Clinical trials: Total Parenteral Nutrition
Parenteral Nutrition Associated Liver Disease PNALD, Cholestasis
Evaluation of Omegaven™ Parenteral Nutrition in Patients With Total Parenteral Nutrition (TPN)-Induced Cholestasis
The purpose of this study is to determine if established parenteral nutrition (PN) associated liver disease can be reversed or its progression halted by using a parenteral fat emulsion prepared from fish oil as measured by…
- Trial name
- NCT00826020
- Testing
- Omegaven™
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- University of Nebraska
Total Parenteral Nutrition, Necrotizing Enterocolitis of Newborn
Probiotics/TPN in the NICU
The purpose of this study is to evaluate the effect of probiotic administration on TPN dependence in infants < 32 weeks GA and BW 1500 grams or less in the Banner - University Medical Center Phoenix and Banner Children's at…
- Trial name
- NCT04977817
- Testing
- Similac Probiotic Tri-Blend
- Where
- 2 sites in United States
- Volunteers
- 150 people
- Sponsor
- Pediatrix
Stable Neonates, Receiving Total Parenteral Nutrition (TPN)
Phenylalanine, Methionine and Histidine Requirements in TPN Fed Neonates
This is a single center project assessing the requirements for three essential amino acids in TPN fed neonates. Using the Carbon Oxidation method (indicator amino oxidation and direct amino acid oxidation method), the…
- Trial name
- NCT05562310
- Testing
- Total parenteral nutrition (TPN). This is total nutrition provided by central vein.
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- The Hospital for Sick Children
Total Parenteral Nutrition-induced Cholestasis
Intravenous Fat Emulsion Comprised of Fish Oil in the Treatment of Parenteral Nutrition Induced Liver Injury in Infants
To provide a mechanism for critically ill infants with parenteral nutrition (PN) associated cholestasis to receive Omegaven for compassionate use situations for which there are no satisfactory alternative treatments.
- Trial name
- NCT02534077
- Testing
- Omegaven
- Where
- United States
- Sponsor
- Pediatrix
Wasting;Muscle(S)
Effects of Total Parenteral Nutrition on Skeletal Muscle Genomics.
The study investigates effects related to muscle protein metabolism at provision of Total Parenteral nutrition.
- Trial name
- NCT03401944
- Testing
- TPN, Control
- Where
- Sweden
- Volunteers
- 24 people
- Sponsor
- Göteborg University
Total Parenteral Nutrition-induced Cholestasis
Compassionate Use of Omegaven® in the Treatment of Parenteral Nutrition Associated Hepatic Injury
The overall purpose of this study is to determine if replacing standard soybean oil based fat emulsions with Omegaven®, a fish oil based fat emulsion, can reverse or prevent the progression of parenteral nutrition associated…
- Trial name
- NCT01412359
- Testing
- Omegaven®
- Where
- United States
- Sponsor
- Jeffrey Rudolph
Short Bowel Syndrome, Malabsorption
Teen and Young Adult Connections for Support From Multidisciplinary Professionals & Peers
12 month study testing mobile delivery of health information and connections to professionals and peers to improve health of teen/young adult HPN users.
- Conditions
- Short Bowel Syndrome, Malabsorption, Malnutrition
- Trial name
- NCT02987569
- Testing
- mConnect plus mobile connections to multidisciplinary professionals & peers, iPad use plus one mobile connections to multidisciplinary professionals & peers
- Where
- United States
- Volunteers
- 83 people
- Sponsor
- University of Kansas Medical Center
Total Parenteral Nutrition-induced Cholestasis
Expanded Access of Omegaven IV Fat Emulsion to Infants and Children With PNALD
This is an expanded access protocol for use of intravenous fish oil infusion, Omegaven, in infants and children with parenteral nutrition associated liver disease (PNALD) to decrease elevated liver enzymes and direct bilirubin.
- Trial name
- NCT02929303
- Testing
- Omegaven IV lipid emulsion
- Where
- United States
- Sponsor
- Wake Forest University Health Sciences
Long Term Antibiotics, Chemotherapy
FX vs. ECG Guidance for PICC Insertion
The aim of this study is to compare two techniques of placing a peripherally inserted central venous catheter (PICC). The first technique, uses ECG based electromagnetic guidance (ECG-EM).
- Conditions
- Long Term Antibiotics, Chemotherapy, Total Parenteral Nutrition
- Trial name
- NCT03652727
- Testing
- ECG-EM Guidance, FX Guidance
- Where
- Switzerland
- Volunteers
- 120 people
- Sponsor
- Salah D. Qanadli
Premature Birth
Total Parenteral Nutrition Associated Cholestasis (TPNAC) and Plasma Amino Acid Levels in Neonates
The purpose of this study is to analyze if the infants who received Primene solution, have lower serum levels of methionine and cysteine and higher serum levels of taurine, we also analyze if the infants who received Primene…
- Trial name
- TPNAC (NCT01062724)
- Testing
- Primene 10 % from Baxter
- Where
- Mexico
- Volunteers
- 94 people
- Sponsor
- Coordinación de Investigación en Salud, Mexico
Short Bowel Syndrome, Malabsorption
Home Parenteral Nutrition (HPN) Families' Mobile Distance Connections to Care Research
The purpose of this study is to test Mobile Technologies in Assisting Patients \& Family Caregivers in Healthy Living and complex home care by connecting to information and professionals from a distance.
- Conditions
- Short Bowel Syndrome, Malabsorption, Malnutrition
- Trial name
- NCT01900288
- Testing
- HPN Group Clinic Appointments using Mobile Devices (experimental)
- Where
- United States
- Volunteers
- 121 people
- Sponsor
- University of Kansas Medical Center
Genomic and Metabolomic Variations, Preterm Birth
Effects of Genomic and Metabolomic Variations of Choline on Risk of Preterm Birth and Clinical Outcomes in Preterms
The incidence of preterm birth increases annually. Premature delivery has become the leading cause of neonatal illness and death.
- Conditions
- Genomic and Metabolomic Variations, Preterm Birth, Total Parenteral Nutrition
- Trial name
- NCT02841813
- Testing
- No intervention
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Nutrition Disorders
Limited Long Term Survival in Patients After In-hospital Intestinal Failure Requiring Total Parenteral Nutrition
The purpose of this study is to determine what the long term survival is after in hospital use of total parenteral nutrition due to intestinal failure.
- Trial name
- NCT02189993
- Where
- Netherlands
- Volunteers
- 437 people
- Sponsor
- Amsterdam UMC, location VUmc
Severe Acute Pancreatitis
Comparative Study About the Impact of Two Oil Emulsions Administered Intravenously on Severe Acute Pancreatitis
The purpose of this study is to comparatively assess the potential antiinflammatory effects of intravenous lipid emulsions rich in omega 3 polyunsaturated fatty acids and olive oil versus intravenous lipid emulsions made…
- Trial name
- NCT01376817
- Testing
- Fat emulsion with MCT, LCT, olive oil and omega 3 fatty acids, Fat emulsion with MCT and LCT
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Hyperglycemia
TPN-Induced Hyperglycemia: Impact on Clinical Outcome in Intensive Care Unit (ICU) and Non-ICU Patients
A growing body of evidence suggests hyperglycemia is associated with adverse outcomes in patients with and without diabetes. Observational studies document an association between hyperglycemia and poor clinical outcomes in…
- Trial name
- NCT00604669
- Where
- United States
- Volunteers
- 170 people
- Sponsor
- Emory University
Neonates on TPN, Stable Neonates
Isoleucine, Leucine, Valine and Tryptophan Requirements in TPN Fed Neonates
This project will be conducted in 2 hospitals in Brazil to assess the requirements for four essential amino acids in TPN fed neonates.
- Conditions
- Neonates on TPN, Stable Neonates, Neonates Managed in the ICU
- Trial name
- NCT06372314
- Testing
- Total parenteral nutrition (TPN): this is total nutrition provided by central vein.
- Where
- Brazil
- Volunteers
- 80 people
- Sponsor
- The Hospital for Sick Children
Cholestasis, Jaundice, Obstructive
SMOFlipid to Lessen the Severity of Neonatal Cholestasis
Parenteral nutrition (PN) provides intravenous nutritional supplementation for infants unable to absorb adequate enteral nutrients secondary to insufficient intestinal length or function.
- Trial name
- NCT02721277
- Testing
- SMOFlipid
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- University of Florida
Pediatric Intestinal Failure
KiteLock 4% EDTA Lock Solution for the Prevention of Occlusions in Children With Intestinal Failure
A multi-site, randomized, 2-arm open-label trial to determine if 4% Tetrasodium (EDTA) catheter lock solution is more effective than heparin lock (standard of care) in preventing central venous catheter occlusions in children…
- Trial name
- NCT05879835
- Testing
- KiteLock 4% Sterile Catheter Lock Solution, Heparin Lock Solution
- Where
- 8 sites in United States
- Volunteers
- 124 people
- Sponsor
- SterileCare Inc.
Cancer, Surgery
Study on Blood Glucose Variations in Tumor Patients Before and After Total Parenteral Nutrition
The purpose of this study is to determine the relationship among TPN, tumor and blood glucose.
- Conditions
- Cancer, Surgery, Nutrition Related Cancer
- Trial name
- TPN (NCT02024321)
- Where
- China
- Volunteers
- 86 people
- Sponsor
- Chinese Academy of Medical Sciences
Total Parenteral Nutrition-induced Cholestasis
Omegaven® in the Treatment of Parenteral Nutrition (PN) Induced Liver Injury
The purpose of this study is to determine whether the omega-3 fatty acid emulsion (Omegaven®), when used in place of the conventional soy-based fat emulsion (Intralipid), is effective in treating parenteral nutrition associated…
- Trial name
- NCT01845116
- Testing
- Omegaven®
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Wake Forest University Health Sciences