Clinical trials: Total Knee Replacements
Osteoarthritis
A Multicenter Study to Evaluate Functional Outcome After Knee Replacement
Patients will be consecutively enrolled by implant. Implant groups will be those who have undergone surgery with either a ConforMIS iTotal® CR TKA or an Off-the- Shelf (OTS) system.
- Trial name
- NCT02494544
- Testing
- Off the Shelf Total Knee Replacement, ConforMIS iTotal Knee Replacement
- Where
- 8 sites in United States
- Volunteers
- 215 people
- Sponsor
- Restor3D
Total Knee Replacement
Antibiotic Elution in Total Knee Arthroplasty
The purpose of the study is to characterize and quantify the level of antibiotics eluted from antibiotic laden cement after primary cemented total knee arthroplasty.
- Trial name
- NCT03928522
- Testing
- hand mixed vancomycin, hand mixed tobramycin, pre-mixed tobramycin
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Washington University School of Medicine
Total Knee Arthroplasty, Osteo Arthritis Knee
In Vivo Kinematics for Subjects Implanted With Klassic Total Knee Arthroplasty (TKA)
In vivo knee kinematics will be assessed for 20 subjects that have been implanted with a Total Joint Orthopedics Klassic knee system by Dr.
- Conditions
- Total Knee Arthroplasty, Osteo Arthritis Knee, Knee Implant, Knee Injuries
- Trial name
- TKA (NCT04113785)
- Testing
- Klassic Knee System
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- The University of Tennessee, Knoxville
Postoperative Pain
A Comparison of Naropin and Ketorolac for Postoperative Analgesia After Total Knee Arthroplasty
The purpose of this study is to determine wether ketorolac is effective in the treatment of postoperative pain after total knee arthroplasty
- Trial name
- NCT00868348
- Testing
- Ketorolac, Saline
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- University of Aarhus
Arthroplasty, Replacement, Knee
Evaluation of Triathlon - a New Total Knee Prosthesis System - Triathlon vs. Duracon
The objective is to investigate the Clinical, Radiographic, Roentgen Stereophotogrammetric behaviour and patient outcome when using the Triathlon total knee prosthesis in a prospective randomized clinical trial.
- Trial name
- NCT00436982
- Testing
- Cemented Triathlon total knee system, Duracon total knee system
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Stryker Orthopaedics
Osteoarthritis, Osteo Arthritis Knee
Functionally Aligned vs Mechanical Axis Aligned Total Knee Arthroplasty
The objective of this study is to compare clinical and radiological outcomes in robotic-arm assisted TKA using mechanical alignment (MA TKA) versus robotic-arm assisted TKA with functional alignment (FA TKA).
- Trial name
- FATKAvsMATKA (NCT04748510)
- Testing
- Functionally Aligned Total Knee Arthroplasty, Mechanically Aligned Total Knee Arthroplasty
- Where
- 2 sites in Australia
- Volunteers
- 100 people
- Sponsor
- Perth Hip and Knee
Blood Loss
The Use of FLOSEAL to Reduce Bleeding in Total Knee Replacement Surgery
The purpose of this study is to determine if the agent, Floseal, can decrease the amount of blood patients lose after total knee replacement (TKR) surgery.
- Trial name
- NCT00990288
- Testing
- Hemostatic Matrix
- Where
- United States
- Volunteers
- 196 people
- Sponsor
- Hospital for Special Surgery, New York
Total Knee Arthroplasty, Osteoarthritis
A Study to Compare the NexGen CR and CR-Flex Knee Implants
The purpose of this study is to test for significant differences in functional outcomes, specifically pre-operative ROM and post-operative ROM obtained by using a NexGen CR versus a NexGen CR-Flex knee implant.
- Trial name
- NCT00761956
- Testing
- NexGen CR-Flex Fixed Bearing Knee, NexGen CR Knee
- Where
- 8 sites in United States
- Volunteers
- 189 people
- Sponsor
- Zimmer Biomet
Local Anesthetic Complication, Local Anesthetic Drug Adverse Reaction
Defining Normal Postoperative Magnetic Resonance Imaging After Total Knee Arthroplasty
The aim of this study was to describe the postoperative "baseline" magnetic resonance imaging (MRI) appearance of the ipsilateral thigh musculature after total knee arthroplasty (TKA).
- Trial name
- NCT04821245
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Benaroya Research Institute
Total Knee Arthroplasty, Osteoarthritis
Kinematic Analysis: Posterior Stabilized, Fixed Bearing Total Knee Arthroplasty With Attune Knee System
A better understanding of knee joint kinematics is important to explain the premature polyethylene wear failures within total knee arthroplasties (TKAs) and to help design a prosthesis that most closely approximates the normal…
- Trial name
- NCT02204748
- Testing
- DePuy Attune posterior stabilizing fixed bearing knee system
- Where
- 2 sites in United States
- Volunteers
- 5 people
- Sponsor
- The University of Tennessee, Knoxville
Arthroplasty Complications
Safety of Total Knee Replacement Surgery Before and After the Implementation of Enhanced Recovery Program
The objectives are to describe the transition from traditional care to an enhanced recovery program for the management of total knee arthroplasty, and to evaluate the effect on patient outcomes.
- Trial name
- NCT05028426
- Testing
- Enhanced recovery program
- Where
- France
- Volunteers
- 455 people
- Sponsor
- Groupe Hospitalier de la Rochelle Ré Aunis
Arthropathy of Knee Joint
Improving Function After Knee Arthroplasty With Weight-Bearing Biofeedback
The purpose of this study is to determine if rehabilitation using weight-bearing biofeedback training following total knee arthroplasty (TKA) is more effective than standard rehabilitation methods in promoting weight-bearing…
- Trial name
- RELOAD (NCT01333189)
- Testing
- Weight-bearing biofeedback exercise, Standard of care exercise
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- University of Colorado, Denver
Knee Osteoarthritis
Evaluation of the Safety and Effectiveness of the Kinamed Gem Ceramic Femoral Component for Total Knee Replacement
The aim of this study is to provide evidence that the safety and effectiveness of the ceramic femoral component of the Gem Total Knee System is similar to FDA approved implants used in total knee replacement surgery.
- Trial name
- NCT00743717
- Testing
- zirconia femoral component, cobalt chrome femoral component
- Volunteers
- 4 people
- Sponsor
- Kinamed Incorporated
Total Knee Arthroplasty
Effect of Low Dose Corticosteroids on Perioperative Markers of Thrombosis and Fibrinolysis in Total Knee Arthroplasty
One postoperative complication following unilateral or bilateral total knee arthroplasty is thrombosis (blood clot formation). In this prospective, double-blinded randomized controlled clinical trial, researchers are…
- Trial name
- NCT01815918
- Testing
- Hydrocortisone
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Hospital for Special Surgery, New York
Osteoarthritis
StepRite Evaluation
The purpose of this study is to compare the short-term changes in gait parameters and functional outcomes after total knee arthroplasty between those who use the StepRite device and those who follow a standard therapy program…
- Trial name
- NCT02270684
- Testing
- StepRite
- Volunteers
- 4 people
- Sponsor
- University of Southern California
Arthroplasty, Replacement, Knee
Does Radiofrequency Ablation of the Articular Nerves of the Knee Prior to Total Knee Replacement Improve Pain Outcomes
More than 300,000 total knee joint replacement surgeries are performed per year in the United States and safe, effective management of post-operative pain in these patients, often elderly, deconditioned, obese, or with co-morbid…
- Trial name
- NCT02746874
- Testing
- Radiofrequency Ablation (RFA), Simulated Radiofrequency Ablation (RFA)
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Northwestern University
Arthroplasty, Replacement, Prevention of Venous Thromboembolism
Treatment of Patients Undergoing Primary Unilateral Elective Total Knee or Hip Replacement With Dabigatran Etexilate
To supplement the current evidence of the effect of Pradaxa® (dabigatran etexilate) on coagulation parameters, including a calibrated thrombin time test, in patients with moderate renal impairment undergoing elective total hip…
- Conditions
- Arthroplasty, Replacement, Prevention of Venous Thromboembolism, Moderate Renal Impairment (CrCl 30-50 mL/Min)
- Trial name
- NCT01184989
- Testing
- Dabigatran etexilate
- Where
- 10 sites in Austria, Canada and 4 more
- Volunteers
- 142 people
- Sponsor
- Boehringer Ingelheim
Total Knee Arthroplasty
Can Dexmedetomidine For Procedural Sedation In Knee Arthroplasty Reduce Postoperative Pain? A Randomized Control Study
Dexmedetomidine has been often used for procedural sedation. It has also has been shown to have a pain sparing effect. Therefore the investigators propose that if Dexmedetomidine is used for sedation in total knee replacements…
- Trial name
- NCT02026141
- Testing
- Dexmedetomidine
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Saskatchewan
Total Knee Arthroplasty
Medrol Dosepak Taper for Delayed Post-op Recovery After TKA
To evaluate the efficacy of a methylprednisolone taper on patients with decreased range of motion (ROM) or delayed recovery in the acute postoperative period following total knee arthroplasty (TKA).
- Trial name
- NCT05113901
- Testing
- Methylprednisolone
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Osteoarthritis
Blood Loss Reduction After Total Knee Arthroplasty. Comparison Topical Tranexamic Acid vs Platelet Rich Plasma
The investigators will include patients who will be schedule for total knee arthroplasty with a diagnosis of osteoarthritis. The patients will be divided in two groups.
- Trial name
- NCT02650856
- Testing
- Group 1 Tranexamic Acid, Group 2 Platelet rich plasma
- Where
- Mexico
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universidad Autonoma de Nuevo Leon