Clinical trials: Total Knee Replacement Surgeries
Sleep Duration on the First Night After Surgery
Postoperative Sleep Disturbances After Zolpidem Treatment in Fast-track Hip and Knee Replacement
Sleep after surgery has been found to be very distrubed immediately after major surgery. This is also seen after fast-track hip and knee replacement with length of stay of less than 3 days.
- Trial name
- NCT01551485
- Testing
- Zolpidem
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Total Knee Arthroplasty
Impact of Different Perioperative Tourniquets on Blood Loss and Surgeon Satisfaction in Total Knee Arthroplasty
The present study investigates the impact of two different perioperative tourniquets with different closing features on operative blood los, surgical field quality and surgeon satisfaction.
- Trial name
- NCT06947655
- Testing
- VBM Tourniquet, Adaptive Cuff
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- University Hospital, Bonn
Knee Osteoarthritis, Total Knee Arthroplasty
Effect of Preoperative Cold Therapy on Early Postoperative Outcomes in Total Knee Arthroplasty
This prospective, single-center, randomized controlled trial investigates the effects of preoperative cold therapy on early postoperative outcomes in patients undergoing unilateral primary total knee arthroplasty (TKA).
- Conditions
- Knee Osteoarthritis, Total Knee Arthroplasty, Cryotherapy, Postoperative Pain Management
- Trial name
- NCT07134283
- Testing
- Preoperative and Postoperative Cold Therapy with Gel Cold Pack, Postoperative Cold Therapy with Gel Cold Pack
- Where
- Turkey (Türkiye)
- Volunteers
- 208 people
- Sponsor
- Ankara City Hospital Bilkent
Post-operation Pain
A Feasibility Dose-escalating Study of MDT-10013 for Acute Postoperative Pain Following Total Knee Arthroplasty
This is an open-label dose-escalating study to evaluate the tolerability and systemic exposure of MDT-10013 in men and women at least 18 years of age who are undergoing primary unilateral TKA.
- Trial name
- NCT02263222
- Testing
- MDT-10013
- Where
- 3 sites in United States
- Sponsor
- Medtronic Spinal and Biologics
Osteoarthritis: Joint Replacement Surgery
Amniotic Umbilical Cord Particulate During Total Knee Arthroplasty
Total knee arthroplasty (TKA) is the most common joint replacement surgery and its incidence is expected to increase 673% to 3.48 million procedures annually by 2030.
- Trial name
- NCT03912116
- Testing
- CLARIX FLO, Saline
- Where
- United States
- Sponsor
- BioTissue Holdings, Inc
Osteoarthritis
Trial Comparing Navigated and Conventional Implantation Techniques in Knee Replacement Surgery
This study is undertaken to investigate the effect of navigated knee implantation surgery on physical function, joint stiffness, pain, quality of life and coordinative abilities.
- Trial name
- NCT00431509
- Testing
- conventional vs. navigated total knee arthroplasty
- Where
- 8 sites in Germany
- Volunteers
- 477 people
- Sponsor
- University Hospital Schleswig-Holstein
Postsurgical Pain
Study to Evaluate Safety/Efficacy of a Single Pre-Op Dose of AYX1 Injection to Treat Pain After Knee Replacement Surgery
The objectives of this proof of concept study are to evaluate the safety and preventive analgesic efficacy of a single preoperative intrathecal administration of AYX1 Injection in patients undergoing unilateral total knee…
- Trial name
- NCT01731730
- Testing
- AYX1 Injection 110 mg, AYX1 Injection 330 mg
- Where
- 7 sites in United States
- Volunteers
- 102 people
- Sponsor
- Adynxx, Inc.
Osteoarthritis, Knee
Blood Flow Restriction Exercise Study
This pilot study will investigate the effects of blood flow restriction (BFR) exercise for up to 4-6 weeks prior to total knee arthroplasty (TKA) surgery in older patients to measure clinical outcomes such as strength, lower…
- Trial name
- BFR (NCT02868021)
- Testing
- Strength testing, Short Physical Performance Battery (SPPB), Six-minute walk (SMW)
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Florida
Total Knee Replacement Surgery, Post-operative Pain
Suzetrigine for Treatment and Reduction of Intense Discomfort After knEe Replacement PAIN
This is a prospective, randomized study. The purpose of this study is to evaluate if the addition of Suzetrigine, a new pain medication, to well established peri-operative pain regimen used for total knee replacement surgery will…
- Trial name
- STRIDE-PAIN (NCT07548385)
- Testing
- Suzetrigine
- Where
- United States
- Volunteers
- 235 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Arthroplasty, Replacement, Knee, Unicompartmental Knee Arthroplasty
Study to Evaluate Patient Outcomes and Safety and Effectiveness of Robotic Assisted Unicompartmental Knee Replacements Versus Conventional Unicompartmental Knee for Subjects With Primary Arthritis of the Knee Joint Involving One (UKA) Compartment (Medial or Lateral)
The overall aim of this trial is to compare functional and patient-reported outcomes and to assess the safety and effectiveness and long-term performance of the Smith+Nephew Robotic Systems for Unicompartmental Knee Replacements…
- Trial name
- NCT06036212
- Testing
- Robotic System, Conventional
- Where
- 5 sites in United Kingdom
- Sponsor
- Smith & Nephew, Inc.
Arthritis, Osteoarthritis, Knee
Switching Drug Therapy for the Prevention of Blood Clot Formation From Enoxaparin to Rivaroxaban After Orthopedic Surgery for Either Total Hip or Total Knee Replacement
The study will describe the short-term effects the study drug, rivaroxaban, has on the body when a patient is switched from enoxaparin injection (by needle) to oral rivaroxaban (by mouth) for the prevention of blood clotting in…
- Conditions
- Arthritis, Osteoarthritis, Knee, Osteoarthritis, Hip, Thromboembolism
- Trial name
- NCT01094886
- Testing
- Rivaroxaban
- Where
- 5 sites in United States
- Volunteers
- 56 people
- Sponsor
- Ortho-McNeil Janssen Scientific Affairs, LLC
Total Knee Arthroplasty, Total Knee Arthroplasty Recovery
Pilot Study on EXPAREL as an Intra-articular Posteromedial Surgeon Administered (IPSA) Block vs. Local Infiltration Analgesia in Knee Replacement Surgery
The study aims to test the safety and effectiveness of two different surgeon-administered methods of the anesthesia medication EXPAREL during knee replacement surgery.
- Trial name
- CRS-121 (NCT07584915)
- Testing
- Intra-articular Posteromedial Surgeon Administered (IPSA) Block with LIA, Local Infiltration Analgesia (LIA), Bupivacaine liposome injectable suspension (IPSA block)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Cedars-Sinai Medical Center
Infection, Surgical Site
IO vs IV Vancomycin in Tourniquetless TKA
Purpose of this study is to compare the efficacy of intravenous and intraosseous antibiotic administration techniques during tourniquetless total knee arthroplasty.
- Trial name
- NCT05705843
- Testing
- Intraosseous Vancomycin Injection, Intravenous Vancomycin
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- The Methodist Hospital Research Institute
Rehabilitation Exercise
Evaluating the Efficacy of a "Quiet Knee Protocol" in Primary Total Knee Arthroplasty (TKA): A Prospective Randomized Study
The goal of this randomized clinical trial is to access the following: 1. Compare the effectiveness of the QKP versus a standard rehabilitation protocol in improving postoperative pain control, ROM, and functional recovery…
- Trial name
- QKP (NCT07879014)
- Testing
- Quiet Knee Protocol, Post Operative Standard of Care
- Where
- 2 sites in United States
- Volunteers
- 170 people
- Sponsor
- Mayo Clinic
Total Knee Replacement Surgery, Patient Education
The Effect of Quick Response Coded Teaching Plan, Patients With Total Knee Replacement
With the developments in the field of health, Total Knee Replacement (TKR) surgeries are performed by applying evidence-based rapid recovery programs in many hospitals and patients can be discharged in a very short time.
- Trial name
- NCT05088538
- Testing
- Patient Education
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people
- Sponsor
- Bozok University
Psychological Stress, Cardiopulmonary Bypass Surgery
CARINAE for Stress Relief in Perioperative Care
Preventing pre-surgical stress can help patients achieve positive outcomes on health and well-being. However, very few patients receive adequate stress relief support prior to a surgical procedure.
- Conditions
- Psychological Stress, Cardiopulmonary Bypass Surgery, Coronary Artery Bypass Surgery, Cardiac Valve Replacement
- Trial name
- CARINAE (NCT05184725)
- Testing
- SaMD CARINAE
- Where
- 5 sites in Italy, Netherlands and 1 more
- Volunteers
- 50 people
- Sponsor
- Adhera Health, Inc.
Knee Osteoarthritis, Musculoskeletal Disease
Use of Corticosteroid in Intraopertive Injections in Total Knee Replacement Surgery.
The goal of this clinical trial is to find out which type of steroid medicine, when added to a standard pain-control injection during total knee replacement surgery, works best at reducing pain, limiting opioid use, and improving…
- Conditions
- Knee Osteoarthritis, Musculoskeletal Disease, Surgery
- Trial name
- TKACSI (NCT07151417)
- Testing
- PAI, PAI + steroid, PAI + zilretta
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Walter Reed National Military Medical Center
Osteoarthritis, Knee, Arthroplasty, Replacement, Knee
Predicting Outcome of Total Knee Replacement Surgery in Patients With Knee Osteoarthritis
Osteoarthritis (OA) is the main cause of pain and disability in elderly. For knee OA, a total knee replacement (TKR) is an effective surgical treatment, and the majority of patients report substantial pain relief and functional…
- Trial name
- NCT05380648
- Testing
- Total knee arthroplasty
- Where
- Belgium
- Volunteers
- 223 people
- Sponsor
- Universiteit Antwerpen
Total Knee Replacement Surgery, Virtual Reality
Effect of Intraoperative Virtual Reality on Anxiety and Vital Findings in Patients Total Knee Replacement Surgery
Although total knee replacement surgery improves the quality of life of the patients, a significant reduction in knee pain and normalization of the knee joint, the awareness of the surrounding events is a major concern for the…
- Trial name
- NCT05668143
- Testing
- Virtual reality
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Bucak State Hospital
Non-inflammatory Degenerative Joint Disease
A Trial Evaluating TKR Compared to BKR Performed Using Stryker's Mako Robot
A prospective, randomised controlled trial evaluating Total Knee Replacement with the Stryker Triathlon Primary Total Knee System, compared to Bicompartmental Knee Replacement with Restoris MCK Multicompartmental Knee System…
- Trial name
- NCT02650284
- Testing
- Stryker Triathlon Primary Total Knee System, Restoris MCK Multicompartmental Knee System
- Where
- Australia
- Volunteers
- 18 people
- Sponsor
- Stryker South Pacific