Clinical trials: Total Knee Replacement Arthroplasty
Quad Atrophy
Trial of Essential Amino Acid Supplementation in Protein Deficient Patients Following Total Knee Arthroplasty
The goal of this trial is to assess the efficacy of essential amino acids (EAA) on muscle atrophy and malnutrition compared to a placebo in patients following a total knee arthroplasty.
- Trial name
- Amino Acid (NCT02926235)
- Testing
- Amino Acid
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Hospital for Special Surgery, New York
Total Knee Arthroplasty, Arthroplasty, Replacement, Hip
Retrospective Chart Analysis in the Effective Use of FloSeal in Post-Operative Joint Replacements
The purpose of this analysis is to compare Hemoglobin and Hematocrit levels following total hip or knee arthroplasty. The utilization of FloSeal intraoperatively will improve hemostasis postoperatively.
- Trial name
- NCT00958945
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Desert Orthopedic Center Medical Research Foundation
Quadriceps Function Monitored With Electromyography
Compare the Quadriceps Function of Adductor Canal Block Versus Femoral Nerve Block With Electromyography Following Total Knee Arthroplasty
Adductor canal block and femoral nerve block are the most commonly used nerve blocks for pain control after total knee arthroplasty.
- Trial name
- NCT04778774
- Testing
- Nerve block
- Where
- Taiwan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Arthroplasty, Replacement, Knee
Does Radiofrequency Ablation of the Articular Nerves of the Knee Prior to Total Knee Replacement Improve Pain Outcomes
More than 300,000 total knee joint replacement surgeries are performed per year in the United States and safe, effective management of post-operative pain in these patients, often elderly, deconditioned, obese, or with co-morbid…
- Trial name
- NCT02746874
- Testing
- Radiofrequency Ablation (RFA), Simulated Radiofrequency Ablation (RFA)
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Northwestern University
HIP AND KNEE OSTEOARTHRITIS
Prepare II - Predictive Model Training and External Validation
The general aim of the project is training and testing a predictive model of inpatient rehabilitation stay after hip and knee replacement for osteoarthritis.
- Trial name
- NCT07304323
- Testing
- Functional rehabilitation
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Transcutaneous Electric Nerve Stimulation, Pain
Transcutaneous Electrical Nerve Stimulation After Total Knee Arthroplasty.
Total knee arthroplasty (TKA) consists of a surgical replacement of this joint by a prosthesis, and it is mainly carried out in cases of knee osteoarthrosis.
- Trial name
- NCT03046225
- Testing
- Transcutaneous electrical nerve stimulation, Continuous passive movement device, Exercises
- Volunteers
- 26 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Total Knee Arthroplasty, Tourniquet-Induced Ischemia-Reperfusion Injury
The Effect of Propofol Infusion on Total Antioxidant Status During Tourniquet-Induced Ischemia-Reperfusion Injury
The release of tourniquet produces reactive oxygen species which can cause injury. Propofol is chemically similar to phenol-based free radical scavengers.
- Trial name
- NCT01638624
- Testing
- Propofol
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Diskapi Teaching and Research Hospital
Total Knee Arthroplasty
Perfusion Assessment of Wound Closure Techniques in Primary Total Knee Arthroplasty
This study will assess which of the three most common methods of wound closure in primary total knee arthroplasty (staples, interrupted vertical mattress, or running subcuticular suture) provide the best wound vascular perfusion.
- Trial name
- NCT01924403
- Testing
- Staple Closure, Vertical Mattress Closure, Running Subcuticular Closure
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Pulmonary Embolism
Genetic Markers of Patients With History of Pulmonary Embolism Post Total Joint Arthroplasty
This study seeks to uncover potential genetic determinants of pulmonary embolism (PE). Our translational goal is to ultimately identify certain genetic markers that will allow us to stratify patients in terms of their PE risk…
- Trial name
- NCT03275610
- Testing
- Blood sample
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Southern California
Pain, Postoperative
Parecoxib for Pain Management After Total Knee Arthroplasty and Total Hip Arthroplasty
Evaluated the effect of perioperative parecoxib administration on postoperative pain, analgesic use, function recovery, inflammatory response and bleeding risk.
- Trial name
- NCT02272660
- Testing
- Parecoxib sodium, Normal saline injection
- Where
- China
- Volunteers
- 74 people
- Sponsor
- Peking Union Medical College Hospital
Acquired Fixed Flexion Deformity of the Knee (Disorder)
Effects of Dynamic Splinting on Knee Flexion Angle After Total Knee Arthroplasty: A Randomized Controlled Trial
To evaluate the effects of a knee flexion Dynasplint orthosis on knee flexion angle after a total knee arthroplasty. Sixty participants, who underwent a total knee arthroplasty, were randomly assigned in two groups: control group…
- Trial name
- NCT02928835
- Testing
- Knee flexion Dynasplint orthosis
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Universidade Norte do Paraná
Knee Arthroplasty, Total
FactOr XIa inhibiTion for the pRevention of venOus Thromboembolism in Patients Undergoing Total Knee Arthroplasty
This study was to compare the study drug BAY1213790 to existing therapies, i.e. enoxaparin or apixaban, for the prevention of blood clotting and safety in patients undergoing total knee arthroplasty (TKA).
- Trial name
- FOXTROT (NCT03276143)
- Testing
- Enoxaparin, Apixaban, BAY1213790
- Where
- 54 sites in Bulgaria, Canada and 11 more
- Volunteers
- 813 people
- Sponsor
- Bayer
Total Knee Arthroplasty
Total Knee Arthroplasty Robot Assisted With MAKO™ Robotic System Compared to the Conventional Total Knee Arthroplasty by Mechanical Ancillary
For the total knee arthrorplasty (TKA), the placement of a prosthesis is delicate and the correct positioning of the implants determines the result of the surgery.
- Trial name
- TKA-MAKO (NCT03566875)
- Testing
- Total knee arthroplasty with the Stryker's MAKO™ system, Total knee arthroplasty with mechanical ancillary
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Grenoble
Postoperative Pain
Study of Transdermal Fentanyl Patch to Treat Postoperative Pain in Total Knee Arthroplasty
The purpose of this study is to determine whether transdermal fentanyl patch
- Trial name
- TFP (NCT01348984)
- Testing
- transdermal fentanyl patch
- Where
- Thailand
- Volunteers
- 40 people
- Sponsor
- Khon Kaen University
Total Knee Replacement, Osteoarthritis
Knee Replacement Outcome Predicted by Physiotherapists
The aim is to assess if physiotherapists attending inpatients at elective orthopaedic wards can predict the future course (post hospitalisation) of recovery of patients undergoing KA.
- Trial name
- NCT02982785
- Testing
- Standard post-operative rehabilitation
- Where
- 2 sites in Denmark
- Volunteers
- 364 people
- Sponsor
- Marius Henriksen
Knee Replacement, Total, Knee Arthroplasty, Total
Improving Physical Activity and Gait Symmetry After Total Knee Arthroplasty
The purpose of this pilot study is to examine the effectiveness of the Physical Activity and Symmetry (PAS) program, compared to an attention (ATT)control group, for patients with post-total knee arthroplasty (TKA).
- Trial name
- PAS-TKA (NCT04090125)
- Testing
- PAS Intervention, Attention Control
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of North Carolina, Chapel Hill
Deep Venous Thrombosis
Clinical Investigation of a Novel Approach for the Prevention of Deep Venous Thrombosis After Total Knee Replacement
Venous thromboembolism, including deep vein thrombosis (DVT), has long been recognized as the most frequent complication within 7 to 14 days after orthopedic surgery, especially total joint arthroplasty.
- Trial name
- NCT04979026
- Testing
- active ankle pumping with a regular watch alarm, intermittent pneumatic compression
- Where
- Taiwan
- Volunteers
- 90 people
- Sponsor
- Show Chwan Memorial Hospital
Osteoarthritis, Knee
Evaluation of Robot-assisted Total Knee Arthroplasty with Automatic Balancing
The goal is to evaluate the outcomes and learning curve of a robot-assisted total knee arthroplasty device with automatic ligament balancing.
- Trial name
- NCT04724915
- Testing
- Conventional Total Knee Arthroplasty, Robot-Assisted Total Knee Arthroplasty
- Where
- Belgium
- Volunteers
- 60 people
- Sponsor
- University Hospital, Ghent
Knee Arthroplasty
Intrathecal Morphine and Fentanyl for Knee Arthroplasty
This study is planned to investigate the efficacy of combined infusion of intrathecal morphine and fentanyl in patients undergoing total knee arthroplasty.
- Trial name
- NCT03365115
- Testing
- Intrathecal morphine, Intrathecal fentanyl
- Volunteers
- 111 people
- Sponsor
- Keimyung University Dongsan Medical Center
Primary Knee Arthroplasty
Evaluation of Blood Loss During Knee Arthroplasty
Primary arthroplasties are frequent interventions that can present hemorrhagic complications: postoperative hematoma, deglobulization justifying monitoring blood tests and blood transfusion if necessary.
- Trial name
- SAD (NCT06052982)
- Testing
- Drainage
- Where
- France
- Volunteers
- 510 people
- Sponsor
- Groupe Hospitalier Diaconesses Croix Saint-Simon
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