Clinical trials: Tourette's Syndrome
Tourette Syndrome, Tic Disorders
Brain Dynamics Involved in Generating Tics and Controlling Voluntary Movement
This study will use electroencephalography (EEG) and electromyography (EMG) to examine how the brain generates tics and controls voluntary movement in patients with Tourette's syndrome and chronic motor tic disorder.
- Trial name
- NCT00056420
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Tourette Syndrome
Combined CBIT and rTMS to Improve Tourette's Syndrome
The investigator will apply 16 sessions of repetitive transcranial magnetic stimulation (rTMS) over 4 consecutive days for adult patients suffering from Tourette's Syndrome.
- Trial name
- STOP-TIC (NCT04795908)
- Testing
- Transcranial Magnetic Stimulation, Comprehensive behavioral intervention
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Florida
Tics, Tic Disorders
Clinical Characteristics and Temporal Properties of Individual Tics in Persistent Tic Disorder
The goal of this clinical study is to learn more about the timing of tics (sudden, fast movements and sounds that people do and make without meaning to) in people who have multiple tics that have been going on for more than one…
- Conditions
- Tics, Tic Disorders, Vocal Tic, Motor Tic
- Trial name
- PTD (NCT06385535)
- Testing
- Habit Reversal Training (HRT)
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Utah
Tourette Syndrome
Washed Microbiota Transplantation for Tourette's Syndrome
This study aimed to evaluate the efficacy of washed microbiota transplantation in the treatment of Tourette's syndrome (TS).
- Trial name
- WMT (NCT03764748)
- Testing
- Washed Microbiota Transplantation
- Where
- 2 sites in China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The Second Hospital of Nanjing Medical University
Tourette Syndrome
Phase II Double Blind Placebo Controlled Trial of Risperidone in Tourette Syndrome
OBJECTIVES: I. Conduct a randomized, double blind, placebo controlled, parallel study of the atypical neuroleptic risperidone (RIS) in the treatment of children and adults with moderate to severe Tourette Syndrome. II.
- Trial name
- NCT00004393
- Testing
- risperidone
- Volunteers
- 50 people
- Sponsor
- National Center for Research Resources (NCRR)
Movement Disorder, Tourette Syndrome
Investigation of Neurofeedback With Real-Time fMRI in Healthy Volunteers and Patients With Hyperkinetic Movement Disorders
Background: Many people can learn to use feedback about brain activity to modify that activity, but is it not known if people with Tourette syndrome can modify their brain activity.
- Conditions
- Movement Disorder, Tourette Syndrome, Healthy Volunteer
- Trial name
- NCT00885040
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Tourette Syndrome, Tic Disorders
Study of Tics in Patients With Tourette's Syndrome and Chronic Motor Tic Disorder
This study will investigate which areas of the brain are primarily involved in and responsible for tics in patients with Tourette's syndrome and chronic motor disorder.
- Trial name
- NCT00033995
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Tourette Syndrome
Brain Activity Associated With Tics in Patients With Tourette Syndrome
This study will examine brain activity associated with the involuntary urges or uncontrolled movements, called "tics," experienced by people who have Tourette syndrome (TS).
- Trial name
- NCT00141869
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Tourette Syndrome
Multi-site Transcranial Magnetic Stimulation Therapy of the Supplementary Motor Area in Children With Tourette Syndrome
The investigators are investigating the effectiveness of a wearable multisite transcranial magnetic stimulation (mTMS) device that can deliver stimuli at multiple cortical sites simultaneously or sequentially for the treatment of…
- Trial name
- NCT03642951
- Testing
- Active Treatment
- Where
- United States
- Sponsor
- Children's Mercy Hospital Kansas City
Tourette Syndrome
Sensory Processing in Tourette Syndrome
The purpose of this study is to learn more about how patients with Tourette Syndrome deal with sensory stimuli in their environment such as bright lights, loud noises, physical sensations such as shirt tags, etcetera.
- Trial name
- NCT02512406
- Testing
- The Sensory Profile, The Adult/Adolescent Sensory Profile, Children's Yale-Brown Obsessive Compulsive Scale
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Florida
Tourette Syndrome, Habit Reversal Training
Extinction Learning in Adults With Tourette Syndrome
Aversive sensory phenomena such as premonitory urges play a central role in the behavioral treatment model of tics. Extinction learning and extinction recall are learning processes implicated within this model, but are still…
- Conditions
- Tourette Syndrome, Habit Reversal Training, Tic Disorders, Tics
- Trial name
- NCT04498364
- Testing
- Habit Reversal Training
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Chronic Tic Disorder
Group Therapy Versus Individual Therapy for Tourette Syndrome and Chronic Tic Disorder
Chronic tic disorder (CTD) may have a huge impact on life quality. Habit Reversal Training (HRT) and Exposure Response Prevention (ERP) are effective therapeutic modalities.
- Trial name
- NCT04594044
- Testing
- tics training including habit reversal training and exposure response prevention
- Volunteers
- 59 people
- Sponsor
- Aarhus University Hospital
Tourette Syndrome
A Study to Examine the Efficacy of a Therapeutic THX-110 for Tourette Syndrome
This study evaluates the efficacy and safety of THX-110 in the management of tics and other symptoms (e.g. rage attacks, anxiety, depression, sleep difficulties) in patients with Tourette syndrome.
- Trial name
- NCT03651726
- Testing
- THX-110 (dronabinol plus PEA)
- Where
- 2 sites in Germany
- Volunteers
- 60 people
- Sponsor
- Neurothera Labs Inc.
Obsessive Compulsive Disorder, Body Dysmorphic Disorder
Outcomes of Cognitive Behavioral Therapy (CBT) Interventions Provided by Unlicensed Professionals
To examine the effectiveness and clinical care outcomes of cognitive-behavioral therapy interventions at Massachusetts General Hospital (MGH).
- Conditions
- Obsessive Compulsive Disorder, Body Dysmorphic Disorder, Tourette Syndrome, Trichotillomania
- Trial name
- NCT01075672
- Testing
- Cognitive behavioral therapy (CBT)
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Massachusetts General Hospital
Tourette Syndrome
Behavioral Therapy for Tourette Syndrome
This research is being done to determine whether a home-based behavioral therapy can be successfully used to treat tics in children with Tourette syndrome (TS).
- Trial name
- BTTS:HBTA (NCT03019731)
- Testing
- Therapist-directed Behavioral Therapy, Home-based DVD Therapy
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Johns Hopkins University
Gilles de la Tourette Syndrome, Tics
Repetitive Transcranial Magnetic Stimulation of the Posterior Parietal Cortex in Patients Suffering From Gilles de la Tourette Syndrome
Repetitive transcranial stimulation (rTMS) of the posterior parietal cortex will be applied daily over five days in adult Gilles de la Tourette patients.
- Trial name
- rTMSPPCGT (NCT01043549)
- Testing
- rTMS
- Where
- France
- Volunteers
- 5 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Parkinson Disease, Neurologic Disorder
Brain Tissue Imprint
This exploratory study aims to validate the collection and analysis of brain tissue imprints during the DBS by using a CE marked Medical Device in patients presenting one of the following five disorders: Parkinson's disease (PD)…
- Trial name
- BTI (NCT03929406)
- Testing
- Brain Tissue Imprint
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Grenoble
Tourette Syndrome
Thalamic Deep Brain Stimulation for Tourette Syndrome
In this single-center trial, we aim to include 8 patients with severe and medically refractory Tourette's syndrome. All patients undergo deep brain stimulation surgery with two electrodes located in the…
- Trial name
- NCT03958617
- Testing
- Bilateral Deep brain stimulation of the thalamus, Medtronic Device
- Where
- Germany
- Volunteers
- 8 people
- Sponsor
- University of Cologne
Tourette Syndrome
Open-Trial of EPI-743 for Adults With Tourette Syndrome
The purpose of this study is to examine the effects of EPI-743 on tic severity in adults with Tourette syndrome.
- Trial name
- NCT01719523
- Testing
- EPI-743
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Yale University
Tourette Syndrome, Deep Brain Stimulation
Deep Brain Stimulation in Tourette Syndrome
Op-TICS is a clinical investigation of the use of Deep Brain Stimulation (DBS), with a CE marked implantable device, to reduce severe motor and vocal tics in patients who suffer from Tourette Syndrome (TS).
- Trial name
- Op-TICS (NCT06388291)
- Testing
- Deep Brain Stimulation
- Where
- United Kingdom
- Volunteers
- 18 people
- Sponsor
- University College, London