Clinical trials: Tourette Syndrome
Tourette's Syndrome
Ecopipam Treatment of Tourette's Syndrome in Subjects 7-17 Years
Tourette's Syndrome is a neurological disease characterized by motor and vocal tics. It has been hypothesized that abnormal interactions of dopamine with its receptors may cause the tics.
- Trial name
- NCT02102698
- Testing
- Ecopipam
- Where
- 11 sites in United States
- Volunteers
- 40 people
- Sponsor
- Emalex Biosciences Inc.
Tourette Syndrome
Role of Frontal Cortex in the Pathophysiology of Gilles de la Tourette Syndrome (GTS)
Tourette's syndrome (TS) is a debilitating and severe syndrome whose pathophysiology remains unclear. In order to precise the cortical regions involved in the generation of tics, investigators will realize an electroencephalogram…
- Trial name
- TIC-EEG (NCT03604510)
- Testing
- Electroencephalographic recordings
- Where
- France
- Volunteers
- 14 people
- Sponsor
- University Hospital, Bordeaux
Tics, Tourette Syndrome
CBIT+TMS R33 Phase
Chronic tics are a disabling neuropsychiatric symptom associated with multiple child-onset mental disorders. Chronic tics affect 1-3% of youth 1 and are associated with impaired functioning, emotional and behavioral problems…
- Trial name
- NCT06678737
- Testing
- CBIT +cTBS
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Minnesota
Tourette Syndrome, Tourette's Disorder
Remote Delivery of a Mindfulness-based Intervention for Tics
This research study is being done to compare a mindfulness-based intervention for tics (MBIT) to psychoeducation with relaxation and supportive therapy (PRST) for individuals with Tourette's syndrome or Persistent Tic Disorders…
- Conditions
- Tourette Syndrome, Tourette's Disorder, Chronic Motor Tic Disorder, Chronic Vocal Tic Disorder
- Trial name
- MBIT (NCT06408662)
- Testing
- mindfulness-based intervention for tics (MBIT), psychoeducation with relaxation and supportive therapy (PRST)
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Johns Hopkins University
Tourette Syndrome
Longitudinal Impact of Stressors in Adults With Tourette Syndrome
The Investigators propose a two-year, longitudinal pilot study of TS adults (>18) to determine impact of lifetime environmental stress exposure on tic severity, psychiatric comorbidity severity, and health-related quality of life…
- Trial name
- LISA-TS (NCT04851678)
- Testing
- None - observational study
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- Vanderbilt University Medical Center
Tourette Syndrome
SCI-110 in the Treatment of Tourette Syndrome
To evaluate the efficacy, safety and tolerability of the cannabinoid-based medication SCI-110 compared to placebo in subjects with Tourette syndrome.
- Trial name
- NCT05126888
- Testing
- SCI-110
- Where
- 3 sites in United States, Germany and 1 more
- Volunteers
- 164 people
- Sponsor
- Neurothera Labs Inc.
Tourette Syndrome, Tourette Syndrome in Children
Theta Burst Stimulation to Improve Inhibitory Motor Physiology in Tourette Syndrome
Decades of Tourette Syndrome (TS) neuroimaging research has revealed abnormal cortical and subcortical motor system network, hypothesized to result from maladaptive plasticity.
- Conditions
- Tourette Syndrome, Tourette Syndrome in Children, Tourette Syndrome in Adolescence, Tourette Syndrome, Modifier of
- Trial name
- NCT05628805
- Testing
- iTBS
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Dystonia, Epilepsy in Children
A Multicenter Pediatric Deep Brain Stimulation Registry
There is limited data on outcomes for children who have undergone deep brain stimulation (DBS) for movement disorders, and individual centers performing this surgery often lack sufficient cases to power research studies…
- Conditions
- Dystonia, Epilepsy in Children, Cerebral Palsy, Tourette Syndrome
- Trial name
- DBS-R (NCT06585618)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Boston Children's Hospital
Tourette Syndrome
Sensory Symptoms in Tourette Syndrome
Patients with tics will be asked to complete a series of validated questionnaires (in electronic and/or paper format) regarding symptoms and conditions often associated with Tourette syndrome, including premonitory urges, sensory…
- Trial name
- SenST (NCT03851484)
- Where
- 2 sites in United States
- Volunteers
- 214 people
- Sponsor
- Vanderbilt University Medical Center
Tourette Syndrome
Efficacy and Safety of Gemlapodect (NOE-105) in Adults and Adolescents With Tourette Syndrome
This study is designed to evaluate the efficacy and safety of gemlapodect (NOE-105) on reducing tics associated with Tourette Syndrome (TS) in adults with TS.
- Trial name
- ALLEVIA2 (NCT06315751)
- Testing
- Gemlapodect
- Where
- 46 sites in United States, Belgium and 5 more
- Volunteers
- 164 people
- Sponsor
- Noema Pharma AG
Tourette Syndrome
Observational Database on Deep Brain Stimulation in Tourette Syndrome
Within an ongoing deep brain stimulation (DBS) program for Tourette syndrome (TS) at the Department of Neurology, Pitié-Salpêtrière Hospital, Paris/France, the investigator team plans to evaluate patients pre-operatively and then…
- Trial name
- POSTSTIC (NCT04449068)
- Testing
- Neurological and neuropsychological Follow-up after deep brain stimulation, EEG recordings
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Tourette Syndrome
Characterising Sleep Disorders in Children With Tourette Syndrome
Healthy sleep is essential for a young person's growth, development, and wellbeing. It is estimated that up to 80% of young people with Tourette Syndrome experience sleep difficulties.
- Trial name
- NCT07450079
- Volunteers
- 34 people
- Sponsor
- Steffi Baker
Tourette Syndrome
Epidemiology of Assertiveness and Emotion Management Disorders in People With Tourette's Syndrome
The goal of this study is to evaluate the proportion of assertiveness difficulties in Tourette syndrome. Participants will complete several e-questionnaires (on assertiveness, Tourette severity, quality of life, self-esteem and…
- Trial name
- AFFIRMATICS (NCT06136572)
- Testing
- Rathus Assertiveness scale
- Where
- France
- Volunteers
- 350 people
- Sponsor
- University Hospital, Clermont-Ferrand
Obsessive Compulsive Disorder, Body Dysmorphic Disorder
Outcomes of Cognitive Behavioral Therapy (CBT) Interventions Provided by Unlicensed Professionals
To examine the effectiveness and clinical care outcomes of cognitive-behavioral therapy interventions at Massachusetts General Hospital (MGH).
- Conditions
- Obsessive Compulsive Disorder, Body Dysmorphic Disorder, Tourette Syndrome, Trichotillomania
- Trial name
- NCT01075672
- Testing
- Cognitive behavioral therapy (CBT)
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Massachusetts General Hospital
OCD, Tic Disorders
Objective Characterizatoion of Repetitive Behaviors
Introduction: Repetitive behaviors (RB) constitute a broad range of symptoms across different psychiatric/neurologic disorders. The most famous are stereotypies (found in autism), compulsions (found in…
- Conditions
- OCD, Tic Disorders, Gilles de la Tourette Syndrome
- Trial name
- NCT06050369
- Testing
- EEG, MRI
- Where
- 3 sites in France
- Volunteers
- 50 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Tourette's Syndrome
Effects of Lactobacillus Plantarum PS128 in Patients With Tourette's Syndrome
To evaluate whether supplementing with PS128 can improve the symptoms and quality of life related to Tourette's disease in children.
- Trial name
- NCT04805385
- Testing
- PS128
- Where
- Taiwan
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Tourette Syndrome
Thalamic Deep Brain Stimulation for the Treatment of Refractory Tourette Syndrome
This research is being performed to try to understand if the use of deep brain stimulation or DBS can treat the symptoms of Tourette syndrome that do not respond well to current medications.
- Trial name
- NCT01817517
- Testing
- Medtronic Activa Deep Brain Stimulation System
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Johns Hopkins University
Post-Acute COVID-19 Syndrome, ME/CFS
Unhide® Project: A Digital Health Platform to Collect Lifestyle Data for Brain Inflammation Research
The unhide® Project is a non-interventional, longitudinal research study designed to establish a secure data repository of demographic, health, and lifestyle information from individuals with brain inflammation and related…
- Conditions
- Post-Acute COVID-19 Syndrome, ME/CFS, Rheumatic Arthritis, Juvenile Rheumatoid Arthritis (JRA)
- Trial name
- NCT04806620
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Brain Inflammation Collaborative
Tourette Syndrome, Sensory Disorders
Neural Correlates of Sensory Phenomena in Tourette Syndrome
The most pervasive sensory manifestation of TS is sensory over-responsivity (SOR). SOR is defined as excessive behavioral response to commonplace environmental stimuli.
- Conditions
- Tourette Syndrome, Sensory Disorders, Hypersensitivity, Tics
- Trial name
- NCT03914664
- Testing
- Electroencephalogram (EEG) testing procedure, Autonomic function testing procedure
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Tourette Disorder, Sensory Gating
Sensorimotor Integration in Patients With Tourette Syndrome
The present study investigates the mechanisms underlying the sense of agency in patients with Tourette Syndrome (TS). Previous research has shown that individuals with TS display impairments in both explicit and implicit aspects…
- Trial name
- ISM (NCT07290920)
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio