Clinical trials: Total Laryngectomy
Total Laryngectomy
Laryngectomy Education
Patients undergoing total laryngectomy are at high risk for 30-day unplanned readmission. Many of these readmissions are related to stomal care, and it is thought that the readmissions could be prevented with better patient and…
- Trial name
- NCT02601638
- Testing
- Demographics and Health History Questionnaire, Pre-Class Laryngectomy Survey, Counseling session with speech pathologist
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Washington University School of Medicine
Larynx Carcinoma
The Role of the Free/Pedunculated Flap in Total Laryngectomy After (Chemo-)Radiotherapy Failure for Laryngeal Carcinoma: Impact on the Risk of Pharyngocutaneous Fistula (PCF)
Multicenter, prospective, randomized study aimed at evaluating the difference in risk of PCF after salvage laryngectomy in two groups of patients: one cohort treated with Total Laryngectomy (LT) with primary suture, a second…
- Trial name
- NCT06287034
- Testing
- Primary suture
- Where
- Italy
- Volunteers
- 102 people
- Sponsor
- Regina Elena Cancer Institute
Laryngectomy
Effect of Zinc and Probiotics Supplementation on Laryngeal Cancer Patients Undergoing Laryngectomy Surgery to Improve Prognosis and Better Wound Healing
using zinc and probiotics supplementation for providing better prognosis for laryngeal cancer patients under going total or partial laryngectomy.
- Trial name
- NCT06674564
- Testing
- Zinc Acetate 50 Mg Oral Capsule, Probiotic
- Where
- Egypt
- Volunteers
- 140 people
- Sponsor
- Ain Shams University
To Calculate Total Blood Loss Immediately Postoperative
Efficacy of Topical Versus Intravenous Tranexamic Acid in Controlling Blood Loss
Total laryngectomy with bilateral block neck dissection is considered one of the major head and neck surgeries. Intraoperative bleeding is considered a risk factor for this operation specially that the population of this…
- Trial name
- NCT06188052
- Testing
- Tranexamic acid
- Where
- Egypt
- Volunteers
- 45 people
- Sponsor
- Kasr El Aini Hospital
Larynx Cancer
Clinical Feasibility of New Tracheoesophageal Puncture Set
During a total laryngectomy a puncture is created in the tracheoesophageal wall and a voice prosthesis is inserted. With this voice prosthesis the patient learns to speak again.
- Trial name
- NCT01045057
- Testing
- Puncture Set and Flexible Protector
- Where
- 5 sites in Belgium, Germany and 2 more
- Volunteers
- 27 people
- Sponsor
- Atos Medical AB
Laryngectomy
Cost-effectiveness Analysis of Vocal Rehabilitation With Strengthened Tracheoesophageal Voice Implant Prosthesis Versus Standard Voice Prosthesis in Case of Repeated Intra-prosthetic Leakage After Total Laryngectomy
The purpose of this study is to determine the cost-effectiveness of vocal rehabilitation with reinforced inter-tracheoesophageal voice prosthesis versus standard voice prosthesis in case of repeated intra-prosthetic leakage in…
- Trial name
- PHRASAL (NCT04100954)
- Testing
- Reinforced prosthesis, Standard prosthesis
- Where
- 13 sites in France
- Volunteers
- 81 people
- Sponsor
- Nantes University Hospital
Quality of Life, Depressive Symptoms
The Effect of Art Therapy on Total Laryngectomy Patients
Total laryngectomy (TL) patients suffer from a myriad of psychological and physiological difficulties following surgery. One of their main difficulties in communication due to problems in speaking.
- Trial name
- NCT03503435
- Testing
- Group art therapy
- Sponsor
- University of Haifa
Carcinomatous Disease
Establishment of an Artificial Larynx After Total Laryngectomy
This study aims to evaluate the effectiveness of an artificial larynx on the restoration of laryngeal functions, mainly breathing and swallowing.
- Trial name
- LA (NCT01474005)
- Testing
- PROTIP MEDICAL ( Artificial larynx prosthesis)
- Where
- France
- Volunteers
- 5 people
- Sponsor
- University Hospital, Strasbourg, France
Total Laryngectomy
Pre-operative Counselling in Laryngectomized Patients
The investigators aim to verify the effects of pre-operative Speech-Language Pathology (SLP) counselling on patients undergoing total laryngectomy in terms of levels of distress, post-traumatic stress symptoms, anxious-depressive…
- Trial name
- NCT04491487
- Testing
- pre-operative counselling
- Where
- Italy
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Laryngectomy; Status
Effect of Dexmedetomidine in Preventing Cough and Postoperative Pain After Laryngeal Surgery for Cancer
Background: During emergence from anesthesia for partial and total laryngectomy, severe airway reflex and systemic hypertension during recovery may lead to pneumoderm, hemorrhage, pneumomediastinum or pneumothorax.
- Trial name
- NCT03918889
- Testing
- Dexmedetomidine Injectable Product, Midazolam injection
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Eye & ENT Hospital of Fudan University
Patients With Total Laryngectomy and Their Close Relatives
FRENCH THERAPEUTIC EDUCATION PROGRAM AIMING TO IMPROVE LARYNGECTOMIZED PATIENTS' AND THEIR FAMILY CAREGIVER'S QUALITY OF LIFE
The therapeutic education of patients and their close relations is, as yet, poorly developed in France in the field of oncology (Pérol2007), in particular for cancers of the upper aerodigestive tract (Allison2010).
- Trial name
- PETAL2 (NCT04569500)
- Testing
- PETAL program
- Where
- France
- Volunteers
- 264 people
- Sponsor
- University Hospital, Caen
Laryngeal Cancer, Total Laryngectomy
Aortic Laryngeal Rehabilitation Graft
The larynx is a cartilaginous organ of the respiratory system located in the throat, which plays an essential role in respiratory function, swallowing and sound production.
- Trial name
- GRAAL (NCT04650919)
- Testing
- Total laryngectomy and reconstruction by stented aortic allograft (using human tissue and device).
- Where
- France
- Volunteers
- 4 people
- Sponsor
- University Hospital, Strasbourg, France
Neck Cancer, Larynx
Bilateral Elective Neck Dissection in Salvage Total Laryngectomy
The aim of this study is to evaluate the role of elective bilateral neck dissection in patients with clinically negative lymph nodes (cN0) who underwent salvage total laryngectomy, by estimating the prevalence of histologically…
- Conditions
- Neck Cancer, Larynx, Larynx Cancer, Neck
- Trial name
- NCT05746780
- Testing
- Elective bilateral neck dissection in cN0 patients
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Total Laryngectomy
Long-term Clinical Feasibility of the New Indwelling Provox Vega 20 Voice Prosthesis
The purpose of this study is to investigate long-term clinical feasibility of a new voice prosthesis and insertion system Provox Vega 20 with SmartInserter) for voice rehabilitation after total laryngectomy.
- Trial name
- NCT00661570
- Testing
- Provox Vega voice prosthesis (20 Fr)
- Where
- Netherlands
- Volunteers
- 26 people
- Sponsor
- Atos Medical AB
Malignant Tumor of the Larynx
Role of Cervical Fascia Flap in Decreasing the Incidence of Pharyngocutaneous Fistula After Total Laryngectomy
This study was conducted to evaluate the potential role of using the cervical fascia flap over the pharyngeal closure line to enhance healing and subsequently to decrease the incidence of pharyngocutaneous fistula after total…
- Trial name
- NCT07241611
- Testing
- Total laryngectomy
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Mansoura University
Laryngeal Cancer, Laryngectomy
SpeakFree Heat and Moisture Exchanger (HME)
The purpose of the study is to evaluate the new Blom-Singer SpeakFree disposable hands free valve heat and moisture exchanger (HME).
- Trial name
- SPEAKFREE (NCT05349487)
- Testing
- SpeakFree HME Hands Free Valve, Digital Occlusion, Digital Depression HME
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Miami
Cognitive Aging, Hyposmia
Mechanical and Sensorial Training in the Olfactive Rehabilitation of Patients With Total Laryngectomy
To assess the efficacy of two olfactory rehabilitation protocols (Nasal Airflow-Inducing Maneuver (NAIM) with or without ol-factory training) on olfactory function (sniffing stick test) and quality of life (questionnaire Self-MOQ…
- Conditions
- Cognitive Aging, Hyposmia, Total Laryngectomy
- Trial name
- OLFAC-TL (NCT07122037)
- Testing
- DosMedical Smell Training Set, Nasal Airflow Inducing Maneuver
- Where
- Belgium
- Volunteers
- 16 people
- Sponsor
- University Hospital of Mont-Godinne
Laryngeal Cancer, Hypopharynx Cancer
A Novel Modified Tracheo-Esophageal Voice Prosthesis for Total Laryngectomy Patients
This study is being conducted at Healthcare Global Enterprises Ltd to evaluate the role of a novel Tracheo-Esophageal voice Prosthesis for total laryngectomy +/- partial pharyngectomy patients.
- Trial name
- TEP (NCT03039465)
- Testing
- Modified Trans-Esophageal Prosthesis
- Where
- India
- Volunteers
- 50 people
- Sponsor
- HealthCare Global Enterprise Ltd.
Cancer, Otorhinolaryngeal
Rehabilitation Improved by Early Detection of Fisyulas Post (Pharyngo) -Total Laryngectomy by Cytokine Measurement on Drainage Fluid on the Second Post-Operative Day
Post-pharyngo-laryngectomy fistula is a frequent surgical complication, resulting in delayed patient management and reduced quality of life.
- Trial name
- RADEFILAC (NCT06604494)
- Testing
- early feeding resumption, late feeding resumption
- Where
- 7 sites in France
- Volunteers
- 250 people
- Sponsor
- University Hospital, Clermont-Ferrand