Clinical trials: Total Knee Replacement Surgeries
Arthroplasties, Hip Replacement, Arthroplasties, Knee Replacement
The Effect of A New Perioperative Practice Model on Patient, Nursing And Organisational Outcomes
The aim of the study is to improve the surgical patients' care process. The objective is to explore the effect of a new perioperative practice model on 1) patient outcomes (satisfaction, surgery-related anxiety and quality of…
- Trial name
- NCT02906033
- Testing
- New perioperative practice model
- Where
- Finland
- Volunteers
- 517 people
- Sponsor
- Hospital District of Helsinki and Uusimaa
Total Knee Replacement, Surgery
Ultrasound Guided Obturator Nerve Block for Total Knee Replacement (TKR)
Total Knee Replacement can be performed under the combination of posterior lumbar plexus block plus sciatic nerve block. The investigators can have the same outcome by performing instead of posterior lumbar plexus block more…
- Trial name
- NCT01755117
- Testing
- Sciatic, femoral, obturator nerve blocks, Sciatic nerve block, posterior lumbar plexus block
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- Larissa University Hospital
Total Knee Arthroplasty
Effectiveness of Exparel Anesthetic Administered by the Surgeon During Knee Surgery
Intra-articular Posteromedial Surgeon Administered (IPSA) Block in this study describes a new type of medical procedure where a surgeon provides anesthetic medication directly into a specific area inside a knee joint to numb the…
- Trial name
- NCT06946368
- Testing
- Intra-articular Posteromedial Surgeon Administered (IPSA) Block of EXPAREL, Adductor Canal Block (ACB) and Local Local Infiltration Analgesia of EXPAREL, Local Infiltration Analgesia (LIA) of EXPAREL
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- The Cleveland Clinic
Knee Osteoarthritis, Arthritis
Surgery Induced Trauma After Total Versus Medial Unicompartmental Knee Arthroplasty (SITA)
Osteoarthritis (OA) is the most common type of arthritis, characterized by pain and physical disability. More than 10% of persons > 55 years have symptomatic OA, primarily involving the knees.
- Conditions
- Knee Osteoarthritis, Arthritis, Surgery, Total Knee Arthroplasty
- Trial name
- SITA (NCT05735847)
- Testing
- Total Knee Arthroplasty (TKA), Unicompartmental Knee Arthroplasty (UKA)
- Where
- Denmark
- Volunteers
- 29 people
- Sponsor
- Hvidovre University Hospital
Knee Osteoarthritis
Minimally Invasive Knee Replacement Outcomes (MIKRO) Study
The purpose of this study is to evaluate and compare the clinical, radiographic (x-ray) and cost effectiveness outcomes (cost relative to risks and benefits) of two different minimally invasive knee joint replacement surgical…
- Trial name
- MIKRO (NCT00633113)
- Testing
- MPPA, SV
- Where
- United States
- Volunteers
- 131 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Total Knee Arthroplasty
Minimal Sedation During Knee Replacement Surgery
This study will test the use of active noise cancelling headphones with music or a movie during knee replacement surgery. Feedback from the surgical team and from patients regarding the headset system will be gathered to see if…
- Trial name
- NCT07371390
- Testing
- Active Noise Cancelling Headset System
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Mayo Clinic
Osteoarthritis, Knee, Osteoarthritis, Hip
Impact of a POPOP on Preoperative Health, Eligibility, and Clinical & Patient-Reported Outcomes in TJA
In this pilot study, we will test the hypothesis that a POPOP for currently ineligible UAMS orthopedic surgery patients wanting hip or knee replacement improves markers of preoperative health, ability to reach a BMI threshold <40…
- Conditions
- Osteoarthritis, Knee, Osteoarthritis, Hip, Avascular Necrosis, Rheumatoid Arthritis
- Trial name
- NCT04910048
- Testing
- POPOP (preoperative patient optimization program), SOC (standard of care)
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- University of Arkansas
Knee Osteoarthritis, Anxiety
Comparison of Music and Ambient Noise Cancellation in Patients Undergoing Total Knee Arthroplasty (TKA)
The aim of this clinical trial is to compare the effects of music and ambient noise cancellation during total knee arthroplasty and to analyse the effects on patients.
- Conditions
- Knee Osteoarthritis, Anxiety, Post Operative Pain, Noise Exposure
- Trial name
- TKA (NCT06401018)
- Testing
- No noise cancellation and no music playing, Noise cancelled but not allowed to listen to music, Music is played but noise is not cancelled
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Ankara City Hospital Bilkent
Total Knee Arthroplasty, Chronic Postoperative Pain
Postoperative Painful Chronicization After Knee Replacement Surgery : Exploratory Study of BDNF's Kinetics
Chronic pain is an extremely disabling disease. It is a major public health problem due to the lack of effective therapy. Chronic postoperative pain (CPOP) is defined by a painful symptomatology in the operated area unrelated to…
- Trial name
- KNEE BDNF (NCT04604847)
- Testing
- blood test
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Montpellier
Pressure Sore, Orthopedic Disorder
Body Temperature Changes and Early Postoperatıve Pressure Sore
This study aims to determine effect of body temperature changes during total knee arthroplasty surgery on early postoperative pressure sore formation.
- Conditions
- Pressure Sore, Orthopedic Disorder, Hypothermia, Nursing Caries
- Trial name
- NCT05552599
- Testing
- woolen blanket
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Hitit University
Opioid Use, Pain, Post Operative
A Pilot Study Investigating the nCAP Signal Relief Patch in Subjects Undergoing Primary Hip or Knee Replacement Surgery
Opioid addiction in post-operative patients is recognized but not fully understood; therefore, in order to address this growing crisis, it is essential to explore alternative approaches to managing pain and apply them to the…
- Trial name
- NCT05252858
- Testing
- nCAP Signal Relief Patch, Standard of Care
- Where
- United States
- Volunteers
- 79 people
- Sponsor
- Jacques E. Chelly
Total Knee Replacement
Comparison of Surgical Site Infection After Skin Closure by Prolene or Staples in Bilateral Knee Arthroplasty Patients
Knee arthroplasty also known as the total knee replacement is an orthopedic surgical procedure done to resurface the knee that has been severely damaged by arthritis.
- Trial name
- NCT04492852
- Testing
- Polypropylene (PROLENE) sutures, Staple Sutures
- Volunteers
- 82 people
- Sponsor
- Indus Hospital and Health Network
Total Knee Arthroplasty
Total Knee Arthroplasty Robot Assisted With MAKO™ Robotic System Compared to the Conventional Total Knee Arthroplasty by Mechanical Ancillary
For the total knee arthrorplasty (TKA), the placement of a prosthesis is delicate and the correct positioning of the implants determines the result of the surgery.
- Trial name
- TKA-MAKO (NCT03566875)
- Testing
- Total knee arthroplasty with the Stryker's MAKO™ system, Total knee arthroplasty with mechanical ancillary
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Grenoble
Prosthetic Infections
Surgical Field Bacterial Contamination in Primary Total Hip (THA) and Knee (TKA) Arthroplasty
In Denmark, approximately 13,000 operations are carried out every year. Prosthetic infection is a very serious condition and despite extensive prophylactic measures, prosthetic infections appear in 1-2 percent of the operated…
- Trial name
- NCT01493375
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- Northern Orthopaedic Division, Denmark
Degenerative Arthritis of Knee
Visionaire™ Versus Standard Instrumentation Safety and Efficacy in Total Knee Arthroplasty (TKA)
The objective of this study is to assess outcomes following TKA, utilizing two surgical techniques. Patients will be randomized to one of two arms: TKA with standard instrumentation and TKA with VISIONAIRE™ patient-matched…
- Trial name
- NCT01084772
- Testing
- VISIONAIRE Total Knee Arthroplasty, Standard Total Knee Arthroplasty
- Where
- 7 sites in United States, Australia
- Volunteers
- 134 people
- Sponsor
- Smith & Nephew, Inc.
Knee Surgery With Tourniquet
Effect of Spinal or Sevoflurane Anesthesia on Neutrophil Activation During Knee Surgery With Pneumatic Tourniquet
Aim of study : Assessement of neutrophil activation during ischemia reperfusion associated with tourniquet use for total knee arthroplasty.
- Trial name
- NCT03470363
- Testing
- Sevoflurane Volatile Liquid, Bupivacaine / SUFentanil
- Volunteers
- 40 people
- Sponsor
- University of Liege
Arthroplasty Complications, Pain, Postoperative
The Effectiveness of High-intensity Laser Therapy on Post-surgical Rehabilitation After Total Knee Arthroplasty
This randomized controlled trial aims to evaluate the effectiveness of high-intensity laser therapy (HILT) as an adjunct to conventional rehabilitation in patients undergoing total knee arthroplasty (TKA).
- Trial name
- NCT07568262
- Testing
- High level laser therapy
- Where
- Italy
- Volunteers
- 46 people
- Sponsor
- Istituto Ortopedico Rizzoli
Knee Arthroplasty, Pain
The Efficacy of Kinesiotaping on Pain, Edema and Functionality After Total Knee Arthroplasty
In this prospective, randomized controlled trial; To evaluate the effect of kinesiology taping applied for edema on pain, edema and functions in the early period after total knee replacement.Patients who underwent total knee…
- Conditions
- Knee Arthroplasty, Pain, Edema
- Trial name
- NCT05457686
- Testing
- kinesio tape, Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 187 people
- Sponsor
- Kirsehir Ahi Evran Universitesi
Osteo Arthritis Knee, Knee Pain Chronic
Anterior Knee Pain Between Unisex Knee Prosthesis VS Gender Specific Knee Prosthesis Following MIS TKA
Unisex knee prosthesis and patient specific knee prosthesis has the same anterior knee pain and patellar tracking
- Trial name
- NCT05045651
- Testing
- Gender Solution®posterior stabilized NexGen® LPS Hi-Flex; Zimmer Biomet, Inc, Warsaw, IN, USA and standard posterior stabilized NexGen® LPS Hi-Flex; Zimmer Biomet, Inc, Warsaw, IN, USA
- Volunteers
- 80 people
- Sponsor
- Thammasat University
Osteoarthritis, Blood Loss, Surgical
Non-inferiority Trial of Oral Tranexamic Acid vs. Intravenous Tranexamic Acid in Joint Replacement Surgery
The purpose of this research is to determine if the oral form of a medication (tranexamic acid) to reduce bleeding can be used in place of an intravenous (IV) form, to learn the best way to give tranexamic acid: either a pill by…
- Conditions
- Osteoarthritis, Blood Loss, Surgical, Blood Loss, Postoperative
- Trial name
- NCT02438566
- Testing
- Tranexamic Acid (Oral), Tranexamic Acid (Intravenous)
- Where
- United States
- Volunteers
- 118 people
- Sponsor
- The New England Baptist Hospital