Clinical trials: Total Knee Replacement Surgeries
Osteoarthritis
Total Knee Arthroplasty With Personalized Implantation: Computer Navigation-Assisted Surgery Versus Robotic-Assisted Surgery
Title: Personalized Total Knee Arthroplasty: Computer-Assisted Navigation vs. Robotic Assistance (CAN-ARD). Summary: Knee osteoarthritis is frequently treated with Total Knee Arthroplasty (TKA).
- Trial name
- CAN-ARD (NCT07574762)
- Testing
- Robotic-Arm Assisted Surgery (RA), Computer-Assisted Navigation (CAN)
- Where
- France
- Volunteers
- 140 people
- Sponsor
- Groupe Hospitalier Diaconesses Croix Saint-Simon
Total Knee Replacement
Knee4Life Project: Empowering Knee Recovery After Total Knee Replacement Through Digital Health
The research project will investigate the extent to which a smartphone camera sensor tool can help predict and measure knee stiffness and pain after Total Knee Replacement Surgery (TKR) and how a tool such as this could be…
- Trial name
- K4L (NCT06429462)
- Testing
- smartphone camera sensor tool
- Where
- United Kingdom
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Arthroplasty, Replacement, Knee
Short- Versus Long-duration Tourniquet Use During Total Knee Replacement (TKR)
To establish whether a short duration of tourniquet application (from cement fixation to cement setting)is associated with better patient functional outcomes compared to a long duration of tourniquet application (from surgical…
- Trial name
- NCT01162720
- Testing
- Long duration tourniquet, Short duration tourniquet
- Where
- Australia
- Volunteers
- 65 people
- Sponsor
- Fairfield Hospital, Australia
Arthroplasty, Replacement, Prevention of Venous Thromboembolism
Treatment of Patients Undergoing Primary Unilateral Elective Total Knee or Hip Replacement With Dabigatran Etexilate
To supplement the current evidence of the effect of Pradaxa® (dabigatran etexilate) on coagulation parameters, including a calibrated thrombin time test, in patients with moderate renal impairment undergoing elective total hip…
- Conditions
- Arthroplasty, Replacement, Prevention of Venous Thromboembolism, Moderate Renal Impairment (CrCl 30-50 mL/Min)
- Trial name
- NCT01184989
- Testing
- Dabigatran etexilate
- Where
- 10 sites in Austria, Canada and 4 more
- Volunteers
- 142 people
- Sponsor
- Boehringer Ingelheim
Knee Arthroplasty, Total
Comparison of the Analgesic Efficacy of Adductor Canal Block and Combined Adductor Canal Block Plus IPACK Block in Knee Surgery
To evaluate the effectiveness of Adductor Canal Block and combined Adductor Canal plus IPACK block in reducing postoperative pain and analgesic requirements in patients undergoing knee surgery.
- Trial name
- NCT07526831
- Testing
- Adductor Canal Block Group (Group I), Adductor Canal + iPACK Block Group (Group II)"
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- TC Erciyes University
Osteoarthritis
Roentgen Stereophotogrammetric Analysis (RSA) to Evaluate Fixation of Biofoam Advance Total Knee Arthroplasty Components
Hip and knee replacement arthroplasty are profoundly successful operative interventions, however, some joint replacements do fail and the life expectancy of a hip or knee arthroplasty is finite.
- Trial name
- NCT00657956
- Testing
- Advance Biofoam porous metal backed tibial component with or without screw augmentation
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Dalhousie University
Knee Replacement
Study of an All Polyethylene Tibial Component
This will be a prospective single cohort investigation of the Columbus all polyethylene tibia (Aesculap AG, Tuttlingen, Germany) used in total knee arthroplasty (TKA) surgery.
- Trial name
- NCT02540902
- Testing
- All-polyethylene tibia (Aesculap AG)
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Golden Jubilee National Hospital
Blood Loss, Surgical
Arista Hemostatic Powder for Total Knee Post Operative Outcomes Study
To examine in Arista hemostatic powder results in less post-total knee arthroplasty blood loss, hematoma formation, and improved range of motion when compared to patients who did not receive the product.
- Trial name
- NCT05522153
- Testing
- Arista
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Virtua Health, Inc.
Total Knee Replacement
A Comparison of Anaesthetic Methods for Total Knee Replacement Surgery
Open-labelled, randomised controlled trial. Patients will be assessed pre-operatively, at 24 and 48 hours for the primary outcome and secondary outcomes (except for Oxford Knee Score which will be assessed pre-operatively and at…
- Trial name
- NCT02249481
- Testing
- Adductor Canal catheter delivering 0.0625% L- Bupivacaine, Femoral nerve catheter delivering 0.0625% L- Bupivacaine
- Where
- United Kingdom
- Volunteers
- 6 people
- Sponsor
- University Hospital Plymouth NHS Trust
Total Knee-replacement, Total Hip-replacement
Clinical Trial for Fibrin Sealant in Knee Surgery
Thermogenesis is a company that sells a machine for the production of fibrin sealant of single donor plasma, the CryoSeal Fibrin Sealant System (CS-1). Fibrin sealant consists of two components: cryoprecipitate and thrombin.
- Trial name
- NCT00440921
- Testing
- Single donor Allogenous Fibrin Sealant
- Sponsor
- Sanquin Research & Blood Bank Divisions
Total Knee Arthroplasty
Effect of Different Cold Therapy Programs in Patients Received Total Knee Arthroplasty Operation
This study conducts clinical experiments on the form, temperature, frequency and other issues of cooling therapy, so as to provide scientific evidence for the practice of cooling therapy and improve the comfort and effect of…
- Trial name
- NCT07021287
- Testing
- mixed ice and water, continuous ice application, mixed ice and water, intermittent ice compress, full ice, continuous ice compress
- Where
- 2 sites in China
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Hip, Knee
The Fast-track Centre for Hip and Knee Replacement Database
This is a prospective study-registry on preoperative patient characteristics and postoperative complications in patients having fast-track hip and knee replacement surgery in 8 Danish dedicated arthroplasty departments from all…
- Conditions
- Hip, Knee, Fast-track Surgery, Enhanced Recovery After Surgery
- Trial name
- FCD (NCT05613439)
- Testing
- Day-surgery, High-risk patient, Main Group
- Where
- 8 sites in Denmark
- Volunteers
- 45,000 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Pain, Complications
Comparison of Three Kinds of Postoperative Analgesia After Total Knee Arthroplasty
Postoperative pain after total knee arthroplasty (TKA) can be difficult to manage and may delay recovery. There are multimodal postoperative pain management after TKA, including intravenous opioids, epidural analgesia, peripheral…
- Trial name
- NCT02094339
- Testing
- Local analgesic, Nerve Block, Intravenous analgesic
- Where
- China
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Guangzhou General Hospital of Guangzhou Military Command
Osteoarthritis of the Knee
MINIMALLY INVASIVE SURGERY in Total Knee Arthroplasty
Overall study design: A prospective, randomized, multi-center clinical studies comparing the minimal invasive and the standard surgical total knee replacement technique (control) using the Genesis II total knee system.
- Trial name
- MIS GEN II (NCT00853398)
- Testing
- surgical technique
- Where
- Germany
- Sponsor
- Smith & Nephew Orthopaedics AG
Hip Arthropathy Associated With Other Conditions
Socio-professional Categories and Return to Work After Hip or Knee Replacement Surgery
A significant proportion of patients (15 to 45%) who have benefited from a total hip or knee replacement surgery (THKA), are put on sick leave (SL).
- Trial name
- ARRET-Pro (NCT04262908)
- Testing
- Telephone call
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Groupe Hospitalier Diaconesses Croix Saint-Simon
Post-operative Pain, Anesthesia, Local
Evaluation of the Analgesic Benefit of Adding the Blocks of the Intermediate and Medial Femoral Cutaneous Nerves in Addition to the Femoral Triangle Block for Postoperative Analgesia After a Knee Replacement Surgery
Total knee replacement surgery can be associated with a significant postoperative pain burden and an inability to mobilize adequately, which can lead to the failure of the ambulatory course.
- Trial name
- NCT06038851
- Testing
- Para-Sartorial Compartments (PACS) Block, Femoral Triangle Block (FTB), Infiltration between popliteal artery and capsule of the knee (IPACK) block
- Where
- Canada
- Volunteers
- 122 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Knee Prosthesis
Positioning of the Tibial Cut in Unicompartmental Medial Knee Replacement by Using Patient Specific Cutting Guides.
Unicompartmental knee replacements are performed to treat osteoarthritis or osteonecrosis of the knee especially when it affects only the medial femoro-tibial compartment. To place the prosthesis, bone removal is necessary.
- Trial name
- PSI-PUC (NCT02018484)
- Testing
- Unicompartmental Knee Replacement
- Where
- France
- Volunteers
- 32 people
- Sponsor
- Rennes University Hospital
Total Knee Arthroplasty
The Influence of the Femoral Nerve Block on Quadriceps Strength
Total knee replacement is a frequent procedure in Québec's hospitals and the muscular strength of the quadriceps is the best indicator of the patient's functional recovery post surgery.
- Trial name
- NCT01111513
- Testing
- 48-hour ropivacaine infusions, Single dose ropivacaine, Patient controlled analgesics
- Where
- Canada
- Volunteers
- 135 people
- Sponsor
- Hopital de l'Enfant-Jesus
Arthroplasty Replacement, Knee, Arthroplasty Total Hip Replacement
A Prospective, Single-arm, Trial to Determine Contamination Rates When Using an Antibacterial Incise Drape During Orthopedic Surgery
The goal of this clinical study is to generate data on the intended use of a chlorhexidine gluconate (CHG)-impregnated antimicrobial incise drape.
- Trial name
- NCT07356323
- Testing
- 3M™ Ioban™ CHG Chlorhexidine Gluconate Incise Drape (2% w/w CHG)
- Where
- 2 sites in United States
- Volunteers
- 179 people
- Sponsor
- Solventum US LLC
Knee Osteoarthritis
Prosthesis and Surgery Guide System for Personalized Total Knee Arthroplasty
The subject is planned to carry out the clinical trails of femoral condyle prosthesis, tibial tray prosthesis and meniscus prosthesis; At the same time, in order to achieve personalized precision bone resection, the clinical…
- Trial name
- NCT04963491
- Testing
- Personalized TKA prosthesis, Zimmer NexGen prostheses
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital