Clinical trials: Total Knee Replacement Surgeries
Osteoarthritis, Knee
Comparison of Surgical Time and Efficiency of Total Knee Arthroplasty
This study is designed to compare the surgical efficiency of TruMatch® Personalized Solutions surgical technique compared to conventional surgical technique.
- Trial name
- NCT01301950
- Testing
- Custom Patient Instrumentation, Conventional Instruments
- Where
- 3 sites in United States
- Volunteers
- 30 people
- Sponsor
- DePuy Orthopaedics
Arthroplasty, Replacement, Knee, Recovery of Function
The Influence of Rapid Recovery on Sleep Quality Following Total Knee Replacement Surgery
The purpose of this study is to evaluate the influence of rapid recovery on sleep quality following total knee replacement surgery.
- Conditions
- Arthroplasty, Replacement, Knee, Recovery of Function, Arthritis, Rheumatoid
- Trial name
- NCT02845960
- Testing
- rapid recovery
- Where
- China
- Volunteers
- 170 people
- Sponsor
- Southwest Hospital, China
Hip and Knee Replacement Surgeries
California Joint Replacement Registry
The California Joint Replacement Registry (CJRR) was created to meet the need for comprehensive, scientific assessment of devices, treatment protocols, surgical approaches, and patient factors influencing the results of hip and…
- Trial name
- CJRR (NCT01787812)
- Where
- United States
- Volunteers
- 2,500 people
- Sponsor
- California Joint Replacement Registry
DVT, Osteoarthritis
Does Thinning the Blood During Surgery Prevent Blood Clots Following Total Knee Replacement Surgery
The goal of this study is to prevent blood clots from forming during surgery and a few days after total knee replacement surgery.
- Trial name
- NCT00253851
- Testing
- unfractionated heparin
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Ottawa Hospital Research Institute
Patients With Total Knee Arthroplasty
4-7-8 Breathing and Teach-Back Method for Pain, Anxiety, and Sleep After Knee Surgery: A Clinical Trial
Total knee arthroplasty (TKA) is a surgical procedure performed to reduce pain and improve quality of life in elderly individuals with knee dysfunction due to osteoarthritis, rheumatoid arthritis, or other knee joint disorders.
- Trial name
- NCT06912750
- Testing
- 4-7-8 Breathing Exercise with Teach-Back Method
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Erzurum Technical University
Knee Disease, Knee Deformity
Ultrasound-Guided Adductor Canal Block for Total Knee Arthroplasty Surgery
The ultrasound-guided selective blockade of the saphenous nerve in the adductor canal provides effective analgesia and reduces postoperative pain in patients undergoing arthroscopic medial meniscectomy.
- Conditions
- Knee Disease, Knee Deformity, Knee Pain Chronic, Knee Arthropathy
- Trial name
- NCT06084403
- Testing
- 20 ml volume adductor canal block, 30 ml volume adductor canal block, 40 ml volume adductor canal block
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Bursa City Hospital
Arthropathy of Knee, Arthropathy of Hip
Pre-operative Inspiratory Muscle Strength Training in Total Joint Surgery
The purpose of this research study is to evaluate effects of respiratory strengthening exercises on breathing function, in people who have orthopedic surgery.
- Conditions
- Arthropathy of Knee, Arthropathy of Hip, Lower Extremity Fracture, Orthopedic Disorder
- Trial name
- NCT05381818
- Testing
- Daily Inspiratory Muscle Training (dIMT), Acute Inspiratory Muscle Training (aIMT), Standard of Care (SOC)
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Florida
Post-op Pain
Adductor Canal Nerve Block Following Total Knee Arthroplasty
The purpose of this study is that an adductor canal nerve block (putting numbing medicine near the nerve) has been shown to produce excellent pain relief with less pain medication use after knee replacement surgery.The…
- Trial name
- NCT01939379
- Testing
- Morphine PCA started at the end of surgery, 1 Percocet 1/325mg every 4 hours; may receive a second Percocet if needed., For the 30ml ropivacaine the intervention would be the subject can request extra pain medication which would be Percocet and/or morphine PCA.
- Where
- United States
- Sponsor
- Loma Linda University
Knee Osteoarthritis, Knee Arthropathy
Ultrasound-Guided Adductor Canal Block for Total Knee Arthroplasty Surgery
The ultrasound-guided selective blockade of the saphenous nerve in the adductor canal provides effective analgesia and reduces postoperative pain in patients undergoing arthroscopic medial meniscectomy.
- Conditions
- Knee Osteoarthritis, Knee Arthropathy, Knee Pain Chronic, Knee Deformity
- Trial name
- NCT04189640
- Testing
- Postoperative analgesia management
- Where
- Turkey (Türkiye)
- Sponsor
- Medipol University
Total Knee Replacement Surgery
Iodine Impregnated Incision Drapes and Bacterial Recolonization in Simulated Knee Surgery. A Controlled Randomized Experimental Trial.
This study evaluates the effect of Iodine-impregnated self-adhesive plastic drapes (IIAD) on the quantity of skin bacteria, which is a known factor in the development of surgical site infections in orthopedic surgery.
- Trial name
- NCT02342561
- Testing
- Ioban 2 incision drape, 3M
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Odense University Hospital
Knee Arthropathy, Post Operative Pain
Function and Pain Following Knee Replacement
The goal of this interventional study is to compare pain management techniques (femoral nerve block, intra-articular block, none) in TKA patients.
- Conditions
- Knee Arthropathy, Post Operative Pain, Pain, Postoperative
- Trial name
- NCT05478005
- Testing
- Femoral nerve block, Intra-articular block
- Where
- Israel
- Volunteers
- 54 people
- Sponsor
- University of Haifa
Osteoarthritis
Study of AQUACEL™ Ag Surgical Cover Dressing Following Total Knee Replacement
The aim of the study is to determine whether the AQUACEL™ Ag SURGICAL cover dressing is successful in reducing the incidence of wound infection in high risk patients following total knee replacement.
- Trial name
- NCT02217202
- Testing
- Aquacel Ag dressing
- Sponsor
- Golden Jubilee National Hospital
Arthroplasty, Replacement, Knee, Blood Loss, Surgical
Early Outcome of Simultaneous Bilateral Total Knee Replacement With and Without Tourniquet
This randomized controlled trial compared early outcomes after replacement of both knees during the same operation, with and without tourniquet use.
- Conditions
- Arthroplasty, Replacement, Knee, Blood Loss, Surgical, Pain, Postoperative
- Trial name
- NCT07905495
- Testing
- Simultaneous Bilateral Total Knee Replacement with Tourniquet, Simultaneous Bilateral Total Knee Replacement without Tourniquet
- Where
- Pakistan
- Volunteers
- 84 people
- Sponsor
- Shifa International Hospital
Rheumatoid Arthritis
Effect of Fish Oil on Surgery Pain After Knee Replacement Patients: Randomized, Prospective, Double Blind, Placebo Control Trial
This is a single-center, prospective, randomized, double blind, placebo control study. The aim of this study is to assess the effect of fish oil capsules on pain intensity and postoperative analgesics consumption in patients…
- Trial name
- EFOPaKR-01 (NCT01274910)
- Testing
- EPAX 6000 EE 1000mg (0.6 gr DHA+EPA)
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Rabin Medical Center
Articulation Disorders
Correlation Between Deficits in Knee ROM Recovery and Difficulty in Dorsiflexing the Tibio-tarsal Joint in Patients Undergoing Total Knee Replacement Surgery.
To demonstrate that the deficit in dorsiflexion-tibia-talar joint range of motion can have an effect on the knee operated by arthroplasty by limiting full extension and, in general, the recovery of a full range of motion.
- Trial name
- NODORSIFLEX (NCT07016243)
- Where
- Italy
- Volunteers
- 197 people
- Sponsor
- Istituto Ortopedico Rizzoli
Blood Loss
Efficacy Comparison of Topical and Intravenous Tranexamic Acid to Reduce the Number of Blood Transfusions in TKA
The main objective is to evaluate the efficacy and safety of topical Tranexamic Acid (TA) to reduce the blood transfusion rate in total knee arthroplasty.
- Trial name
- TRANEX1 (NCT01881568)
- Testing
- Tranexamic Acid
- Where
- Spain
- Volunteers
- 79 people
- Sponsor
- Hospital Universitario La Paz
Venous Thromboembolism
Phase IIa Venous Thromboembolism (VTE) Prevention Study In Total Knee Replacement (TKR)
This study was designed to assess the safety and efficacy of GW813893 in the prophylaxis of VTE following TKR and to provide evidence to enable the selection of the appropriate dose(s) and dose regimen of GW813893 for future…
- Trial name
- NCT00541320
- Testing
- GW813893
- Where
- 8 sites in United States
- Sponsor
- GlaxoSmithKline
Spinal Anesthesia, Total Knee Arthroplasty
Frontal QRS Axis Changes in Patients Undergoing Total Knee Arthroplasty With Spinal Anesthesia (FQRS-TKA)
This prospective, single-center, observational study aims to evaluate changes in the frontal QRS axis on ECG before and after spinal anesthesia in patients undergoing total knee arthroplasty.
- Trial name
- FQRS-TKA (NCT07112313)
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Sevim Şenol Karataş
Postoperative Pain
Safety and Efficacy of Patient Controlled Analgesia Using the Sublingual Sufentanil Tablet System (SSTS) in a Fast Track Rehabilitation Program After Total Knee Arthroplasty
The sufentanil sublingual tablet system (SSTS) is an innovative patient-controlled analgesia (PCA) device for the management of acute moderate to severe postoperative pain in hospital settings in adult patients.
- Trial name
- Zalviso (NCT04432428)
- Testing
- Sufentanil Sublingual Tablet
- Where
- Belgium
- Volunteers
- 90 people
- Sponsor
- University Hospital, Ghent
Osteo Arthritis Knee, Total Knee Arthroplasty
Comparing Surgical and Economical Parameters of Total Knee Replacement.
Randomized study comparing surgical and economic parameter of Total Knee Arthroplasty performed using two different specific surgical techniques.
- Trial name
- NCT03427047
- Testing
- MyKnee with single use Efficiency Instrument, Stryker Navigational with conventional metal instruments
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Medacta USA