Clinical trials: Total Knee Replacement Surgeries
Knee Arthroplasty, Total
Manual Lymphatic Drainage Following Total Knee Arthroplasty Surgery
The purpose of this study is to evaluate the efficiency of manual lymphatic drainage to decrease the swelling of the knee after total knee replacement surgery
- Trial name
- NCT00711711
- Testing
- Manual lymphatic drainage, relaxation
- Where
- 2 sites in Switzerland
- Volunteers
- 60 people
- Sponsor
- Haute Ecole de Santé Vaud
Hypnosis, Perioperative Care
Hypnosis for Symptom Management in Elective Orthopedic Surgery
The purpose of the study is to determine if teaching self-hypnosis techniques to patients prior to knee replacement surgery will decrease their pain medication requirements, pain medication side-effects, length of stay in the…
- Conditions
- Hypnosis, Perioperative Care, Knee Arthroplasty, Total, Postoperative Pain
- Trial name
- NCT03308071
- Testing
- Hypnosis
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Stanford University
Knee Prosthesis
Study of the Prognostic Value of the Coagulolytic Balance Dependent on Circulating Microvesicles in the Occurrence of Thrombotic Events After Total Knee Replacement in Orthopedic Surgery.
This is a prospective multicenter cohort study to evaluate the prognostic value of new biological markers in predicting thrombotic events after orthopedic surgery.
- Trial name
- MOTiVE (NCT05387694)
- Testing
- Thrombotic risk assessment
- Where
- France
- Volunteers
- 387 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Arthroplasty Complications
Are Elastic Restraints Still Necessary in Improved Rehabilitation Programs After Hip and Knee Prosthetic Surgery?
Venous thrombosis and pulmonary embolism are considered serious and potentially preventable complications of hip and knee replacement surgery.
- Trial name
- NCT06563531
- Testing
- Pharmacological thromboprophylaxis and elastic compression, Pharmacological thromboprophylaxis without elastic compression
- Where
- France
- Volunteers
- 1,274 people
- Sponsor
- Clinique Pasteur Lanroze
Acute or Programmed Hip Replacement (Gamma Nail, Total Prosthesis or Throuhg DHS) / Knee Surgery
Assessment of Blood Loss With a Point Of Care Device
Main Objective: The purpose of this study is to demonstrate whether there is a correlation between perioperative blood loss and the degree of platelet inhibition assessed by a point of care assay in patients undergoing hip or…
- Trial name
- BLOOD (NCT01430273)
- Where
- 3 sites in France
- Volunteers
- 28 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Chronic Post-Surgical Pain
Pre-op Cognitive Behavior Therapy to Decrease Chronic Post-Surgical Pain in TKA
A significant number of patients develop chronic post-surgical pain (CPSP) following knee replacement surgery. Proposed is the testing of a novel computer-assisted behavioral intervention integrating motivational interviewing in…
- Trial name
- NCT04814992
- Testing
- Computer-Assisted Preoperative CBT Intervention (PAINTrainer)
- Where
- 4 sites in United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Total Knee Replacement
The Feasibility of a Nurse-Initiated Weighted Blanket in Orthopedic Surgical Patients Undergoing Total Knee Arthroplasty
The purpose of this study is to explore the acceptability and feasibility of weighted blankets in total knee replacement (TKR) patients.
- Trial name
- NCT07219329
- Testing
- Weighted Blanket
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- NYU Langone Health
Knee Prosthesis
Effect of Normothermia Care Bundle in Knee Replacement Surgery
Osteoarthritis is a disease characterized by disruption of the integrity of articular cartilage as a result of erosion of articular cartilage.
- Trial name
- NCT06454877
- Testing
- active heating, pasive heating
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Istanbul Saglik Bilimleri University
Drainage
Evaluating the Effectiveness of 2 Surgical Skin Preparation Methods in Reducing Surgical Wound Drainage After Total Hip or Knee Replacement
Surgical skin complications can be costly and could contribute to extended in-patient stay following total joint replacement or even the need for re-admission.
- Trial name
- NCT01097135
- Testing
- Duraprep Surgical Solution
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- Rothman Institute Orthopaedics
Total Knee Arthroplasty
Effectiveness of Exparel Anesthetic Administered by the Surgeon During Knee Surgery
Intra-articular Posteromedial Surgeon Administered (IPSA) Block in this study describes a new type of medical procedure where a surgeon provides anesthetic medication directly into a specific area inside a knee joint to numb the…
- Trial name
- NCT06946368
- Testing
- Intra-articular Posteromedial Surgeon Administered (IPSA) Block of EXPAREL, Adductor Canal Block (ACB) and Local Local Infiltration Analgesia of EXPAREL, Local Infiltration Analgesia (LIA) of EXPAREL
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- The Cleveland Clinic
Osteoarthritis, Knee
Is Non Surgical CaRE Using Treat to Target Multimodal meDIcal Strategies aBLE to Delay or Avoid Total Knee Replacement?
Knee is the most common site of osteoarthritis. Treatment of knee osteoarthritis starts with a full course of medical therapy, followed by surgery to replace the knee with a prosthesis if this strategy fails, or in advanced…
- Trial name
- INCREDIBLE (NCT06643845)
- Testing
- arthroplasty, Medical and non-medical treatments
- Where
- 21 sites in France
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Brest
Inflammation, Surgery
The Effects of Lipinova on Inflammatory and Proresolving Lipid Mediator Profiles After Orthopedic Surgery
The aim of this pilot study is to investigate whether pre-operative supplementation with an over the counter dietary supplement containing a fractionated marine lipid concentrate derived from anchovy and sardine oil, Lipinova®…
- Trial name
- NCT03434236
- Testing
- low dose Lipinova (30 mL daily), high dose Lipinova (60mL)
- Volunteers
- 30 people
- Sponsor
- Brigham and Women's Hospital
Orthopedic Surgery, Total Hip Prosthesis
Evaluating the Influence of the Strategy Intraoperative Anesthetic (Desflurane Versus Propofol) on Cognitive and Psychomotor Functions in Output Post Interventional Room Monitoring - COGNIDES
The recovery of cognitive and psychomotor functions is best performed under anesthesia after desflurane when propofol in that obtaining a Aldrete score> 8/10 output of the allowing SSPI.
- Conditions
- Orthopedic Surgery, Total Hip Prosthesis, Total Knee Replacement
- Trial name
- Cognides (NCT02036736)
- Testing
- Intraoperative anesthetic strategy by Propofol, Intraoperative anesthetic strategy by Desflurane
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Knee Osteoarthritis (OA), Artrosis of the Knee
PROPRIOCEPTION, KINESIOPHOBIA AND FUNCTIONAL RECOVERY AFTER GONARTHROSIS SURGERY
This observational study aims to investigate the relationships between proprioception, causes of kinesiophobia, sensory processing characteristics, and functional recovery in individuals undergoing gonarthrosis surgery.
- Trial name
- NCT07480473
- Where
- Turkey (Türkiye)
- Volunteers
- 47 people
- Sponsor
- Medipol University
Rheumatoid Arthritis
Effect of Fish Oil on Surgery Pain After Knee Replacement Patients: Randomized, Prospective, Double Blind, Placebo Control Trial
This is a single-center, prospective, randomized, double blind, placebo control study. The aim of this study is to assess the effect of fish oil capsules on pain intensity and postoperative analgesics consumption in patients…
- Trial name
- EFOPaKR-01 (NCT01274910)
- Testing
- EPAX 6000 EE 1000mg (0.6 gr DHA+EPA)
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Rabin Medical Center
Total Knee Replacement Surgery, Post-operative Pain
Suzetrigine for Treatment and Reduction of Intense Discomfort After knEe Replacement PAIN
This is a prospective, randomized study. The purpose of this study is to evaluate if the addition of Suzetrigine, a new pain medication, to well established peri-operative pain regimen used for total knee replacement surgery will…
- Trial name
- STRIDE-PAIN (NCT07548385)
- Testing
- Suzetrigine
- Where
- United States
- Volunteers
- 235 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Knee Osteoarthritis
Prosthesis and Surgery Guide System for Personalized Total Knee Arthroplasty
The subject is planned to carry out the clinical trails of femoral condyle prosthesis, tibial tray prosthesis and meniscus prosthesis; At the same time, in order to achieve personalized precision bone resection, the clinical…
- Trial name
- NCT04963491
- Testing
- Personalized TKA prosthesis, Zimmer NexGen prostheses
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Osteo Arthritis Knee, Knee Pain Chronic
Anterior Knee Pain Between Unisex Knee Prosthesis VS Gender Specific Knee Prosthesis Following MIS TKA
Unisex knee prosthesis and patient specific knee prosthesis has the same anterior knee pain and patellar tracking
- Trial name
- NCT05045651
- Testing
- Gender Solution®posterior stabilized NexGen® LPS Hi-Flex; Zimmer Biomet, Inc, Warsaw, IN, USA and standard posterior stabilized NexGen® LPS Hi-Flex; Zimmer Biomet, Inc, Warsaw, IN, USA
- Volunteers
- 80 people
- Sponsor
- Thammasat University
Revision Total Knee Arthroplasty
ATTUNE Revision System in the Revision Total Knee Arthroplasty Population
Five-year, Prospective, multi-center, non-randomized, non-controlled study of the ATTUNE® Revision total knee prostheses, utilizing the fixed bearing (FB) and rotating platform (RP) tibial component with the posterior stabilizing…
- Trial name
- NCT03153475
- Testing
- ATTUNE Revision Knee System in Revision Total Knee Arthroplasty
- Where
- 38 sites in United States, Australia and 11 more
- Volunteers
- 400 people
- Sponsor
- DePuy Orthopaedics
Knee Replacement Surgery, Osteoarthritis
Efficacy and Safety of FLOSEAL for Hemostasis in Total Knee Arthroplasty
The purpose of this study is to compare the efficacy and safety of FLOSEAL to standard of care for hemostasis in subjects undergoing total knee arthroplasty.
- Trial name
- NCT01410240
- Testing
- Standard of Care, FLOSEAL Hemostatic Matrix + Standard of care
- Where
- 12 sites in United States
- Volunteers
- 137 people
- Sponsor
- Baxter Healthcare Corporation