep City Hospital
Anesthesia, Surgery-Complications
REmimazolam vs Propofol Total Intravenous Anesthesia on Outcomes After Major Noncardiac SurgEry
The goal of this randomized controlled trial is to compare total intravenous anesthesia with remimazolam vs total intravenous anesthesia with propofol in moderate-to-high risk patients undergoing major elective noncardiac surgery…
- Trial name
- REPOSE-2 (NCT05728775)
- Testing
- Remimazolam, Propofol
- Where
- 44 sites in China
- Volunteers
- 7,188 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Pancreatic Adenocarcinoma
Impact of Total Intravenous Anesthesia Following Cancer Surgery, TIVACS Study
This phase II trials studies the impact of total intravenous anesthesia (TIVA) following cancer surgery. Surgery and the anesthesia delivered causes physiologic stress and trauma resulting in immune suppression.
- Trial name
- NCT04992507
- Testing
- Anesthesia Procedure, General Anesthesia Procedure, Resection
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Emergence From Anesthesia
Electroencephalographic Trajectories During Emergence From Inhalational and Total Intravenous Anesthesia
General anesthesia emergence is a critical transition during which patients recover from an anesthetic-induced unconscious state to consciousness.
- Trial name
- NCT07806903
- Testing
- No Intervention: Observational Cohort
- Where
- China
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Ruijin Hospital
Postoperative Pain
Study to Investigate TIVA With Propofol on Postoperative Pain and Side Effects
Propofol is a commonly used anaesthetic with rapid recovery and less side effects and total intravenous anaesthesia (TIVA) with propofol is a common technique now.
- Trial name
- NCT03058354
- Testing
- Propofol, general anaesthesia
- Where
- Hong Kong
- Sponsor
- The University of Hong Kong
Total Abdominal Hysterectomy
S Ketamine Use in Total Abdominal Hysterectomy
This study investigates the effect of low dose S+ketamine compared to placebo on cumulative morphine consumption at 24 hours in women undergoing open abdominal hysterectomy with remifentanil-propofol target controlled infusion.
- Trial name
- SKET (NCT02543385)
- Testing
- S Ketamine
- Sponsor
- KK Women's and Children's Hospital
Patients Undergoing Spine Surgery
Comparison of Postoperative QoR-15 Scores Between Propofol and Remimazolam
Remimazolam is a ultra-short-acting benzodiazepine, and unlike conventional benzodiazepine drugs, it is rapidly metabolized in plasma and not accumulates in the body for long periods of infusion or even with high dose…
- Trial name
- NCT04994704
- Testing
- Propfol group, Remimazolam group
- Where
- South Korea
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Gangnam Severance Hospital