Clinical trials: Total Joint Arthroplasty
Mild Cognitive Impairment (MCI), Opioid Use
Postsurgical Pain and Opioid Use in Older Adults: Effects of Mild Cognitive Impairment
Mild cognitive impairment (MCI) affects a substantial proportion of older adults undergoing major surgery and may alter pain processing, pain experience, and opioid use after surgery.
- Conditions
- Mild Cognitive Impairment (MCI), Opioid Use, Cognitive Dysfunction, Postoperative Pain
- Trial name
- NCT07885085
- Where
- United States
- Volunteers
- 552 people
- Sponsor
- Miklos Kertai
Postoperative Pain, Acute, Hemodynamics
Nalbuphine Timing Effects on Hemodynamics and Analgesia in Elderly Patients
In total knee arthroplasty (TKA), the use of a tourniquet and controlled hypotension is common. However, ischemia-reperfusion injury induced by the tourniquet and inappropriate controlled hypotension can lead to cardiac and…
- Conditions
- Postoperative Pain, Acute, Hemodynamics, Total Knee Arthroplasty (TKA)
- Trial name
- TKA (NCT07271849)
- Testing
- Nalbuphine Hydrochloride injection was administered during anesthesia induction., Nalbuphine Hydrochloride injection was administered after cement implantation., Standard general anesthesia regimen ( nalbuphine was not administered throughout the entire anesthesia process.)
- Where
- China
- Volunteers
- 162 people
- Sponsor
- Qianfoshan Hospital
Hip Osteoarthritis, Hip Arthroplasty
Collared Versus Collarless Femoral Implants for Total Hip Arthroplasty
This is a randomized control trial that will investigate whether a collared hip replacement implant provides greater stability compared to a collarless option.
- Trial name
- NCT03558217
- Testing
- Collared Femoral Implant, Collarless Femoral Implant
- Where
- Canada
- Volunteers
- 96 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Hip Osteoarthritis, Knee Osteoarthritis
What Matters to Patients With Severe Hip or Knee Osteoarthritis?
This clinical trial aims to investigate if shared decision-making, and the use of an in-consultation patient decision aid (PtDA), increases the decisional quality and therefore treatment satisfaction and outcome of patients with…
- Trial name
- PATI-Project (NCT05972525)
- Testing
- Shared decision-making supported by an in-consultation PtDA to patients with severe osteoarthritis in their hip or knee
- Where
- 3 sites in Denmark
- Volunteers
- 615 people
- Sponsor
- Vejle Hospital
Osteoarthritis, Hip, Rheumatoid Arthritis
Acetabular Shell Positioning Using Patient Specific Instruments
The proposed study is a double-blinded randomized controlled trial comparing patient specific instruments with solely standardized instruments and pre-operative planning used for the placement of the acetabular cup prosthesis…
- Conditions
- Osteoarthritis, Hip, Rheumatoid Arthritis, Avascular Necrosis
- Trial name
- NCT01791738
- Testing
- Acetabular positioning system
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- The Cleveland Clinic
Total Hip Arthroplasty
Bone Remodeling Around a Trabecular Titanium Cup in Total Hip Arthroplasty
The goal of this randomized controlled trial is to measure the periprosthetic bone mineral density changes around a 3D-printed highly-porous titanium acetabular cup used in primary total hip arthroplasty compared to a standard…
- Trial name
- NCT06287021
- Testing
- Jump System Traser® cup, Jump System HAX-Pore® cup
- Where
- 2 sites in Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Permedica spa
Arthritis, Infection of Total Ankle Joint Prosthesis
INBONE™ Total Ankle Prosthesis With Long Talar Stem
The primary objective of this study is to collect preoperative, operative and postoperative clinical assessments of patients that qualify for surgical implantation of the INBONE™ Total Ankle Prosthesis.
- Trial name
- NCT01641848
- Testing
- INBONE™ Total Ankle Prosthesis with Long Talar Stem
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Stryker Trauma and Extremities
Osteoarthritis, Knee, Total Knee Arthroplasty
Oral Fluid vs IV Fluid After Primary TKA
The goal of this study is to compared efficacy of oral fluid and intravenous fluid after primary unilateral total knee arthroplasty.
- Conditions
- Osteoarthritis, Knee, Total Knee Arthroplasty, Oral Fluid Replacement
- Trial name
- NCT06288815
- Testing
- Oral fluid, IV fluid
- Where
- Thailand
- Volunteers
- 130 people
- Sponsor
- Thammasat University Hospital
Pain Management, Arthroplasty
Effect of Preoperative Pain Education on Anxiety, Pain, and Analgesic Use in Total Knee and Hip Replacement Patients
This randomized controlled trial evaluates whether a standardized preoperative pain education session delivered by a nurse reduces postoperative pain intensity and surgical anxiety among adult elective orthopedic surgery patients…
- Conditions
- Pain Management, Arthroplasty, Knee Replacement, Hip Replacement
- Trial name
- Pain-Anxiety (NCT07362589)
- Testing
- Pain education
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Yeditepe University
Total Knee Arthroplasty, Intraoperative Hypothermia
The Effect of Preoperative Active Warming on Intraoperative Body Temperature
A randomized controlled study was conducted to examine the effect of active warming before total knee arthroplasty on intraoperative body temperature and comfort.
- Trial name
- NCT05334589
- Testing
- Prewarming
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people
- Sponsor
- Burdur Mehmet Akif Ersoy University
Osteoarthritis, Knee
Experimental Study of Strength Training to Activate the Quadriceps Muscle After Total Knee Arthroplasty
Background: Progressive strength training is a training modality used in rehabilitation after total knee arthroplasty (TKA). Strength deficits up to 80% in the quadriceps muscle is shown to be present in the operated leg after…
- Trial name
- NCT01713140
- Testing
- 1 strength training set performed until contraction failure
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Copenhagen University Hospital, Hvidovre
Rheumatoid Arthritis, Non-inflammatory Degenerative Joint Disease
PMCF Study on the Safety, Performance and Clinical Benefits Data of the NexGen TM Augmentation Patella
The study is a single-center, retrospective and prospective, non-randomized, non-controlled and consecutive series post-market study.
- Conditions
- Rheumatoid Arthritis, Non-inflammatory Degenerative Joint Disease, Functional Deformity, Revision Total Knee Arthroplasty
- Trial name
- NCT05253976
- Where
- Switzerland
- Sponsor
- Zimmer Biomet
Osteoarthritis
Total Knee Arthroplasty Comparing Cementless to Cemented Fixation
The purpose of this study is to determine if there are any clinical or radiographic differences in cemented and cementless fixation in total knee replacement.
- Trial name
- NCT01335438
- Testing
- Cementless (Nexgen), Cemented (Nexgen)
- Where
- South Korea
- Volunteers
- 96 people
- Sponsor
- Young Hoo Kim
Pain, Postoperative
Analgesic Efficacy of Interscalene Nerve Block Versus Local Infiltration Analgesia Following Total Shoulder Arthroplasty
Total shoulder arthroplasty (TSA) is considered to be a major surgical procedure resulting in severe postoperative pain, especially in the first 48 hours after surgery.
- Trial name
- NCT02876055
- Testing
- Single shot interscalene nerve block, Continuous interscalene nerve block, Local Infiltration Analgesia (LIA)
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Drainage
Evaluating the Effectiveness of 2 Surgical Skin Preparation Methods in Reducing Surgical Wound Drainage After Total Hip or Knee Replacement
Surgical skin complications can be costly and could contribute to extended in-patient stay following total joint replacement or even the need for re-admission.
- Trial name
- NCT01097135
- Testing
- Duraprep Surgical Solution
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- Rothman Institute Orthopaedics
Total Knee Arthroplasty, Revision Total Knee Arthroplasty
Multigen Plus CCK and AMF TT Cones Follow Up Study
This study is aimed to provide a clinical and radiographic evaluation of 68 condylar-constrained Total Knee Arthroplasty (TKA) using a single type of prosthesis (Multigen Plus CCK configuration), alone or involving the AMF TT…
- Trial name
- NCT05314491
- Testing
- Multigen Plus CCK, AMF TT cones
- Where
- 3 sites in Portugal, Slovakia and 1 more
- Volunteers
- 68 people
- Sponsor
- Limacorporate S.p.a
Hip Fracture, Osteoarthritis
Effectiveness of Two Types of Treatment in Restoring Muscle After Hip or Knee Surgery
The purpose of this study is to determine the effects of two postoperative interventions designed to preserve muscle protein after major hip or knee surgery.
- Conditions
- Hip Fracture, Osteoarthritis, Femur Head Necrosis
- Trial name
- NCT00393848
- Testing
- Essential amino acid supplement, Ketoconazole
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Arkansas
POSTOPERATIVE ANALGESIA FOR TKA PARECOXIB/CFB
Combination of Continuous Femoral Block and Intravenous Parecoxib For Postoperative Analgesia After Total Knee Arthroplasty
Combination of continuous femoral block with parEcoxib vs placebo. Investigation of morphine consumption, opioid sparing effects, VAS pain scores, haemodynamics, Anxierty scores, transfusion requirements , Range of motion and…
- Trial name
- NCT02185924
- Testing
- Parecoxib, CONTINUOUS FEMORAL BLOCK WITH ROPIVACAINE 0,2%, N/S 0.9%
- Where
- Greece
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Asklepieion Voulas General Hospital
HIP AND KNEE OSTEOARTHRITIS
Prepare II - Predictive Model Training and External Validation
The general aim of the project is training and testing a predictive model of inpatient rehabilitation stay after hip and knee replacement for osteoarthritis.
- Trial name
- NCT07304323
- Testing
- Functional rehabilitation
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Total Knee Arthroplasty, Knee Osteoarthritis
Gait in Fixed Or Rotating Cementless Total Knee Arthroplasties
The number of patients requiring knee replacements is increasing every year due to the combination of an aging population, increased patient expectancy, and rising levels of obesity.
- Trial name
- G-FORCE (NCT06483178)
- Testing
- Attune knee implant, Triathlon knee implant
- Where
- United Kingdom
- Volunteers
- 90 people
- Sponsor
- Belfast Health and Social Care Trust
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