Clinical trials: Total Knee Replacements
Osteoarthritis, Rheumatoid Arthritis
Clinical Investigation of the LCS® Complete Posterior Stabilized Mobile-bearing Total Knee System
Prospective, multi-center clinical study to evaluate the clinical outcomes of the posterior stabilized design of the LCS® Complete Mobile-bearing Total Knee System
- Conditions
- Osteoarthritis, Rheumatoid Arthritis, Post-traumatic Arthritis, Juvenile Arthritis
- Trial name
- NCT00487565
- Testing
- Total knee arthroplasty
- Where
- 3 sites in United States
- Volunteers
- 210 people
- Sponsor
- DePuy Orthopaedics
Postoperative Pain
Safety of Buprenorphine Transdermal System (BTDS) in Subjects With Acute Postoperative Pain After Total Knee Replacement
The objectives in this study are to evaluate: (1) efficacy of buprenorphine transdermal system (BTDS, Butrans™) on postoperative pain following total knee replacement surgery; (2) the impact of BTDS on functional rehabilitative…
- Trial name
- NCT00403234
- Testing
- Buprenorphine transdermal patch
- Where
- 5 sites in United States
- Volunteers
- 10 people
- Sponsor
- Purdue Pharma LP
Pain, Postoperative, Total Knee Arthroplasty (TKA)
Continuous Adductor Canal Blocks Vs. Low Dose Femoral Nerve Blocks For Early Rehabilitation After Total Knee Arthroplasty
Recently, several articles have suggested or reported that Adductor Canal Blocks (ACBs) offer adequate or equal analgesia and may promote better performance in early rehabilitation following Total Knee Arthroplasty (TKA) when…
- Trial name
- FemVsACB (NCT02453321)
- Testing
- Continuous Femoral Nerve Block, Nerve Block, Continuous Adductor Canal, Continuous Sciatic Nerve Block
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Kevin King, DO
Osteoarthritis, Knee
TSolution One® Total Knee Arthroplasty
The goal of this prospective, non-randomized, multicenter clinical trial is to determine whether robotic-assisted total knee arthroplasty performed with TSolution One® System is safe and effective for use as an alternative to the…
- Trial name
- NCT03017261
- Testing
- TSolution One®
- Where
- 6 sites in United States
- Volunteers
- 115 people
- Sponsor
- Think Surgical Inc.
Osteoarthritis
The Use of Evicel to Reduce Blood Loss in Total Knee Replacement Surgery
Application of "Evicel" hemostatic matrix during operation for unilateral total knee replacement surgery (TKA) will result in decreased bleeding and postoperative drain output, a reduction in transfusion requirements, and less…
- Trial name
- NCT01235715
- Testing
- Evicel fibrin sealant
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Hospital for Special Surgery, New York
Arthroplasty, Replacement, Knee
Traditional vs Oral Fluid Management in Total Knee Arthroplasty
Purpose: Evidence-based guidelines on optimal perioperative fluid management have not been established in patients undergoing orthopaedic surgery.
- Trial name
- NCT03719378
- Testing
- Pre Operative Oral Fluids
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Colorado Joint Replacement
Deep Vein Thrombosis, Fibrillation, Atrial
Odiparcil For The Prevention Of Venous Thromboembolism
Odiparcil is being studied to determine if it can prevent blood clots from forming after a total knee replacement and also to prove that odiparcil is safe.
- Conditions
- Deep Vein Thrombosis, Fibrillation, Atrial, Venous Thromboembolism, Pulmonary Embolism
- Trial name
- NCT00244725
- Testing
- Odiparcil, Warfarin, Coumadin
- Where
- 101 sites in United States, Australia and 11 more
- Volunteers
- 961 people
- Sponsor
- GlaxoSmithKline
Total Knee Athroplasty
Does PAI Reduce Pain After TKA Among Knee Arthroplasty Patients Receiving ACB & IPACK?
The goal of this clinical trial is to determine whether Periarticular Injection (PAI) alongside Adductor Canal Block (ACB) and Infiltration between the Popliteal Artery and Capsule of the Knee (IPACK) block can decrease…
- Trial name
- NCT04749615
- Testing
- Periarticular Injection (PAI), Saline Control Periarticular Injection (PAI)
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- Hospital for Special Surgery, New York
Total Knee Arthroplasty(TKA), Total Knee Replacement
Flexion Versus Extension Soft Tissue Repair in Total Knee Arthroplasty
The purpose of the present study is to determine the influence of position of soft tissue repair (flexion versus extension) in post operative range of motion(ROM) and functional outcome in patients who underwent primary total…
- Trial name
- NCT02067533
- Testing
- soft tissue repair in flexion position, soft tissue repair in extension position
- Where
- Iran
- Volunteers
- 91 people
- Sponsor
- Isfahan University of Medical Sciences
Osteoarthritis, Knee
Home Monitoring After Primary Total Knee Arthroplasty
Home monitoring technologies have recently emerged in many different areas of healthcare. These technologies are being used to provide rehabilitation to patients, and to prevent, identify, and manage complications.
- Trial name
- NCT03032068
- Testing
- At-Home Monitoring
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- The Cleveland Clinic
Analgesia
Total Knee Arthroplasty (TKA) Study of HTX-011 in an Multimodal Analgesic Regimen (MMA) Regimen
Phase 3b, open-label single-arm study in which all subjects receive HTX-011 as part of a scheduled non-opioid MMA regimen.
- Trial name
- NCT03974932
- Testing
- HTX-011, Ibuprofen, Acetaminophen
- Where
- 6 sites in United States
- Volunteers
- 116 people
- Sponsor
- Heron Therapeutics
Knee Arthropathy
Adductor Canal Block With Periarticular Injection and IPACK (ACB/PAI/IPACK) Versus Periarticular Injection (PAI)
A comparison of two pain control methods - the combination of Adductor Canal Block (ACB)/Periarticular Injection (PAI)/Infiltration of the interspace between the popliteal artery and the capsule of the posterior knee (IPACK)…
- Trial name
- IPACK (NCT03094663)
- Testing
- Bupivacaine with epinephrine, Methylprednisolone, Cefazolin
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- Hospital for Special Surgery, New York
Osteoarthritis, Degenerative Joint Disease
Comparative Effectiveness of an Activity-specific Monitoring Device- StepRite
Partial or Total Knee Arthroplasty are procedures commonly used in severe degeneration of the knee joint due to osteoarthritis. With an increasing number of Partial or Total Knee Arthroplasty performed in a population that is…
- Trial name
- NCT02900781
- Testing
- Steprite™, Standard of care
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Texas Tech University Health Sciences Center
Musculoskeletal Diseases
Medacta NextAR TKA Pivotal Trial
The goal of this study is to assess the efficacy and safety of a navigation system providing personalized soft tissue balance data in medially-stabilized total knee arthroplasty (TKA).
- Trial name
- NCT04844879
- Testing
- NextAR TKA system
- Where
- 4 sites in Switzerland
- Volunteers
- 40 people
- Sponsor
- Medacta International SA
Total Knee Arthroplasty
Does Duloxetine Reduce Sub-Acute Pain After Knee Arthroplasty?
We are investigating the impact of duloxetine ("Cymbalta"), a serotonin and norepinephrine reuptake inhibitor, on pain after total knee arthroplasty (TKA).
- Trial name
- NCT02005601
- Testing
- Duloxetine 60mg
- Where
- United States
- Volunteers
- 106 people
- Sponsor
- Hospital for Special Surgery, New York
Arthroplasty, Replacement, Knee, Thromboembolism
Dabigatran Etexilate vs Enoxaparin in Prevention of Venous Thromboembolism (VTE) Post Total Knee Replacement
To determine the comparative efficacy and safety of two different doses (75mg day 1 followed by 150 mg day 2-completion, and 110 mg day 1 followed by 220 mg day 2-completion) of dabigatran administered orally (capsules), compared…
- Trial name
- NCT00152971
- Testing
- Dabigatran Dose 1 - day 2 to completion, Dabigatran Dose 1 - day 1, Dabigatran Dose 2 - day 2 to completion
- Where
- 94 sites in United States, Canada and 2 more
- Volunteers
- 2,615 people
- Sponsor
- Boehringer Ingelheim
Post-operative Pain
Liposomal Bupivacaine for Post Operative Pain After Knee Replacement Surgery
Continuous femoral nerve blocks (CFNB) provide effective pain control to patients undergoing total knee replacement (TKR). However the resulting motor blockade can lead to decreased quadriceps muscle strength and delayed…
- Trial name
- NCT02274870
- Testing
- Liposome Bupivacaine, Bupivacaine HCl
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Northwell Health
Osteo Arthritis Knee
Use of Interferential Current (IFC) Therapy After Total Knee Arthroplasty
Interferential Current Therapy (IFC) is a form of electrical therapy that utilizes two simultaneous low frequency electrical stimulation which when they cross interfere with one another resulting in an interference or beat…
- Trial name
- IFC (NCT04137731)
- Testing
- Interferential Current Therapy
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Montefiore Medical Center
Arthroplasty, Replacement, Thromboembolism
Pradaxa (Dabigatran Etexilate 220 mg/q.d. in the General Population After Hip or Knee Replacement Surgery
An observational cohort study on safety and efficacy of the 220 mg dose Pradaxa to generate additional data in predefined sub populations of patients at increased risk of bleeding or VTE
- Trial name
- NCT00846807
- Where
- 112 sites in Austria, France and 7 more
- Volunteers
- 5,476 people
- Sponsor
- Boehringer Ingelheim
Chronic Post-Surgical Pain
Pre-op Cognitive Behavior Therapy to Decrease Chronic Post-Surgical Pain in TKA
A significant number of patients develop chronic post-surgical pain (CPSP) following knee replacement surgery. Proposed is the testing of a novel computer-assisted behavioral intervention integrating motivational interviewing in…
- Trial name
- NCT04814992
- Testing
- Computer-Assisted Preoperative CBT Intervention (PAINTrainer)
- Where
- 4 sites in United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania